Evidence Based Medicine on FHIR Implementation Guide
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This page is part of the Evidence Based Medicine on FHIR Implementation Guide (v1.0.0-ballot2: STU1 Ballot 2) based on FHIR (HL7® FHIR® Standard) v6.0.0. No current official version has been published yet. For a full list of available versions, see the Directory of published versions

: MAGIC-derived Evidence: Cardiovascular mortality with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk - TTL Representation

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@prefix fhir: <http://hl7.org/fhir/> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

# - resource -------------------------------------------------------------------

 a fhir:Evidence ;
  fhir:nodeRole fhir:treeRoot ;
  fhir:id [ fhir:v "236543"] ; # 
  fhir:meta [
fhir:versionId [ fhir:v "65" ] ;
fhir:lastUpdated [ fhir:v "2025-03-20T18:40:09.616Z"^^xsd:dateTime ] ;
    ( fhir:profile [
fhir:v "http://hl7.org/fhir/uv/ebm/StructureDefinition/comparative-evidence"^^xsd:anyURI ;
fhir:link <http://hl7.org/fhir/uv/ebm/StructureDefinition/comparative-evidence>     ] )
  ] ; # 
  fhir:text [
fhir:status [ fhir:v "extensions" ] ;
fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p class=\"res-header-id\"><b>Generated Narrative: Evidence 236543</b></p><a name=\"236543\"> </a><a name=\"hc236543\"> </a><a name=\"236543-en-US\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">version: 65; Last updated: 2025-03-20 18:40:09+0000</p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-comparative-evidence.html\">ComparativeEvidence</a></p></div><blockquote><p><b>RelatesTo</b></p><ul><li>type: part-of</li><li>targetReference: MAGICapp Conversion Report: SGLT2 inhibitors and GLP-1 RA for type 2 diabetes (Identifier: FEvIR Linking Identifier/MAGIC-5288-j1Wqrn-conversion-report)</li></ul></blockquote><p><b>url</b>: <a href=\"https://fevir.net/resources/Evidence/236543\">https://fevir.net/resources/Evidence/236543</a></p><p><b>identifier</b>: FEvIR Object Identifier/https://fevir.net/FOI/236543, outcomeId/313877, picoId/85789, sectionId/73212</p><p><b>name</b>: Cardiovascular_mortality_from_MAGICapp_313877</p><p><b>title</b>: MAGIC-derived Evidence: Cardiovascular mortality with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk</p><p><b>status</b>: Active</p><p><b>publisher</b>: Computable Publishing LLC</p><p><b>contact</b>: <a href=\"mailto:support@computablepublishing.com\">support@computablepublishing.com</a></p><p><b>author</b>: Computable Publishing®: MAGIC-to-FEvIR Converter: </p><h3>UseContexts</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"CodeSystem-179423.html#179423-evidence-communication\">Evidence Based Medicine on FHIR Implementation Guide Code System evidence-communication</a>: Evidence Communication</td><td><span title=\"Codes:{https://fevir.net/resources/CodeSystem/179423 ComparativeEvidence}\">ComparativeEvidence</span></td></tr></table><p><b>copyright</b>: </p><div><p>https://creativecommons.org/licenses/by-nc-sa/4.0/</p>\n</div><p><b>description</b>: </p><div><p>This Evidence Resource is referenced in an example for the EBMonFHIR Implementation Guide.</p>\n</div><p><b>assertion</b>: </p><div><p>GLP-1 receptor agonists probably reduce the risk of cardiovascular death compared with standard care.