Evidence Based Medicine on FHIR Implementation Guide
1.0.0-ballot2 - STU 1 ballot
Evidence Based Medicine on FHIR Implementation Guide
1.0.0-ballot2 - STU 1 ballot
This page is part of the Evidence Based Medicine on FHIR Implementation Guide (v1.0.0-ballot2: STU1 Ballot 2) based on FHIR (HL7® FHIR® Standard) v6.0.0. No current official version has been published yet. For a full list of available versions, see the Directory of published versions
| Page standards status: Informative |
@prefix fhir: <http://hl7.org/fhir/> . @prefix mesh: <http://id.nlm.nih.gov/mesh/> . @prefix owl: <http://www.w3.org/2002/07/owl#> . @prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> . @prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> . @prefix xsd: <http://www.w3.org/2001/XMLSchema#> . # - resource ------------------------------------------------------------------- a fhir:Citation ; fhir:nodeRole fhir:treeRoot ; fhir:id [ fhir:v "179627"] ; # fhir:meta [ fhir:versionId [ fhir:v "9" ] ; fhir:lastUpdated [ fhir:v "2025-03-27T12:26:13.587Z"^^xsd:dateTime ] ; ( fhir:profile [ fhir:v "http://hl7.org/fhir/uv/ebm/StructureDefinition/journal-article-citation"^^xsd:anyURI ; fhir:link <http://hl7.org/fhir/uv/ebm/StructureDefinition/journal-article-citation> ] ) ] ; # fhir:text [ fhir:status [ fhir:v "extensions" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p class=\"res-header-id\"><b>Generated Narrative: Citation 179627</b></p><a name=\"179627\"> </a><a name=\"hc179627\"> </a><a name=\"179627-en-US\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">version: 9; Last updated: 2025-03-27 12:26:13+0000</p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-journal-article-citation.html\">JournalArticleCitation</a></p></div><p><b>url</b>: <a href=\"Citation-179627.html\">Citation 19091394 Endocrine treatment, with or without radiotherapy, in locally advanced prostate cancer (SPCG-7/SFUO-3): an open randomised phase III trial.</a></p><p><b>identifier</b>: FEvIR Object Identifier/https://fevir.net/FOI/179627, <code>https://pubmed.ncbi.nlm.nih.gov</code>/19091394, <a href=\"http://terminology.hl7.org/6.2.0/NamingSystem-uri.html\" title=\"As defined by RFC 3986 (http://www.ietf.org/rfc/rfc3986.txt)(with many schemes defined in many RFCs). For OIDs and UUIDs, use the URN form (urn:oid:(note: lowercase) and urn:uuid:). See http://www.ietf.org/rfc/rfc3001.txt and http://www.ietf.org/rfc/rfc4122.txt \r\n\r\nThis oid is used as an identifier II.root to indicate the the extension is an absolute URI (technically, an IRI). Typically, this is used for OIDs and GUIDs. Note that when this OID is used with OIDs and GUIDs, the II.extension should start with urn:oid or urn:uuid: \r\n\r\nNote that this OID is created to aid with interconversion between CDA and FHIR - FHIR uses urn:ietf:rfc:3986 as equivalent to this OID. URIs as identifiers appear more commonly in FHIR.\r\n\r\nThis OID may also be used in CD.codeSystem.\">Uniform Resource Identifier (URI)</a>/urn:oid:2.16.840.1.113883.4.642.40.44.15.29</p><p><b>version</b>: 1.0.0-ballot2</p><p><b>title</b>: 19091394 Endocrine treatment, with or without radiotherapy, in locally advanced prostate cancer (SPCG-7/SFUO-3): an open randomised phase III trial.</p><p><b>status</b>: Active</p><p><b>date</b>: 2025-03-28 17:11:38+0000</p><p><b>publisher</b>: HL7 International / Clinical Decision Support</p><p><b>contact</b>: HL7 International / Clinical Decision Support: <a href=\"http://www.hl7.org/Special/committees/dss\">http://www.hl7.org/Special/committees/dss</a></p><p><b>description</b>: </p><div><p>This Citation Resource is referenced in an example for the EBMonFHIR Implementation Guide.</p>\n</div><h3>UseContexts</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"http://hl7.org/fhir/R5/codesystem-citation-classification-type.html#citation-classification-type-fevir-platform-use\">Citation Classification Type fevir-platform-use</a>: FEvIR Platform Use</td><td><span title=\"Codes:{http://hl7.org/fhir/citation-artifact-classifier medline-base}\">Medline Base</span></td></tr></table><p><b>jurisdiction</b>: <span title=\"Codes:{http://unstats.un.org/unsd/methods/m49/m49.htm 001}\">World</span></p><p><b>copyright</b>: </p><div><p>https://creativecommons.org/licenses/by-nc-sa/4.0/</p>\n</div><p><b>approvalDate</b>: 2009-02-05</p><p><b>lastReviewDate</b>: 2022-03-30</p><p><b>author</b>: Computable Publishing®: MEDLINE-to-FEvIR Converter: </p><blockquote><p><b>classification</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-classification-type citation-source}\">Citation Source</span></p><p><b>classifier</b>: <span title=\"Codes:\">MEDLINE</span></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-classification-type medline-owner}\">MEDLINE Citation Owner</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/bsd/licensee/elements_descriptions.html#owner_value NLM}\">National Library of Medicine, Index Section</span></p></blockquote><p><b>currentState</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-status-type medline-medline}\">Medline Citation Status of Medline</span>, <span title=\"Codes:{http://hl7.org/fhir/citation-status-type pubmed-publication-status-ppublish}\">PubMed PublicationStatus of ppublish</span></p><blockquote><p><b>statusDate</b></p><p><b>activity</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-status-type pubmed-pubstatus-entrez}\">PubMed Pubstatus of Entrez</span></p><p><b>period</b>: ?? --> 2008-12-19 