Evidence Based Medicine on FHIR Implementation Guide
1.0.0-ballot2 - STU 1 ballot
Evidence Based Medicine on FHIR Implementation Guide
1.0.0-ballot2 - STU 1 ballot
This page is part of the Evidence Based Medicine on FHIR Implementation Guide (v1.0.0-ballot2: STU1 Ballot 2) based on FHIR (HL7® FHIR® Standard) v6.0.0. No current official version has been published yet. For a full list of available versions, see the Directory of published versions
| Page standards status: Informative |
@prefix fhir: <http://hl7.org/fhir/> . @prefix mesh: <http://id.nlm.nih.gov/mesh/> . @prefix owl: <http://www.w3.org/2002/07/owl#> . @prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> . @prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> . @prefix xsd: <http://www.w3.org/2001/XMLSchema#> . # - resource ------------------------------------------------------------------- a fhir:Citation ; fhir:nodeRole fhir:treeRoot ; fhir:id [ fhir:v "179617"] ; # fhir:meta [ fhir:versionId [ fhir:v "10" ] ; fhir:lastUpdated [ fhir:v "2025-03-27T12:31:11.299Z"^^xsd:dateTime ] ; ( fhir:profile [ fhir:v "http://hl7.org/fhir/uv/ebm/StructureDefinition/journal-article-citation"^^xsd:anyURI ; fhir:link <http://hl7.org/fhir/uv/ebm/StructureDefinition/journal-article-citation> ] ) ] ; # fhir:text [ fhir:status [ fhir:v "extensions" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p class=\"res-header-id\"><b>Generated Narrative: Citation 179617</b></p><a name=\"179617\"> </a><a name=\"hc179617\"> </a><a name=\"179617-en-US\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">version: 10; Last updated: 2025-03-27 12:31:11+0000</p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-journal-article-citation.html\">JournalArticleCitation</a></p></div><p><b>url</b>: <a href=\"Citation-179617.html\">Citation 25301760 Survival with Newly Diagnosed Metastatic Prostate Cancer in the "Docetaxel Era": Data from 917 Patients in the Control Arm of the STAMPEDE Trial (MRC PR08, CRUK/06/019).</a></p><p><b>identifier</b>: FEvIR Object Identifier/https://fevir.net/FOI/179617, <code>https://pubmed.ncbi.nlm.nih.gov</code>/25301760, <a href=\"http://terminology.hl7.org/6.2.0/NamingSystem-uri.html\" title=\"As defined by RFC 3986 (http://www.ietf.org/rfc/rfc3986.txt)(with many schemes defined in many RFCs). For OIDs and UUIDs, use the URN form (urn:oid:(note: lowercase) and urn:uuid:). See http://www.ietf.org/rfc/rfc3001.txt and http://www.ietf.org/rfc/rfc4122.txt \r\n\r\nThis oid is used as an identifier II.root to indicate the the extension is an absolute URI (technically, an IRI). Typically, this is used for OIDs and GUIDs. Note that when this OID is used with OIDs and GUIDs, the II.extension should start with urn:oid or urn:uuid: \r\n\r\nNote that this OID is created to aid with interconversion between CDA and FHIR - FHIR uses urn:ietf:rfc:3986 as equivalent to this OID. URIs as identifiers appear more commonly in FHIR.\r\n\r\nThis OID may also be used in CD.codeSystem.\">Uniform Resource Identifier (URI)</a>/urn:oid:2.16.840.1.113883.4.642.40.44.15.51</p><p><b>version</b>: 1.0.0-ballot2</p><p><b>title</b>: 25301760 Survival with Newly Diagnosed Metastatic Prostate Cancer in the "Docetaxel Era": Data from 917 Patients in the Control Arm of the STAMPEDE Trial (MRC PR08, CRUK/06/019).</p><p><b>status</b>: Active</p><p><b>date</b>: 2025-03-28 17:11:38+0000</p><p><b>publisher</b>: HL7 International / Clinical Decision Support</p><p><b>contact</b>: HL7 International / Clinical Decision Support: <a href=\"http://www.hl7.org/Special/committees/dss\">http://www.hl7.org/Special/committees/dss</a></p><p><b>description</b>: </p><div><p>This Citation Resource is referenced in an example for the EBMonFHIR Implementation Guide.</p>\n</div><h3>UseContexts</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"http://hl7.org/fhir/R5/codesystem-citation-classification-type.html#citation-classification-type-fevir-platform-use\">Citation Classification Type fevir-platform-use</a>: FEvIR Platform Use</td><td><span title=\"Codes:{http://hl7.org/fhir/citation-artifact-classifier medline-base}\">Medline Base</span></td></tr></table><p><b>jurisdiction</b>: <span title=\"Codes:{http://unstats.un.org/unsd/methods/m49/m49.htm 001}\">World</span></p><p><b>copyright</b>: </p><div><p>https://creativecommons.org/licenses/by-nc-sa/4.0/</p>\n</div><p><b>approvalDate</b>: 2016-04-07</p><p><b>lastReviewDate</b>: 2022-12-08</p><p><b>author</b>: Computable Publishing®: MEDLINE-to-FEvIR Converter: </p><blockquote><p><b>classification</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-classification-type citation-source}\">Citation Source</span></p><p><b>classifier</b>: <span title=\"Codes:\">MEDLINE</span></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-classification-type medline-owner}\">MEDLINE Citation Owner</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/bsd/licensee/elements_descriptions.html#owner_value NLM}\">National Library of Medicine, Index Section</span></p></blockquote><p><b>currentState</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-status-type medline-medline}\">Medline Citation Status of Medline</span>, <span title=\"Codes:{http://hl7.org/fhir/citation-status-type pubmed-publication-status-ppublish}\">PubMed PublicationStatus of ppublish</span></p><blockquote><p><b>statusDate</b></p><p><b>activity</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-status-type pubmed-pubstatus-received}\">PubMed Pubstatus of Received</span></p><p><b>period</b>: ?? --> 2014-07-23</p></blockquote><blockquote><p><b>statusDate</b></p><p><b>activity</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-status-type pubmed-pubstatus-accepted}\">PubMed Pubstatus of Accepted</span></p><p><b>period</b>: ?? --> 2014-09-19</p></blockquote><blockquote><p><b>statusDate</b></p><p><b>activity</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-status-type pubmed-pubstatus-entrez}\">PubMed Pubstatus of Entrez</span></p><p><b>period</b>: ?? --> 2014-10-11 06:00:00+0000</p></blockquote><blockquote><p><b>statusDate</b></p><p><b>activity</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-status-type pubmed-pubstatus-pubmed}\">PubMed Pubstatus of Pubmed</span></p><p><b>period</b>: ?? --> 2014-10-11 06:00:00+0000</p></blockquote><blockquote><p><b>statusDate</b></p><p><b>activity</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-status-type pubmed-pubstatus-medline}\">PubMed Pubstatus of Medline</span></p><p><b>period</b>: ?? --> 2016-04-08 06:00:00+0000</p></blockquote><blockquote><p><b>citedArtifact</b></p><p><b>identifier</b>: <code>https://pubmed.ncbi.nlm.nih.gov</code>/25301760, <code>https://doi.org</code>/10.1016/j.eururo.2014.09.032, pii/S0302-2838(14)00969-5</p><h3>Titles</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Language</b></td><td><b>Text</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://hl7.org/fhir/title-type primary}\">Primary title</span></td><td><span title=\"Codes:{urn:ietf:bcp:47 en}\">English</span></td><td><div><p>Survival with Newly Diagnosed Metastatic Prostate Cancer in the "Docetaxel Era": Data from 917 Patients in the Control Arm of the STAMPEDE Trial (MRC PR08, CRUK/06/019).</p>\n</div></td></tr></table><h3>Abstracts</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Text</b></td><td><b>Copyright</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://hl7.org/fhir/cited-artifact-abstract-type primary-human-use}\">Primary human use</span></td><td><div><p><strong>BACKGROUND:</strong> Prostate cancer (PCa) is the second most common disease among men worldwide. It is important to know survival outcomes and prognostic factors for this disease. Recruitment for the largest therapeutic randomised controlled trial in PCa--the Systemic Therapy in Advancing or Metastatic Prostate Cancer: Evaluation of Drug Efficacy: A Multi-Stage Multi-Arm Randomised Controlled Trial (STAMPEDE)--includes men with newly diagnosed metastatic PCa who are commencing long-term androgen deprivation therapy (ADT); the control arm provides valuable data for a prospective cohort.