Genomics Reporting Implementation Guide
3.0.0-ballot - Ballot
Genomics Reporting Implementation Guide
3.0.0-ballot - Ballot
This page is part of the Genetic Reporting Implementation Guide (v3.0.0-ballot: STU 3 Ballot 1) based on FHIR (HL7® FHIR® Standard) R4. The current version which supersedes this version is 2.0.0. For a full list of available versions, see the Directory of published versions
<Bundle xmlns="http://hl7.org/fhir">
<id value="bundle-CG-IG-HLA-FullBundle-01"/>
<type value="transaction"/>
<entry>
<fullUrl value="urn:uuid:13f34265-335c-4853-bc38-0815315edafa"/>
<resource>
<Patient>
<id value="CG-IG-HLA-FullBundle-01-1"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: Patient</b><a name="CG-IG-HLA-FullBundle-01-1"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Patient "CG-IG-HLA-FullBundle-01-1" </p></div><p><b>identifier</b>: Donor Registration Number: 12345 (use: USUAL, period: 2012-11-10 --> (ongoing))</p><p><b>name</b>: John Storm(OFFICIAL), Johnny Storm(NICKNAME), The Human Torch(NICKNAME)</p><p><b>gender</b>: male</p><p><b>birthDate</b>: 1986-12-31</p></div>
</text>
<identifier>
<use value="usual"/>
<type>
<coding>
<system value="http://terminology.hl7.org/CodeSystem/v2-0203"/>
<code value="DR"/>
</coding>
</type>
<system value="urn:oid:0.0.0.0.0.0.0"/>
<value value="12345"/>
<period>
<start value="2012-11-10"/>
</period>
<assigner>
<display value="aDonorRegistry"/>
</assigner>
</identifier>
<name>
<use value="official"/>
<text value="John Storm"/>
<family value="Storm"/>
<given value="John"/>
</name>
<name>
<use value="nickname"/>
<text value="Johnny Storm"/>
<family value="Storm"/>
<given value="Johnny"/>
</name>
<name>
<use value="nickname"/>
<text value="The Human Torch"/>
</name>
<gender value="male"/>
<birthDate value="1986-12-31"/>
</Patient>
</resource>
<request>
<method value="POST"/>
<url value="Patient"/>
</request>
</entry>
<entry>
<fullUrl value="urn:uuid:e44fbe33-6084-4ae2-a95e-8bc451c63340"/>
<resource>
<Specimen>
<id value="CG-IG-HLA-FullBundle-01-2"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: Specimen</b><a name="CG-IG-HLA-FullBundle-01-2"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Specimen "CG-IG-HLA-FullBundle-01-2" </p></div><p><b>identifier</b>: id: 123</p><p><b>accessionIdentifier</b>: id: 456</p><p><b>type</b>: Venous blood specimen <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://browser.ihtsdotools.org/">SNOMED CT</a>#122555007)</span></p><p><b>subject</b>: <a href="#Patient_CG-IG-HLA-FullBundle-01-1">See above (urn:uuid:13f34265-335c-4853-bc38-0815315edafa: John Storm)</a></p></div>
</text>
<identifier>
<system value="http://myorgsurl.com"/>
<value value="123"/>
</identifier>
<accessionIdentifier>
<system value="http://mylabsurl.com"/>
<value value="456"/>
</accessionIdentifier>
<type>
<coding>
<system value="http://snomed.info/sct"/>
<code value="122555007"/>
<display value="Venous blood specimen"/>
</coding>
</type>
<subject>
<reference value="urn:uuid:13f34265-335c-4853-bc38-0815315edafa"/>
<type value="Patient"/>
<display value="John Storm"/>
</subject>
</Specimen>
</resource>
<request>
<method value="POST"/>
<url value="Specimen"/>
</request>
</entry>
<entry>
<fullUrl value="urn:uuid:9243cc20-27bd-4f87-ba90-0328ed474950"/>
<resource>
<Organization>
<id value="CG-IG-HLA-FullBundle-01-3"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: Organization</b><a name="CG-IG-HLA-FullBundle-01-3"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Organization "CG-IG-HLA-FullBundle-01-3" </p></div><p><b>name</b>: aTypingLab Inc</p><p><b>alias</b>: aTL</p><p><b>telecom</b>: ph: 1-800-555-1234(WORK)</p><p><b>address</b>: 123 Main St, Sometown, ND 99999(WORK)</p></div>
</text>
<name value="aTypingLab Inc"/>
<alias value="aTL"/>
<telecom>
<system value="phone"/>
<value value="1-800-555-1234"/>
<use value="work"/>
<rank value="1"/>
</telecom>
<address>
<use value="work"/>
<type value="both"/>
<text value="123 Main St, Sometown, ND 99999"/>
<line value="123 Main St"/>
<city value="Sometown"/>
<state value="ND"/>
<postalCode value="99999"/>
<country value="USA"/>
</address>
</Organization>
</resource>
<request>
<method value="POST"/>
<url value="Organization"/>
</request>
</entry>
<entry>
<fullUrl value="urn:uuid:00ef18ad-ed04-4b2c-81ee-b69bb243f0d5"/>
<resource>
<Organization>
<id value="CG-IG-HLA-FullBundle-01-4"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: Organization</b><a name="CG-IG-HLA-FullBundle-01-4"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Organization "CG-IG-HLA-FullBundle-01-4" </p></div><p><b>name</b>: aDonorRegistry</p><p><b>alias</b>: ADR</p><p><b>telecom</b>: ph: 1-800-555-6789(WORK)</p><p><b>address</b>: 456 Main St, Anytown ND, 00000(WORK)</p></div>
</text>
<name value="aDonorRegistry"/>
<alias value="ADR"/>
<telecom>
<system value="phone"/>
<value value="1-800-555-6789"/>
<use value="work"/>
<rank value="1"/>
</telecom>
<address>
<use value="work"/>
<type value="both"/>
<text value="456 Main St, Anytown ND, 00000"/>
<line value="456 Main St"/>
<city value="Anytown"/>
<state value="ND"/>
<postalCode value="00000"/>
<country value="USA"/>
</address>
</Organization>
</resource>
<request>
<method value="POST"/>
<url value="Organization"/>
</request>
</entry>
<entry>
<fullUrl value="urn:uuid:99309303-045e-4cf4-90d7-250d7a7476ea"/>
<resource>
<ServiceRequest>
<id value="CG-IG-HLA-FullBundle-01-5"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: ServiceRequest</b><a name="CG-IG-HLA-FullBundle-01-5"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource ServiceRequest "CG-IG-HLA-FullBundle-01-5" </p></div><p><b>status</b>: completed</p><p><b>intent</b>: order</p><p><b>code</b>: HLA-A+B+C (class I) [Type] <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#13303-3)</span></p><p><b>subject</b>: <a href="#Patient_CG-IG-HLA-FullBundle-01-1">See above (urn:uuid:13f34265-335c-4853-bc38-0815315edafa: John Storm)</a></p><p><b>authoredOn</b>: 2016-11-15</p><p><b>requester</b>: <a href="#Organization_CG-IG-HLA-FullBundle-01-4">See above (urn:uuid:00ef18ad-ed04-4b2c-81ee-b69bb243f0d5: aDonorRegistry)</a></p><p><b>performer</b>: <a href="#Organization_CG-IG-HLA-FullBundle-01-3">See above (urn:uuid:9243cc20-27bd-4f87-ba90-0328ed474950: aTypingLab, Inc)</a></p><p><b>reasonCode</b>: tissue typing for donor registry <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></p></div>
</text>
<status value="completed"/>
<intent value="order"/>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="13303-3"/>
<display value="HLA-A+B+C (class I) [Type]"/>
</coding>
</code>
<subject>
<reference value="urn:uuid:13f34265-335c-4853-bc38-0815315edafa"/>
<type value="Patient"/>
<display value="John Storm"/>
</subject>
<authoredOn value="2016-11-15"/>
<requester>
<reference value="urn:uuid:00ef18ad-ed04-4b2c-81ee-b69bb243f0d5"/>
<type value="Organization"/>
<display value="aDonorRegistry"/>
</requester>
<performer>
<reference value="urn:uuid:9243cc20-27bd-4f87-ba90-0328ed474950"/>
<type value="Organization"/>
<display value="aTypingLab, Inc"/>
</performer>
<reasonCode>
<text value="tissue typing for donor registry"/>
</reasonCode>
</ServiceRequest>
</resource>
<request>
<method value="POST"/>
<url value="ServiceRequest"/>
</request>
</entry>
<entry>
<fullUrl value="urn:uuid:8200dab6-18a2-4550-b913-a7db480c0804"/>
<resource>
<MolecularSequence>
<id value="CG-IG-HLA-FullBundle-01-6"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: MolecularSequence</b><a name="CG-IG-HLA-FullBundle-01-6"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource MolecularSequence "CG-IG-HLA-FullBundle-01-6" </p></div><p><b>type</b>: dna</p><p><b>coordinateSystem</b>: 0</p><h3>ReferenceSeqs</h3><table class="grid"><tr><td style="display: none">-</td><td><b>ReferenceSeqId</b></td><td><b>WindowStart</b></td><td><b>WindowEnd</b></td></tr><tr><td style="display: none">*</td><td>HLA-A*01:01:01:01 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (hla[3.23]#HLA00001)</span></td><td>503</td><td>773</td></tr></table><p><b>observedSeq</b>: GCTCCCACTCCATGAGGTATTTCTTCACATCCGTGTCCCGGCCCGGCCGCGGGGAGCCCCGCTTCATCGCCGTGGGCTACGTGGACGACACGCAGTTCGTGCGGTTCGACAGCGACGCCGCGAGCCAGAAGATGGAGCCGCGGGCGCCGTGGATAGAGCAGGAGGGGCCGGAGTATTGGGACCAGGAGACACGGAATATGAAGGCCCACTCACAGACTGACCGAGCGAACCTGGGGACCCTGCGCGGCTACTACAACCAGAGCGAGGACG</p></div>
</text>
<type value="dna"/>
<coordinateSystem value="0"/>
<referenceSeq>
<referenceSeqId>
<coding>
<system value="http://www.ebi.ac.uk/ipd/imgt/hla"/>
<version value="3.23"/>
<code value="HLA00001"/>
</coding>
<text value="HLA-A*01:01:01:01"/>
</referenceSeqId>
<windowStart value="503"/>
<windowEnd value="773"/>
</referenceSeq>
<observedSeq
value="GCTCCCACTCCATGAGGTATTTCTTCACATCCGTGTCCCGGCCCGGCCGCGGGGAGCCCCGCTTCATCGCCGTGGGCTACGTGGACGACACGCAGTTCGTGCGGTTCGACAGCGACGCCGCGAGCCAGAAGATGGAGCCGCGGGCGCCGTGGATAGAGCAGGAGGGGCCGGAGTATTGGGACCAGGAGACACGGAATATGAAGGCCCACTCACAGACTGACCGAGCGAACCTGGGGACCCTGCGCGGCTACTACAACCAGAGCGAGGACG"/>
</MolecularSequence>
</resource>
<request>
<method value="POST"/>
<url value="MolecularSequence"/>
</request>
</entry>
<entry>
<fullUrl value="urn:uuid:7c393185-f15c-45bc-a714-c0fdbea32675"/>
<resource>
<MolecularSequence>
