Evidence Based Medicine on FHIR Implementation Guide
1.0.0-ballot2 - STU 1 ballot
Evidence Based Medicine on FHIR Implementation Guide
1.0.0-ballot2 - STU 1 ballot
This page is part of the Evidence Based Medicine on FHIR Implementation Guide (v1.0.0-ballot2: STU1 Ballot 2) based on FHIR (HL7® FHIR® Standard) v6.0.0. No current official version has been published yet. For a full list of available versions, see the Directory of published versions
| Page standards status: Informative |
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"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>0.12</p></div>"
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🔗 "reference" : "Evidence/236541",
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"text" : {
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"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>0.11</p></div>"
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🔗 "reference" : "Evidence/293872",
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{
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"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>10.7%</p></div>"
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🔗 "reference" : "Evidence/236540",
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{
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"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>Risk Difference -1.3% ( -1.8% to -0.6%); Odds Ratio 0.88 ( 0.83 to 0.94)</p></div>"
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"display" : "MAGIC-derived Evidence: All-cause mortality with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
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"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>GLP-1 receptor agonists probably reduce the risk of death compared with standard care.</p></div>"
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{
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"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>Cardiovascular mortality</p></div>"
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"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>20 studies, 63455 participants</p></div>"
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"display" : "MAGIC-derived ComparatorOnlyEvidence: Cardiovascular mortality in Standard care Group in Adults with type 2 diabetes with moderate CV risk"
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🔗 "reference" : "Evidence/293873",
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},
"display" : "MAGIC-derived InterventionOnlyEvidence: Cardiovascular mortality in GLP-1 RA Group in Adults with type 2 diabetes with moderate CV risk"
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},
{
"title" : "Result With Treatment--Derived",
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"text" : "result with intervention with calculated value derived from the control group and effect estimate"
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"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>7%</p></div>"
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},
"display" : "MAGIC-derived ComparatorOnlyEvidence: Cardiovascular mortality in Standard care Group in Adults with type 2 diabetes with moderate CV risk"
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{
🔗 "reference" : "Evidence/236543",
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"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-dichotomous-outcome-313877-comparative-evidence",
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}
},
"display" : "MAGIC-derived Evidence: Cardiovascular mortality with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title" : "Effect Estimate",
"code" : {
"coding" : [
{
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"display" : "Result with intervention vs. comparator"
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]
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>Risk Difference -0.9% ( -1.5% to -0.3%); Odds Ratio 0.88 ( 0.8 to 0.96)</p></div>"
},
"entry" : [
{
🔗 "reference" : "Evidence/236543",
"type" : "Evidence",
"identifier" : {
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"value" : "MAGIC-5288-j1Wqrn-dichotomous-outcome-313877-comparative-evidence",
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}
},
"display" : "MAGIC-derived Evidence: Cardiovascular mortality with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title" : "Certainty of Evidence",
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"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
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"display" : "Certainty of Evidence"
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]
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>Moderate certainty</p></div>"
},
"entry" : [
{
🔗 "reference" : "Evidence/236543",
"type" : "Evidence",
"identifier" : {
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"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-dichotomous-outcome-313877-comparative-evidence",
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}
},
"display" : "MAGIC-derived Evidence: Cardiovascular mortality with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title" : "Assertion",
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{
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"display" : "Assertion"
}
]
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>GLP-1 receptor agonists probably reduce the risk of cardiovascular death compared with standard care.</p></div>"
},
"entry" : [
{
🔗 "reference" : "Evidence/236543",
"type" : "Evidence",
"identifier" : {
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"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
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}
},
"display" : "MAGIC-derived Evidence: Cardiovascular mortality with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
}
]
},
{
"title" : "Nonfatal myocardial infarction",
"code" : {
"coding" : [
{
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"code" : "summary-of-findings-entry-for-a-single-outcome",
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]
},
"focus" : {
🔗 "reference" : "EvidenceVariable/236545",
"type" : "EvidenceVariable",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
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"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-313878",
"assigner" : {