\n<strong>OBJECTIVE:</strong> Describe survival outcomes, along with current treatment standards and factors associated with prognosis, to inform future trial design in this patient group.\n<strong>DESIGN, SETTING, AND PARTICIPANTS:</strong> STAMPEDE trial control arm comprising men newly diagnosed with M1 disease who were recruited between October 2005 and January 2014.\n<strong>OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS:</strong> Overall survival (OS) and failure-free survival (FFS) were reported by primary disease characteristics using Kaplan-Meier methods. Hazard ratios and 95% confidence intervals (CIs) were derived from multivariate Cox models.\n<strong>RESULTS AND LIMITATIONS:</strong> A cohort of 917 men with newly diagnosed M1 disease was recruited to the control arm in the specified interval. Median follow-up was 20 mo. Median age at randomisation was 66 yr (interquartile range [IQR]: 61-71), and median prostate-specific antigen level was 112 ng/ml (IQR: 34-373). Most men (n=574; 62%) had bone-only metastases, whereas 237 (26%) had both bone and soft tissue metastases; soft tissue metastasis was found mainly in distant lymph nodes. There were 238 deaths, 202 (85%) from PCa. Median FFS was 11 mo; 2-yr FFS was 29% (95% CI, 25-33). Median OS was 42 mo; 2-yr OS was 72% (95% CI, 68-76). Survival time was influenced by performance status, age, Gleason score, and metastases distribution. Median survival after FFS event was 22 mo. Trial eligibility criteria meant men were younger and fitter than general PCa population.\n<strong>CONCLUSIONS:</strong> Survival remains disappointing in men presenting with M1 disease who are started on only long-term ADT, despite active treatments being available at first failure of ADT. Importantly, men with M1 disease now spend the majority of their remaining life in a state of castration-resistant relapse.\n<strong>PATIENT SUMMARY:</strong> Results from this control arm cohort found survival is relatively short and highly influenced by patient age, fitness, and where prostate cancer has spread in the body.</p>\n</div></td><td><div><p>Copyright © 2014 The Authors. Published by Elsevier B.V. All rights reserved.</p>\n</div></td></tr></table><blockquote><p><b>relatesTo</b></p><p><b>TargetUri</b>: <a href=\"https://pubmed.ncbi.nlm.nih.gov/25544634/\">https://pubmed.ncbi.nlm.nih.gov/25544634/</a></p><p><b>type</b>: comment-in</p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D016420}\">Comment</span></p><p><b>citation</b>: </p><div><p>Eur Urol. 2015 Jun;67(6):1039-1041. doi: 10.1016/j.eururo.2014.12.004.</p>\n</div></blockquote><blockquote><p><b>relatesTo</b></p><p><b>TargetUri</b>: <a href=\"https://pubmed.ncbi.nlm.nih.gov/26852973/\">https://pubmed.ncbi.nlm.nih.gov/26852973/</a></p><p><b>type</b>: comment-in</p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D016420}\">Comment</span></p><p><b>citation</b>: </p><div><p>J Urol. 2016 Feb;195(2):350. doi: 10.1016/j.juro.2015.10.165.</p>\n</div></blockquote><blockquote><p><b>publicationForm</b></p><blockquote><p><b>publishedIn</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/published-in-type D020492}\">Periodical</span></p><p><b>identifier</b>: Electronic ISSN Type/1873-7560, ISOAbbreviation/Eur Urol, ISSN Linking/0302-2838, Medline Title Abbreviation/Eur Urol, NLM Unique ID/7512719</p><p><b>title</b>: European urology</p><p><b>publisherLocation</b>: Switzerland</p></blockquote><p><b>citedMedium</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-medium internet}\">Internet</span></p><p><b>volume</b>: 67</p><p><b>issue</b>: 6</p><p><b>articleDate</b>: 2015-06</p><p><b>publicationDateText</b>: 2015-Jun</p><p><b>pageString</b>: 1028-1038</p></blockquote><blockquote><p><b>publicationForm</b></p><p><b>citedMedium</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-medium internet-without-issue}\">Internet without issue</span></p><p><b>articleDate</b>: 2014-10-06</p></blockquote><blockquote><p><b>webLocation</b></p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/artifact-url-classifier abstract}\">Abstract</span></p><p><b>url</b>: <a href=\"https://pubmed.ncbi.nlm.nih.gov/25301760/\">https://pubmed.ncbi.nlm.nih.gov/25301760/</a></p></blockquote><blockquote><p><b>webLocation</b></p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/artifact-url-classifier doi-based}\">DOI Based</span></p><p><b>url</b>: <a href=\"https://doi.org/10.1016/j.eururo.2014.09.032\">https://doi.org/10.1016/j.eururo.2014.09.032</a></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type publishing-model}\">Publishing Model</span></p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-artifact-classifier Print-Electronic}\">Print Electronic</span></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type keyword}\">Keyword</span></p><p><b>artifactAssessment</b>: <a href=\"#hc179617/keywords0\">Keywords provided by NOTNLM</a></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type chemical}\">Chemical</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D000726}\">Androgen Antagonists</span>, <span title=\"Codes:{https://www.nlm.nih.gov/mesh D043823}\">Taxoids</span>, <span title=\"Codes:{https://www.cas.org/support/documentation/chemical-substances 15H5577CQD}, {https://www.nlm.nih.gov/mesh D000077143}\">Docetaxel</span>, <span title=\"Codes:{https://www.cas.org/support/documentation/chemical-substances EC 3.4.21.77}, {https://www.nlm.nih.gov/mesh D017430}\">Prostate-Specific Antigen</span></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">MeSH heading</span></p><p><b>artifactAssessment</b>: <a href=\"#hc179617/meshHeading0\">ArtifactAssessment: artifact[x] = this resource</a></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type publication-type}\">Publication type</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D016428}\">Journal Article</span>, <span title=\"Codes:{https://www.nlm.nih.gov/mesh D016449}\">Randomized Controlled Trial</span>, <span title=\"Codes:{https://www.nlm.nih.gov/mesh D013485}\">Research Support, Non-U.S. Gov't</span></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type knowledge-artifact-type}\">Knowledge Artifact Type</span></p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}\">Journal Article</span></p><p><b>artifactAssessment</b>: Classifier added by Computable Publishing LLC</p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type citation-subset}\">Citation subset</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/bsd/licensee/elements_descriptions.html#citationsubset IM}\">IM</span></p></blockquote><blockquote><p><b>contributorship</b></p><p><b>complete</b>: true</p><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179617/contributor0\">James ND</a></p><p><b>forenameInitials</b>: ND</p><p><b>affiliation</b>: University of Warwick, Coventry, UK. Electronic address: N.D.James@warwick.ac.uk.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179617/contributor1\">Spears MR</a></p><p><b>forenameInitials</b>: MR</p><p><b>affiliation</b>: Medical Research Council Clinical Trials Unit at University College London, London, UK.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179617/contributor2\">Clarke NW</a></p><p><b>forenameInitials</b>: NW</p><p><b>affiliation</b>: Department of Urology, The Christie NHS Foundation Trust, Manchester, UK.