09:00:00+0000</p></blockquote><blockquote><p><b>statusDate</b></p><p><b>activity</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-status-type pubmed-pubstatus-pubmed}\">PubMed Pubstatus of Pubmed</span></p><p><b>period</b>: ?? --> 2008-12-19 09:00:00+0000</p></blockquote><blockquote><p><b>statusDate</b></p><p><b>activity</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-status-type pubmed-pubstatus-medline}\">PubMed Pubstatus of Medline</span></p><p><b>period</b>: ?? --> 2009-02-06 09:00:00+0000</p></blockquote><blockquote><p><b>citedArtifact</b></p><p><b>identifier</b>: <code>https://pubmed.ncbi.nlm.nih.gov</code>/19091394, <code>https://doi.org</code>/10.1016/S0140-6736(08)61815-2, pii/S0140-6736(08)61815-2</p><p><b>relatedIdentifier</b>: ISRCTN01534787</p><h3>Titles</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Language</b></td><td><b>Text</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://hl7.org/fhir/title-type primary}\">Primary title</span></td><td><span title=\"Codes:{urn:ietf:bcp:47 en}\">English</span></td><td><div><p>Endocrine treatment, with or without radiotherapy, in locally advanced prostate cancer (SPCG-7/SFUO-3): an open randomised phase III trial.</p>\n</div></td></tr></table><h3>Abstracts</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Text</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://hl7.org/fhir/cited-artifact-abstract-type primary-human-use}\">Primary human use</span></td><td><div><p><strong>BACKGROUND:</strong> Several studies have shown the efficacy of endocrine therapy in combination with radiotherapy in high-risk prostate cancer. To assess the effect of radiotherapy, we did an open phase III study comparing endocrine therapy with and without local radiotherapy, followed by castration on progression.\n<strong>METHODS:</strong> This randomised trial included men from 47 centres in Norway, Sweden, and Denmark. Between February, 1996, and December, 2002, 875 patients with locally advanced prostate cancer (T3; 78%; PSA<70; N0; M0) were centrally randomly assigned by computer to endocrine treatment alone (3 months of total androgen blockade followed by continuous endocrine treatment using flutamide; 439 patients), or to the same endocrine treatment combined with radiotherapy (436 patients). The primary endpoint was prostate-cancer-specific survival, and analysis was by intention to treat. This study is registered as an international standard randomised controlled trial, number ISRCTN01534787.\n<strong>FINDINGS:</strong> After a median follow-up of 7.6 years, 79 men in the endocrine alone group and 37 men in the endocrine plus radiotherapy group had died of prostate cancer. The cumulative incidence at 10 years for prostate-cancer-specific mortality was 23.9% in the endocrine alone group and 11.9% in the endocrine plus radiotherapy group (difference 12.0%, 95% CI 4.9-19.1%), for a relative risk of 0.44 (0.30-0.66). At 10 years, the cumulative incidence for overall mortality was 39.4% in the endocrine alone group and 29.6% in the endocrine plus radiotherapy group (difference 9.8%, 0.8-18.8%), for a relative risk of 0.68 (0.52-0.89). Cumulative incidence at 10 years for PSA recurrence was substantially higher in men in the endocrine-alone group (74.7%vs 25.9%, p<0.0001; HR 0.16; 0.12-0.20). After 5 years, urinary, rectal, and sexual problems were slightly more frequent in the endocrine plus radiotherapy group.\n<strong>INTERPRETATION:</strong> In patients with locally advanced or high-risk local prostate cancer, addition of local radiotherapy to endocrine treatment halved the 10-year prostate-cancer-specific mortality, and substantially decreased overall mortality with fully acceptable risk of side-effects compared with endocrine treatment alone. In the light of these data, endocrine treatment plus radiotherapy should be the new standard.</p>\n</div></td></tr></table><blockquote><p><b>relatesTo</b></p><p><b>type</b>: correction-in</p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D016425}\">Published Erratum</span></p><p><b>citation</b>: </p><div><p>Lancet. 2009 Apr 4;373(9670):1174</p>\n</div></blockquote><blockquote><p><b>relatesTo</b></p><p><b>TargetUri</b>: <a href=\"https://pubmed.ncbi.nlm.nih.gov/19091392/\">https://pubmed.ncbi.nlm.nih.gov/19091392/</a></p><p><b>type</b>: comment-in</p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D016420}\">Comment</span></p><p><b>citation</b>: </p><div><p>Lancet. 2009 Jan 24;373(9660):274-6. doi: 10.1016/S0140-6736(08)61816-4.</p>\n</div></blockquote><blockquote><p><b>relatesTo</b></p><p><b>TargetUri</b>: <a href=\"https://pubmed.ncbi.nlm.nih.gov/19424171/\">https://pubmed.ncbi.nlm.nih.gov/19424171/</a></p><p><b>type</b>: comment-in</p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D016420}\">Comment</span></p><p><b>citation</b>: </p><div><p>Nat Rev Urol. 2009 May;6(5):250-1. doi: 10.1038/nrurol.2009.56.</p>\n</div></blockquote><blockquote><p><b>relatesTo</b></p><p><b>TargetUri</b>: <a href=\"https://pubmed.ncbi.nlm.nih.gov/19528551/\">https://pubmed.ncbi.nlm.nih.gov/19528551/</a></p><p><b>type</b>: comment-in</p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D016420}\">Comment</span></p><p><b>citation</b>: </p><div><p>Ann Intern Med. 2009 Jun 16;150(12):JC6-6. doi: 10.7326/0003-4819-150-12-200906160-02006.</p>\n</div></blockquote><blockquote><p><b>relatesTo</b></p><p><b>TargetUri</b>: <a href=\"https://pubmed.ncbi.nlm.nih.gov/19650206/\">https://pubmed.ncbi.nlm.nih.gov/19650206/</a></p><p><b>type</b>: comment-in</p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D016420}\">Comment</span></p><p><b>citation</b>: </p><div><p>Eur Urol. 2009 May;55(5):1240. doi: 10.1016/j.eururo.2009.01.059.