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: ConceptualComparatorDefinition: Usual-care pharmacologic thromboprophylaxis - XML Representation

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<Group xmlns="http://hl7.org/fhir">
  <id value="179785"/>
  <meta>
    <versionId value="9"/>
    <lastUpdated value="2025-03-15T21:01:03.463Z"/>
    <profile
             value="http://hl7.org/fhir/uv/ebm/StructureDefinition/conceptual-comparator-definition"/>
  </meta>
  <text>
    <status value="empty"/>
    <div xmlns="http://www.w3.org/1999/xhtml"><p>[No data.]</p></div>
  </text>
  <extension url="http://hl7.org/fhir/StructureDefinition/artifact-author">
    <valueContactDetail>
      <name value="Brian S. Alper"/>
    </valueContactDetail>
  </extension>
  <extension url="http://hl7.org/fhir/uv/ebm/StructureDefinition/cite-as">
    <valueMarkdown
                   value="ConceptualComparatorDefinition: Usual-care pharmacologic thromboprophylaxis [Database Entry: FHIR Group Resource]. Contributors: Brian S. Alper [Authors/Creators]. In: Fast Evidence Interoperability Resources (FEvIR) Platform, FOI 179785. Revised 2024-12-27. Available at: https://fevir.net/resources/Group/179785. Computable resource at: https://fevir.net/resources/Group/179785#json."/>
  </extension>
  <url value="https://fevir.net/resources/Group/179785"/>
  <identifier>
    <type>
      <coding>
        <system value="http://terminology.hl7.org/CodeSystem/v2-0203"/>
        <code value="ACSN"/>
        <display value="Accession ID"/>
      </coding>
      <text value="FEvIR Object Identifier"/>
    </type>
    <system value="urn:ietf:rfc:3986"/>
    <value value="https://fevir.net/FOI/179785"/>
    <assigner>
      <display value="Computable Publishing LLC"/>
    </assigner>
  </identifier>
  <name
        value="ConceptualComparatorDefinition_Usual_care_pharmacologic_thromboprophylaxis"/>
  <title
         value="ConceptualComparatorDefinition: Usual-care pharmacologic thromboprophylaxis"/>
  <status value="active"/>
  <publisher value="Computable Publishing LLC"/>
  <contact>
    <telecom>
      <system value="email"/>
      <value value="support@computablepublishing.com"/>
    </telecom>
  </contact>
  <description
               value="Description: usual-care pharmacologic thromboprophylaxis
Note: Thromboprophylaxis was provided at a dose and duration determined by the treating clinician according to local practice.
Note: Usual-care pharmacological thromboprophylaxis included both intermediate-intensity (in 27%) and prophylactic-intensity dosing (in 72%). Subgroup analyses may be informative to determine if there is a difference related to the intensity used in the control arm of the trial."/>
  <copyright value="https://creativecommons.org/licenses/by-nc-sa/4.0/"/>
  <membership value="conceptual"/>
  <combinationMethod value="any-of"/>
  <characteristic>
    <code>
      <text value="Defined by CodeableConcept"/>
    </code>
    <valueCodeableConcept>
      <text
            value="Standard venous thromboprophylaxis according to local guidelines or usual practice. Dose of chosen agent should not be more than half of the approved therapeutic dose for the treatment of venous thromboembolism."/>
    </valueCodeableConcept>
    <exclude value="false"/>
    <description value="ATTACC comparator arm"/>
    <timing>
      <contextCode>
        <text value="Start of trial"/>
      </contextCode>
      <offsetRange>
        <low>
          <value value="0"/>
        </low>
        <high>
          <value value="14"/>
          <unit value="days"/>
          <system value="http://unitsofmeasure.org"/>
          <code value="d"/>
        </high>
      </offsetRange>
      <text
            value="Up to 14 days or until hospital discharge, whichever comes first. After this period, decisions regarding thromboprophylaxis are at discretion of treating clinician."/>
    </timing>
  </characteristic>
  <characteristic>
    <code>
      <text value="Defined by CodeableConcept"/>
    </code>
    <valueCodeableConcept>
      <text
            value="Any one of enoxaparin, dalteparin, tinzaparin, fondaparinux, or heparin according to local preference. Dose of agent specified to be consistent with guidelines for low dose thromboprophylaxis."/>
    </valueCodeableConcept>
    <exclude value="false"/>
    <description value="ACTIV-4a comparator arm"/>
    <timing>
      <contextCode>
        <text value="Start of trial"/>
      </contextCode>
      <offsetRange>
        <low>
          <value value="0"/>
        </low>
        <high>
          <value value="14"/>
          <unit value="days"/>
          <system value="http://unitsofmeasure.org"/>
          <code value="d"/>
        </high>
      </offsetRange>
      <text
            value="Up to 14 days or until hospital discharge, whichever comes first. After this period, decisions regarding thromboprophylaxis are at discretion of treating clinician."/>
    </timing>
  </characteristic>
  <characteristic>
    <code>
      <text value="Defined by CodeableConcept"/>
    </code>
    <valueCodeableConcept>
      <text
            value="Standard venous thromboprophylaxis according to local guidelines or usual practice. Dose of chosen agent should not be sufficient to result in therapeutic anticoagulation."/>
    </valueCodeableConcept>
    <exclude value="false"/>
    <description value="REMAP-CAP comparator arm"/>
    <timing>
      <contextCode>
        <text value="Start of trial"/>
      </contextCode>
      <offsetRange>
        <low>
          <value value="0"/>
        </low>
        <high>
          <value value="14"/>
          <unit value="days"/>
          <system value="http://unitsofmeasure.org"/>
          <code value="d"/>
        </high>
      </offsetRange>
      <text
            value="Up to 14 days or until hospital discharge, whichever comes first. After this period, decisions regarding thromboprophylaxis are at discretion of treating clinician."/>
    </timing>
  </characteristic>
</Group>