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179617/contributor3\">Dearnaley DP</a></p><p><b>forenameInitials</b>: DP</p><p><b>affiliation</b>: Institute of Cancer Research, London, UK; The Royal Marsden NHS Foundation Trust, London and Sutton, UK.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179617/contributor4\">De Bono JS</a></p><p><b>forenameInitials</b>: JS</p><p><b>affiliation</b>: Institute of Cancer Research, London, UK; The Royal Marsden NHS Foundation Trust, London and Sutton, UK.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179617/contributor5\">Gale J</a></p><p><b>forenameInitials</b>: J</p><p><b>affiliation</b>: Queen Alexandra Hospital, Portsmouth, UK.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179617/contributor6\">Hetherington J</a></p><p><b>forenameInitials</b>: J</p><p><b>affiliation</b>: Hull & East Yorkshire Hospitals NHS Trust, Hull, UK.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179617/contributor7\">Hoskin PJ</a></p><p><b>forenameInitials</b>: PJ</p><p><b>affiliation</b>: Mount Vernon Hospital, Northwood, Middlesex, UK.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179617/contributor8\">Jones RJ</a></p><p><b>forenameInitials</b>: RJ</p><p><b>affiliation</b>: University of Glasgow, Beatson West of Scotland Cancer Centre, Glasgow, UK.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179617/contributor9\">Laing R</a></p><p><b>forenameInitials</b>: R</p><p><b>affiliation</b>: Royal Surrey County Hospital, Guildford, UK.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179617/contributor10\">Lester JF</a></p><p><b>forenameInitials</b>: JF</p><p><b>affiliation</b>: Velindre Hospital, Cardiff, UK.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179617/contributor11\">McLaren D</a></p><p><b>forenameInitials</b>: D</p><p><b>affiliation</b>: Western General Hospital, Edinburgh, UK.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179617/contributor12\">Parker CC</a></p><p><b>forenameInitials</b>: CC</p><p><b>affiliation</b>: Institute of Cancer Research, London, UK; The Royal Marsden NHS Foundation Trust, London and Sutton, UK.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179617/contributor13\">Parmar MKB</a></p><p><b>forenameInitials</b>: MKB</p><p><b>affiliation</b>: Medical Research Council Clinical Trials Unit at University College London, London, UK.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179617/contributor14\">Ritchie AWS</a></p><p><b>forenameInitials</b>: AWS</p><p><b>affiliation</b>: Medical Research Council Clinical Trials Unit at University College London, London, UK.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179617/contributor15\">Russell JM</a></p><p><b>forenameInitials</b>: JM</p><p><b>affiliation</b>: Institute of Cancer Sciences, University of Glasgow, Glasgow, UK.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179617/contributor16\">Strebel RT</a></p><p><b>forenameInitials</b>: RT</p><p><b>affiliation</b>: Kantonsspital Graübunden, Chur, Switzerland.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179617/contributor17\">Thalmann GN</a></p><p><b>forenameInitials</b>: GN</p><p><b>affiliation</b>: Department of Urology, University Hospital, Bern, Switzerland.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179617/contributor18\">Mason MD</a></p><p><b>forenameInitials</b>: MD</p><p><b>affiliation</b>: Velindre Hospital, Cardiff, UK.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179617/contributor19\">Sydes MR</a></p><p><b>forenameInitials</b>: MR</p><p><b>affiliation</b>: Medical Research Council Clinical Trials Unit at University College London, London, UK.</p></blockquote></blockquote></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: ArtifactAssessment #keywords0</b></p><a name=\"179617/keywords0\"> </a><a name=\"hc179617/keywords0\"> </a><a name=\"179617/keywords0-en-US\"> </a><p><b>artifact</b>: <a href=\"#hc179617\">Citation 25301760 Survival with Newly Diagnosed Metastatic Prostate Cancer in the "Docetaxel Era": Data from 917 Patients in the Control Arm of the STAMPEDE Trial (MRC PR08, CRUK/06/019).</a></p><blockquote><p><b>content</b></p><p><b>classifier</b>: <span title=\"Codes:\">Control arm cohort</span></p></blockquote><blockquote><p><b>content</b></p><p><b>classifier</b>: <span title=\"Codes:\">Hormone-naïve</span></p></blockquote><blockquote><p><b>content</b></p><p><b>classifier</b>: <span title=\"Codes:\">Metastatic</span></p></blockquote><blockquote><p><b>content</b></p><p><b>classifier</b>: <span title=\"Codes:\">Natural history</span></p></blockquote><blockquote><p><b>content</b></p><p><b>classifier</b>: <span title=\"Codes:\">Prognostic factors</span></p></blockquote><blockquote><p><b>content</b></p><p><b>classifier</b>: <span title=\"Codes:\">Prospective data</span></p></blockquote><blockquote><p><b>content</b></p><p><b>classifier</b>: <span title=\"Codes:\">Prostate cancer</span></p></blockquote><blockquote><p><b>content</b></p><p><b>classifier</b>: <span title=\"Codes:\">Survival</span></p></blockquote><blockquote><p><b>content</b></p><p><b>classifier</b>: <span title=\"Codes:\">Time to progression</span></p></blockquote></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor0</b></p><a name=\"179617/contributor0\"> </a><a name=\"hc179617/contributor0\"> </a><a name=\"179617/contributor0-en-US\"> </a><p><b>name</b>: Nicholas David James </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor1</b></p><a name=\"179617/contributor1\"> </a><a name=\"hc179617/contributor1\"> </a><a name=\"179617/contributor1-en-US\"> </a><p><b>name</b>: Melissa R Spears </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor2</b></p><a name=\"179617/contributor2\"> </a><a name=\"hc179617/contributor2\"> </a><a name=\"179617/contributor2-en-US\"> </a><p><b>name</b>: Noel W Clarke </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor3</b></p><a name=\"179617/contributor3\"> </a><a name=\"hc179617/contributor3\"> </a><a name=\"179617/contributor3-en-US\"> </a><p><b>name</b>: David P Dearnaley </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor4</b></p><a name=\"179617/contributor4\"> </a><a name=\"hc179617/contributor4\"> </a><a name=\"179617/contributor4-en-US\"> </a><p><b>name</b>: Johann S De Bono </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor5</b></p><a name=\"179617/contributor5\"> </a><a name=\"hc179617/contributor5\"> </a><a name=\"179617/contributor5-en-US\"> </a><p><b>name</b>: Joanna Gale </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor6</b></p><a name=\"179617/contributor6\"> </a><a name=\"hc179617/contributor6\"> </a><a name=\"179617/contributor6-en-US\"> </a><p><b>name</b>: John Hetherington </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor7</b></p><a name=\"179617/contributor7\"> </a><a name=\"hc179617/contributor7\"> </a><a name=\"179617/contributor7-en-US\"> </a><p><b>name</b>: Peter J Hoskin </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor8</b></p><a name=\"179617/contributor8\"> </a><a name=\"hc179617/contributor8\"> </a><a name=\"179617/contributor8-en-US\"> </a><p><b>name</b>: Robert J Jones </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor9</b></p><a name=\"179617/contributor9\"> </a><a name=\"hc179617/contributor9\"> </a><a name=\"179617/contributor9-en-US\"> </a><p><b>name</b>: Robert Laing </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor10</b></p><a name=\"179617/contributor10\"> </a><a name=\"hc179617/contributor10\"> </a><a name=\"179617/contributor10-en-US\"> </a><p><b>name</b>: Jason F Lester </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor11</b></p><a