</p>\n</div></blockquote><blockquote><p><b>relatesTo</b></p><p><b>TargetUri</b>: <a href=\"https://pubmed.ncbi.nlm.nih.gov/19650231/\">https://pubmed.ncbi.nlm.nih.gov/19650231/</a></p><p><b>type</b>: comment-in</p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D016420}\">Comment</span></p><p><b>citation</b>: </p><div><p>Eur Urol. 2009 May;55(5):1239-40. doi: 10.1016/j.eururo.2009.01.058.</p>\n</div></blockquote><blockquote><p><b>publicationForm</b></p><blockquote><p><b>publishedIn</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/published-in-type D020492}\">Periodical</span></p><p><b>identifier</b>: Electronic ISSN Type/1474-547X, ISOAbbreviation/Lancet, ISSN Linking/0140-6736, Medline Title Abbreviation/Lancet, NLM Unique ID/2985213R</p><p><b>title</b>: Lancet (London, England)</p><p><b>publisherLocation</b>: England</p></blockquote><p><b>citedMedium</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-medium internet}\">Internet</span></p><p><b>volume</b>: 373</p><p><b>issue</b>: 9660</p><p><b>articleDate</b>: 2009-01-24</p><p><b>publicationDateText</b>: 2009-Jan-24</p><p><b>pageString</b>: 301-8</p></blockquote><blockquote><p><b>publicationForm</b></p><p><b>citedMedium</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-medium internet-without-issue}\">Internet without issue</span></p><p><b>articleDate</b>: 2008-12-16</p></blockquote><blockquote><p><b>webLocation</b></p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/artifact-url-classifier abstract}\">Abstract</span></p><p><b>url</b>: <a href=\"https://pubmed.ncbi.nlm.nih.gov/19091394/\">https://pubmed.ncbi.nlm.nih.gov/19091394/</a></p></blockquote><blockquote><p><b>webLocation</b></p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/artifact-url-classifier doi-based}\">DOI Based</span></p><p><b>url</b>: <a href=\"https://doi.org/10.1016/S0140-6736(08)61815-2\">https://doi.org/10.1016/S0140-6736(08)61815-2</a></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type publishing-model}\">Publishing Model</span></p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-artifact-classifier Print-Electronic}\">Print Electronic</span></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type chemical}\">Chemical</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D000726}\">Androgen Antagonists</span>, <span title=\"Codes:{https://www.cas.org/support/documentation/chemical-substances 76W6J0943E}, {https://www.nlm.nih.gov/mesh D005485}\">Flutamide</span></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">MeSH heading</span></p><p><b>artifactAssessment</b>: <a href=\"#hc179627/meshHeading0\">ArtifactAssessment: artifact[x] = this resource</a></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type publication-type}\">Publication type</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D017428}\">Clinical Trial, Phase III</span>, <span title=\"Codes:{https://www.nlm.nih.gov/mesh D016428}\">Journal Article</span>, <span title=\"Codes:{https://www.nlm.nih.gov/mesh D016448}\">Multicenter Study</span>, <span title=\"Codes:{https://www.nlm.nih.gov/mesh D016449}\">Randomized Controlled Trial</span>, <span title=\"Codes:{https://www.nlm.nih.gov/mesh D013485}\">Research Support, Non-U.S. Gov't</span></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type knowledge-artifact-type}\">Knowledge Artifact Type</span></p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}\">Journal Article</span></p><p><b>artifactAssessment</b>: Classifier added by Computable Publishing LLC</p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type citation-subset}\">Citation subset</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/bsd/licensee/elements_descriptions.html#citationsubset IM}\">IM</span></p></blockquote><blockquote><p><b>contributorship</b></p><p><b>complete</b>: true</p><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179627/contributor0\">Widmark A</a></p><p><b>forenameInitials</b>: A</p><p><b>affiliation</b>: Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179627/contributor1\">Klepp O</a></p><p><b>forenameInitials</b>: O</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179627/contributor2\">Solberg A</a></p><p><b>forenameInitials</b>: A</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179627/contributor3\">Damber JE</a></p><p><b>forenameInitials</b>: JE</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179627/contributor4\">Angelsen A</a></p><p><b>forenameInitials</b>: A</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179627/contributor5\">Fransson P</a></p><p><b>forenameInitials</b>: P</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179627/contributor6\">Lund JA</a></p><p><b>forenameInitials</b>: JA</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179627/contributor7\">Tasdemir I</a></p><p><b>forenameInitials</b>: I</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179627/contributor8\">Hoyer M</a></p><p><b>forenameInitials</b>: M</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179627/contributor9\">Wiklund F</a></p><p><b>forenameInitials</b>: F</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179627/contributor10\">Fosså SD</a></p><p><b>forenameInitials</b>: SD</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179627/contributor11\">Scandinavian Prostate Cancer Group Study 7</a></p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179627/contributor12\">Swedish Association for