<id value="CG-IG-HLA-FullBundle-01-7"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: MolecularSequence</b><a name="CG-IG-HLA-FullBundle-01-7"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource MolecularSequence "CG-IG-HLA-FullBundle-01-7" </p></div><p><b>type</b>: dna</p><p><b>coordinateSystem</b>: 0</p><h3>ReferenceSeqs</h3><table class="grid"><tr><td style="display: none">-</td><td><b>ReferenceSeqId</b></td><td><b>WindowStart</b></td><td><b>WindowEnd</b></td></tr><tr><td style="display: none">*</td><td>HLA-A*01:01:01:01 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (hla[3.23]#HLA00001)</span></td><td>1014</td><td>1290</td></tr></table><p><b>observedSeq</b>: GTTCTCACACCATCCAGATAATGTATGGCTGCGACGTGGGGCCGGACGGGCGCTTCCTCCGCGGGTACCGGCAGGACGCCTACGACGGCAAGGATTACATCGCCCTGAACGAGGACCTGCGCTCTTGGACCGCGGCGGACATGGCAGCTCAGATCACCAAGCGCAAGTGGGAGGCGGTCCATGCGGCGGAGCAGCGGAGAGTCTACCTGGAGGGCCGGTGCGTGGACGGGCTCCGCAGATACCTGGAGAACGGGAAGGAGACGCTGCAGCGCACGG</p></div>
</text>
<type value="dna"/>
<coordinateSystem value="0"/>
<referenceSeq>
<referenceSeqId>
<coding>
<system value="http://www.ebi.ac.uk/ipd/imgt/hla"/>
<version value="3.23"/>
<code value="HLA00001"/>
</coding>
<text value="HLA-A*01:01:01:01"/>
</referenceSeqId>
<windowStart value="1014"/>
<windowEnd value="1290"/>
</referenceSeq>
<observedSeq
value="GTTCTCACACCATCCAGATAATGTATGGCTGCGACGTGGGGCCGGACGGGCGCTTCCTCCGCGGGTACCGGCAGGACGCCTACGACGGCAAGGATTACATCGCCCTGAACGAGGACCTGCGCTCTTGGACCGCGGCGGACATGGCAGCTCAGATCACCAAGCGCAAGTGGGAGGCGGTCCATGCGGCGGAGCAGCGGAGAGTCTACCTGGAGGGCCGGTGCGTGGACGGGCTCCGCAGATACCTGGAGAACGGGAAGGAGACGCTGCAGCGCACGG"/>
</MolecularSequence>
</resource>
<request>
<method value="POST"/>
<url value="MolecularSequence"/>
</request>
</entry>
<entry>
<fullUrl value="urn:uuid:65c85f14-c3a0-4b72-818f-820e04fcc621"/>
<resource>
<MolecularSequence>
<id value="CG-IG-HLA-FullBundle-01-8"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: MolecularSequence</b><a name="CG-IG-HLA-FullBundle-01-8"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource MolecularSequence "CG-IG-HLA-FullBundle-01-8" </p></div><p><b>type</b>: dna</p><p><b>coordinateSystem</b>: 0</p><h3>ReferenceSeqs</h3><table class="grid"><tr><td style="display: none">-</td><td><b>ReferenceSeqId</b></td><td><b>WindowStart</b></td><td><b>WindowEnd</b></td></tr><tr><td style="display: none">*</td><td>HLA-A*01:02 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (hla[3.23]#HLA00002)</span></td><td>503</td><td>773</td></tr></table><p><b>observedSeq</b>: GCTCCCACTCCATGAGGTATTTCTCCACATCCGTGTCCCGGCCCGGCAGTGGAGAGCCCCGCTTCATCGCAGTGGGCTACGTGGACGACACGCAGTTCGTGCGGTTCGACAGCGACGCCGCGAGCCAGAAGATGGAGCCGCGGGCGCCGTGGATAGAGCAGGAGGGGCCGGAGTATTGGGACCAGGAGACACGGAATATGAAGGCCCACTCACAGACTGACCGAGCGAACCTGGGGACCCTGCGCGGCTACTACAACCAGAGCGAGGACG</p></div>
</text>
<type value="dna"/>
<coordinateSystem value="0"/>
<referenceSeq>
<referenceSeqId>
<coding>
<system value="http://www.ebi.ac.uk/ipd/imgt/hla"/>
<version value="3.23"/>
<code value="HLA00002"/>
</coding>
<text value="HLA-A*01:02"/>
</referenceSeqId>
<windowStart value="503"/>
<windowEnd value="773"/>
</referenceSeq>
<observedSeq
value="GCTCCCACTCCATGAGGTATTTCTCCACATCCGTGTCCCGGCCCGGCAGTGGAGAGCCCCGCTTCATCGCAGTGGGCTACGTGGACGACACGCAGTTCGTGCGGTTCGACAGCGACGCCGCGAGCCAGAAGATGGAGCCGCGGGCGCCGTGGATAGAGCAGGAGGGGCCGGAGTATTGGGACCAGGAGACACGGAATATGAAGGCCCACTCACAGACTGACCGAGCGAACCTGGGGACCCTGCGCGGCTACTACAACCAGAGCGAGGACG"/>
</MolecularSequence>
</resource>
<request>
<method value="POST"/>
<url value="MolecularSequence"/>
</request>
</entry>
<entry>
<fullUrl value="urn:uuid:fbba9fe7-0ece-4ec1-9233-a437a8d242a0"/>
<resource>
<MolecularSequence>
<id value="CG-IG-HLA-FullBundle-01-9"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: MolecularSequence</b><a name="CG-IG-HLA-FullBundle-01-9"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource MolecularSequence "CG-IG-HLA-FullBundle-01-9" </p></div><p><b>type</b>: dna</p><p><b>coordinateSystem</b>: 0</p><h3>ReferenceSeqs</h3><table class="grid"><tr><td style="display: none">-</td><td><b>ReferenceSeqId</b></td><td><b>WindowStart</b></td><td><b>WindowEnd</b></td></tr><tr><td style="display: none">*</td><td>HLA-A*01:02 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (hla[3.23]#HLA00002)</span></td><td>1014</td><td>1290</td></tr></table><p><b>observedSeq</b>: GTTCTCACACCATCCAGATAATGTATGGCTGCGACGTGGGGCCGGACGGGCGCTTCCTCCGCGGGTACCGGCAGGACGCCTACGACGGCAAGGATTACATCGCCCTGAACGAGGACCTGCGCTCTTGGACCGCGGCGGACATGGCAGCTCAGATCACCAAGCGCAAGTGGGAGGCGGTCCATGCGGCGGAGCAGCGGAGAGTCTACCTGGAGGGCCGGTGCGTGGACGGGCTCCGCAGATACCTGGAGAACGGGAAGGAGACGCTGCAGCGCACGG</p></div>
</text>
<type value="dna"/>
<coordinateSystem value="0"/>
<referenceSeq>
<referenceSeqId>
<coding>
<system value="http://www.ebi.ac.uk/ipd/imgt/hla"/>
<version value="3.23"/>
<code value="HLA00002"/>
</coding>
<text value="HLA-A*01:02"/>
</referenceSeqId>
<windowStart value="1014"/>
<windowEnd value="1290"/>
</referenceSeq>
<observedSeq
value="GTTCTCACACCATCCAGATAATGTATGGCTGCGACGTGGGGCCGGACGGGCGCTTCCTCCGCGGGTACCGGCAGGACGCCTACGACGGCAAGGATTACATCGCCCTGAACGAGGACCTGCGCTCTTGGACCGCGGCGGACATGGCAGCTCAGATCACCAAGCGCAAGTGGGAGGCGGTCCATGCGGCGGAGCAGCGGAGAGTCTACCTGGAGGGCCGGTGCGTGGACGGGCTCCGCAGATACCTGGAGAACGGGAAGGAGACGCTGCAGCGCACGG"/>
</MolecularSequence>
</resource>
<request>
<method value="POST"/>
<url value="MolecularSequence"/>
</request>
</entry>
<entry>
<fullUrl value="urn:uuid:b7765bbf-df40-486a-9f2f-404309643de6"/>
<resource>
<Observation>
<id value="CG-IG-HLA-FullBundle-01-10"/>
<meta>
<profile
value="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/haplotype"/>
</meta>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: Observation</b><a name="CG-IG-HLA-FullBundle-01-10"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "CG-IG-HLA-FullBundle-01-10" </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-haplotype.html">Haplotype</a></p></div><p><b>status</b>: final</p><p><b>category</b>: Laboratory <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-observation-category.html">Observation Category Codes</a>#laboratory)</span>, Genetics <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-v2-0074.html">diagnosticServiceSectionId</a>#GE)</span></p><p><b>code</b>: Haplotype name <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#84414-2)</span></p><p><b>subject</b>: <a href="#Patient_CG-IG-HLA-FullBundle-01-1">See above (urn:uuid:13f34265-335c-4853-bc38-0815315edafa: John Storm)</a></p><p><b>effective</b>: 2016-12-15</p><p><b>performer</b>: <a href="#Organization_CG-IG-HLA-FullBundle-01-3">See above (urn:uuid:9243cc20-27bd-4f87-ba90-0328ed474950: aTypingLab, Inc)</a></p><p><b>value</b>: HLA-A*01:01:01G <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (hla[3.23]#HLA-A*01:01:01G)</span></p><p><b>method</b>: NGS based Class I HLA-A, -B, -C genotyping <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (gtr#GTR000000000.0)</span></p><p><b>specimen</b>: <a href="#Specimen_CG-IG-HLA-FullBundle-01-2">See above (urn:uuid:e44fbe33-6084-4ae2-a95e-8bc451c63340: buccal swab from John Storm)</a></p><p><b>derivedFrom</b>: </p><ul><li><a href="#MolecularSequence_CG-IG-HLA-FullBundle-01-6">See above (urn:uuid:8200dab6-18a2-4550-b913-a7db480c0804: HLA-A*01:01:01:01, exon 2)</a></li><li><a href="#MolecularSequence_CG-IG-HLA-FullBundle-01-7">See above (urn:uuid:7c393185-f15c-45bc-a714-c0fdbea32675: HLA-A*01:01:01:01, exon 3)</a></li></ul><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td>Gene studied [ID] <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#48018-6)</span></td><td>HLA-A <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-v3-hgnc.html">HUGO Gene Nomenclature Committee Genes</a>#HGNC:4931)</span></td></tr></table></div>
</text>
<status value="final"/>
<category>
<coding>
<system
value="http://terminology.hl7.org/CodeSystem/observation-category"/>
<code value="laboratory"/>
</coding>
</category>
<category>
<coding>
<system value="http://terminology.hl7.org/CodeSystem/v2-0074"/>
<code value="GE"/>
</coding>
</category>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="84414-2"/>
<display value="Haplotype name"/>
</coding>
</code>
<subject>
<reference value="urn:uuid:13f34265-335c-4853-bc38-0815315edafa"/>
<type value="Patient"/>
<display value="John Storm"/>
</subject>
<effectiveDateTime value="2016-12-15"/>
<performer>
<reference value="urn:uuid:9243cc20-27bd-4f87-ba90-0328ed474950"/>
<display value="aTypingLab, Inc"/>
</performer>
<valueCodeableConcept>
<coding>
<system value="http://www.ebi.ac.uk/ipd/imgt/hla"/>
<version value="3.23"/>
<code value="HLA-A*01:01:01G"/>
<display value="HLA-A*01:01:01G"/>
</coding>
</valueCodeableConcept>
<method>
<coding>
<system value="http://www.ncbi.nlm.nih.gov/gtr"/>
<code value="GTR000000000.0"/>
</coding>
<text value="NGS based Class I HLA-A, -B, -C genotyping"/>
</method>
<specimen>
<reference value="urn:uuid:e44fbe33-6084-4ae2-a95e-8bc451c63340"/>
<display value="buccal swab from John Storm"/>
</specimen>
<derivedFrom>
<reference value="urn:uuid:8200dab6-18a2-4550-b913-a7db480c0804"/>
<type value="MolecularSequence"/>
<display value="HLA-A*01:01:01:01, exon 2"/>
</derivedFrom>
<derivedFrom>
<reference value="urn:uuid:7c393185-f15c-45bc-a714-c0fdbea32675"/>
<type value="MolecularSequence"/>
<display value="HLA-A*01:01:01:01, exon 3"/>
</derivedFrom>
<component>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="48018-6"/>
<display value="Gene studied [ID]"/>
</coding>
</code>
<valueCodeableConcept>
<coding>
<system value="http://www.genenames.org"/>
<code value="HGNC:4931"/>
<display value="HLA-A"/>