name=\"179617/contributor11\"> </a><a name=\"hc179617/contributor11\"> </a><a name=\"179617/contributor11-en-US\"> </a><p><b>name</b>: Duncan McLaren </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor12</b></p><a name=\"179617/contributor12\"> </a><a name=\"hc179617/contributor12\"> </a><a name=\"179617/contributor12-en-US\"> </a><p><b>name</b>: Christopher C Parker </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor13</b></p><a name=\"179617/contributor13\"> </a><a name=\"hc179617/contributor13\"> </a><a name=\"179617/contributor13-en-US\"> </a><p><b>name</b>: Mahesh K B Parmar </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor14</b></p><a name=\"179617/contributor14\"> </a><a name=\"hc179617/contributor14\"> </a><a name=\"179617/contributor14-en-US\"> </a><p><b>name</b>: Alastair W S Ritchie </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor15</b></p><a name=\"179617/contributor15\"> </a><a name=\"hc179617/contributor15\"> </a><a name=\"179617/contributor15-en-US\"> </a><p><b>name</b>: J Martin Russell </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor16</b></p><a name=\"179617/contributor16\"> </a><a name=\"hc179617/contributor16\"> </a><a name=\"179617/contributor16-en-US\"> </a><p><b>name</b>: Räto T Strebel </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor17</b></p><a name=\"179617/contributor17\"> </a><a name=\"hc179617/contributor17\"> </a><a name=\"179617/contributor17-en-US\"> </a><p><b>name</b>: George N Thalmann </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor18</b></p><a name=\"179617/contributor18\"> </a><a name=\"hc179617/contributor18\"> </a><a name=\"179617/contributor18-en-US\"> </a><p><b>name</b>: Malcolm D Mason </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor19</b></p><a name=\"179617/contributor19\"> </a><a name=\"hc179617/contributor19\"> </a><a name=\"179617/contributor19-en-US\"> </a><p><b>name</b>: Matthew R Sydes </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: ArtifactAssessment #meshHeading0</b></p><a name=\"179617/meshHeading0\"> </a><a name=\"hc179617/meshHeading0\"> </a><a name=\"179617/meshHeading0-en-US\"> </a><p><b>artifact</b>: <a href=\"#hc179617\">Citation 25301760 Survival with Newly Diagnosed Metastatic Prostate Cancer in the "Docetaxel Era": Data from 917 Patients in the Control Arm of the STAMPEDE Trial (MRC PR08, CRUK/06/019).</a></p><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D000328}\">Adult</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D000367}\">Age Factors</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D000368}\">Aged</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D000369}\">Aged, 80 and over</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D000726}\">Androgen Antagonists</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:\">is not a major topic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh Q000627}\">therapeutic use</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">is Major topic</span></td><td><span title=\"Codes:{http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl C49488}\">Yes</span></td></tr></table></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D015331}\">Cohort Studies</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D018572}\">Disease-Free Survival</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D000077143}\">Docetaxel</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D055088}\">Early Detection of Cancer</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:\">is not a major topic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh Q000401}\">mortality</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">is Major topic</span></td><td><span title=\"Codes:{http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl C49487}\">No</span></td></tr></table></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D005500}\">Follow-Up Studies</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D006801}\">Humans</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D053208}\">Kaplan-Meier Estimate</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D008297}\">Male</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D008875}\">Middle Aged</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D060787}\">Neoplasm Grading</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D009362}\">Neoplasm Metastasis</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:\">is not a major topic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh Q000175}\">diagnosis</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">is Major topic</span></td><td><span title=\"Codes:{http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl C49487}\">No</span></td></tr></table></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh Q000473}\">pathology</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">is Major topic</span></td><td><span title=\"Codes:{http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl C49487}\">No</span></td></tr></table></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh Q000628}\">therapy</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">is Major topic</span></td><td><span title=\"Codes:{http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl C49488}\">Yes</span></td></tr></table></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D010809}\">Physical Fitness</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D011379}\">Prognosis</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D016016}\">Proportional Hazards Models</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D017430}\">Prostate-Specific Antigen</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:\">is not a major topic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh Q000097}\">blood</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">is Major topic</span></td><td><span title=\"Codes:{http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl C49487}\">No</span></td></tr></table></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D011471}\">Prostatic Neoplasms</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:\">is not a major topic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh Q000175}\">diagnosis</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">is Major topic</span></td><td><span title=\"Codes:{http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl C49487}\">No</span></td></tr></table></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh Q000188}\">drug therapy</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">is Major topic</span></td><td><span title=\"Codes:{http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl C49488}\">Yes</span></td></tr></table></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh Q000401}\">mortality</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">is Major topic</span></td><td><span title=\"Codes:{http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl C49487}\">No</span></td></tr></table></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh Q000473}\">pathology</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">is Major topic</span></td><td><span title=\"Codes:{http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl C49487}\">No</span></td></tr></table></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D012307}\">Risk Factors</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D043823}\">Taxoids</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:\">is not a major topic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh Q000627}\">therapeutic use</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">is Major