"display" : "Computable Publishing LLC"
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},
"display" : "OutcomeDefinition: Nonfatal myocardial infarction"
},
"text" : {
"status" : "empty",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>[No data.]</p></div>"
},
"section" : [
{
"title" : "Outcome",
"code" : {
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{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "outcome-measure",
"display" : "Outcome Measure"
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]
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>Nonfatal myocardial infarction</p></div>"
},
"entry" : [
{
🔗 "reference" : "EvidenceVariable/236545",
"type" : "EvidenceVariable",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
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"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-313878",
"assigner" : {
"display" : "Computable Publishing LLC"
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},
"display" : "OutcomeDefinition: Nonfatal myocardial infarction"
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]
},
{
"title" : "Sample Size",
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"coding" : [
{
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"code" : "sample-size",
"display" : "Sample Size"
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]
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"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>32 studies, 67956 participants</p></div>"
},
"entry" : [
{
🔗 "reference" : "Evidence/236546",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-dichotomous-outcome-313878-comparative-evidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived Evidence: Nonfatal myocardial infarction with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title" : "Result Without Treatment",
"code" : {
"coding" : [
{
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"code" : "result-with-comparator-alone",
"display" : "Result with comparator alone"
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]
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>0.11</p></div>"
},
"entry" : [
{
🔗 "reference" : "Evidence/236547",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-dichotomous-outcome-313878-comparator-only-evidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived ComparatorOnlyEvidence: Nonfatal myocardial infarction in Standard care Group in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title" : "Result With Treatment--Observed",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "result-with-intervention-alone",
"display" : "Result with intervention alone"
}
]
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>0.1</p></div>"
},
"entry" : [
{
🔗 "reference" : "Evidence/293874",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-dichotomous-outcome-313878-intervention-only-evidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived InterventionOnlyEvidence: Nonfatal myocardial infarction in GLP-1 RA Group in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title" : "Result With Treatment--Derived",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "result-with-intervention-alone-calculated",
"display" : "Result with intervention alone (calculated)"
}
],
"text" : "result with intervention with calculated value derived from the control group and effect estimate"
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>10%</p></div>"
},
"entry" : [
{
🔗 "reference" : "Evidence/236547",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-dichotomous-outcome-313878-comparator-only-evidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived ComparatorOnlyEvidence: Nonfatal myocardial infarction in Standard care Group in Adults with type 2 diabetes with moderate CV risk"
},
{
🔗 "reference" : "Evidence/236546",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-dichotomous-outcome-313878-comparative-evidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived Evidence: Nonfatal myocardial infarction with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title" : "Effect Estimate",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "result-with-intervention-vs-comparator",
"display" : "Result with intervention vs. comparator"
}
]
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>Risk Difference -0.8% ( -1.5% to -0.1%); Odds Ratio 0.92 ( 0.85 to 0.99)</p></div>"
},
"entry" : [
{
🔗 "reference" : "Evidence/236546",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-dichotomous-outcome-313878-comparative-evidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived Evidence: Nonfatal myocardial infarction with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title" : "Certainty of Evidence",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "certainty-of-evidence",
"display" : "Certainty of Evidence"
}
]
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>Moderate certainty</p></div>"
},
"entry" : [
{
🔗 "reference" : "Evidence/236546",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-dichotomous-outcome-313878-comparative-evidence",
"assigner" : {
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}
},
"display" : "MAGIC-derived Evidence: Nonfatal myocardial infarction with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title" : "Assertion",
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"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "assertion",
"display" : "Assertion"
}
]
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>GLP-1 receptor agonists probably reduce the risk of nonfatal myocardial infarction compared with standard care.</p></div>"
},
"entry" : [
{
🔗 "reference" : "Evidence/236546",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-dichotomous-outcome-313878-comparative-evidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived Evidence: Nonfatal myocardial infarction with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
}
]
},
{
"title" : "Nonfatal stroke",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "summary-of-findings-entry-for-a-single-outcome",
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]
},
"focus" : {
🔗 "reference" : "EvidenceVariable/236548",
"type" : "EvidenceVariable",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
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"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-313879",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "OutcomeDefinition: Nonfatal stroke"