</coding>
</valueCodeableConcept>
</component>
</Observation>
</resource>
<request>
<method value="POST"/>
<url value="Observation"/>
</request>
</entry>
<entry>
<fullUrl value="urn:uuid:d98d92a7-0e86-4ae5-b036-b7e1bba6ec32"/>
<resource>
<Observation>
<id value="CG-IG-HLA-FullBundle-01-11"/>
<meta>
<profile
value="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/haplotype"/>
</meta>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: Observation</b><a name="CG-IG-HLA-FullBundle-01-11"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "CG-IG-HLA-FullBundle-01-11" </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-haplotype.html">Haplotype</a></p></div><p><b>status</b>: final</p><p><b>category</b>: Laboratory <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-observation-category.html">Observation Category Codes</a>#laboratory)</span>, Genetics <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-v2-0074.html">diagnosticServiceSectionId</a>#GE)</span></p><p><b>code</b>: Haplotype name <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#84414-2)</span></p><p><b>subject</b>: <a href="#Patient_CG-IG-HLA-FullBundle-01-1">See above (urn:uuid:13f34265-335c-4853-bc38-0815315edafa: John Storm)</a></p><p><b>effective</b>: 2016-12-15</p><p><b>performer</b>: <a href="#Organization_CG-IG-HLA-FullBundle-01-3">See above (urn:uuid:9243cc20-27bd-4f87-ba90-0328ed474950: aTypingLab, Inc)</a></p><p><b>value</b>: HLA-A*01:02 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (hla[3.23]#HLA-A*01:02)</span></p><p><b>method</b>: NGS based Class I HLA-A, -B, -C genotyping <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (gtr#GTR000000000.0)</span></p><p><b>specimen</b>: <a href="#Specimen_CG-IG-HLA-FullBundle-01-2">See above (urn:uuid:e44fbe33-6084-4ae2-a95e-8bc451c63340: buccal swab from John Storm)</a></p><p><b>derivedFrom</b>: </p><ul><li><a href="#MolecularSequence_CG-IG-HLA-FullBundle-01-8">See above (urn:uuid:65c85f14-c3a0-4b72-818f-820e04fcc621: HLA-A*01:02, exon 2)</a></li><li><a href="#MolecularSequence_CG-IG-HLA-FullBundle-01-9">See above (urn:uuid:fbba9fe7-0ece-4ec1-9233-a437a8d242a0: HLA-A*01:02, exon 3)</a></li></ul><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td>Gene studied [ID] <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#48018-6)</span></td><td>HLA-A <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-v3-hgnc.html">HUGO Gene Nomenclature Committee Genes</a>#HGNC:4931)</span></td></tr></table></div>
</text>
<status value="final"/>
<category>
<coding>
<system
value="http://terminology.hl7.org/CodeSystem/observation-category"/>
<code value="laboratory"/>
</coding>
</category>
<category>
<coding>
<system value="http://terminology.hl7.org/CodeSystem/v2-0074"/>
<code value="GE"/>
</coding>
</category>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="84414-2"/>
<display value="Haplotype name"/>
</coding>
</code>
<subject>
<reference value="urn:uuid:13f34265-335c-4853-bc38-0815315edafa"/>
<type value="Patient"/>
<display value="John Storm"/>
</subject>
<effectiveDateTime value="2016-12-15"/>
<performer>
<reference value="urn:uuid:9243cc20-27bd-4f87-ba90-0328ed474950"/>
<display value="aTypingLab, Inc"/>
</performer>
<valueCodeableConcept>
<coding>
<system value="http://www.ebi.ac.uk/ipd/imgt/hla"/>
<version value="3.23"/>
<code value="HLA-A*01:02"/>
<display value="HLA-A*01:02"/>
</coding>
</valueCodeableConcept>
<method>
<coding>
<system value="http://www.ncbi.nlm.nih.gov/gtr"/>
<code value="GTR000000000.0"/>
</coding>
<text value="NGS based Class I HLA-A, -B, -C genotyping"/>
</method>
<specimen>
<reference value="urn:uuid:e44fbe33-6084-4ae2-a95e-8bc451c63340"/>
<display value="buccal swab from John Storm"/>
</specimen>
<derivedFrom>
<reference value="urn:uuid:65c85f14-c3a0-4b72-818f-820e04fcc621"/>
<type value="MolecularSequence"/>
<display value="HLA-A*01:02, exon 2"/>
</derivedFrom>
<derivedFrom>
<reference value="urn:uuid:fbba9fe7-0ece-4ec1-9233-a437a8d242a0"/>
<type value="MolecularSequence"/>
<display value="HLA-A*01:02, exon 3"/>
</derivedFrom>
<component>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="48018-6"/>
<display value="Gene studied [ID]"/>
</coding>
</code>
<valueCodeableConcept>
<coding>
<system value="http://www.genenames.org"/>
<code value="HGNC:4931"/>
<display value="HLA-A"/>
</coding>
</valueCodeableConcept>
</component>
</Observation>
</resource>
<request>
<method value="POST"/>
<url value="Observation"/>
</request>
</entry>
<entry>
<fullUrl value="urn:uuid:49a86246-4004-42eb-9bdc-f542f93f9228"/>
<resource>
<Observation>
<id value="CG-IG-HLA-FullBundle-01-12"/>
<meta>
<profile
value="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genotype"/>
</meta>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: Observation</b><a name="CG-IG-HLA-FullBundle-01-12"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "CG-IG-HLA-FullBundle-01-12" </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-genotype.html">Genotype</a></p></div><p><b>basedOn</b>: <a href="#ServiceRequest_CG-IG-HLA-FullBundle-01-5">See above (urn:uuid:99309303-045e-4cf4-90d7-250d7a7476ea: Class I HLA genotyping for John Storm)</a></p><p><b>status</b>: final</p><p><b>category</b>: Laboratory <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-observation-category.html">Observation Category Codes</a>#laboratory)</span>, Genetics <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-v2-0074.html">diagnosticServiceSectionId</a>#GE)</span></p><p><b>code</b>: Genotype display name <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#84413-4)</span></p><p><b>subject</b>: <a href="#Patient_CG-IG-HLA-FullBundle-01-1">See above (urn:uuid:13f34265-335c-4853-bc38-0815315edafa: John Storm)</a></p><p><b>effective</b>: 2016-12-15</p><p><b>performer</b>: <a href="#Organization_CG-IG-HLA-FullBundle-01-3">See above (urn:uuid:9243cc20-27bd-4f87-ba90-0328ed474950: aTypingLab, Inc)</a></p><p><b>value</b>: hla#3.23.0#HLA-A:01:01G+HLA-A*01:02 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (glstring.org[1.0]#hla#3.23.0#HLA-A:01:01G+HLA-A*01:02)</span></p><p><b>method</b>: NGS based Class I HLA-A, -B, -C genotyping <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (gtr#GTR000000000.0)</span></p><p><b>specimen</b>: <a href="#Specimen_CG-IG-HLA-FullBundle-01-2">See above (urn:uuid:e44fbe33-6084-4ae2-a95e-8bc451c63340: buccal swab from John Storm)</a></p><p><b>derivedFrom</b>: </p><ul><li><a href="#Observation_CG-IG-HLA-FullBundle-01-10">See above (urn:uuid:b7765bbf-df40-486a-9f2f-404309643de6: HLA-A*01:01:01G, exons 2 and 3)</a></li><li><a href="#Observation_CG-IG-HLA-FullBundle-01-11">See above (urn:uuid:d98d92a7-0e86-4ae5-b036-b7e1bba6ec32: HLA-A*01:02, exons 2 and 3)</a></li></ul><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td>Gene studied [ID] <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#48018-6)</span></td><td>HLA-A <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-v3-hgnc.html">HUGO Gene Nomenclature Committee Genes</a>#HGNC:4931)</span></td></tr></table></div>
</text>
<basedOn>
<reference value="urn:uuid:99309303-045e-4cf4-90d7-250d7a7476ea"/>
<type value="ServiceRequest"/>
<display value="Class I HLA genotyping for John Storm"/>
</basedOn>
<status value="final"/>
<category>
<coding>
<system
value="http://terminology.hl7.org/CodeSystem/observation-category"/>
<code value="laboratory"/>
</coding>
</category>
<category>
<coding>
<system value="http://terminology.hl7.org/CodeSystem/v2-0074"/>
<code value="GE"/>
</coding>
</category>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="84413-4"/>
<display value="Genotype display name"/>
</coding>
</code>
<subject>
<reference value="urn:uuid:13f34265-335c-4853-bc38-0815315edafa"/>
<type value="Patient"/>
<display value="John Storm"/>
</subject>
<effectiveDateTime value="2016-12-15"/>
<performer>
<reference value="urn:uuid:9243cc20-27bd-4f87-ba90-0328ed474950"/>
<display value="aTypingLab, Inc"/>
</performer>
<valueCodeableConcept>
<coding>
<system value="http://glstring.org"/>
<version value="1.0"/>
<code value="hla#3.23.0#HLA-A:01:01G+HLA-A*01:02"/>
</coding>
</valueCodeableConcept>
<method>
<coding>
<system value="http://www.ncbi.nlm.nih.gov/gtr"/>
<code value="GTR000000000.0"/>
</coding>
<text value="NGS based Class I HLA-A, -B, -C genotyping"/>
</method>
<specimen>
<reference value="urn:uuid:e44fbe33-6084-4ae2-a95e-8bc451c63340"/>
<display value="buccal swab from John Storm"/>
</specimen>
<derivedFrom>
<reference value="urn:uuid:b7765bbf-df40-486a-9f2f-404309643de6"/>
<type value="Observation"/>
<display value="HLA-A*01:01:01G, exons 2 and 3"/>
</derivedFrom>
<derivedFrom>
<reference value="urn:uuid:d98d92a7-0e86-4ae5-b036-b7e1bba6ec32"/>
<type value="Observation"/>
<display value="HLA-A*01:02, exons 2 and 3"/>
</derivedFrom>
<component>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="48018-6"/>
<display value="Gene studied [ID]"/>
</coding>
</code>
<valueCodeableConcept>
<coding>
<system value="http://www.genenames.org"/>
<code value="HGNC:4931"/>
<display value="HLA-A"/>
</coding>
</valueCodeableConcept>
</component>
</Observation>
</resource>
<request>
<method value="POST"/>
<url value="Observation"/>
</request>
</entry>
<entry>
<fullUrl value="urn:uuid:cbabf93e-1b4b-46f2-ba1e-d84862670670"/>
<resource>
<MolecularSequence>