topic</span></td><td><span title=\"Codes:{http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl C49488}\">Yes</span></td></tr></table></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/mesh D016896}\">Treatment Outcome</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote></blockquote></div>"^^rdf:XMLLiteral ] ; # fhir:contained ( [ a fhir:ArtifactAssessment ; fhir:id [ fhir:v "keywords0" ] ; fhir:artifact [ a fhir:Reference ; fhir:reference [ fhir:v "#" ] ; fhir:type [ fhir:v "Citation"^^xsd:anyURI ] ] ; ( fhir:content [ ( fhir:classifier [ fhir:text [ fhir:v "Control arm cohort" ] ] ) ] [ ( fhir:classifier [ fhir:text [ fhir:v "Hormone-naïve" ] ] ) ] [ ( fhir:classifier [ fhir:text [ fhir:v "Metastatic" ] ] ) ] [ ( fhir:classifier [ fhir:text [ fhir:v "Natural history" ] ] ) ] [ ( fhir:classifier [ fhir:text [ fhir:v "Prognostic factors" ] ] ) ] [ ( fhir:classifier [ fhir:text [ fhir:v "Prospective data" ] ] ) ] [ ( fhir:classifier [ fhir:text [ fhir:v "Prostate cancer" ] ] ) ] [ ( fhir:classifier [ fhir:text [ fhir:v "Survival" ] ] ) ] [ ( fhir:classifier [ fhir:text [ fhir:v "Time to progression" ] ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor0" ] ; ( fhir:name [ fhir:family [ fhir:v "James" ] ; ( fhir:given [ fhir:v "Nicholas David" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor1" ] ; ( fhir:name [ fhir:family [ fhir:v "Spears" ] ; ( fhir:given [ fhir:v "Melissa R" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor2" ] ; ( fhir:name [ fhir:family [ fhir:v "Clarke" ] ; ( fhir:given [ fhir:v "Noel W" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor3" ] ; ( fhir:name [ fhir:family [ fhir:v "Dearnaley" ] ; ( fhir:given [ fhir:v "David P" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor4" ] ; ( fhir:name [ fhir:family [ fhir:v "De Bono" ] ; ( fhir:given [ fhir:v "Johann S" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor5" ] ; ( fhir:name [ fhir:family [ fhir:v "Gale" ] ; ( fhir:given [ fhir:v "Joanna" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor6" ] ; ( fhir:name [ fhir:family [ fhir:v "Hetherington" ] ; ( fhir:given [ fhir:v "John" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor7" ] ; ( fhir:name [ fhir:family [ fhir:v "Hoskin" ] ; ( fhir:given [ fhir:v "Peter J" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor8" ] ; ( fhir:name [ fhir:family [ fhir:v "Jones" ] ; ( fhir:given [ fhir:v "Robert J" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor9" ] ; ( fhir:name [ fhir:family [ fhir:v "Laing" ] ; ( fhir:given [ fhir:v "Robert" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor10" ] ; ( fhir:name [ fhir:family [ fhir:v "Lester" ] ; ( fhir:given [ fhir:v "Jason F" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor11" ] ; ( fhir:name [ fhir:family [ fhir:v "McLaren" ] ; ( fhir:given [ fhir:v "Duncan" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor12" ] ; ( fhir:name [ fhir:family [ fhir:v "Parker" ] ; ( fhir:given [ fhir:v "Christopher C" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor13" ] ; ( fhir:name [ fhir:family [ fhir:v "Parmar" ] ; ( fhir:given [ fhir:v "Mahesh K B" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor14" ] ; ( fhir:name [ fhir:family [ fhir:v "Ritchie" ] ; ( fhir:given [ fhir:v "Alastair W S" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor15" ] ; ( fhir:name [ fhir:family [ fhir:v "Russell" ] ; ( fhir:given [ fhir:v "J Martin" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor16" ] ; ( fhir:name [ fhir:family [ fhir:v "Strebel" ] ; ( fhir:given [ fhir:v "Räto T" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor17" ] ; ( fhir:name [ fhir:family [ fhir:v "Thalmann" ] ; ( fhir:given [ fhir:v "George N" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor18" ] ; ( fhir:name [ fhir:family [ fhir:v "Mason" ] ; ( fhir:given [ fhir:v "Malcolm D" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "contributor19" ] ; ( fhir:name [ fhir:family [ fhir:v "Sydes" ] ; ( fhir:given [ fhir:v "Matthew R" ] ) ] ) ] [ a fhir:ArtifactAssessment ; fhir:id [ fhir:v "meshHeading0" ] ; fhir:artifact [ a fhir:Reference ; fhir:reference [ fhir:v "#" ] ; fhir:type [ fhir:v "Citation"^^xsd:anyURI ] ] ; ( fhir:content [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; ( fhir:classifier [ ( fhir:coding [ a mesh:D000328 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ] ; fhir:code [ fhir:v "D000328" ] ; fhir:display [ fhir:v "Adult" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ) ; fhir:freeToShare [ fhir:v true ] ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] ) ] [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; ( fhir:classifier [ ( fhir:coding [ a mesh:D000367 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ] ; fhir:code [ fhir:v "D000367" ] ; fhir:display [ fhir:v "Age Factors" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ) ; fhir:freeToShare [ fhir:v true ] ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] ) ] [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; ( fhir:classifier [ ( fhir:coding [ a mesh:D000368 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ] ; fhir:code [ fhir:v "D000368" ] ; fhir:display [ fhir:v "Aged" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ) ; fhir:freeToShare [ fhir:v true ] ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] ) ] [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; ( fhir:classifier [ ( fhir:coding [ a mesh:D000369 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ] ; fhir:code [ fhir:v "D000369" ] ; fhir:display [ fhir:v "Aged, 80 and over" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ) ; fhir:freeToShare [ fhir:v true ] ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] ) ] [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; ( fhir:classifier [ ( fhir:coding [ a mesh:D000726 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ] ; fhir:code [ fhir:v "D000726" ] ; fhir:display [ fhir:v "Androgen Antagonists" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ) ; fhir:freeToShare [ fhir:v true ] ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ ( fhir:coding [ a mesh:Q000627 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ] ; fhir:code [ fhir:v "Q000627" ] ; fhir:display [ fhir:v "therapeutic use" ] ] ) ] ) ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "is Major topic" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl"^^xsd:anyURI ] ; fhir:code [ fhir:v "C49488" ] ; fhir:display [ fhir:v "Yes" ] ] ) ] ) ] ) ] ) ] [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; ( fhir:classifier [ ( fhir:coding [ a mesh:D015331 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ] ; fhir:code [ fhir:v "D015331" ] ; fhir:display [ fhir:v "Cohort Studies" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ) ; fhir:freeToShare [ fhir:v true ] ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] ) ] [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; ( fhir:classifier [ ( fhir:coding [ a mesh:D018572 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ] ; fhir:code [ fhir:v "D018572" ] ; fhir:display [ fhir:v "Disease-Free Survival" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ) ; fhir:freeToShare [ fhir:v true ] ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] ) ] [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; ( fhir:classifier [ ( fhir:coding [ a mesh:D000077143 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ] ; fhir:code [ fhir:v "D000077143" ] ; fhir:display [ fhir:v "Docetaxel" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ) ; fhir:freeToShare [ fhir:v true ] ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] ) ] [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; ( fhir:classifier [ ( fhir:coding [ a mesh:D055088 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ] ; fhir:code [ fhir:v "D055088" ] ; fhir:display [ fhir:v "Early Detection of Cancer" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ) ; fhir:freeToShare [ fhir:v true ] ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ ( fhir:coding [ a mesh:Q000401 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ] ; fhir:code [ fhir:v "Q000401" ] ; fhir:display [ fhir:v "mortality" ] ] ) ] ) ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "is Major topic" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl"^^xsd:anyURI ] ; fhir:code [ fhir:v "C49487" ] ; fhir:display [ fhir:v "No" ] ] ) ] ) ] ) ] ) ] [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; ( fhir:classifier [ ( fhir:coding [ a mesh:D005500 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ] ; fhir:code [ fhir:v "D005500" ] ; fhir:display [ fhir:v "Follow-Up Studies" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ) ; fhir:freeToShare [ fhir:v true ] ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] ) ] [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; ( fhir:classifier [ ( fhir:coding [ a mesh:D006801 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ] ; fhir:code [ fhir:v "D006801" ] ; fhir:display [ fhir:v "Humans" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ) ; fhir:freeToShare [ fhir:v true ] ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] ) ] [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; ( fhir:classifier [ ( fhir:coding [ a mesh:D053208 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ] ; fhir:code [ fhir:v "D053208" ] ; fhir:display [ fhir:v "Kaplan-Meier Estimate" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ) ; fhir:freeToShare [ fhir:v true ] ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] ) ] [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; ( fhir:classifier [ ( fhir:coding [ a mesh:D008297 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ] ; fhir:code [ fhir:v "D008297" ] ; fhir:display [ fhir:v "Male" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ) ; fhir:freeToShare [ fhir:v true ] ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] ) ] [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; ( fhir:classifier [ ( fhir:coding [ a mesh:D008875 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ] ; fhir:code [ fhir:v "D008875" ] ; fhir:display [ fhir:v "Middle Aged" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ) ; fhir:freeToShare [ fhir:v true ] ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] ) ] [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; ( fhir:classifier [ ( fhir:coding [ a mesh:D060787 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ] ; fhir:code [ fhir:v "D060787" ] ; fhir:display [ fhir:v "Neoplasm Grading" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ) ; fhir:freeToShare [ fhir:v true ] ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] ) ] [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; ( fhir:classifier [ ( fhir:coding [ a mesh:D009362 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ] ; fhir:code [ fhir:v "D009362" ] ; fhir:display [ fhir:v "Neoplasm Metastasis" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ) ; fhir:freeToShare [ fhir:v true ] ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ ( fhir:coding [ a mesh:Q000175 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ] ; fhir:code [ fhir:v "Q000175" ] ; fhir:display [ fhir:v "diagnosis" ] ] ) ] ) ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "is Major topic" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl"^^xsd:anyURI ] ; fhir:code [ fhir:v "C49487" ] ; fhir:display [ fhir:v "No" ] ] ) ] ) ] ) ] [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ ( fhir:coding [ a mesh:Q000473 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ] ; fhir:code [ fhir:v "Q000473" ] ; fhir:display [ fhir:v "pathology" ] ] ) ] ) ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "is Major topic" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl"^^xsd:anyURI ] ; fhir:code [ fhir:v "C49487" ] ; fhir:display [ fhir:v "No" ] ] ) ] ) ] ) ] [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ ( fhir:coding [ a mesh:Q000628 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ] ; fhir:code [ fhir:v "Q000628" ] ; fhir:display [ fhir:v "therapy" ] ] ) ] ) ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "is Major topic" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl"^^xsd:anyURI ] ; fhir:code [ fhir:v "C49488" ] ; fhir:display [ fhir:v "Yes" ] ] ) ] ) ] ) ] ) ] [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; ( fhir:classifier [ ( fhir:coding [ a mesh:D010809 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ] ; fhir:code [ fhir:v "D010809" ] ; fhir:display [ fhir:v "Physical Fitness" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ) ; fhir:freeToShare [ fhir:v true ] ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] ) ] [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; ( fhir:classifier [ ( fhir:coding [ a mesh:D011379 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ] ; fhir:code [ fhir:v "D011379" ] ; fhir:display [ fhir:v "Prognosis" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ) ; fhir:freeToShare [ fhir:v true ] ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] ) ] [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; ( fhir:classifier [ ( fhir:coding [ a mesh:D016016 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ] ; fhir:code [ fhir:v "D016016" ] ; fhir:display [ fhir:v "Proportional Hazards Models" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ) ; fhir:freeToShare [ fhir:v true ] ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] ) ] [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; ( fhir:classifier [ ( fhir:coding [ a mesh:D017430 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ] ; fhir:code [ fhir:v "D017430" ] ; fhir:display [ fhir:v "Prostate-Specific Antigen" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ) ; fhir:freeToShare [ fhir:v true ] ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ ( fhir:coding [ a mesh:Q000097 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ] ; fhir:code [ fhir:v "Q000097" ] ; fhir:display [ fhir:v "blood" ] ] ) ] ) ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "is Major topic" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl"^^xsd:anyURI ] ; fhir:code [ fhir:v "C49487" ] ; fhir:display [ fhir:v "No" ] ] ) ] ) ] ) ] ) ] [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; ( fhir:classifier [ ( fhir:coding [ a mesh:D011471 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ] ; fhir:code [ fhir:v "D011471" ] ; fhir:display [ fhir:v "Prostatic Neoplasms" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ) ; fhir:freeToShare [ fhir:v true ] ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ ( fhir:coding [ a mesh:Q000175 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ] ; fhir:code [ fhir:v "Q000175" ] ; fhir:display [ fhir:v "diagnosis" ] ] ) ] ) ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "is Major topic" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl"^^xsd:anyURI ] ; fhir:code [ fhir:v "C49487" ] ; fhir:display [ fhir:v "No" ] ] ) ] ) ] ) ] [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ ( fhir:coding [ a mesh:Q000188 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ] ; fhir:code [ fhir:v "Q000188" ] ; fhir:display [ fhir:v "drug therapy" ] ] ) ] ) ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "is Major