Urological Oncology 3</a></p></blockquote></blockquote></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor0</b></p><a name=\"179627/contributor0\"> </a><a name=\"hc179627/contributor0\"> </a><a name=\"179627/contributor0-en-US\"> </a><p><b>name</b>: Anders Widmark </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor1</b></p><a name=\"179627/contributor1\"> </a><a name=\"hc179627/contributor1\"> </a><a name=\"179627/contributor1-en-US\"> </a><p><b>name</b>: Olbjørn Klepp </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor2</b></p><a name=\"179627/contributor2\"> </a><a name=\"hc179627/contributor2\"> </a><a name=\"179627/contributor2-en-US\"> </a><p><b>name</b>: Arne Solberg </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor3</b></p><a name=\"179627/contributor3\"> </a><a name=\"hc179627/contributor3\"> </a><a name=\"179627/contributor3-en-US\"> </a><p><b>name</b>: Jan-Erik Damber </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor4</b></p><a name=\"179627/contributor4\"> </a><a name=\"hc179627/contributor4\"> </a><a name=\"179627/contributor4-en-US\"> </a><p><b>name</b>: Anders Angelsen </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor5</b></p><a name=\"179627/contributor5\"> </a><a name=\"hc179627/contributor5\"> </a><a name=\"179627/contributor5-en-US\"> </a><p><b>name</b>: Per Fransson </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor6</b></p><a name=\"179627/contributor6\"> </a><a name=\"hc179627/contributor6\"> </a><a name=\"179627/contributor6-en-US\"> </a><p><b>name</b>: Jo-Asmund Lund </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor7</b></p><a name=\"179627/contributor7\"> </a><a name=\"hc179627/contributor7\"> </a><a name=\"179627/contributor7-en-US\"> </a><p><b>name</b>: Ilker Tasdemir </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor8</b></p><a name=\"179627/contributor8\"> </a><a name=\"hc179627/contributor8\"> </a><a name=\"179627/contributor8-en-US\"> </a><p><b>name</b>: Morten Hoyer </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor9</b></p><a name=\"179627/contributor9\"> </a><a name=\"hc179627/contributor9\"> </a><a name=\"179627/contributor9-en-US\"> </a><p><b>name</b>: Fredrik Wiklund </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor10</b></p><a name=\"179627/contributor10\"> </a><a name=\"hc179627/contributor10\"> </a><a name=\"179627/contributor10-en-US\"> </a><p><b>name</b>: Sophie D Fosså </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Organization #contributor11</b></p><a name=\"179627/contributor11\"> </a><a name=\"hc179627/contributor11\"> </a><a name=\"179627/contributor11-en-US\"> </a><p><b>name</b>: Scandinavian Prostate Cancer Group Study 7</p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Organization #contributor12</b></p><a name=\"179627/contributor12\"> </a><a name=\"hc179627/contributor12\"> </a><a name=\"179627/contributor12-en-US\"> </a><p><b>name</b>: Swedish Association for Urological Oncology 3</p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: ArtifactAssessment #meshHeading0</b></p><a name=\"179627/meshHeading0\"> </a><a name=\"hc179627/meshHeading0\"> </a><a name=\"179627/meshHeading0-en-US\"> </a><p><b>artifact</b>: <a href=\"#hc179627\">Citation 19091394 Endocrine treatment, with or without radiotherapy, in locally advanced prostate cancer (SPCG-7/SFUO-3): an open randomised phase III trial.</a></p><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D000368}\">Aged</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D000726}\">Androgen Antagonists</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:\">is not a major topic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh Q000627}\">therapeutic use</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">is Major topic</span></td><td><span title=\"Codes:{http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl C49488}\">Yes</span></td></tr></table></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D003131}\">Combined Modality Therapy</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D005485}\">Flutamide</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:\">is not a major topic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh Q000627}\">therapeutic use</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">is Major topic</span></td><td><span title=\"Codes:{http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl C49488}\">Yes</span></td></tr></table></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D006801}\">Humans</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D008297}\">Male</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D011468}\">Prostatectomy</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D011471}\">Prostatic Neoplasms</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:\">is not a major topic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh Q000188}\">drug therapy</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">is Major topic</span></td><td><span title=\"Codes:{http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl C49488}\">Yes</span></td></tr></table></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh Q000401}\">mortality</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">is Major topic</span></td><td><span title=\"Codes:{http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl C49487}\">No</span></td></tr></table></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh Q000532}\">radiotherapy</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">is