</p>\n</div><blockquote><p><b>variableDefinition</b></p><p><b>description</b>: </p><div><p>Adults with type 2 diabetes with moderate CV risk</p>\n</div><p><b>variableRole</b>: Population</p><p><b>observed</b>: <a href=\"Group-236533.html\">Adults with type 2 diabetes and established CVD (but no CKD)</a></p></blockquote><blockquote><p><b>variableDefinition</b></p><p><b>description</b>: </p><div><p>GroupAssignment: GLP-1 RA vs. Standard care</p>\n</div><p><b>variableRole</b>: Exposure</p><p><b>comparatorCategory</b>: Standard care</p><p><b>observed</b>: <a href=\"EvidenceVariable-236536.html\">GroupAssignment: GLP-1 RA vs. Standard care</a></p></blockquote><blockquote><p><b>variableDefinition</b></p><p><b>description</b>: </p><div><p>Cardiovascular mortality</p>\n</div><p><b>variableRole</b>: Outcome</p><p><b>observed</b>: <a href=\"EvidenceVariable-236542.html\">Cardiovascular mortality</a></p></blockquote><p><b>synthesisType</b>: <span title=\"Codes:\">SYSTEMATIC_REVIEW</span></p><p><b>studyDesign</b>: <span title=\"Codes:{http://hl7.org/fhir/study-design SEVCO:01003}\">randomized assignment</span></p><blockquote><p><b>statistic</b></p><p><b>description</b>: </p><div><p>Risk Difference -0.9% (CI95 -1.5% to -0.3%)</p>\n</div><p><b>statisticType</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/statistic-type 0000424}\">Risk Difference</span></p><p><b>quantity</b>: -0.009</p><h3>SampleSizes</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>NumberOfStudies</b></td><td><b>NumberOfParticipants</b></td></tr><tr><td style=\"display: none\">*</td><td>20</td><td>63455</td></tr></table><h3>AttributeEstimates</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Range</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">CI95</span></td><td>-0.015--0.003</td></tr></table></blockquote><blockquote><p><b>statistic</b></p><p><b>description</b>: </p><div><p>OR 0.88 (CI95 0.8 to 0.96)</p>\n</div><p><b>statisticType</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/statistic-type C16932}\">Odds Ratio</span></p><p><b>quantity</b>: 0.88</p><h3>SampleSizes</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>NumberOfStudies</b></td><td><b>NumberOfParticipants</b></td></tr><tr><td style=\"display: none\">*</td><td>20</td><td>63455</td></tr></table><h3>AttributeEstimates</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Range</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">CI95</span></td><td>0.8-0.96</td></tr></table></blockquote><blockquote><p><b>certainty</b></p><p><b>description</b>: </p><div><p>Due to serious imprecision</p>\n</div><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/certainty-type Overall}\">Overall certainty</span></p><p><b>rating</b>: <span title=\"Codes:{https://fevir.net/resources/CodeSystem/27834 RJCS-2004}\">Moderate certainty</span></p><h3>Subcomponents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Rating</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">Risk of Bias</span></td><td><span title=\"Codes:\">NOTSET</span></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">Inconsistency</span></td><td><span title=\"Codes:\">NOTSET</span></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">Indirectness</span></td><td><span title=\"Codes:\">NOTSET</span></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">Imprecision</span></td><td><span title=\"Codes:\">NOTSET</span></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">Publication Bias</span></td><td><span title=\"Codes:\">NOTSET</span></td></tr></table></blockquote></div>"^^rdf:XMLLiteral
  ] ; # 
  fhir:extension ( [
    ( fhir:extension [
fhir:url [ fhir:v "type"^^xsd:anyURI ] ;
fhir:value [
a fhir:code ;
fhir:v "part-of"       ]     ] [
fhir:url [ fhir:v "targetReference"^^xsd:anyURI ] ;
fhir:value [
a fhir:Reference ;
fhir:type [ fhir:v "Composition"^^xsd:anyURI ] ;
fhir:identifier [
fhir:type [
fhir:text [ fhir:v "FEvIR Linking Identifier" ]           ] ;
fhir:system [ fhir:v "https://fevir.net/FLI"^^xsd:anyURI ] ;
fhir:value [ fhir:v "MAGIC-5288-j1Wqrn-conversion-report" ] ;
fhir:assigner [
fhir:display [ fhir:v "Computable Publishing LLC" ]           ]         ] ;