<id value="CG-IG-HLA-FullBundle-01-13"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: MolecularSequence</b><a name="CG-IG-HLA-FullBundle-01-13"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource MolecularSequence "CG-IG-HLA-FullBundle-01-13" </p></div><p><b>type</b>: dna</p><p><b>coordinateSystem</b>: 0</p><h3>ReferenceSeqs</h3><table class="grid"><tr><td style="display: none">-</td><td><b>ReferenceSeqId</b></td><td><b>WindowStart</b></td><td><b>WindowEnd</b></td></tr><tr><td style="display: none">*</td><td>HLA-B*15:01:01:01 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (hla[3.23]#HLA00162)</span></td><td>486</td><td>756</td></tr></table><p><b>observedSeq</b>: GCTCCCACTCCATGAGGTATTTCTACACCGCCATGTCCCGGCCCGGCCGCGGGGAGCCCCGCTTCATCGCAGTGGGCTACGTGGACGACACCCAGTTCGTGAGGTTCGACAGCGACGCCGCGAGTCCGAGGATGGCGCCCCGGGCGCCATGGATAGAGCAGGAGGGGCCGGAGTATTGGGACCGGGAGACACAGATCTCCAAGACCAACACACAGACTTACCGAGAGAGCCTGCGGAACCTGCGCGGCTACTACAACCAGAGCGAGGCCG</p></div>
</text>
<type value="dna"/>
<coordinateSystem value="0"/>
<referenceSeq>
<referenceSeqId>
<coding>
<system value="http://www.ebi.ac.uk/ipd/imgt/hla"/>
<version value="3.23"/>
<code value="HLA00162"/>
</coding>
<text value="HLA-B*15:01:01:01"/>
</referenceSeqId>
<windowStart value="486"/>
<windowEnd value="756"/>
</referenceSeq>
<observedSeq
value="GCTCCCACTCCATGAGGTATTTCTACACCGCCATGTCCCGGCCCGGCCGCGGGGAGCCCCGCTTCATCGCAGTGGGCTACGTGGACGACACCCAGTTCGTGAGGTTCGACAGCGACGCCGCGAGTCCGAGGATGGCGCCCCGGGCGCCATGGATAGAGCAGGAGGGGCCGGAGTATTGGGACCGGGAGACACAGATCTCCAAGACCAACACACAGACTTACCGAGAGAGCCTGCGGAACCTGCGCGGCTACTACAACCAGAGCGAGGCCG"/>
</MolecularSequence>
</resource>
<request>
<method value="POST"/>
<url value="MolecularSequence"/>
</request>
</entry>
<entry>
<fullUrl value="urn:uuid:c233ad3d-1572-48d6-93da-0a583535e138"/>
<resource>
<MolecularSequence>
<id value="CG-IG-HLA-FullBundle-01-14"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: MolecularSequence</b><a name="CG-IG-HLA-FullBundle-01-14"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource MolecularSequence "CG-IG-HLA-FullBundle-01-14" </p></div><p><b>type</b>: dna</p><p><b>coordinateSystem</b>: 0</p><h3>ReferenceSeqs</h3><table class="grid"><tr><td style="display: none">-</td><td><b>ReferenceSeqId</b></td><td><b>WindowStart</b></td><td><b>WindowEnd</b></td></tr><tr><td style="display: none">*</td><td>HLA-B*15:01:01:01 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (hla[3.23]#HLA00162)</span></td><td>1001</td><td>1277</td></tr></table><p><b>observedSeq</b>: GGTCTCACACCCTCCAGAGGATGTACGGCTGCGACGTGGGGCCGGACGGGCGCCTCCTCCGCGGGCATGACCAGTCCGCCTACGACGGCAAGGATTACATCGCCCTGAACGAGGACCTGAGCTCCTGGACCGCGGCGGACACGGCGGCTCAGATCACCCAGCGCAAGTGGGAGGCGGCCCGTGAGGCGGAGCAGTGGAGAGCCTACCTGGAGGGCCTGTGCGTGGAGTGGCTCCGCAGATACCTGGAGAACGGGAAGGAGACGCTGCAGCGCGCGG</p></div>
</text>
<type value="dna"/>
<coordinateSystem value="0"/>
<referenceSeq>
<referenceSeqId>
<coding>
<system value="http://www.ebi.ac.uk/ipd/imgt/hla"/>
<version value="3.23"/>
<code value="HLA00162"/>
</coding>
<text value="HLA-B*15:01:01:01"/>
</referenceSeqId>
<windowStart value="1001"/>
<windowEnd value="1277"/>
</referenceSeq>
<observedSeq
value="GGTCTCACACCCTCCAGAGGATGTACGGCTGCGACGTGGGGCCGGACGGGCGCCTCCTCCGCGGGCATGACCAGTCCGCCTACGACGGCAAGGATTACATCGCCCTGAACGAGGACCTGAGCTCCTGGACCGCGGCGGACACGGCGGCTCAGATCACCCAGCGCAAGTGGGAGGCGGCCCGTGAGGCGGAGCAGTGGAGAGCCTACCTGGAGGGCCTGTGCGTGGAGTGGCTCCGCAGATACCTGGAGAACGGGAAGGAGACGCTGCAGCGCGCGG"/>
</MolecularSequence>
</resource>
<request>
<method value="POST"/>
<url value="MolecularSequence"/>
</request>
</entry>
<entry>
<fullUrl value="urn:uuid:05fa52d7-5c67-460a-8722-d3460b24d6fe"/>
<resource>
<MolecularSequence>
<id value="CG-IG-HLA-FullBundle-01-15"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: MolecularSequence</b><a name="CG-IG-HLA-FullBundle-01-15"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource MolecularSequence "CG-IG-HLA-FullBundle-01-15" </p></div><p><b>type</b>: dna</p><p><b>coordinateSystem</b>: 0</p><h3>ReferenceSeqs</h3><table class="grid"><tr><td style="display: none">-</td><td><b>ReferenceSeqId</b></td><td><b>WindowStart</b></td><td><b>WindowEnd</b></td></tr><tr><td style="display: none">*</td><td>HLA-B*57:01:01 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (hla[3.23]#HLA00381)</span></td><td>485</td><td>755</td></tr></table><p><b>observedSeq</b>: GCTCCCACTCCATGAGGTATTTCTACACCGCCATGTCCCGGCCCGGCCGCGGGGAGCCCCGCTTCATCGCAGTGGGCTACGTGGACGACACCCAGTTCGTGAGGTTCGACAGCGACGCCGCGAGTCCGAGGATGGCGCCCCGGGCGCCATGGATAGAGCAGGAGGGGCCGGAGTATTGGGACGGGGAGACACGGAACATGAAGGCCTCCGCGCAGACTTACCGAGAGAACCTGCGGATCGCGCTCCGCTACTACAACCAGAGCGAGGCCG</p></div>
</text>
<type value="dna"/>
<coordinateSystem value="0"/>
<referenceSeq>
<referenceSeqId>
<coding>
<system value="http://www.ebi.ac.uk/ipd/imgt/hla"/>
<version value="3.23"/>
<code value="HLA00381"/>
</coding>
<text value="HLA-B*57:01:01"/>
</referenceSeqId>
<windowStart value="485"/>
<windowEnd value="755"/>
</referenceSeq>
<observedSeq
value="GCTCCCACTCCATGAGGTATTTCTACACCGCCATGTCCCGGCCCGGCCGCGGGGAGCCCCGCTTCATCGCAGTGGGCTACGTGGACGACACCCAGTTCGTGAGGTTCGACAGCGACGCCGCGAGTCCGAGGATGGCGCCCCGGGCGCCATGGATAGAGCAGGAGGGGCCGGAGTATTGGGACGGGGAGACACGGAACATGAAGGCCTCCGCGCAGACTTACCGAGAGAACCTGCGGATCGCGCTCCGCTACTACAACCAGAGCGAGGCCG"/>
</MolecularSequence>
</resource>
<request>
<method value="POST"/>
<url value="MolecularSequence"/>
</request>
</entry>
<entry>
<fullUrl value="urn:uuid:db69e549-6267-4777-b4b9-8813f3329309"/>
<resource>
<MolecularSequence>
<id value="CG-IG-HLA-FullBundle-01-16"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: MolecularSequence</b><a name="CG-IG-HLA-FullBundle-01-16"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource MolecularSequence "CG-IG-HLA-FullBundle-01-16" </p></div><p><b>type</b>: dna</p><p><b>coordinateSystem</b>: 0</p><h3>ReferenceSeqs</h3><table class="grid"><tr><td style="display: none">-</td><td><b>ReferenceSeqId</b></td><td><b>WindowStart</b></td><td><b>WindowEnd</b></td></tr><tr><td style="display: none">*</td><td>HLA-B*57:01:01 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (hla[3.23]#HLA00381)</span></td><td>1001</td><td>1277</td></tr></table><p><b>observedSeq</b>: GGTCTCACATCATCCAGGTGATGTATGGCTGCGACGTGGGGCCGGACGGGCGCCTCCTCCGCGGGCATGACCAGTCCGCCTACGACGGCAAGGATTACATCGCCCTGAACGAGGACCTGAGCTCCTGGACCGCGGCGGACACGGCGGCTCAGATCACCCAGCGCAAGTGGGAGGCGGCCCGTGTGGCGGAGCAGCTGAGAGCCTACCTGGAGGGCCTGTGCGTGGAGTGGCTCCGCAGATACCTGGAGAACGGGAAGGAGACGCTGCAGCGCGCGG</p></div>
</text>
<type value="dna"/>
<coordinateSystem value="0"/>
<referenceSeq>
<referenceSeqId>
<coding>
<system value="http://www.ebi.ac.uk/ipd/imgt/hla"/>
<version value="3.23"/>
<code value="HLA00381"/>
</coding>
<text value="HLA-B*57:01:01"/>
</referenceSeqId>
<windowStart value="1001"/>
<windowEnd value="1277"/>
</referenceSeq>
<observedSeq
value="GGTCTCACATCATCCAGGTGATGTATGGCTGCGACGTGGGGCCGGACGGGCGCCTCCTCCGCGGGCATGACCAGTCCGCCTACGACGGCAAGGATTACATCGCCCTGAACGAGGACCTGAGCTCCTGGACCGCGGCGGACACGGCGGCTCAGATCACCCAGCGCAAGTGGGAGGCGGCCCGTGTGGCGGAGCAGCTGAGAGCCTACCTGGAGGGCCTGTGCGTGGAGTGGCTCCGCAGATACCTGGAGAACGGGAAGGAGACGCTGCAGCGCGCGG"/>
</MolecularSequence>
</resource>
<request>
<method value="POST"/>
<url value="MolecularSequence"/>
</request>
</entry>
<entry>
<fullUrl value="urn:uuid:e2092243-2970-49d2-a90f-b90d1d49715a"/>
<resource>
<Observation>
<id value="CG-IG-HLA-FullBundle-01-17"/>
<meta>
<profile
value="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/haplotype"/>
</meta>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: Observation</b><a name="CG-IG-HLA-FullBundle-01-17"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "CG-IG-HLA-FullBundle-01-17" </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-haplotype.html">Haplotype</a></p></div><p><b>status</b>: final</p><p><b>category</b>: Laboratory <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-observation-category.html">Observation Category Codes</a>#laboratory)</span>, Genetics <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-v2-0074.html">diagnosticServiceSectionId</a>#GE)</span></p><p><b>code</b>: Haplotype name <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#84414-2)</span></p><p><b>subject</b>: <a href="#Patient_CG-IG-HLA-FullBundle-01-1">See above (urn:uuid:13f34265-335c-4853-bc38-0815315edafa: John Storm)</a></p><p><b>effective</b>: 2016-12-15</p><p><b>performer</b>: <a href="#Organization_CG-IG-HLA-FullBundle-01-3">See above (urn:uuid:9243cc20-27bd-4f87-ba90-0328ed474950: aTypingLab, Inc)</a></p><p><b>value</b>: HLA-B*15:01:01G <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (hla[3.23]#HGG00041)</span></p><p><b>method</b>: NGS based Class I HLA-A, -B, -C genotyping <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (gtr#GTR000000000.0)</span></p><p><b>specimen</b>: <a href="#Specimen_CG-IG-HLA-FullBundle-01-2">See above (urn:uuid:e44fbe33-6084-4ae2-a95e-8bc451c63340: buccal swab from John Storm)</a></p><p><b>derivedFrom</b>: </p><ul><li><a href="#MolecularSequence_CG-IG-HLA-FullBundle-01-13">See above (urn:uuid:cbabf93e-1b4b-46f2-ba1e-d84862670670: HLA-B*15:01:01:01, exon 2)</a></li><li><a href="#MolecularSequence_CG-IG-HLA-FullBundle-01-14">See above (urn:uuid:c233ad3d-1572-48d6-93da-0a583535e138: HLA-B*15:01:01:01, exon 3)</a></li></ul><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td>Gene studied [ID] <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#48018-6)</span></td><td>HLA-B <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-v3-hgnc.html">HUGO Gene Nomenclature Committee Genes</a>#HGNC:4932)</span></td></tr></table></div>