},
"text" : {
"status" : "empty",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>[No data.]</p></div>"
},
"section" : [
{
"title" : "Outcome",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "outcome-measure",
"display" : "Outcome Measure"
}
]
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>Nonfatal stroke</p></div>"
},
"entry" : [
{
🔗 "reference" : "EvidenceVariable/236548",
"type" : "EvidenceVariable",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
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"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-313879",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "OutcomeDefinition: Nonfatal stroke"
}
]
},
{
"title" : "Sample Size",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "sample-size",
"display" : "Sample Size"
}
]
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>29 studies, 66900 participants</p></div>"
},
"entry" : [
{
🔗 "reference" : "Evidence/236549",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-dichotomous-outcome-313879-comparative-evidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived Evidence: Nonfatal stroke with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title" : "Result Without Treatment",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "result-with-comparator-alone",
"display" : "Result with comparator alone"
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]
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>0.11</p></div>"
},
"entry" : [
{
🔗 "reference" : "Evidence/236550",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-dichotomous-outcome-313879-comparator-only-evidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived ComparatorOnlyEvidence: Nonfatal stroke in Standard care Group in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title" : "Result With Treatment--Observed",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "result-with-intervention-alone",
"display" : "Result with intervention alone"
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]
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>0.09</p></div>"
},
"entry" : [
{
🔗 "reference" : "Evidence/293875",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-dichotomous-outcome-313879-intervention-only-evidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived InterventionOnlyEvidence: Nonfatal stroke in GLP-1 RA Group in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title" : "Result With Treatment--Derived",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "result-with-intervention-alone-calculated",
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],
"text" : "result with intervention with calculated value derived from the control group and effect estimate"
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>9.2%</p></div>"
},
"entry" : [
{
🔗 "reference" : "Evidence/236550",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-dichotomous-outcome-313879-comparator-only-evidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived ComparatorOnlyEvidence: Nonfatal stroke in Standard care Group in Adults with type 2 diabetes with moderate CV risk"
},
{
🔗 "reference" : "Evidence/236549",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-dichotomous-outcome-313879-comparative-evidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived Evidence: Nonfatal stroke with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title" : "Effect Estimate",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "result-with-intervention-vs-comparator",
"display" : "Result with intervention vs. comparator"
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]
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>Risk Difference -1.6% ( -2.4% to -0.7%); Odds Ratio 0.84 ( 0.76 to 0.93)</p></div>"
},
"entry" : [
{
🔗 "reference" : "Evidence/236549",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
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"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-dichotomous-outcome-313879-comparative-evidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived Evidence: Nonfatal stroke with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title" : "Certainty of Evidence",
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"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "certainty-of-evidence",
"display" : "Certainty of Evidence"
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]
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>Moderate certainty</p></div>"
},
"entry" : [
{
🔗 "reference" : "Evidence/236549",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
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"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-dichotomous-outcome-313879-comparative-evidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived Evidence: Nonfatal stroke with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title" : "Assertion",
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"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "assertion",
"display" : "Assertion"
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]
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>GLP-1 receptor agonists probably reduce the risk of nonfatal stroke compared with standard care.</p></div>"
},
"entry" : [
{
🔗 "reference" : "Evidence/236549",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
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"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-dichotomous-outcome-313879-comparative-evidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived Evidence: Nonfatal stroke with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
}
]
},
{
"title" : "End-stage kidney disease",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "summary-of-findings-entry-for-a-single-outcome",
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]
},
"focus" : {
🔗 "reference" : "EvidenceVariable/236551",
"type" : "EvidenceVariable",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
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"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-313880",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "OutcomeDefinition: End-stage kidney disease"
},
"text" : {
"status" : "empty",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>[No data.]</p></div>"
},
"section" : [
{
"title" : "Outcome",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "outcome-measure",
"display" : "Outcome Measure"