topic" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl"^^xsd:anyURI ] ; fhir:code [ fhir:v "C49488" ] ; fhir:display [ fhir:v "Yes" ] ] ) ] ) ] ) ] [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ ( fhir:coding [ a mesh:Q000401 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ] ; fhir:code [ fhir:v "Q000401" ] ; fhir:display [ fhir:v "mortality" ] ] ) ] ) ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "is Major topic" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl"^^xsd:anyURI ] ; fhir:code [ fhir:v "C49487" ] ; fhir:display [ fhir:v "No" ] ] ) ] ) ] ) ] [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ ( fhir:coding [ a mesh:Q000473 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ] ; fhir:code [ fhir:v "Q000473" ] ; fhir:display [ fhir:v "pathology" ] ] ) ] ) ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "is Major topic" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl"^^xsd:anyURI ] ; fhir:code [ fhir:v "C49487" ] ; fhir:display [ fhir:v "No" ] ] ) ] ) ] ) ] ) ] [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; ( fhir:classifier [ ( fhir:coding [ a mesh:D012307 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ] ; fhir:code [ fhir:v "D012307" ] ; fhir:display [ fhir:v "Risk Factors" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ) ; fhir:freeToShare [ fhir:v true ] ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] ) ] [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; ( fhir:classifier [ ( fhir:coding [ a mesh:D043823 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ] ; fhir:code [ fhir:v "D043823" ] ; fhir:display [ fhir:v "Taxoids" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ) ; fhir:freeToShare [ fhir:v true ] ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ ( fhir:coding [ a mesh:Q000627 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ] ; fhir:code [ fhir:v "Q000627" ] ; fhir:display [ fhir:v "therapeutic use" ] ] ) ] ) ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "is Major topic" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl"^^xsd:anyURI ] ; fhir:code [ fhir:v "C49488" ] ; fhir:display [ fhir:v "Yes" ] ] ) ] ) ] ) ] ) ] [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; ( fhir:classifier [ ( fhir:coding [ a mesh:D016896 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ] ; fhir:code [ fhir:v "D016896" ] ; fhir:display [ fhir:v "Treatment Outcome" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ) ; fhir:freeToShare [ fhir:v true ] ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] ) ] ) ] ) ; # fhir:url [ fhir:v "https://fevir.net/resources/Citation/179617"^^xsd:anyURI] ; # fhir:identifier ( [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v2-0203"^^xsd:anyURI ] ; fhir:code [ fhir:v "ACSN" ] ; fhir:display [ fhir:v "Accession ID" ] ] ) ; fhir:text [ fhir:v "FEvIR Object Identifier" ] ] ; fhir:system [ fhir:v "urn:ietf:rfc:3986"^^xsd:anyURI ] ; fhir:value [ fhir:v "https://fevir.net/FOI/179617" ] ; fhir:assigner [ fhir:display [ fhir:v "Computable Publishing LLC" ] ] ] [ fhir:system [ fhir:v "https://pubmed.ncbi.nlm.nih.gov"^^xsd:anyURI ] ; fhir:value [ fhir:v "25301760" ] ] [ fhir:system [ fhir:v "urn:ietf:rfc:3986"^^xsd:anyURI ] ; fhir:value [ fhir:v "urn:oid:2.16.840.1.113883.4.642.40.44.15.51" ] ] ) ; # fhir:version [ fhir:v "1.0.0-ballot2"] ; # fhir:title [ fhir:v "25301760 Survival with Newly Diagnosed Metastatic Prostate Cancer in the \"Docetaxel Era\": Data from 917 Patients in the Control Arm of the STAMPEDE Trial (MRC PR08, CRUK/06/019)."] ; # fhir:status [ fhir:v "active"] ; # fhir:date [ fhir:v "2025-03-28T17:11:38+00:00"^^xsd:dateTime] ; # fhir:publisher [ fhir:v "HL7 International / Clinical Decision Support"] ; # fhir:contact ( [ fhir:name [ fhir:v "HL7 International / Clinical Decision Support" ] ; ( fhir:telecom [ fhir:system [ fhir:v "url" ] ; fhir:value [ fhir:v "http://www.hl7.org/Special/committees/dss" ] ] ) ] ) ; # fhir:description [ fhir:v "This Citation Resource is referenced in an example for the EBMonFHIR Implementation Guide."] ; # fhir:useContext ( [ fhir:code [ fhir:system [ fhir:v "http://hl7.org/fhir/citation-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "fevir-platform-use" ] ; fhir:display [ fhir:v "FEvIR Platform Use" ] ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/citation-artifact-classifier"^^xsd:anyURI ] ; fhir:code [ fhir:v "medline-base" ] ; fhir:display [ fhir:v "Medline Base" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ] ) ; # fhir:jurisdiction ( [ ( fhir:coding [ fhir:system [ fhir:v "http://unstats.un.org/unsd/methods/m49/m49.htm"^^xsd:anyURI ] ; fhir:code [ fhir:v "001" ] ; fhir:display [ fhir:v "World" ] ] ) ] ) ; # fhir:copyright [ fhir:v "https://creativecommons.org/licenses/by-nc-sa/4.0/"] ; # fhir:approvalDate [ fhir:v "2016-04-07"^^xsd:date] ; # fhir:lastReviewDate [ fhir:v "2022-12-08"^^xsd:date] ; # fhir:author ( [ fhir:name [ fhir:v "Computable Publishing®: MEDLINE-to-FEvIR Converter" ] ] ) ; # fhir:classification ( [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/citation-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "citation-source" ] ; fhir:display [ fhir:v "Citation Source" ] ] ) ] ; ( fhir:classifier [ fhir:text [ fhir:v "MEDLINE" ] ] ) ] [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/citation-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "medline-owner" ] ; fhir:display [ fhir:v "MEDLINE Citation Owner" ] ] ) ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "https://www.nlm.nih.gov/bsd/licensee/elements_descriptions.html#owner_value"^^xsd:anyURI ] ; fhir:code [ fhir:v "NLM" ] ; fhir:display [ fhir:v "National Library of Medicine, Index Section" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ) ] ) ; # fhir:currentState ( [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/citation-status-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "medline-medline" ] ; fhir:display [ fhir:v "Medline Citation Status of Medline" ] ] ) ] [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/citation-status-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "pubmed-publication-status-ppublish" ] ; fhir:display [ fhir:v "PubMed PublicationStatus of ppublish" ] ] ) ] ) ; # fhir:statusDate ( [ fhir:activity [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/citation-status-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "pubmed-pubstatus-received" ] ; fhir:display [ fhir:v "PubMed Pubstatus of Received" ] ] ) ] ; fhir:period [ fhir:end [ fhir:v "2014-07-23"^^xsd:date ] ] ] [ fhir:activity [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/citation-status-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "pubmed-pubstatus-accepted" ] ; fhir:display [ fhir:v "PubMed Pubstatus of Accepted" ] ] ) ] ; 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fhir:identifier [ fhir:system [ fhir:v "https://pubmed.ncbi.nlm.nih.gov"^^xsd:anyURI ] ; fhir:value [ fhir:v "25301760" ] ] [ fhir:system [ fhir:v "https://doi.org"^^xsd:anyURI ] ; fhir:value [ fhir:v "10.1016/j.eururo.2014.09.032" ] ] [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v2-0203"^^xsd:anyURI ] ; fhir:code [ fhir:v "ACSN" ] ; fhir:display [ fhir:v "Accession ID" ] ] ) ; fhir:text [ fhir:v "pii" ] ] ; fhir:value [ fhir:v "S0302-2838(14)00969-5" ] ] ) ; ( fhir:title [ ( fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/title-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "primary" ] ; fhir:display [ fhir:v "Primary title" ] ] ) ] ) ; fhir:language [ ( fhir:coding [ fhir:system [ fhir:v "urn:ietf:bcp:47"^^xsd:anyURI ] ; fhir:code [ fhir:v "en" ] ; fhir:display [ fhir:v "English" ] ] ) ] ; fhir:text [ fhir:v "Survival with Newly Diagnosed Metastatic Prostate Cancer in the \"Docetaxel Era\": Data from 917 Patients in the Control Arm of the STAMPEDE Trial (MRC PR08, CRUK/06/019)." ] ] ) ; ( fhir:abstract [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-abstract-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "primary-human-use" ] ; fhir:display [ fhir:v "Primary human use" ] ] ) ] ; fhir:text [ fhir:v "**BACKGROUND:** Prostate cancer (PCa) is the second most common disease among men worldwide. It is important to know survival outcomes and prognostic factors for this disease. Recruitment for the largest therapeutic randomised controlled trial in PCa--the Systemic Therapy in Advancing or Metastatic Prostate Cancer: Evaluation of Drug Efficacy: A Multi-Stage Multi-Arm Randomised Controlled Trial (STAMPEDE)--includes men with newly diagnosed metastatic PCa who are commencing long-term androgen deprivation therapy (ADT); the control arm provides valuable data for a prospective cohort.