</text>
<status value="final"/>
<category>
<coding>
<system
value="http://terminology.hl7.org/CodeSystem/observation-category"/>
<code value="laboratory"/>
</coding>
</category>
<category>
<coding>
<system value="http://terminology.hl7.org/CodeSystem/v2-0074"/>
<code value="GE"/>
</coding>
</category>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="84414-2"/>
<display value="Haplotype name"/>
</coding>
</code>
<subject>
<reference value="urn:uuid:13f34265-335c-4853-bc38-0815315edafa"/>
<type value="Patient"/>
<display value="John Storm"/>
</subject>
<effectiveDateTime value="2016-12-15"/>
<performer>
<reference value="urn:uuid:9243cc20-27bd-4f87-ba90-0328ed474950"/>
<display value="aTypingLab, Inc"/>
</performer>
<valueCodeableConcept>
<coding>
<system value="http://www.ebi.ac.uk/ipd/imgt/hla"/>
<version value="3.23"/>
<code value="HGG00041"/>
<display value="HLA-B*15:01:01G"/>
</coding>
</valueCodeableConcept>
<method>
<coding>
<system value="http://www.ncbi.nlm.nih.gov/gtr"/>
<code value="GTR000000000.0"/>
</coding>
<text value="NGS based Class I HLA-A, -B, -C genotyping"/>
</method>
<specimen>
<reference value="urn:uuid:e44fbe33-6084-4ae2-a95e-8bc451c63340"/>
<display value="buccal swab from John Storm"/>
</specimen>
<derivedFrom>
<reference value="urn:uuid:cbabf93e-1b4b-46f2-ba1e-d84862670670"/>
<type value="MolecularSequence"/>
<display value="HLA-B*15:01:01:01, exon 2"/>
</derivedFrom>
<derivedFrom>
<reference value="urn:uuid:c233ad3d-1572-48d6-93da-0a583535e138"/>
<type value="MolecularSequence"/>
<display value="HLA-B*15:01:01:01, exon 3"/>
</derivedFrom>
<component>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="48018-6"/>
<display value="Gene studied [ID]"/>
</coding>
</code>
<valueCodeableConcept>
<coding>
<system value="http://www.genenames.org"/>
<code value="HGNC:4932"/>
<display value="HLA-B"/>
</coding>
</valueCodeableConcept>
</component>
</Observation>
</resource>
<request>
<method value="POST"/>
<url value="Observation"/>
</request>
</entry>
<entry>
<fullUrl value="urn:uuid:792be53e-d4fb-4887-a367-815ef6c706e5"/>
<resource>
<Observation>
<id value="CG-IG-HLA-FullBundle-01-18"/>
<meta>
<profile
value="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/haplotype"/>
</meta>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: Observation</b><a name="CG-IG-HLA-FullBundle-01-18"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "CG-IG-HLA-FullBundle-01-18" </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-haplotype.html">Haplotype</a></p></div><p><b>status</b>: final</p><p><b>category</b>: Laboratory <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-observation-category.html">Observation Category Codes</a>#laboratory)</span>, Genetics <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-v2-0074.html">diagnosticServiceSectionId</a>#GE)</span></p><p><b>code</b>: Haplotype name <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#84414-2)</span></p><p><b>subject</b>: <a href="#Patient_CG-IG-HLA-FullBundle-01-1">See above (urn:uuid:13f34265-335c-4853-bc38-0815315edafa: John Storm)</a></p><p><b>effective</b>: 2016-12-15</p><p><b>performer</b>: <a href="#Organization_CG-IG-HLA-FullBundle-01-3">See above (urn:uuid:9243cc20-27bd-4f87-ba90-0328ed474950: aTypingLab, Inc)</a></p><p><b>value</b>: HLA-B*57:01:01G <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (hla[3.23]#HLA-B*57:01:01G)</span></p><p><b>method</b>: NGS based Class I HLA-A, -B, -C genotyping <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (gtr#GTR000000000.0)</span></p><p><b>specimen</b>: <a href="#Specimen_CG-IG-HLA-FullBundle-01-2">See above (urn:uuid:e44fbe33-6084-4ae2-a95e-8bc451c63340: buccal swab from John Storm)</a></p><p><b>derivedFrom</b>: </p><ul><li><a href="#MolecularSequence_CG-IG-HLA-FullBundle-01-15">See above (urn:uuid:05fa52d7-5c67-460a-8722-d3460b24d6fe: HLA-B*57:01:01, exon 2)</a></li><li><a href="#MolecularSequence_CG-IG-HLA-FullBundle-01-16">See above (urn:uuid:db69e549-6267-4777-b4b9-8813f3329309: HLA-B*57:01:01, exon 3)</a></li></ul><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td>Gene studied [ID] <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#48018-6)</span></td><td>HLA-B <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-v3-hgnc.html">HUGO Gene Nomenclature Committee Genes</a>#HGNC:4932)</span></td></tr></table></div>
</text>
<status value="final"/>
<category>
<coding>
<system
value="http://terminology.hl7.org/CodeSystem/observation-category"/>
<code value="laboratory"/>
</coding>
</category>
<category>
<coding>
<system value="http://terminology.hl7.org/CodeSystem/v2-0074"/>
<code value="GE"/>
</coding>
</category>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="84414-2"/>
<display value="Haplotype name"/>
</coding>
</code>
<subject>
<reference value="urn:uuid:13f34265-335c-4853-bc38-0815315edafa"/>
<type value="Patient"/>
<display value="John Storm"/>
</subject>
<effectiveDateTime value="2016-12-15"/>
<performer>
<reference value="urn:uuid:9243cc20-27bd-4f87-ba90-0328ed474950"/>
<display value="aTypingLab, Inc"/>
</performer>
<valueCodeableConcept>
<coding>
<system value="http://www.ebi.ac.uk/ipd/imgt/hla"/>
<version value="3.23"/>
<code value="HLA-B*57:01:01G"/>
<display value="HLA-B*57:01:01G"/>
</coding>
</valueCodeableConcept>
<method>
<coding>
<system value="http://www.ncbi.nlm.nih.gov/gtr"/>
<code value="GTR000000000.0"/>
</coding>
<text value="NGS based Class I HLA-A, -B, -C genotyping"/>
</method>
<specimen>
<reference value="urn:uuid:e44fbe33-6084-4ae2-a95e-8bc451c63340"/>
<display value="buccal swab from John Storm"/>
</specimen>
<derivedFrom>
<reference value="urn:uuid:05fa52d7-5c67-460a-8722-d3460b24d6fe"/>
<type value="MolecularSequence"/>
<display value="HLA-B*57:01:01, exon 2"/>
</derivedFrom>
<derivedFrom>
<reference value="urn:uuid:db69e549-6267-4777-b4b9-8813f3329309"/>
<type value="MolecularSequence"/>
<display value="HLA-B*57:01:01, exon 3"/>
</derivedFrom>
<component>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="48018-6"/>
<display value="Gene studied [ID]"/>
</coding>
</code>
<valueCodeableConcept>
<coding>
<system value="http://www.genenames.org"/>
<code value="HGNC:4932"/>
<display value="HLA-B"/>
</coding>
</valueCodeableConcept>
</component>
</Observation>
</resource>
<request>
<method value="POST"/>
<url value="Observation"/>
</request>
</entry>
<entry>
<fullUrl value="urn:uuid:60613a43-c4cb-4502-b3e2-cf9215feaa70"/>
<resource>
<Observation>
<id value="CG-IG-HLA-FullBundle-01-19"/>
<meta>
<profile
value="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genotype"/>
</meta>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: Observation</b><a name="CG-IG-HLA-FullBundle-01-19"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "CG-IG-HLA-FullBundle-01-19" </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-genotype.html">Genotype</a></p></div><p><b>basedOn</b>: <a href="#ServiceRequest_CG-IG-HLA-FullBundle-01-5">See above (urn:uuid:99309303-045e-4cf4-90d7-250d7a7476ea: Class I HLA genotyping for John Storm)</a></p><p><b>status</b>: final</p><p><b>category</b>: Laboratory <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-observation-category.html">Observation Category Codes</a>#laboratory)</span>, Genetics <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-v2-0074.html">diagnosticServiceSectionId</a>#GE)</span></p><p><b>code</b>: Genotype display name <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#84413-4)</span></p><p><b>subject</b>: <a href="#Patient_CG-IG-HLA-FullBundle-01-1">See above (urn:uuid:13f34265-335c-4853-bc38-0815315edafa: John Storm)</a></p><p><b>effective</b>: 2016-12-15</p><p><b>performer</b>: <a href="#Organization_CG-IG-HLA-FullBundle-01-3">See above (urn:uuid:9243cc20-27bd-4f87-ba90-0328ed474950: aTypingLab, Inc)</a></p><p><b>value</b>: hla#3.23.0#HLA-B*15:01:01G+HLA-B*57:01:01G <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (glstring.org[1.0]#hla#3.23.0#HLA-B*15:01:01G+HLA-B*57:01:01G)</span></p><p><b>method</b>: NGS based Class I HLA-A, -B, -C genotyping <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (gtr#GTR000000000.0)</span></p><p><b>specimen</b>: <a href="#Specimen_CG-IG-HLA-FullBundle-01-2">See above (urn:uuid:e44fbe33-6084-4ae2-a95e-8bc451c63340: buccal swab from John Storm)</a></p><p><b>derivedFrom</b>: </p><ul><li><a href="#Observation_CG-IG-HLA-FullBundle-01-17">See above (urn:uuid:e2092243-2970-49d2-a90f-b90d1d49715a: HLA-B*15:01:01G, exons 2 and 3)</a></li><li><a href="#Observation_CG-IG-HLA-FullBundle-01-18">See above (urn:uuid:792be53e-d4fb-4887-a367-815ef6c706e5: HLA-B*57:01:01G, exons 2 and 3)</a></li></ul><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td>Gene studied [ID] <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#48018-6)</span></td><td>HLA-B <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-v3-hgnc.html">HUGO Gene Nomenclature Committee Genes</a>#HGNC:4932)</span></td></tr></table></div>
</text>
<basedOn>
<reference value="urn:uuid:99309303-045e-4cf4-90d7-250d7a7476ea"/>
<type value="ServiceRequest"/>
<display value="Class I HLA genotyping for John Storm"/>
</basedOn>
<status value="final"/>
<category>
<coding>
<system
value="http://terminology.hl7.org/CodeSystem/observation-category"/>