}
]
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>End-stage kidney disease</p></div>"
},
"entry" : [
{
🔗 "reference" : "EvidenceVariable/236551",
"type" : "EvidenceVariable",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-313880",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "OutcomeDefinition: End-stage kidney disease"
}
]
},
{
"title" : "Sample Size",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "sample-size",
"display" : "Sample Size"
}
]
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>4 studies, 10762 participants</p></div>"
},
"entry" : [
{
🔗 "reference" : "Evidence/236552",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-dichotomous-outcome-313880-comparative-evidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived Evidence: End-stage kidney disease with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title" : "Result Without Treatment",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "result-with-comparator-alone",
"display" : "Result with comparator alone"
}
]
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>0.02</p></div>"
},
"entry" : [
{
🔗 "reference" : "Evidence/236553",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-dichotomous-outcome-313880-comparator-only-evidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived ComparatorOnlyEvidence: End-stage kidney disease in Standard care Group in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title" : "Result With Treatment--Observed",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "result-with-intervention-alone",
"display" : "Result with intervention alone"
}
]
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>0.02</p></div>"
},
"entry" : [
{
🔗 "reference" : "Evidence/293876",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-dichotomous-outcome-313880-intervention-only-evidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived InterventionOnlyEvidence: End-stage kidney disease in GLP-1 RA Group in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title" : "Result With Treatment--Derived",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "result-with-intervention-alone-calculated",
"display" : "Result with intervention alone (calculated)"
}
],
"text" : "result with intervention with calculated value derived from the control group and effect estimate"
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>1.6%</p></div>"
},
"entry" : [
{
🔗 "reference" : "Evidence/236553",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-dichotomous-outcome-313880-comparator-only-evidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived ComparatorOnlyEvidence: End-stage kidney disease in Standard care Group in Adults with type 2 diabetes with moderate CV risk"
},
{
🔗 "reference" : "Evidence/236552",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-dichotomous-outcome-313880-comparative-evidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived Evidence: End-stage kidney disease with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title" : "Effect Estimate",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "result-with-intervention-vs-comparator",
"display" : "Result with intervention vs. comparator"
}
]
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>Risk Difference -0.4% ( -0.7% to -0.2%); Odds Ratio 0.78 ( 0.67 to 0.92)</p></div>"
},
"entry" : [
{
🔗 "reference" : "Evidence/236552",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-dichotomous-outcome-313880-comparative-evidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived Evidence: End-stage kidney disease with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title" : "Certainty of Evidence",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "certainty-of-evidence",
"display" : "Certainty of Evidence"
}
]
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>High certainty</p></div>"
},
"entry" : [
{
🔗 "reference" : "Evidence/236552",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-dichotomous-outcome-313880-comparative-evidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived Evidence: End-stage kidney disease with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title" : "Assertion",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "assertion",
"display" : "Assertion"
}
]
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>There is no important difference between GLP-1 receptor agonists and standard care.</p></div>"
},
"entry" : [
{
🔗 "reference" : "Evidence/236552",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-dichotomous-outcome-313880-comparative-evidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived Evidence: End-stage kidney disease with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
}
]
},
{
"title" : "Heart failure",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "summary-of-findings-entry-for-a-single-outcome",
"display" : "Summary of findings entry for a single outcome"
}
]
},
"focus" : {
🔗 "reference" : "EvidenceVariable/236554",
"type" : "EvidenceVariable",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-313881",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "OutcomeDefinition: Heart failure"
},
"text" : {
"status" : "empty",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>[No data.]</p></div>"
},
"section" : [
{
"title" : "Outcome",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "outcome-measure",
"display" : "Outcome Measure"
}
]
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>Heart failure</p></div>"
},
"entry" : [
{
🔗 "reference" : "EvidenceVariable/236554",
"type" : "EvidenceVariable",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-313881",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "OutcomeDefinition: Heart failure"
}
]
},
{
"title" : "Sample Size",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "sample-size",
"display" : "Sample Size"
}
]
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>13 studies, 46696 participants</p></div>"
},
"entry" : [
{
🔗 "reference" : "Evidence/236555",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-dichotomous-outcome-313881-comparative-evidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived Evidence: Heart failure with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title" : "Result Without Treatment",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "result-with-comparator-alone",
"display" : "Result with comparator alone"
}
]
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>0.08</p></div>"