Major topic</span></td><td><span title=\"Codes:{http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl C49488}\">Yes</span></td></tr></table></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D012720}\">Severity of Illness Index</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D016019}\">Survival Analysis</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote></blockquote></div>"^^rdf:XMLLiteral ] ; # fhir:contained ( [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor0" ] ; ( fhir:name [ fhir:family [ fhir:v "Widmark" ] ; ( fhir:given [ fhir:v "Anders" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor1" ] ; ( fhir:name [ fhir:family [ fhir:v "Klepp" ] ; ( fhir:given [ fhir:v "Olbjørn" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor2" ] ; ( fhir:name [ fhir:family [ fhir:v "Solberg" ] ; ( fhir:given [ fhir:v "Arne" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor3" ] ; ( fhir:name [ fhir:family [ fhir:v "Damber" ] ; ( fhir:given [ fhir:v "Jan-Erik" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor4" ] ; ( fhir:name [ fhir:family [ fhir:v "Angelsen" ] ; ( fhir:given [ fhir:v "Anders" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor5" ] ; ( fhir:name [ fhir:family [ fhir:v "Fransson" ] ; ( fhir:given [ fhir:v "Per" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor6" ] ; ( fhir:name [ fhir:family [ fhir:v "Lund" ] ; ( fhir:given [ fhir:v "Jo-Asmund" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor7" ] ; ( fhir:name [ fhir:family [ fhir:v "Tasdemir" ] ; ( fhir:given [ fhir:v "Ilker" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor8" ] ; ( fhir:name [ fhir:family [ fhir:v "Hoyer" ] ; ( fhir:given [ fhir:v "Morten" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor9" ] ; ( fhir:name [ fhir:family [ fhir:v "Wiklund" ] ; ( fhir:given [ fhir:v "Fredrik" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor10" ] ; ( fhir:name [ fhir:family [ fhir:v "Fosså" ] ; ( fhir:given [ fhir:v "Sophie D" ] ) ] ) ] [ a fhir:Organization ; fhir:id [ fhir:v "contributor11" ] ; fhir:name [ fhir:v "Scandinavian Prostate Cancer Group Study 7" ] ] [ a fhir:Organization ; fhir:id [ fhir:v "contributor12" ] ; fhir:name [ fhir:v "Swedish Association for Urological Oncology 3" ] ] [ a fhir:ArtifactAssessment ; fhir:id [ fhir:v "meshHeading0" ] ; fhir:artifact [ a fhir:Reference ; fhir:reference [ fhir:v "#" ] ; fhir:type [ fhir:v "Citation"^^xsd:anyURI ] ] ; ( fhir:content [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; ( fhir:classifier [ ( fhir:coding [ a mesh:D000368 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ] ; fhir:code [ fhir:v "D000368" ] ; fhir:display [ fhir:v "Aged" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ) ; fhir:freeToShare [ fhir:v true ] ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] ) ] [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; ( fhir:classifier [ ( fhir:coding [ a mesh:D000726 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ] ; fhir:code [ fhir:v "D000726" ] ; fhir:display [ fhir:v "Androgen Antagonists" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ) ; fhir:freeToShare [ fhir:v true ] ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ ( fhir:coding [ a mesh:Q000627 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ] ; fhir:code [ fhir:v "Q000627" ] ; fhir:display [ fhir:v "therapeutic use" ] ] ) ] ) ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "is Major topic" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl"^^xsd:anyURI ] ; fhir:code [ fhir:v "C49488" ] ; fhir:display [ fhir:v "Yes" ] ] ) ] ) ] ) ] ) ] [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; ( fhir:classifier [ ( fhir:coding [ a mesh:D003131 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ] ; fhir:code [ fhir:v "D003131" ] ; fhir:display [ fhir:v "Combined Modality Therapy" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ) ; fhir:freeToShare [ fhir:v true ] ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] ) ] [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; ( fhir:classifier [ ( fhir:coding [ a mesh:D005485 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ] ; fhir:code [ fhir:v "D005485" ] ; fhir:display [ fhir:v "Flutamide" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ) ; fhir:freeToShare [ fhir:v true ] ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ ( fhir:coding [ a mesh:Q000627 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ] ; fhir:code [ fhir:v "Q000627" ] ; fhir:display [ fhir:v "therapeutic use" ] ] ) ] ) ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "is Major topic" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl"^^xsd:anyURI ] ; fhir:code [ fhir:v "C49488" ] ; fhir:display [ fhir:v "Yes" ] ] ) ] ) ] ) ] ) ] [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; ( fhir:classifier [ ( fhir:coding [ a mesh:D006801 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ] ; fhir:code [ fhir:v "D006801" ] ; fhir:display [ fhir:v "Humans" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ) ; fhir:freeToShare [ fhir:v true ] ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] ) ] [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; ( fhir:classifier [ ( fhir:coding [ a mesh:D008297 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ] ; fhir:code [ fhir:v "D008297" ] ; fhir:display [ fhir:v "Male" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ) ; fhir:freeToShare [ fhir:v true ] ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] ) ] [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; ( fhir:classifier [ ( fhir:coding [ a mesh:D011468 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ] ; fhir:code [ fhir:v "D011468" ] ; fhir:display [ fhir:v "Prostatectomy" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ) ; fhir:freeToShare [ fhir:v true ] ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] ) ] [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; ( fhir:classifier [ ( fhir:coding [ a mesh:D011471 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ] ; fhir:code [ fhir:v "D011471" ] ; fhir:display [ fhir:v "Prostatic Neoplasms" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ) ; fhir:freeToShare [ fhir:v true ] ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ ( fhir:coding [ a mesh:Q000188 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ] ; fhir:code [ fhir:v "Q000188" ] ; fhir:display [ fhir:v "drug therapy" ] ] ) ] ) ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "is Major topic" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl"^^xsd:anyURI ] ; fhir:code [ fhir:v "C49488" ] ; fhir:display [ fhir:v "Yes" ] ] ) ] ) ] ) ] [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ ( fhir:coding [ a mesh:Q000401 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ] ; fhir:code [ fhir:v "Q000401" ] ; fhir:display [ fhir:v "mortality" ] ] ) ] ) ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "is Major topic" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl"^^xsd:anyURI ] ; fhir:code [ fhir:v "C49487" ] ; fhir:display [ fhir:v "No" ] ] ) ] ) ] ) ] [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ ( fhir:coding [ a mesh:Q000532 ; fhir:system [ fhir:v 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fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] ) ] [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; ( fhir:classifier [ ( fhir:coding [ a mesh:D016019 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ] ; fhir:code [ fhir:v "D016019" ] ; fhir:display [ fhir:v "Survival Analysis" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ) ; fhir:freeToShare [ fhir:v true ] ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] ) ] ) ] ) ; # fhir:url [ fhir:v "https://fevir.net/resources/Citation/179627"^^xsd:anyURI] ; # fhir:identifier ( [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v2-0203"^^xsd:anyURI ] ; fhir:code [ fhir:v "ACSN" ] ; fhir:display [ fhir:v "Accession ID" ] ] ) ; fhir:text [ fhir:v "FEvIR Object Identifier" ] ] ; fhir:system [ fhir:v "urn:ietf:rfc:3986"^^xsd:anyURI ] ; fhir:value [ fhir:v "https://fevir.net/FOI/179627" ] ; fhir:assigner [ fhir:display [ fhir:v "Computable Publishing LLC" ] ] ] [ fhir:system [ fhir:v "https://pubmed.ncbi.nlm.nih.gov"^^xsd:anyURI ] ; fhir:value [ fhir:v "19091394" ] ] [ fhir:system [ fhir:v "urn:ietf:rfc:3986"^^xsd:anyURI ] ; fhir:value [ fhir:v "urn:oid:2.16.840.1.113883.4.642.40.44.15.29" ] ] ) ; # fhir:version [ fhir:v "1.0.0-ballot2"] ; # fhir:title [ fhir:v "19091394 Endocrine treatment, with or without radiotherapy, in locally advanced prostate cancer (SPCG-7/SFUO-3): an open randomised phase III trial."] ; # fhir:status [ fhir:v "active"] ; # fhir:date [ fhir:v "2025-03-28T17:11:38+00:00"^^xsd:dateTime] ; # fhir:publisher [ fhir:v "HL7 International / Clinical Decision Support"] ; # fhir:contact ( [ fhir:name [ fhir:v "HL7 International / Clinical Decision Support" ] ; ( fhir:telecom [ fhir:system [ fhir:v "url" ] ; fhir:value [ fhir:v "http://www.hl7.org/Special/committees/dss" ] ] ) ] ) ; # fhir:description [ fhir:v "This Citation Resource is referenced in an example for the EBMonFHIR Implementation Guide."] ; # fhir:useContext ( [ fhir:code [ fhir:system [ fhir:v "http://hl7.org/fhir/citation-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "fevir-platform-use" ] ; fhir:display [ fhir:v "FEvIR Platform Use" ] ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/citation-artifact-classifier"^^xsd:anyURI ] ; fhir:code [ fhir:v "medline-base" ] ; fhir:display [ fhir:v "Medline Base" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ] ) ; # fhir:jurisdiction ( [ ( fhir:coding [ fhir:system [ fhir:v "http://unstats.un.org/unsd/methods/m49/m49.htm"^^xsd:anyURI ] ; fhir:code [ fhir:v "001" ] ; fhir:display [ fhir:v "World" ] ] ) ] ) ; # fhir:copyright [ fhir:v "https://creativecommons.org/licenses/by-nc-sa/4.0/"] ; # fhir:approvalDate [ fhir:v "2009-02-05"^^xsd:date] ; # fhir:lastReviewDate [ fhir:v "2022-03-30"^^xsd:date] ; # fhir:author ( [ fhir:name [ fhir:v "Computable Publishing®: MEDLINE-to-FEvIR Converter" ] ] ) ; # fhir:classification ( [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/citation-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "citation-source" ] ; fhir:display [ fhir:v "Citation Source" ] ] ) ] ; ( fhir:classifier [ fhir:text [ fhir:v "MEDLINE" ] ] ) ] [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/citation-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "medline-owner" ] ; fhir:display [ fhir:v "MEDLINE Citation Owner" ] ] ) ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "https://www.nlm.nih.gov/bsd/licensee/elements_descriptions.html#owner_value"^^xsd:anyURI ] ; fhir:code [ fhir:v "NLM" ] ; fhir:display [ fhir:v "National Library of Medicine, Index Section" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ) ] ) ; # fhir:currentState ( [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/citation-status-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "medline-medline" ] ; fhir:display [ fhir:v "Medline Citation Status of Medline" ] ] ) ] [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/citation-status-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "pubmed-publication-status-ppublish" ] ; fhir:display [ fhir:v "PubMed PublicationStatus of ppublish" ] ] ) ] ) ; # fhir:statusDate ( [ fhir:activity [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/citation-status-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "pubmed-pubstatus-entrez" ] ; fhir:display [ fhir:v "PubMed Pubstatus of Entrez" ] ] ) ] ; fhir:period [ fhir:end [ fhir:v "2008-12-19T09:00:00.000Z"^^xsd:dateTime ] ] ] [ fhir:activity [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/citation-status-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "pubmed-pubstatus-pubmed" ] ; fhir:display [ fhir:v "PubMed Pubstatus of Pubmed" ] ] ) ] ; fhir:period [ fhir:end [ fhir:v "2008-12-19T09:00:00.000Z"^^xsd:dateTime ] ] ] [ fhir:activity [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/citation-status-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "pubmed-pubstatus-medline" ] ; fhir:display [ fhir:v "PubMed Pubstatus of Medline" ] ] ) ] ; fhir:period [ fhir:end [ fhir:v "2009-02-06T09:00:00.000Z"^^xsd:dateTime ] ] ] ) ; # fhir:citedArtifact [ ( fhir:identifier [ fhir:system [ fhir:v "https://pubmed.ncbi.nlm.nih.gov"^^xsd:anyURI ] ; fhir:value [ fhir:v "19091394" ] ] [ fhir:system [ fhir:v "https://doi.org"^^xsd:anyURI ] ; fhir:value [ fhir:v "10.1016/S0140-6736(08)61815-2" ] ] [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v2-0203"^^xsd:anyURI ] ; fhir:code [ fhir:v "ACSN" ] ; fhir:display [ fhir:v "Accession ID" ] ] ) ; fhir:text [ fhir:v "pii" ] ] ; fhir:value [ fhir:v "S0140-6736(08)61815-2" ] ] ) ; ( fhir:relatedIdentifier [ fhir:value [ fhir:v "ISRCTN01534787" ] ; fhir:assigner [ fhir:display [ fhir:v "ISRCTN" ] ] ] ) ; ( fhir:title [ ( fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/title-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "primary" ] ; fhir:display [ fhir:v "Primary title" ] ] ) ] ) ; fhir:language [ ( fhir:coding [ fhir:system [ fhir:v "urn:ietf:bcp:47"^^xsd:anyURI ] ; fhir:code [ fhir:v "en" ] ; fhir:display [ fhir:v "English" ] ] ) ] ; fhir:text [ fhir:v "Endocrine treatment, with or without radiotherapy, in locally advanced prostate cancer (SPCG-7/SFUO-3): an open randomised phase III trial." ] ] ) ; ( fhir:abstract [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-abstract-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "primary-human-use" ] ; fhir:display [ fhir:v "Primary human use" ] ] ) ] ; fhir:text [ fhir:v "**BACKGROUND:** Several studies have shown the efficacy of endocrine therapy in combination with radiotherapy in high-risk prostate cancer. To assess the effect of radiotherapy, we did an open phase III study comparing endocrine therapy with and without local radiotherapy, followed by castration on progression.\n**METHODS:** This randomised trial included men from 47 centres in Norway, Sweden, and Denmark. Between February, 1996, and December, 2002, 875 patients with locally advanced prostate cancer (T3; 78%; PSA<70; N0; M0) were centrally randomly assigned by computer to endocrine treatment alone (3 months of total androgen blockade followed by continuous endocrine treatment using flutamide; 439 patients), or to the same endocrine treatment combined with radiotherapy (436 patients). The primary endpoint was prostate-cancer-specific survival, and analysis was by intention to treat. This study is registered as an international standard randomised controlled trial, number ISRCTN01534787.\n**FINDINGS:** After a median follow-up of 7.6 years, 79 men in the endocrine alone group and 37 men in the endocrine plus radiotherapy group had died of prostate cancer. The cumulative incidence at 10 years for prostate-cancer-specific mortality was 23.9% in the endocrine alone group and 11.9% in the endocrine plus radiotherapy group (difference 12.0%, 95% CI 4.9-19.1%), for a relative risk of 0.44 (0.30-0.66). At 10 years, the cumulative incidence for overall mortality was 39.4% in the endocrine alone group and 29.6% in the endocrine plus radiotherapy group (difference 9.8%, 0.8-18.8%), for a relative risk of 0.68 (0.52-0.89). Cumulative incidence at 10 years for PSA recurrence was substantially higher in men in the endocrine-alone group (74.7%vs 25.9%, p<0.0001; HR 0.16; 0.12-0.20). After 5 years, urinary, rectal, and sexual problems were slightly more frequent in the endocrine plus radiotherapy group.\n**INTERPRETATION:** In patients with locally advanced or high-risk local prostate cancer, addition of local radiotherapy to endocrine treatment halved the 10-year prostate-cancer-specific mortality, and substantially decreased overall mortality with fully acceptable risk of side-effects compared with endocrine treatment alone. In the light of these data, endocrine treatment plus radiotherapy should be the new standard." ] ] ) ; ( fhir:relatesTo [ fhir:type [ fhir:v "correction-in" ] ; ( fhir:classifier [ ( fhir:coding [ a mesh:D016425 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ] ; fhir:code [ fhir:v "D016425" ] ; fhir:display [ fhir:v "Published Erratum" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ) ; fhir:citation [ fhir:v "Lancet. 