<code value="laboratory"/>
</coding>
</category>
<category>
<coding>
<system value="http://terminology.hl7.org/CodeSystem/v2-0074"/>
<code value="GE"/>
</coding>
</category>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="84413-4"/>
<display value="Genotype display name"/>
</coding>
</code>
<subject>
<reference value="urn:uuid:13f34265-335c-4853-bc38-0815315edafa"/>
<type value="Patient"/>
<display value="John Storm"/>
</subject>
<effectiveDateTime value="2016-12-15"/>
<performer>
<reference value="urn:uuid:9243cc20-27bd-4f87-ba90-0328ed474950"/>
<display value="aTypingLab, Inc"/>
</performer>
<valueCodeableConcept>
<coding>
<system value="http://glstring.org"/>
<version value="1.0"/>
<code value="hla#3.23.0#HLA-B*15:01:01G+HLA-B*57:01:01G"/>
</coding>
</valueCodeableConcept>
<method>
<coding>
<system value="http://www.ncbi.nlm.nih.gov/gtr"/>
<code value="GTR000000000.0"/>
</coding>
<text value="NGS based Class I HLA-A, -B, -C genotyping"/>
</method>
<specimen>
<reference value="urn:uuid:e44fbe33-6084-4ae2-a95e-8bc451c63340"/>
<display value="buccal swab from John Storm"/>
</specimen>
<derivedFrom>
<reference value="urn:uuid:e2092243-2970-49d2-a90f-b90d1d49715a"/>
<type value="Observation"/>
<display value="HLA-B*15:01:01G, exons 2 and 3"/>
</derivedFrom>
<derivedFrom>
<reference value="urn:uuid:792be53e-d4fb-4887-a367-815ef6c706e5"/>
<type value="Observation"/>
<display value="HLA-B*57:01:01G, exons 2 and 3"/>
</derivedFrom>
<component>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="48018-6"/>
<display value="Gene studied [ID]"/>
</coding>
</code>
<valueCodeableConcept>
<coding>
<system value="http://www.genenames.org"/>
<code value="HGNC:4932"/>
<display value="HLA-B"/>
</coding>
</valueCodeableConcept>
</component>
</Observation>
</resource>
<request>
<method value="POST"/>
<url value="Observation"/>
</request>
</entry>
<entry>
<fullUrl value="urn:uuid:bb55c2bc-5ad2-4bc1-8ff3-c407d06b12d0"/>
<resource>
<MolecularSequence>
<id value="CG-IG-HLA-FullBundle-01-20"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: MolecularSequence</b><a name="CG-IG-HLA-FullBundle-01-20"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource MolecularSequence "CG-IG-HLA-FullBundle-01-20" </p></div><p><b>type</b>: dna</p><p><b>coordinateSystem</b>: 0</p><h3>ReferenceSeqs</h3><table class="grid"><tr><td style="display: none">-</td><td><b>ReferenceSeqId</b></td><td><b>WindowStart</b></td><td><b>WindowEnd</b></td></tr><tr><td style="display: none">*</td><td>HLA-C*01:02:01 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (hla[3.23]#HLA00401)</span></td><td>486</td><td>756</td></tr></table><p><b>observedSeq</b>: GCTCCCACTCCATGAAGTATTTCTTCACATCCGTGTCCCGGCCTGGCCGCGGAGAGCCCCGCTTCATCTCAGTGGGCTACGTGGACGACACGCAGTTCGTGCGGTTCGACAGCGACGCCGCGAGTCCGAGAGGGGAGCCGCGGGCGCCGTGGGTGGAGCAGGAGGGGCCGGAGTATTGGGACCGGGAGACACAGAAGTACAAGCGCCAGGCACAGACTGACCGAGTGAGCCTGCGGAACCTGCGCGGCTACTACAACCAGAGCGAGGCCG</p></div>
</text>
<type value="dna"/>
<coordinateSystem value="0"/>
<referenceSeq>
<referenceSeqId>
<coding>
<system value="http://www.ebi.ac.uk/ipd/imgt/hla"/>
<version value="3.23"/>
<code value="HLA00401"/>
</coding>
<text value="HLA-C*01:02:01"/>
</referenceSeqId>
<windowStart value="486"/>
<windowEnd value="756"/>
</referenceSeq>
<observedSeq
value="GCTCCCACTCCATGAAGTATTTCTTCACATCCGTGTCCCGGCCTGGCCGCGGAGAGCCCCGCTTCATCTCAGTGGGCTACGTGGACGACACGCAGTTCGTGCGGTTCGACAGCGACGCCGCGAGTCCGAGAGGGGAGCCGCGGGCGCCGTGGGTGGAGCAGGAGGGGCCGGAGTATTGGGACCGGGAGACACAGAAGTACAAGCGCCAGGCACAGACTGACCGAGTGAGCCTGCGGAACCTGCGCGGCTACTACAACCAGAGCGAGGCCG"/>
</MolecularSequence>
</resource>
<request>
<method value="POST"/>
<url value="MolecularSequence"/>
</request>
</entry>
<entry>
<fullUrl value="urn:uuid:46938bb2-0486-4e87-bfd3-89aab2d5e22f"/>
<resource>
<MolecularSequence>
<id value="CG-IG-HLA-FullBundle-01-21"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: MolecularSequence</b><a name="CG-IG-HLA-FullBundle-01-21"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource MolecularSequence "CG-IG-HLA-FullBundle-01-21" </p></div><p><b>type</b>: dna</p><p><b>coordinateSystem</b>: 0</p><h3>ReferenceSeqs</h3><table class="grid"><tr><td style="display: none">-</td><td><b>ReferenceSeqId</b></td><td><b>WindowStart</b></td><td><b>WindowEnd</b></td></tr><tr><td style="display: none">*</td><td>HLA-C*01:02:01 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (hla[3.23]#HLA00401)</span></td><td>1002</td><td>1278</td></tr></table><p><b>observedSeq</b>: GGTCTCACACCCTCCAGTGGATGTGTGGCTGCGACCTGGGGCCCGACGGGCGCCTCCTCCGCGGGTATGACCAGTACGCCTACGACGGCAAGGATTACATCGCCCTGAACGAGGACCTGCGCTCCTGGACCGCCGCGGACACCGCGGCTCAGATCACCCAGCGCAAGTGGGAGGCGGCCCGTGAGGCGGAGCAGCGGAGAGCCTACCTGGAGGGCACGTGCGTGGAGTGGCTCCGCAGATACCTGGAGAACGGGAAGGAGACGCTGCAGCGCGCGG</p></div>
</text>
<type value="dna"/>
<coordinateSystem value="0"/>
<referenceSeq>
<referenceSeqId>
<coding>
<system value="http://www.ebi.ac.uk/ipd/imgt/hla"/>
<version value="3.23"/>
<code value="HLA00401"/>
</coding>
<text value="HLA-C*01:02:01"/>
</referenceSeqId>
<windowStart value="1002"/>
<windowEnd value="1278"/>
</referenceSeq>
<observedSeq
value="GGTCTCACACCCTCCAGTGGATGTGTGGCTGCGACCTGGGGCCCGACGGGCGCCTCCTCCGCGGGTATGACCAGTACGCCTACGACGGCAAGGATTACATCGCCCTGAACGAGGACCTGCGCTCCTGGACCGCCGCGGACACCGCGGCTCAGATCACCCAGCGCAAGTGGGAGGCGGCCCGTGAGGCGGAGCAGCGGAGAGCCTACCTGGAGGGCACGTGCGTGGAGTGGCTCCGCAGATACCTGGAGAACGGGAAGGAGACGCTGCAGCGCGCGG"/>
</MolecularSequence>
</resource>
<request>
<method value="POST"/>
<url value="MolecularSequence"/>
</request>
</entry>
<entry>
<fullUrl value="urn:uuid:2ae2ff34-279e-43c2-9018-b054fd3fc1ce"/>
<resource>
<MolecularSequence>
<id value="CG-IG-HLA-FullBundle-01-22"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: MolecularSequence</b><a name="CG-IG-HLA-FullBundle-01-22"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource MolecularSequence "CG-IG-HLA-FullBundle-01-22" </p></div><p><b>type</b>: dna</p><p><b>coordinateSystem</b>: 0</p><h3>ReferenceSeqs</h3><table class="grid"><tr><td style="display: none">-</td><td><b>ReferenceSeqId</b></td><td><b>WindowStart</b></td><td><b>WindowEnd</b></td></tr><tr><td style="display: none">*</td><td>HLA-C*03:04:01:01 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (hla[3.23]#HLA00413)</span></td><td>486</td><td>756</td></tr></table><p><b>observedSeq</b>: GCTCCCACTCCATGAGGTATTTCTACACCGCTGTGTCCCGGCCCGGCCGCGGGGAGCCCCACTTCATCGCAGTGGGCTACGTGGACGACACGCAGTTCGTGCGGTTCGACAGCGACGCCGCGAGTCCGAGAGGGGAGCCGCGGGCGCCGTGGGTGGAGCAGGAGGGGCCGGAGTATTGGGACCGGGAGACACAGAAGTACAAGCGCCAGGCACAGACTGACCGAGTGAGCCTGCGGAACCTGCGCGGCTACTACAACCAGAGCGAGGCCG</p></div>
</text>
<type value="dna"/>
<coordinateSystem value="0"/>
<referenceSeq>
<referenceSeqId>
<coding>
<system value="http://www.ebi.ac.uk/ipd/imgt/hla"/>
<version value="3.23"/>
<code value="HLA00413"/>
</coding>
<text value="HLA-C*03:04:01:01"/>
</referenceSeqId>
<windowStart value="486"/>
<windowEnd value="756"/>
</referenceSeq>
<observedSeq
value="GCTCCCACTCCATGAGGTATTTCTACACCGCTGTGTCCCGGCCCGGCCGCGGGGAGCCCCACTTCATCGCAGTGGGCTACGTGGACGACACGCAGTTCGTGCGGTTCGACAGCGACGCCGCGAGTCCGAGAGGGGAGCCGCGGGCGCCGTGGGTGGAGCAGGAGGGGCCGGAGTATTGGGACCGGGAGACACAGAAGTACAAGCGCCAGGCACAGACTGACCGAGTGAGCCTGCGGAACCTGCGCGGCTACTACAACCAGAGCGAGGCCG"/>
</MolecularSequence>
</resource>
<request>
<method value="POST"/>
<url value="MolecularSequence"/>
</request>
</entry>
<entry>
<fullUrl value="urn:uuid:19153ef1-68c6-47a2-9676-c4eefbd39af9"/>
<resource>
<MolecularSequence>
<id value="CG-IG-HLA-FullBundle-01-23"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: MolecularSequence</b><a name="CG-IG-HLA-FullBundle-01-23"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource MolecularSequence "CG-IG-HLA-FullBundle-01-23" </p></div><p><b>type</b>: dna</p><p><b>coordinateSystem</b>: 0</p><h3>ReferenceSeqs</h3><table class="grid"><tr><td style="display: none">-</td><td><b>ReferenceSeqId</b></td><td><b>WindowStart</b></td><td><b>WindowEnd</b></td></tr><tr><td style="display: none">*</td><td>HLA-C*03:04:01:01 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (hla[3.23]#HLA00413)</span></td><td>1001</td><td>1277</td></tr></table><p><b>observedSeq</b>: GGTCTCACATCATCCAGAGGATGTATGGCTGCGACGTGGGGCCCGACGGGCGCCTCCTCCGCGGGTATGACCAGTACGCCTACGACGGCAAGGATTACATCGCCCTGAACGAGGATCTGCGCTCCTGGACCGCCGCGGACACGGCGGCTCAGATCACCCAGCGCAAGTGGGAGGCGGCCCGTGAGGCGGAGCAGCTGAGAGCCTACCTGGAGGGCCTGTGCGTGGAGTGGCTCCGCAGATACCTGAAGAATGGGAAGGAGACGCTGCAGCGCGCGG</p></div>
</text>
<type value="dna"/>
<coordinateSystem value="0"/>
<referenceSeq>
<referenceSeqId>
<coding>
<system value="http://www.ebi.ac.uk/ipd/imgt/hla"/>
<version value="3.23"/>
<code value="HLA00413"/>
</coding>
<text value="HLA-C*03:04:01:01"/>
</referenceSeqId>
<windowStart value="1001"/>
<windowEnd value="1277"/>
</referenceSeq>
<observedSeq
value="GGTCTCACATCATCCAGAGGATGTATGGCTGCGACGTGGGGCCCGACGGGCGCCTCCTCCGCGGGTATGACCAGTACGCCTACGACGGCAAGGATTACATCGCCCTGAACGAGGATCTGCGCTCCTGGACCGCCGCGGACACGGCGGCTCAGATCACCCAGCGCAAGTGGGAGGCGGCCCGTGAGGCGGAGCAGCTGAGAGCCTACCTGGAGGGCCTGTGCGTGGAGTGGCTCCGCAGATACCTGAAGAATGGGAAGGAGACGCTGCAGCGCGCGG"/>
</MolecularSequence>
</resource>
<request>
<method value="POST"/>
<url value="MolecularSequence"/>
</request>
</entry>
<entry>
<fullUrl value="urn:uuid:709c5315-9403-4867-9d82-0b953836665f"/>
<resource>
<Observation>
<id value="CG-IG-HLA-FullBundle-01-24"/>
<meta>
<profile
value="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/haplotype"/>