},
"entry" : [
{
🔗 "reference" : "Evidence/236556",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-dichotomous-outcome-313881-comparator-only-evidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived ComparatorOnlyEvidence: Heart failure in Standard care Group in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title" : "Result With Treatment--Observed",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "result-with-intervention-alone",
"display" : "Result with intervention alone"
}
]
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>0.08</p></div>"
},
"entry" : [
{
🔗 "reference" : "Evidence/293877",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-dichotomous-outcome-313881-intervention-only-evidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived InterventionOnlyEvidence: Heart failure in GLP-1 RA Group in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title" : "Result With Treatment--Derived",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "result-with-intervention-alone-calculated",
"display" : "Result with intervention alone (calculated)"
}
],
"text" : "result with intervention with calculated value derived from the control group and effect estimate"
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>7.6%</p></div>"
},
"entry" : [
{
🔗 "reference" : "Evidence/236556",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-dichotomous-outcome-313881-comparator-only-evidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived ComparatorOnlyEvidence: Heart failure in Standard care Group in Adults with type 2 diabetes with moderate CV risk"
},
{
🔗 "reference" : "Evidence/236555",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-dichotomous-outcome-313881-comparative-evidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived Evidence: Heart failure with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title" : "Effect Estimate",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "result-with-intervention-vs-comparator",
"display" : "Result with intervention vs. comparator"
}
]
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>Risk Difference -0.4% ( -1.1% to 0.2%); Odds Ratio 0.94 ( 0.85 to 1.03)</p></div>"
},
"entry" : [
{
🔗 "reference" : "Evidence/236555",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-dichotomous-outcome-313881-comparative-evidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived Evidence: Heart failure with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title" : "Certainty of Evidence",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "certainty-of-evidence",
"display" : "Certainty of Evidence"
}
]
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>Moderate certainty</p></div>"
},
"entry" : [
{
🔗 "reference" : "Evidence/236555",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-dichotomous-outcome-313881-comparative-evidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived Evidence: Heart failure with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title" : "Assertion",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "assertion",
"display" : "Assertion"
}
]
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>GLP-1 receptor agonists probably reduce the risk of heart failure compared with standard care.</p></div>"
},
"entry" : [
{
🔗 "reference" : "Evidence/236555",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-dichotomous-outcome-313881-comparative-evidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived Evidence: Heart failure with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
}
]
},
{
"title" : "Serious hyperglycaemia",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "summary-of-findings-entry-for-a-single-outcome",
"display" : "Summary of findings entry for a single outcome"
}
]
},
"focus" : {
🔗 "reference" : "EvidenceVariable/236557",
"type" : "EvidenceVariable",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-313882",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "OutcomeDefinition: Serious hyperglycaemia"
},
"text" : {
"status" : "empty",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>[No data.]</p></div>"
},
"section" : [
{
"title" : "Outcome",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "outcome-measure",
"display" : "Outcome Measure"
}
]
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>Serious hyperglycaemia</p></div>"
},
"entry" : [
{
🔗 "reference" : "EvidenceVariable/236557",
"type" : "EvidenceVariable",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-313882",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "OutcomeDefinition: Serious hyperglycaemia"
}
]
},
{
"title" : "Sample Size",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "sample-size",
"display" : "Sample Size"
}
]
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>12 studies, 30066 participants</p></div>"
},
"entry" : [
{
🔗 "reference" : "Evidence/236558",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-dichotomous-outcome-313882-comparative-evidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived Evidence: Serious hyperglycaemia with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title" : "Result Without Treatment",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "result-with-comparator-alone",
"display" : "Result with comparator alone"
}
]
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>0.03</p></div>"
},
"entry" : [
{
🔗 "reference" : "Evidence/236559",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-dichotomous-outcome-313882-comparator-only-evidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived ComparatorOnlyEvidence: Serious hyperglycaemia in Standard care Group in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title" : "Result With Treatment--Observed",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "result-with-intervention-alone",
"display" : "Result with intervention alone"
}
]
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>0.01</p></div>"
},
"entry" : [
{
🔗 "reference" : "Evidence/293878",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-dichotomous-outcome-313882-intervention-only-evidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived InterventionOnlyEvidence: Serious hyperglycaemia in GLP-1 RA Group in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title" : "Result With Treatment--Derived",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "result-with-intervention-alone-calculated",
"display" : "Result with intervention alone (calculated)"
