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: ConceptualExposureDefinition: Therapeutic-dose anticoagulation with heparin - JSON Representation

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{
  "resourceType" : "Group",
  "id" : "179786",
  "meta" : {
    "versionId" : "6",
    "lastUpdated" : "2025-03-15T21:01:28.297Z",
    "profile" : [
      🔗 "http://hl7.org/fhir/uv/ebm/StructureDefinition/conceptual-exposure-definition"
    ]
  },
  "text" : {
    "status" : "empty",
    "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>[No data.]</p></div>"
  },
  "extension" : [
    {
      "url" : "http://hl7.org/fhir/StructureDefinition/artifact-author",
      "valueContactDetail" : {
        "name" : "Brian S. Alper"
      }
    },
    {
      "url" : "http://hl7.org/fhir/uv/ebm/StructureDefinition/cite-as",
      "valueMarkdown" : "ConceptualExposureDefinition: Therapeutic-dose anticoagulation with heparin [Database Entry: FHIR Group Resource]. Contributors: Brian S. Alper [Authors/Creators]. In: Fast Evidence Interoperability Resources (FEvIR) Platform, FOI 179786. Revised 2024-12-27. Available at: https://fevir.net/resources/Group/179786. Computable resource at: https://fevir.net/resources/Group/179786#json."
    }
  ],
  "url" : "https://fevir.net/resources/Group/179786",
  "identifier" : [
    {
      "type" : {
        "coding" : [
          {
            "system" : "http://terminology.hl7.org/CodeSystem/v2-0203",
            "code" : "ACSN",
            "display" : "Accession ID"
          }
        ],
        "text" : "FEvIR Object Identifier"
      },
      "system" : "urn:ietf:rfc:3986",
      "value" : "https://fevir.net/FOI/179786",
      "assigner" : {
        "display" : "Computable Publishing LLC"
      }
    }
  ],
  "name" : "ConceptualExposureDefinition_Therapeutic_dose_anticoagulation_with_heparin",
  "title" : "ConceptualExposureDefinition: Therapeutic-dose anticoagulation with heparin",
  "status" : "active",
  "publisher" : "Computable Publishing LLC",
  "contact" : [
    {
      "telecom" : [
        {
          "system" : "email",
          "value" : "support@computablepublishing.com"
        }
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    }
  ],
  "description" : "Description: therapeutic-dose anticoagulation with heparin\nNote: Therapeutic-dose anticoagulation with unfractionated or low-molecular-weight heparin was administered according to local protocols for the treatment of acute venous thromboembolism for up to 14 days or until recovery; the latter was defined as hospital discharge or a discontinuation of supplemental oxygen for at least 24 hours.",
  "copyright" : "https://creativecommons.org/licenses/by-nc-sa/4.0/",
  "membership" : "conceptual",
  "combinationMethod" : "any-of",
  "characteristic" : [
    {
      "code" : {
        "text" : "Defined by CodeableConcept"
      },
      "valueCodeableConcept" : {
        "text" : "Therapeutic anticoagulation for 14 days (or until hospital discharge or liberation from the need for supplemental oxygen, whichever comes first) with preference for low-molecular weight heparin (LMWH), or alternative unfractionated heparin (UFH). LMWH dosed according to patient weight and creatinine clearance according to local practice and policy. For UFH, suggested target of aPTT 1.5 to 2.5 times the upper limit of normal or therapeutic anti-Xa levels."
      },
      "exclude" : false,
      "description" : "ATTACC investigational arm",
      "timing" : [
        {
          "contextCode" : {
            "text" : "Start of trial"
          },
          "offsetRange" : {
            "low" : {
              "value" : 0
            },
            "high" : {
              "value" : 14,
              "unit" : "days",
              "system" : "http://unitsofmeasure.org",
              "code" : "d"
            }
          },
          "text" : "Up to 14 days or until hospital discharge or recovery (defined as liberation from supplemental oxygen>24 hours, provided oxygen was required), whichever comes first."
        }
      ]
    },
    {
      "code" : {
        "text" : "Defined by CodeableConcept"
      },
      "valueCodeableConcept" : {
        "text" : "Low-molecular weight heparin (LMWH) dosed according to patient weight and creatinine clearance. For UFH, suggested target of anti-Xa of 0.3-0.7 IU/ml or aPTT 1.5 to 2.5 times the upper limit of normal."
      },
      "exclude" : false,
      "description" : "ACTIV-4a investigational arm",
      "timing" : [
        {
          "contextCode" : {
            "text" : "Start of trial"
          },
          "offsetRange" : {
            "low" : {
              "value" : 0
            },
            "high" : {
              "value" : 14,
              "unit" : "days",
              "system" : "http://unitsofmeasure.org",
              "code" : "d"
            }
          },
          "text" : "Up to 14 days or until hospital discharge, whichever comes first."
        }
      ]
    },
    {
      "code" : {
        "text" : "Defined by CodeableConcept"
      },
      "valueCodeableConcept" : {
        "text" : "Dosed according to local hospital policy, practice, and guidelines for treatment of venous thromboembolism. Low-molecular weight heparin (LMWH) dosed according to patient weight. For UFH, suggested target for aPTT of 1.5 to 2.5 times the upper limit of normal or therapeutic anti-Xa levels."
      },
      "exclude" : false,
      "description" : "REMAP-CAP investigational arm",
      "timing" : [
        {
          "contextCode" : {
            "text" : "Start of trial"
          },
          "offsetRange" : {
            "low" : {
              "value" : 0
            },
            "high" : {
              "value" : 14,
              "unit" : "days",
              "system" : "http://unitsofmeasure.org",
              "code" : "d"
            }
          },
          "text" : "Up to 14 days or until hospital discharge, whichever comes first."
        }
      ]
    }
  ]
}