fhir:display [ fhir:v "MAGICapp Conversion Report: SGLT2 inhibitors and GLP-1 RA for type 2 diabetes" ]       ]     ] ) ;
fhir:url [ fhir:v "http://hl7.org/fhir/uv/ebm/StructureDefinition/relates-to"^^xsd:anyURI ]
  ] ) ; # 
  fhir:url [ fhir:v "https://fevir.net/resources/Evidence/236543"^^xsd:anyURI] ; # 
  fhir:identifier ( [
fhir:type [
      ( fhir:coding [
fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v2-0203"^^xsd:anyURI ] ;
fhir:code [ fhir:v "ACSN" ] ;
fhir:display [ fhir:v "Accession ID" ]       ] ) ;
fhir:text [ fhir:v "FEvIR Object Identifier" ]     ] ;
fhir:system [ fhir:v "urn:ietf:rfc:3986"^^xsd:anyURI ] ;
fhir:value [ fhir:v "https://fevir.net/FOI/236543" ] ;
fhir:assigner [
fhir:display [ fhir:v "Computable Publishing LLC" ]     ]
  ] [
fhir:type [
fhir:text [ fhir:v "outcomeId" ]     ] ;
fhir:system [ fhir:v "https://app.magicapp.org/#/guidelines"^^xsd:anyURI ] ;
fhir:value [ fhir:v "313877" ]
  ] [
fhir:type [
fhir:text [ fhir:v "picoId" ]     ] ;
fhir:system [ fhir:v "https://app.magicapp.org/#/guidelines"^^xsd:anyURI ] ;
fhir:value [ fhir:v "85789" ]
  ] [
fhir:type [
fhir:text [ fhir:v "sectionId" ]     ] ;
fhir:system [ fhir:v "https://app.magicapp.org/#/guidelines"^^xsd:anyURI ] ;
fhir:value [ fhir:v "73212" ]
  ] ) ; # 
  fhir:name [ fhir:v "Cardiovascular_mortality_from_MAGICapp_313877"] ; # 
  fhir:title [ fhir:v "MAGIC-derived Evidence: Cardiovascular mortality with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"] ; # 
  fhir:status [ fhir:v "active"] ; # 
  fhir:publisher [ fhir:v "Computable Publishing LLC"] ; # 
  fhir:contact ( [
    ( fhir:telecom [
fhir:system [ fhir:v "email" ] ;
fhir:value [ fhir:v "support@computablepublishing.com" ]     ] )
  ] ) ; # 
  fhir:author ( [
fhir:name [ fhir:v "Computable Publishing®: MAGIC-to-FEvIR Converter" ]
  ] ) ; # 
  fhir:useContext ( [
fhir:code [
fhir:system [ fhir:v "https://fevir.net/resources/CodeSystem/179423"^^xsd:anyURI ] ;
fhir:code [ fhir:v "evidence-communication" ] ;
fhir:display [ fhir:v "Evidence Communication" ]     ] ;
fhir:value [
a fhir:CodeableConcept ;
      ( fhir:coding [
fhir:system [ fhir:v "https://fevir.net/resources/CodeSystem/179423"^^xsd:anyURI ] ;
fhir:code [ fhir:v "ComparativeEvidence" ] ;
fhir:display [ fhir:v "ComparativeEvidence" ]       ] )     ]
  ] ) ; # 
  fhir:copyright [ fhir:v "https://creativecommons.org/licenses/by-nc-sa/4.0/"] ; # 
  fhir:description [ fhir:v "This Evidence Resource is referenced in an example for the EBMonFHIR Implementation Guide."] ; # 
  fhir:assertion [ fhir:v "GLP-1 receptor agonists probably reduce the risk of cardiovascular death compared with standard care."] ; # 
  fhir:variableDefinition ( [
fhir:description [ fhir:v "Adults with type 2 diabetes with moderate CV risk" ] ;
fhir:variableRole [ fhir:v "population" ] ;
fhir:observed [
fhir:reference [ fhir:v "Group/236533" ] ;
fhir:type [ fhir:v "Group"^^xsd:anyURI ] ;
fhir:identifier [
fhir:type [
fhir:text [ fhir:v "FEvIR Linking Identifier" ]         ] ;
fhir:system [ fhir:v "https://fevir.net/FLI"^^xsd:anyURI ] ;
fhir:value [ fhir:v "MAGIC-5288-j1Wqrn-population-group-85390-85789" ] ;
fhir:assigner [
fhir:display [ fhir:v "Computable Publishing LLC" ]         ]       ] ;
fhir:display [ fhir:v "Adults with type 2 diabetes and established CVD (but no CKD)" ]     ]
  ] [
fhir:description [ fhir:v "GroupAssignment: GLP-1 RA vs. Standard care" ] ;
fhir:variableRole [ fhir:v "exposure" ] ;
fhir:comparatorCategory [ fhir:v "Standard care" ] ;
fhir:observed [
fhir:reference [ fhir:v "EvidenceVariable/236536" ] ;
fhir:type [ fhir:v "EvidenceVariable"^^xsd:anyURI ] ;
fhir:identifier [
fhir:type [
fhir:text [ fhir:v "FEvIR Linking Identifier" ]         ] ;
fhir:system [ fhir:v "https://fevir.net/FLI"^^xsd:anyURI ] ;