}
],
"text" : "result with intervention with calculated value derived from the control group and effect estimate"
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>1%</p></div>"
},
"entry" : [
{
🔗 "reference" : "Evidence/236559",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-dichotomous-outcome-313882-comparator-only-evidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived ComparatorOnlyEvidence: Serious hyperglycaemia in Standard care Group in Adults with type 2 diabetes with moderate CV risk"
},
{
🔗 "reference" : "Evidence/236558",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-dichotomous-outcome-313882-comparative-evidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived Evidence: Serious hyperglycaemia with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title" : "Effect Estimate",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "result-with-intervention-vs-comparator",
"display" : "Result with intervention vs. comparator"
}
]
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>Risk Difference -1.5% ( -1.9% to -0.9%); Odds Ratio 0.4 ( 0.25 to 0.64)</p></div>"
},
"entry" : [
{
🔗 "reference" : "Evidence/236558",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-dichotomous-outcome-313882-comparative-evidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived Evidence: Serious hyperglycaemia with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title" : "Certainty of Evidence",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "certainty-of-evidence",
"display" : "Certainty of Evidence"
}
]
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>High certainty</p></div>"
},
"entry" : [
{
🔗 "reference" : "Evidence/236558",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-dichotomous-outcome-313882-comparative-evidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived Evidence: Serious hyperglycaemia with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title" : "Assertion",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "assertion",
"display" : "Assertion"
}
]
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>GLP-1 receptor agonists reduce the risk of serious hyperglycaemia compared with standard care.</p></div>"
},
"entry" : [
{
🔗 "reference" : "Evidence/236558",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-dichotomous-outcome-313882-comparative-evidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived Evidence: Serious hyperglycaemia with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
}
]
},
{
"title" : "Severe gastrointestinal events",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "summary-of-findings-entry-for-a-single-outcome",
"display" : "Summary of findings entry for a single outcome"
}
]
},
"focus" : {
🔗 "reference" : "EvidenceVariable/236560",
"type" : "EvidenceVariable",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-313883",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "OutcomeDefinition: Severe gastrointestinal events"
},
"text" : {
"status" : "empty",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>[No data.]</p></div>"
},
"section" : [
{
"title" : "Outcome",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "outcome-measure",
"display" : "Outcome Measure"
}
]
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>Severe gastrointestinal events</p></div>"
},
"entry" : [
{
🔗 "reference" : "EvidenceVariable/236560",
"type" : "EvidenceVariable",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-313883",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "OutcomeDefinition: Severe gastrointestinal events"
}
]
},
{
"title" : "Sample Size",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "sample-size",
"display" : "Sample Size"
}
]
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>7 studies, 24638 participants</p></div>"
},
"entry" : [
{
🔗 "reference" : "Evidence/236561",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-dichotomous-outcome-313883-comparative-evidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived Evidence: Severe gastrointestinal events with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title" : "Result Without Treatment",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "result-with-comparator-alone",
"display" : "Result with comparator alone"
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]
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>0.04</p></div>"
},
"entry" : [
{
🔗 "reference" : "Evidence/236562",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-dichotomous-outcome-313883-comparator-only-evidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived ComparatorOnlyEvidence: Severe gastrointestinal events in Standard care Group in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title" : "Result With Treatment--Observed",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "result-with-intervention-alone",
"display" : "Result with intervention alone"
}
]
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>0.1</p></div>"
},
"entry" : [
{
🔗 "reference" : "Evidence/293879",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-dichotomous-outcome-313883-intervention-only-evidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived InterventionOnlyEvidence: Severe gastrointestinal events in GLP-1 RA Group in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title" : "Result With Treatment--Derived",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "result-with-intervention-alone-calculated",
"display" : "Result with intervention alone (calculated)"
}
],
"text" : "result with intervention with calculated value derived from the control group and effect estimate"
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>10.2%</p></div>"
},
"entry" : [
{
🔗 "reference" : "Evidence/236562",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-dichotomous-outcome-313883-comparator-only-evidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived ComparatorOnlyEvidence: Severe gastrointestinal events in Standard care Group in Adults with type 2 diabetes with moderate CV risk"
},
{
🔗 "reference" : "Evidence/236561",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-dichotomous-outcome-313883-comparative-evidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived Evidence: Severe gastrointestinal events with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title" : "Effect Estimate",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "result-with-intervention-vs-comparator",