</meta>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: Observation</b><a name="CG-IG-HLA-FullBundle-01-24"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "CG-IG-HLA-FullBundle-01-24" </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-haplotype.html">Haplotype</a></p></div><p><b>status</b>: final</p><p><b>category</b>: Laboratory <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-observation-category.html">Observation Category Codes</a>#laboratory)</span>, Genetics <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-v2-0074.html">diagnosticServiceSectionId</a>#GE)</span></p><p><b>code</b>: Haplotype name <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#84414-2)</span></p><p><b>subject</b>: <a href="#Patient_CG-IG-HLA-FullBundle-01-1">See above (urn:uuid:13f34265-335c-4853-bc38-0815315edafa: John Storm)</a></p><p><b>effective</b>: 2016-12-15</p><p><b>performer</b>: <a href="#Organization_CG-IG-HLA-FullBundle-01-3">See above (urn:uuid:9243cc20-27bd-4f87-ba90-0328ed474950: aTypingLab, Inc)</a></p><p><b>value</b>: HLA-C*01:02:01G <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (hla[3.23]#HLA-C*01:02:01G)</span></p><p><b>method</b>: NGS based Class I HLA-A, -B, -C genotyping <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (gtr#GTR000000000.0)</span></p><p><b>specimen</b>: <a href="#Specimen_CG-IG-HLA-FullBundle-01-2">See above (urn:uuid:e44fbe33-6084-4ae2-a95e-8bc451c63340: buccal swab from John Storm)</a></p><p><b>derivedFrom</b>: </p><ul><li><a href="#MolecularSequence_CG-IG-HLA-FullBundle-01-20">See above (urn:uuid:bb55c2bc-5ad2-4bc1-8ff3-c407d06b12d0: HLA-C*01:02:01, exon 2)</a></li><li><a href="#MolecularSequence_CG-IG-HLA-FullBundle-01-21">See above (urn:uuid:46938bb2-0486-4e87-bfd3-89aab2d5e22f: HLA-C*01:02:01, exon 3)</a></li></ul><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td>Gene studied [ID] <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#48018-6)</span></td><td>HLA-C <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-v3-hgnc.html">HUGO Gene Nomenclature Committee Genes</a>#HGNC:4933)</span></td></tr></table></div>
</text>
<status value="final"/>
<category>
<coding>
<system
value="http://terminology.hl7.org/CodeSystem/observation-category"/>
<code value="laboratory"/>
</coding>
</category>
<category>
<coding>
<system value="http://terminology.hl7.org/CodeSystem/v2-0074"/>
<code value="GE"/>
</coding>
</category>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="84414-2"/>
<display value="Haplotype name"/>
</coding>
</code>
<subject>
<reference value="urn:uuid:13f34265-335c-4853-bc38-0815315edafa"/>
<type value="Patient"/>
<display value="John Storm"/>
</subject>
<effectiveDateTime value="2016-12-15"/>
<performer>
<reference value="urn:uuid:9243cc20-27bd-4f87-ba90-0328ed474950"/>
<display value="aTypingLab, Inc"/>
</performer>
<valueCodeableConcept>
<coding>
<system value="http://www.ebi.ac.uk/ipd/imgt/hla"/>
<version value="3.23"/>
<code value="HLA-C*01:02:01G"/>
<display value="HLA-C*01:02:01G"/>
</coding>
</valueCodeableConcept>
<method>
<coding>
<system value="http://www.ncbi.nlm.nih.gov/gtr"/>
<code value="GTR000000000.0"/>
</coding>
<text value="NGS based Class I HLA-A, -B, -C genotyping"/>
</method>
<specimen>
<reference value="urn:uuid:e44fbe33-6084-4ae2-a95e-8bc451c63340"/>
<display value="buccal swab from John Storm"/>
</specimen>
<derivedFrom>
<reference value="urn:uuid:bb55c2bc-5ad2-4bc1-8ff3-c407d06b12d0"/>
<type value="MolecularSequence"/>
<display value="HLA-C*01:02:01, exon 2"/>
</derivedFrom>
<derivedFrom>
<reference value="urn:uuid:46938bb2-0486-4e87-bfd3-89aab2d5e22f"/>
<type value="MolecularSequence"/>
<display value="HLA-C*01:02:01, exon 3"/>
</derivedFrom>
<component>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="48018-6"/>
<display value="Gene studied [ID]"/>
</coding>
</code>
<valueCodeableConcept>
<coding>
<system value="http://www.genenames.org"/>
<code value="HGNC:4933"/>
<display value="HLA-C"/>
</coding>
</valueCodeableConcept>
</component>
</Observation>
</resource>
<request>
<method value="POST"/>
<url value="Observation"/>
</request>
</entry>
<entry>
<fullUrl value="urn:uuid:8b2aa21c-1426-4717-8ab0-a84d83df7d47"/>
<resource>
<Observation>
<id value="CG-IG-HLA-FullBundle-01-25"/>
<meta>
<profile
value="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/haplotype"/>
</meta>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: Observation</b><a name="CG-IG-HLA-FullBundle-01-25"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "CG-IG-HLA-FullBundle-01-25" </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-haplotype.html">Haplotype</a></p></div><p><b>status</b>: final</p><p><b>category</b>: Laboratory <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-observation-category.html">Observation Category Codes</a>#laboratory)</span>, Genetics <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-v2-0074.html">diagnosticServiceSectionId</a>#GE)</span></p><p><b>code</b>: Haplotype name <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#84414-2)</span></p><p><b>subject</b>: <a href="#Patient_CG-IG-HLA-FullBundle-01-1">See above (urn:uuid:13f34265-335c-4853-bc38-0815315edafa: John Storm)</a></p><p><b>effective</b>: 2016-12-15</p><p><b>performer</b>: <a href="#Organization_CG-IG-HLA-FullBundle-01-3">See above (urn:uuid:9243cc20-27bd-4f87-ba90-0328ed474950: aTypingLab, Inc)</a></p><p><b>value</b>: HLA-C*01:02:01G <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (hla[3.23]#HLA-C*01:02:01G)</span></p><p><b>method</b>: NGS based Class I HLA-A, -B, -C genotyping <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (gtr#GTR000000000.0)</span></p><p><b>specimen</b>: <a href="#Specimen_CG-IG-HLA-FullBundle-01-2">See above (urn:uuid:e44fbe33-6084-4ae2-a95e-8bc451c63340: buccal swab from John Storm)</a></p><p><b>derivedFrom</b>: </p><ul><li><a href="#MolecularSequence_CG-IG-HLA-FullBundle-01-22">See above (urn:uuid:2ae2ff34-279e-43c2-9018-b054fd3fc1ce: HLA-C*03:04:01:01, exon 2)</a></li><li><a href="#MolecularSequence_CG-IG-HLA-FullBundle-01-23">See above (urn:uuid:19153ef1-68c6-47a2-9676-c4eefbd39af9: HLA-C*03:04:01:01, exon 3)</a></li></ul><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td>Gene studied [ID] <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#48018-6)</span></td><td>HLA-C <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-v3-hgnc.html">HUGO Gene Nomenclature Committee Genes</a>#HGNC:4933)</span></td></tr></table></div>
</text>
<status value="final"/>
<category>
<coding>
<system
value="http://terminology.hl7.org/CodeSystem/observation-category"/>
<code value="laboratory"/>
</coding>
</category>
<category>
<coding>
<system value="http://terminology.hl7.org/CodeSystem/v2-0074"/>
<code value="GE"/>
</coding>
</category>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="84414-2"/>
<display value="Haplotype name"/>
</coding>
</code>
<subject>
<reference value="urn:uuid:13f34265-335c-4853-bc38-0815315edafa"/>
<type value="Patient"/>
<display value="John Storm"/>
</subject>
<effectiveDateTime value="2016-12-15"/>
<performer>
<reference value="urn:uuid:9243cc20-27bd-4f87-ba90-0328ed474950"/>
<display value="aTypingLab, Inc"/>
</performer>
<valueCodeableConcept>
<coding>
<system value="http://www.ebi.ac.uk/ipd/imgt/hla"/>
<version value="3.23"/>
<code value="HLA-C*01:02:01G"/>
<display value="HLA-C*01:02:01G"/>
</coding>
</valueCodeableConcept>
<method>
<coding>
<system value="http://www.ncbi.nlm.nih.gov/gtr"/>
<code value="GTR000000000.0"/>
</coding>
<text value="NGS based Class I HLA-A, -B, -C genotyping"/>
</method>
<specimen>
<reference value="urn:uuid:e44fbe33-6084-4ae2-a95e-8bc451c63340"/>
<display value="buccal swab from John Storm"/>
</specimen>
<derivedFrom>
<reference value="urn:uuid:2ae2ff34-279e-43c2-9018-b054fd3fc1ce"/>
<type value="MolecularSequence"/>
<display value="HLA-C*03:04:01:01, exon 2"/>
</derivedFrom>
<derivedFrom>
<reference value="urn:uuid:19153ef1-68c6-47a2-9676-c4eefbd39af9"/>
<type value="MolecularSequence"/>
<display value="HLA-C*03:04:01:01, exon 3"/>
</derivedFrom>
<component>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="48018-6"/>
<display value="Gene studied [ID]"/>
</coding>
</code>
<valueCodeableConcept>
<coding>
<system value="http://www.genenames.org"/>
<code value="HGNC:4933"/>
<display value="HLA-C"/>
</coding>
</valueCodeableConcept>
</component>
</Observation>
</resource>
<request>
<method value="POST"/>
<url value="Observation"/>
</request>
</entry>
<entry>
<fullUrl value="urn:uuid:0e0a780e-4486-4cd0-bfae-7243c579f208"/>
<resource>
<Observation>
<id value="CG-IG-HLA-FullBundle-01-26"/>
<meta>
<profile
value="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genotype"/>