fhir:value [ fhir:v "MAGIC-5288-j1Wqrn-group-assignment-85390-85789" ] ;
fhir:assigner [
fhir:display [ fhir:v "Computable Publishing LLC" ]         ]       ] ;
fhir:display [ fhir:v "GroupAssignment: GLP-1 RA vs. Standard care" ]     ]
  ] [
fhir:description [ fhir:v "Cardiovascular mortality" ] ;
fhir:variableRole [ fhir:v "outcome" ] ;
fhir:observed [
fhir:reference [ fhir:v "EvidenceVariable/236542" ] ;
fhir:type [ fhir:v "EvidenceVariable"^^xsd:anyURI ] ;
fhir:identifier [
fhir:type [
fhir:text [ fhir:v "FEvIR Linking Identifier" ]         ] ;
fhir:system [ fhir:v "https://fevir.net/FLI"^^xsd:anyURI ] ;
fhir:value [ fhir:v "MAGIC-5288-j1Wqrn-313877" ] ;
fhir:assigner [
fhir:display [ fhir:v "Computable Publishing LLC" ]         ]       ] ;
fhir:display [ fhir:v "Cardiovascular mortality" ]     ]
  ] ) ; # 
  fhir:synthesisType [
fhir:text [ fhir:v "SYSTEMATIC_REVIEW" ]
  ] ; # 
  fhir:studyDesign ( [
    ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/study-design"^^xsd:anyURI ] ;
fhir:code [ fhir:v "SEVCO:01003" ] ;
fhir:display [ fhir:v "randomized assignment" ]     ] )
  ] ) ; # 
  fhir:statistic ( [
fhir:description [ fhir:v "Risk Difference -0.9% (CI95 -1.5% to -0.3%)" ] ;
fhir:statisticType [
      ( fhir:coding [
fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/statistic-type"^^xsd:anyURI ] ;
fhir:version [ fhir:v "5.0.0-cibuild" ] ;
fhir:code [ fhir:v "0000424" ] ;
fhir:display [ fhir:v "Risk Difference" ]       ] )     ] ;
fhir:quantity [
fhir:value [ fhir:v -0.009 ]     ] ;
fhir:sampleSize [
fhir:numberOfStudies [ fhir:v "20"^^xsd:nonNegativeInteger ] ;
fhir:numberOfParticipants [ fhir:v "63455"^^xsd:nonNegativeInteger ]     ] ;
    ( fhir:attributeEstimate [
fhir:type [
fhir:text [ fhir:v "CI95" ]       ] ;
fhir:range [
fhir:low [
fhir:value [ fhir:v -0.015 ]         ] ;
fhir:high [
fhir:value [ fhir:v -0.003 ]         ]       ]     ] )
  ] [
fhir:description [ fhir:v "OR 0.88 (CI95 0.8 to 0.96)" ] ;
fhir:statisticType [
      ( fhir:coding [
fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/statistic-type"^^xsd:anyURI ] ;
fhir:version [ fhir:v "5.0.0-cibuild" ] ;
fhir:code [ fhir:v "C16932" ] ;
fhir:display [ fhir:v "Odds Ratio" ]       ] )     ] ;
fhir:quantity [
fhir:value [ fhir:v 0.88 ]     ] ;
fhir:sampleSize [
fhir:numberOfStudies [ fhir:v "20"^^xsd:nonNegativeInteger ] ;
fhir:numberOfParticipants [ fhir:v "63455"^^xsd:nonNegativeInteger ]     ] ;
    ( fhir:attributeEstimate [
fhir:type [
fhir:text [ fhir:v "CI95" ]       ] ;
fhir:range [
fhir:low [
fhir:value [ fhir:v 0.8 ]         ] ;
fhir:high [
fhir:value [ fhir:v 0.96 ]         ]       ]     ] )
  ] ) ; # 
  fhir:certainty ( [
fhir:description [ fhir:v "Due to serious imprecision" ] ;
fhir:type [
      ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/certainty-type"^^xsd:anyURI ] ;
fhir:code [ fhir:v "Overall" ] ;
fhir:display [ fhir:v "Overall certainty" ]       ] )     ] ;
fhir:rating [
      ( fhir:coding [
fhir:system [ fhir:v "https://fevir.net/resources/CodeSystem/27834"^^xsd:anyURI ] ;
fhir:code [ fhir:v "RJCS-2004" ] ;
fhir:display [ fhir:v "Moderate certainty" ]       ] )     ] ;
    ( fhir:subcomponent [
fhir:type [
fhir:text [ fhir:v "Risk of Bias" ]       ] ;
fhir:rating [
fhir:text [ fhir:v "NOTSET" ]       ]     ] [
fhir:type [
fhir:text [ fhir:v "Inconsistency" ]       ] ;
fhir:rating [
fhir:text [ fhir:v "NOTSET" ]       ]     ] [
fhir:type [
fhir:text [ fhir:v "Indirectness" ]       ] ;
fhir:rating [
fhir:text [ fhir:v "NOTSET" ]       ]     ] [
fhir:type [
fhir:text [ fhir:v "Imprecision" ]       ] ;
fhir:rating [
fhir:text [ fhir:v "NOTSET" ]       ]     ] [
fhir:type [
fhir:text [ fhir:v "Publication Bias" ]       ] ;
fhir:rating [
fhir:text [ fhir:v "NOTSET" ]       ]     ] )
  ] ) . #