2009 Apr 4;373(9670):1174" ] ] [ ( fhir:extension [ fhir:url [ fhir:v "http://hl7.org/fhir/uv/ebm/StructureDefinition/target-uri"^^xsd:anyURI ] ; fhir:value [ a fhir:uri ; fhir:v "https://pubmed.ncbi.nlm.nih.gov/19091392/"^^xsd:anyURI ] ] ) ; fhir:type [ fhir:v "comment-in" ] ; ( fhir:classifier [ ( fhir:coding [ a mesh:D016420 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ] ; fhir:code [ fhir:v "D016420" ] ; fhir:display [ fhir:v "Comment" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ) ; fhir:citation [ fhir:v "Lancet. 2009 Jan 24;373(9660):274-6. doi: 10.1016/S0140-6736(08)61816-4." ] ] [ ( fhir:extension [ fhir:url [ fhir:v "http://hl7.org/fhir/uv/ebm/StructureDefinition/target-uri"^^xsd:anyURI ] ; 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fhir:type [ fhir:v "ArtifactAssessment"^^xsd:anyURI ] ] ) ] [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "publication-type" ] ; fhir:display [ fhir:v "Publication type" ] ] ) ] ; ( fhir:classifier [ ( fhir:coding [ a mesh:D017428 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ] ; fhir:code [ fhir:v "D017428" ] ; fhir:display [ fhir:v "Clinical Trial, Phase III" ] ; fhir:userSelected [ fhir:v false ] ] ) ] [ ( fhir:coding [ a mesh:D016428 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ] ; fhir:code [ fhir:v "D016428" ] ; fhir:display [ fhir:v "Journal Article" ] ; fhir:userSelected [ fhir:v false ] ] ) ] [ ( fhir:coding [ a mesh:D016448 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ] ; fhir:code [ fhir:v "D016448" ] ; fhir:display [ fhir:v "Multicenter Study" ] ; fhir:userSelected [ fhir:v false ] ] ) ] [ ( fhir:coding [ a mesh:D016449 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ] ; fhir:code [ fhir:v "D016449" ] ; fhir:display [ fhir:v "Randomized Controlled Trial" ] ; fhir:userSelected [ fhir:v false ] ] ) ] [ ( fhir:coding [ a mesh:D013485 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ] ; fhir:code [ fhir:v "D013485" ] ; fhir:display [ fhir:v "Research Support, Non-U.S. Gov't" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ) ] [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "knowledge-artifact-type" ] ; fhir:display [ fhir:v "Knowledge Artifact Type" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/citation-artifact-classifier"^^xsd:anyURI ] ; fhir:code [ fhir:v "D016428" ] ; fhir:display [ fhir:v "Journal Article" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ) ; ( fhir:artifactAssessment [ fhir:display [ fhir:v "Classifier added by Computable Publishing LLC" ] ] ) ] [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "citation-subset" ] ; fhir:display [ fhir:v "Citation subset" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "https://www.nlm.nih.gov/bsd/licensee/elements_descriptions.html#citationsubset"^^xsd:anyURI ] ; fhir:code [ fhir:v "IM" ] ; fhir:display [ fhir:v "IM" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ) ] ) ; fhir:contributorship [ fhir:complete [ fhir:v true ] ; ( fhir:entry [ fhir:contributor [ fhir:reference [ fhir:v "#contributor0" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ; fhir:display [ fhir:v "Widmark A" ] ] ; fhir:forenameInitials [ fhir:v "A" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden." ] ] ) ] [ fhir:contributor [ fhir:reference [ fhir:v "#contributor1" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ; fhir:display [ fhir:v "Klepp O" ] ] ; fhir:forenameInitials [ fhir:v "O" ] ] [ fhir:contributor [ fhir:reference [ fhir:v "#contributor2" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ; fhir:display [ fhir:v "Solberg A" ] ] ; fhir:forenameInitials [ fhir:v "A" ] ] [ fhir:contributor [ fhir:reference [ fhir:v "#contributor3" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ; fhir:display [ fhir:v "Damber JE" ] ] ; fhir:forenameInitials [ fhir:v "JE" ] ] [ fhir:contributor [ fhir:reference [ fhir:v "#contributor4" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ; fhir:display [ fhir:v "Angelsen A" ] ] ; fhir:forenameInitials [ fhir:v "A" ] ] [ fhir:contributor [ fhir:reference [ fhir:v "#contributor5" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ; fhir:display [ fhir:v "Fransson P" ] ] ; fhir:forenameInitials [ fhir:v "P" ] ] [ fhir:contributor [ fhir:reference [ fhir:v "#contributor6" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ; fhir:display [ fhir:v "Lund JA" ] ] ; fhir:forenameInitials [ fhir:v "JA" ] ] [ fhir:contributor [ fhir:reference [ fhir:v "#contributor7" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ; fhir:display [ fhir:v "Tasdemir I" ] ] ; fhir:forenameInitials [ fhir:v "I" ] ] [ fhir:contributor [ fhir:reference [ fhir:v "#contributor8" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ; fhir:display [ fhir:v "Hoyer M" ] ] ; fhir:forenameInitials [ fhir:v "M" ] ] [ fhir:contributor [ fhir:reference [ fhir:v "#contributor9" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ; fhir:display [ fhir:v "Wiklund F" ] ] ; fhir:forenameInitials [ fhir:v "F" ] ] [ fhir:contributor [ fhir:reference [ fhir:v "#contributor10" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ; fhir:display [ fhir:v "Fosså SD" ] ] ; fhir:forenameInitials [ fhir:v "SD" ] ] [ fhir:contributor [ fhir:reference [ fhir:v "#contributor11" ] ; fhir:type [ fhir:v "Organization"^^xsd:anyURI ] ; fhir:display [ fhir:v "Scandinavian Prostate Cancer Group Study 7" ] ] ] [ fhir:contributor [ fhir:reference [ fhir:v "#contributor12" ] ; fhir:type [ fhir:v "Organization"^^xsd:anyURI ] ; fhir:display [ fhir:v "Swedish Association for Urological Oncology 3" ] ] ] ) ] ] . #
IG © 2024+ HL7 International / Clinical Decision Support. Package hl7.fhir.uv.ebm#1.0.0-ballot2 based on FHIR 6.0.0-ballot2. Generated 2025-03-28
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