</meta>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: Observation</b><a name="CG-IG-HLA-FullBundle-01-26"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "CG-IG-HLA-FullBundle-01-26" </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-genotype.html">Genotype</a></p></div><p><b>basedOn</b>: <a href="#ServiceRequest_CG-IG-HLA-FullBundle-01-5">See above (urn:uuid:99309303-045e-4cf4-90d7-250d7a7476ea: Class I HLA genotyping for John Storm)</a></p><p><b>status</b>: final</p><p><b>category</b>: Laboratory <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-observation-category.html">Observation Category Codes</a>#laboratory)</span>, Genetics <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-v2-0074.html">diagnosticServiceSectionId</a>#GE)</span></p><p><b>code</b>: Genotype display name <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#84413-4)</span></p><p><b>subject</b>: <a href="#Patient_CG-IG-HLA-FullBundle-01-1">See above (urn:uuid:13f34265-335c-4853-bc38-0815315edafa: John Storm)</a></p><p><b>effective</b>: 2016-12-15</p><p><b>performer</b>: <a href="#Organization_CG-IG-HLA-FullBundle-01-3">See above (urn:uuid:9243cc20-27bd-4f87-ba90-0328ed474950: aTypingLab, Inc)</a></p><p><b>value</b>: hla#3.23.0#HLA-C*01:02:01G+HLA-C*03:04:01G <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (glstring.org[1.0]#hla#3.23.0#HLA-C*01:02:01G+HLA-C*03:04:01G)</span></p><p><b>method</b>: NGS based Class I HLA-A, -B, -C genotyping <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (gtr#GTR000000000.0)</span></p><p><b>specimen</b>: <a href="#Specimen_CG-IG-HLA-FullBundle-01-2">See above (urn:uuid:e44fbe33-6084-4ae2-a95e-8bc451c63340: buccal swab from John Storm)</a></p><p><b>derivedFrom</b>: </p><ul><li><a href="#Observation_CG-IG-HLA-FullBundle-01-25">See above (urn:uuid:8b2aa21c-1426-4717-8ab0-a84d83df7d47: HLA-C*03:04:01G, exons 2 and 3)</a></li><li><a href="#Observation_CG-IG-HLA-FullBundle-01-24">See above (urn:uuid:709c5315-9403-4867-9d82-0b953836665f: HLA-C*01:02:01G, exons 2 and 3)</a></li></ul><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td>Gene studied [ID] <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#48018-6)</span></td><td>HLA-C <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-v3-hgnc.html">HUGO Gene Nomenclature Committee Genes</a>#HGNC:4933)</span></td></tr></table></div>
</text>
<basedOn>
<reference value="urn:uuid:99309303-045e-4cf4-90d7-250d7a7476ea"/>
<type value="ServiceRequest"/>
<display value="Class I HLA genotyping for John Storm"/>
</basedOn>
<status value="final"/>
<category>
<coding>
<system
value="http://terminology.hl7.org/CodeSystem/observation-category"/>
<code value="laboratory"/>
</coding>
</category>
<category>
<coding>
<system value="http://terminology.hl7.org/CodeSystem/v2-0074"/>
<code value="GE"/>
</coding>
</category>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="84413-4"/>
<display value="Genotype display name"/>
</coding>
</code>
<subject>
<reference value="urn:uuid:13f34265-335c-4853-bc38-0815315edafa"/>
<type value="Patient"/>
<display value="John Storm"/>
</subject>
<effectiveDateTime value="2016-12-15"/>
<performer>
<reference value="urn:uuid:9243cc20-27bd-4f87-ba90-0328ed474950"/>
<display value="aTypingLab, Inc"/>
</performer>
<valueCodeableConcept>
<coding>
<system value="http://glstring.org"/>
<version value="1.0"/>
<code value="hla#3.23.0#HLA-C*01:02:01G+HLA-C*03:04:01G"/>
</coding>
</valueCodeableConcept>
<method>
<coding>
<system value="http://www.ncbi.nlm.nih.gov/gtr"/>
<code value="GTR000000000.0"/>
</coding>
<text value="NGS based Class I HLA-A, -B, -C genotyping"/>
</method>
<specimen>
<reference value="urn:uuid:e44fbe33-6084-4ae2-a95e-8bc451c63340"/>
<display value="buccal swab from John Storm"/>
</specimen>
<derivedFrom>
<reference value="urn:uuid:8b2aa21c-1426-4717-8ab0-a84d83df7d47"/>
<type value="Observation"/>
<display value="HLA-C*03:04:01G, exons 2 and 3"/>
</derivedFrom>
<derivedFrom>
<reference value="urn:uuid:709c5315-9403-4867-9d82-0b953836665f"/>
<type value="Observation"/>
<display value="HLA-C*01:02:01G, exons 2 and 3"/>
</derivedFrom>
<component>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="48018-6"/>
<display value="Gene studied [ID]"/>
</coding>
</code>
<valueCodeableConcept>
<coding>
<system value="http://www.genenames.org"/>
<code value="HGNC:4933"/>
<display value="HLA-C"/>
</coding>
</valueCodeableConcept>
</component>
</Observation>
</resource>
<request>
<method value="POST"/>
<url value="Observation"/>
</request>
</entry>
<entry>
<fullUrl value="urn:uuid:b0a4b18e-94e7-4b1b-8031-c7ae4bdd8db9"/>
<resource>
<DiagnosticReport>
<id value="CG-IG-HLA-FullBundle-01-27"/>
<meta>
<profile
value="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genomic-report"/>
</meta>
<text>
<status value="extensions"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: DiagnosticReport</b><a name="CG-IG-HLA-FullBundle-01-27"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource DiagnosticReport "CG-IG-HLA-FullBundle-01-27" </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-genomic-report.html">Genomic Report</a></p></div><p><b>allele-database</b>: null <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (hla[3.23])</span></p><blockquote><p><b>glstring</b></p><blockquote><p><b>url</b></p><code>text</code></blockquote><p><b>value</b>: HLA-A*01:01:01G+HLA-A*01:02^HLA-B*15:01:01G+HLA-B*57:01:01G^HLA-C*01:02:01G+HLA-C*03:04:01G</p><blockquote><p><b>url</b></p><a href="http://hl7.org/fhir/R4/datatypes.html#url">url</a></blockquote><p><b>value</b>: <a href="https://gl.nmdp.org/imgt-hla/3.23.0/multilocus-unphased-genotype/ex">https://gl.nmdp.org/imgt-hla/3.23.0/multilocus-unphased-genotype/ex</a></p></blockquote><p><b>basedOn</b>: <a href="#ServiceRequest_CG-IG-HLA-FullBundle-01-5">See above (urn:uuid:99309303-045e-4cf4-90d7-250d7a7476ea: Class I HLA genotyping for John Storm)</a></p><p><b>status</b>: final</p><p><b>category</b>: Genetics <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-v2-0074.html">diagnosticServiceSectionId</a>#GE)</span></p><p><b>code</b>: Genetic analysis report <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#51969-4; <a href="http://terminology.hl7.org/5.3.0/CodeSystem-v3-hgnc.html">HUGO Gene Nomenclature Committee Genes</a>#HGNC:588 "Histocompatibility complex (HLA)")</span></p><p><b>subject</b>: <a href="#Patient_CG-IG-HLA-FullBundle-01-1">See above (urn:uuid:13f34265-335c-4853-bc38-0815315edafa: John Storm)</a></p><p><b>effective</b>: 2016-12-15</p><p><b>issued</b>: Dec 15, 2016, 8:15:30 PM</p><p><b>performer</b>: <a href="#Organization_CG-IG-HLA-FullBundle-01-3">See above (urn:uuid:9243cc20-27bd-4f87-ba90-0328ed474950: aTypingLab Inc)</a></p><p><b>specimen</b>: <a href="#Specimen_CG-IG-HLA-FullBundle-01-2">See above (urn:uuid:e44fbe33-6084-4ae2-a95e-8bc451c63340: buccal swab from John Storm)</a></p><p><b>result</b>: </p><ul><li><a href="#Observation_CG-IG-HLA-FullBundle-01-12">See above (urn:uuid:49a86246-4004-42eb-9bdc-f542f93f9228: HLA-A: HLA-A:01:01:01G+HLA-A*01:02)</a></li><li><a href="#Observation_CG-IG-HLA-FullBundle-01-19">See above (urn:uuid:60613a43-c4cb-4502-b3e2-cf9215feaa70: HLA-B: HLA-B*15:01:01G+HLA-B*57:01:01G)</a></li><li><a href="#Observation_CG-IG-HLA-FullBundle-01-26">See above (urn:uuid:0e0a780e-4486-4cd0-bfae-7243c579f208: HLA-C: HLA-C*01:02:01G+HLA-C*03:04:01G)</a></li></ul></div>
</text>
<extension
url="http://hl7.org/fhir/StructureDefinition/hla-genotyping-results-allele-database">
<valueCodeableConcept>
<coding>
<system value="http://www.ebi.ac.uk/ipd/imgt/hla"/>
<version value="3.23"/>
</coding>
</valueCodeableConcept>
</extension>
<extension
url="http://hl7.org/fhir/StructureDefinition/hla-genotyping-results-glstring">
<extension url="text">
<valueString
value="HLA-A*01:01:01G+HLA-A*01:02^HLA-B*15:01:01G+HLA-B*57:01:01G^HLA-C*01:02:01G+HLA-C*03:04:01G"/>
</extension>
<extension url="url">
<valueUri
value="https://gl.nmdp.org/imgt-hla/3.23.0/multilocus-unphased-genotype/ex"/>
</extension>
</extension>
<basedOn>
<reference value="urn:uuid:99309303-045e-4cf4-90d7-250d7a7476ea"/>
<type value="ServiceRequest"/>
<display value="Class I HLA genotyping for John Storm"/>
</basedOn>
<status value="final"/>
<category>
<coding>
<system value="http://terminology.hl7.org/CodeSystem/v2-0074"/>
<code value="GE"/>
<display value="Genetics"/>
</coding>
</category>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="51969-4"/>
<display value="Genetic analysis report"/>
</coding>
<coding>
<system value="http://www.genenames.org"/>
<code value="HGNC:588"/>
<display value="Histocompatibility complex (HLA)"/>
</coding>
</code>
<subject>
<reference value="urn:uuid:13f34265-335c-4853-bc38-0815315edafa"/>
<type value="Patient"/>
<display value="John Storm"/>
</subject>
<effectiveDateTime value="2016-12-15"/>
<issued value="2016-12-15T14:15:30-06:00"/>
<performer>
<reference value="urn:uuid:9243cc20-27bd-4f87-ba90-0328ed474950"/>
<type value="Organization"/>
<display value="aTypingLab Inc"/>
</performer>
<specimen>
<reference value="urn:uuid:e44fbe33-6084-4ae2-a95e-8bc451c63340"/>
<display value="buccal swab from John Storm"/>
</specimen>
<result>
<reference value="urn:uuid:49a86246-4004-42eb-9bdc-f542f93f9228"/>
<type value="Observation"/>
<display value="HLA-A: HLA-A:01:01:01G+HLA-A*01:02"/>
</result>
<result>
<reference value="urn:uuid:60613a43-c4cb-4502-b3e2-cf9215feaa70"/>
<type value="Observation"/>
<display value="HLA-B: HLA-B*15:01:01G+HLA-B*57:01:01G"/>
</result>
<result>
<reference value="urn:uuid:0e0a780e-4486-4cd0-bfae-7243c579f208"/>
<type value="Observation"/>
<display value="HLA-C: HLA-C*01:02:01G+HLA-C*03:04:01G"/>
</result>
</DiagnosticReport>
</resource>
<request>
<method value="POST"/>
<url value="DiagnosticReport"/>
</request>
</entry>
</Bundle>
IG © 2022+ HL7 International / Clinical Genomics. Package hl7.fhir.uv.genomics-reporting#3.0.0-ballot based on FHIR 4.0.1. Generated 2023-12-18
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