"display" : "Result with intervention vs. comparator"
}
]
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>Risk Difference 5.8% ( 0.9% to 14.2%); Odds Ratio 2.46 ( 1.22 to 4.97)</p></div>"
},
"entry" : [
{
🔗 "reference" : "Evidence/236561",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-dichotomous-outcome-313883-comparative-evidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived Evidence: Severe gastrointestinal events with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title" : "Certainty of Evidence",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "certainty-of-evidence",
"display" : "Certainty of Evidence"
}
]
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>Low certainty</p></div>"
},
"entry" : [
{
🔗 "reference" : "Evidence/236561",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-dichotomous-outcome-313883-comparative-evidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived Evidence: Severe gastrointestinal events with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title" : "Assertion",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "assertion",
"display" : "Assertion"
}
]
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>GLP-1 receptor agonists may increase the risk of severe gastrointestinal events compared with standard care.</p></div>"
},
"entry" : [
{
🔗 "reference" : "Evidence/236561",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-dichotomous-outcome-313883-comparative-evidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived Evidence: Severe gastrointestinal events with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
}
]
},
{
"title" : "Health-related quality of life",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "summary-of-findings-entry-for-a-single-outcome",
"display" : "Summary of findings entry for a single outcome"
}
]
},
"focus" : {
🔗 "reference" : "EvidenceVariable/236563",
"type" : "EvidenceVariable",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-109569",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "OutcomeDefinition: Health-related quality of life"
},
"text" : {
"status" : "empty",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>[No data.]</p></div>"
},
"section" : [
{
"title" : "Outcome",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "outcome-measure",
"display" : "Outcome Measure"
}
]
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>Health-related quality of life</p></div>"
},
"entry" : [
{
🔗 "reference" : "EvidenceVariable/236563",
"type" : "EvidenceVariable",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-109569",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "OutcomeDefinition: Health-related quality of life"
}
]
},
{
"title" : "Sample Size",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "sample-size",
"display" : "Sample Size"
}
]
},
"text" : {
"status" : "empty",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>[No sample size data found.]</p></div>"
},
"entry" : [
{
🔗 "reference" : "Evidence/236564",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-continuous-outcome-109569-comparative-evidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived Evidence: Health-related quality of life with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title" : "Result Without Treatment",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "result-with-comparator-alone",
"display" : "Result with comparator alone"
}
]
},
"text" : {
"status" : "empty",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>[Not a proportion.]</p></div>"
},
"entry" : [
{
🔗 "reference" : "Evidence/236565",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-continuous-outcome-109569-comparator-only-evidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived ComparatorOnlyEvidence: Health-related quality of life in Standard care Group in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title" : "Result With Treatment--Observed",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "result-with-intervention-alone",
"display" : "Result with intervention alone"
}
]
},
"text" : {
"status" : "empty",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>[Not a proportion.]</p></div>"
},
"entry" : [
{
🔗 "reference" : "Evidence/293880",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-continuous-outcome-109569-intervention-only-evidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived InterventionOnlyEvidence: Health-related quality of life in GLP-1 RA Group in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title" : "Result With Treatment--Derived",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "result-with-intervention-alone-calculated",
"display" : "Result with intervention alone (calculated)"
}
],
"text" : "result with intervention with calculated value derived from the control group and effect estimate"
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>[Not a proportion.]</p></div>"
},
"entry" : [
{
🔗 "reference" : "Evidence/236565",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-continuous-outcome-109569-comparator-only-evidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived ComparatorOnlyEvidence: Health-related quality of life in Standard care Group in Adults with type 2 diabetes with moderate CV risk"
},
{
🔗 "reference" : "Evidence/236564",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-continuous-outcome-109569-comparative-evidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived Evidence: Health-related quality of life with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title" : "Effect Estimate",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "result-with-intervention-vs-comparator",
"display" : "Result with intervention vs. comparator"
}
]
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>Standardized Mean Difference 0.13 ( 0.03 to 0.23)</p></div>"
},
"entry" : [
{
🔗 "reference" : "Evidence/236564",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-continuous-outcome-109569-comparative-evidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived Evidence: Health-related quality of life with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title" : "Certainty of Evidence",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "certainty-of-evidence",
"display" : "Certainty of Evidence"
}
]
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>Low certainty</p></div>"
},
"entry" : [
{
🔗 "reference" : "Evidence/236564",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-continuous-outcome-109569-comparative-evidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived Evidence: Health-related quality of life with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title" : "Assertion",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "assertion",
"display" : "Assertion"
}
]
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>GLP-1 receptor agonists may have little or no impact on health-related quality of life.</p></div>"
},
"entry" : [
{
🔗 "reference" : "Evidence/236564",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-continuous-outcome-109569-comparative-evidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived Evidence: Health-related quality of life with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
}
]
},
{
"title" : "Body weight",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "summary-of-findings-entry-for-a-single-outcome",
"display" : "Summary of findings entry for a single outcome"
}
]
},
"focus" : {
🔗 "reference" : "EvidenceVariable/236566",
"type" : "EvidenceVariable",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-109570",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "OutcomeDefinition: Body weight"
},
"text" : {
"status" : "empty",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>[No data.]</p></div>"
},
"section" : [
{
"title" : "Outcome",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "outcome-measure",
"display" : "Outcome Measure"
}
]
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>Body weight</p></div>"
},
"entry" : [
{
🔗 "reference" : "EvidenceVariable/236566",
"type" : "EvidenceVariable",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-109570",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "OutcomeDefinition: Body weight"
}
]
},
{
"title" : "Sample Size",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "sample-size",
"display" : "Sample Size"
}
]
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>60 studies, 44432 participants</p></div>"
},
"entry" : [
{
🔗 "reference" : "Evidence/236567",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-continuous-outcome-109570-comparative-evidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived Evidence: Body weight with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title" : "Result Without Treatment",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "result-with-comparator-alone",
"display" : "Result with comparator alone"
}
]
},
"text" : {
"status" : "empty",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>[Not a proportion.]</p></div>"
},
"entry" : [
{
🔗 "reference" : "Evidence/236568",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-continuous-outcome-109570-comparator-only-evidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived ComparatorOnlyEvidence: Body weight in Standard care Group in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title" : "Result With Treatment--Observed",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "result-with-intervention-alone",
"display" : "Result with intervention alone"
}
]
},
"text" : {
"status" : "empty",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>[Not a proportion.]</p></div>"
},
"entry" : [
{
🔗 "reference" : "Evidence/293881",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-continuous-outcome-109570-intervention-only-evidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived InterventionOnlyEvidence: Body weight in GLP-1 RA Group in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title" : "Result With Treatment--Derived",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "result-with-intervention-alone-calculated",
"display" : "Result with intervention alone (calculated)"
}
],
"text" : "result with intervention with calculated value derived from the control group and effect estimate"
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>[Not a proportion.]</p></div>"
},
"entry" : [
{
🔗 "reference" : "Evidence/236568",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-continuous-outcome-109570-comparator-only-evidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived ComparatorOnlyEvidence: Body weight in Standard care Group in Adults with type 2 diabetes with moderate CV risk"
},
{
🔗 "reference" : "Evidence/236567",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-continuous-outcome-109570-comparative-evidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived Evidence: Body weight with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title" : "Effect Estimate",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "result-with-intervention-vs-comparator",
"display" : "Result with intervention vs. comparator"
}
]
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>Mean Difference -1.45 Kg ( -1.72 Kg to -1.18 Kg)</p></div>"
},
"entry" : [
{
🔗 "reference" : "Evidence/236567",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-continuous-outcome-109570-comparative-evidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived Evidence: Body weight with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title" : "Certainty of Evidence",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "certainty-of-evidence",
"display" : "Certainty of Evidence"
}
]
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>Low certainty</p></div>"
},
"entry" : [
{
🔗 "reference" : "Evidence/236567",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-continuous-outcome-109570-comparative-evidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived Evidence: Body weight with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title" : "Assertion",
"code" : {
"coding" : [
{
"system" : "https://fevir.net/resources/CodeSystem/179423",
"code" : "assertion",
"display" : "Assertion"
}
]
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>GLP-1 receptor agonists may reduce body weight compared with standard care.</p></div>"
},
"entry" : [
{
🔗 "reference" : "Evidence/236567",
"type" : "Evidence",
"identifier" : {
"type" : {
"text" : "FEvIR Linking Identifier"
},
"system" : "https://fevir.net/FLI",
"value" : "MAGIC-5288-j1Wqrn-continuous-outcome-109570-comparative-evidence",
"assigner" : {
"display" : "Computable Publishing LLC"
}
},
"display" : "MAGIC-derived Evidence: Body weight with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
}
]
}
]
}
]
}
IG © 2024+ HL7 International / Clinical Decision Support. Package hl7.fhir.uv.ebm#1.0.0-ballot2 based on FHIR 6.0.0-ballot2. Generated 2025-03-28
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