\n**OBJECTIVE:** Describe survival outcomes, along with current treatment standards and factors associated with prognosis, to inform future trial design in this patient group.\n**DESIGN, SETTING, AND PARTICIPANTS:** STAMPEDE trial control arm comprising men newly diagnosed with M1 disease who were recruited between October 2005 and January 2014.\n**OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS:** Overall survival (OS) and failure-free survival (FFS) were reported by primary disease characteristics using Kaplan-Meier methods. Hazard ratios and 95% confidence intervals (CIs) were derived from multivariate Cox models.\n**RESULTS AND LIMITATIONS:** A cohort of 917 men with newly diagnosed M1 disease was recruited to the control arm in the specified interval. Median follow-up was 20 mo. Median age at randomisation was 66 yr (interquartile range [IQR]: 61-71), and median prostate-specific antigen level was 112 ng/ml (IQR: 34-373). Most men (n=574; 62%) had bone-only metastases, whereas 237 (26%) had both bone and soft tissue metastases; soft tissue metastasis was found mainly in distant lymph nodes. There were 238 deaths, 202 (85%) from PCa. Median FFS was 11 mo; 2-yr FFS was 29% (95% CI, 25-33). Median OS was 42 mo; 2-yr OS was 72% (95% CI, 68-76). Survival time was influenced by performance status, age, Gleason score, and metastases distribution. Median survival after FFS event was 22 mo. Trial eligibility criteria meant men were younger and fitter than general PCa population.\n**CONCLUSIONS:** Survival remains disappointing in men presenting with M1 disease who are started on only long-term ADT, despite active treatments being available at first failure of ADT. Importantly, men with M1 disease now spend the majority of their remaining life in a state of castration-resistant relapse.\n**PATIENT SUMMARY:** Results from this control arm cohort found survival is relatively short and highly influenced by patient age, fitness, and where prostate cancer has spread in the body." ] ; fhir:copyright [ fhir:v "Copyright © 2014 The Authors. Published by Elsevier B.V. All rights reserved." ] ] ) ; ( fhir:relatesTo [ ( fhir:extension [ fhir:url [ fhir:v "http://hl7.org/fhir/uv/ebm/StructureDefinition/target-uri"^^xsd:anyURI ] ; fhir:value [ a fhir:uri ; fhir:v "https://pubmed.ncbi.nlm.nih.gov/25544634/"^^xsd:anyURI ] ] ) ; fhir:type [ fhir:v "comment-in" ] ; ( fhir:classifier [ ( fhir:coding [ a mesh:D016420 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ] ; fhir:code [ fhir:v "D016420" ] ; fhir:display [ fhir:v "Comment" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ) ; fhir:citation [ fhir:v "Eur Urol. 2015 Jun;67(6):1039-1041. doi: 10.1016/j.eururo.2014.12.004." ] ] [ ( fhir:extension [ fhir:url [ fhir:v "http://hl7.org/fhir/uv/ebm/StructureDefinition/target-uri"^^xsd:anyURI ] ; fhir:value [ a fhir:uri ; fhir:v "https://pubmed.ncbi.nlm.nih.gov/26852973/"^^xsd:anyURI ] ] ) ; fhir:type [ fhir:v "comment-in" ] ; ( fhir:classifier [ ( fhir:coding [ a mesh:D016420 ; fhir:system [ fhir:v "https://www.nlm.nih.gov/mesh"^^xsd:anyURI ] ; fhir:code [ fhir:v "D016420" ] ; fhir:display [ fhir:v "Comment" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ) ; fhir:citation [ fhir:v "J Urol. 2016 Feb;195(2):350. doi: 10.1016/j.juro.2015.10.165." ] ] ) ; ( fhir:publicationForm [ fhir:publishedIn [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/published-in-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "D020492" ] ; fhir:display [ fhir:v "Periodical" ] ] ) ] ; ( fhir:identifier [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "https://www.nlm.nih.gov/bsd/licensee/elements_descriptions.html#issn"^^xsd:anyURI ] ; fhir:code [ fhir:v "Electronic" ] ; fhir:display [ fhir:v "Electronic" ] ] ) ; fhir:text [ fhir:v "Electronic ISSN Type" ] ] ; fhir:system [ fhir:v "https://portal.issn.org"^^xsd:anyURI ] ; fhir:value [ fhir:v "1873-7560" ] ] [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v2-0203"^^xsd:anyURI ] ; fhir:code [ fhir:v "XX" ] ; fhir:display [ fhir:v "Organization identifier" ] ] ) ; fhir:text [ fhir:v "ISOAbbreviation" ] ] ; 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( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "https://www.nlm.nih.gov/bsd/licensee/elements_descriptions.html#citationsubset"^^xsd:anyURI ] ; fhir:code [ fhir:v "IM" ] ; fhir:display [ fhir:v "IM" ] ; fhir:userSelected [ fhir:v false ] ] ) ] ) ] ) ; fhir:contributorship [ fhir:complete [ fhir:v true ] ; ( fhir:entry [ fhir:contributor [ fhir:reference [ fhir:v "#contributor0" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ; fhir:display [ fhir:v "James ND" ] ] ; fhir:forenameInitials [ fhir:v "ND" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "University of Warwick, Coventry, UK. Electronic address: N.D.James@warwick.ac.uk." ] ] ) ] [ fhir:contributor [ fhir:reference [ fhir:v "#contributor1" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ; fhir:display [ fhir:v "Spears MR" ] ] ; fhir:forenameInitials [ fhir:v "MR" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "Medical Research Council Clinical Trials Unit at University College London, London, UK." ] ] ) ] [ fhir:contributor [ fhir:reference [ fhir:v "#contributor2" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ; fhir:display [ fhir:v "Clarke NW" ] ] ; fhir:forenameInitials [ fhir:v "NW" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "Department of Urology, The Christie NHS Foundation Trust, Manchester, UK." ] ] ) ] [ fhir:contributor [ fhir:reference [ fhir:v "#contributor3" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ; fhir:display [ fhir:v "Dearnaley DP" ] ] ; fhir:forenameInitials [ fhir:v "DP" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "Institute of Cancer Research, London, UK; The Royal Marsden NHS Foundation Trust, London and Sutton, UK." ] ] ) ] [ fhir:contributor [ fhir:reference [ fhir:v "#contributor4" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ; fhir:display [ fhir:v "De Bono JS" ] ] ; fhir:forenameInitials [ fhir:v "JS" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "Institute of Cancer Research, London, UK; The Royal Marsden NHS Foundation Trust, London and Sutton, UK." ] ] ) ] [ fhir:contributor [ fhir:reference [ fhir:v "#contributor5" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ; fhir:display [ fhir:v "Gale J" ] ] ; fhir:forenameInitials [ fhir:v "J" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "Queen Alexandra Hospital, Portsmouth, UK." ] ] ) ] [ fhir:contributor [ fhir:reference [ fhir:v "#contributor6" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ; fhir:display [ fhir:v "Hetherington J" ] ] ; fhir:forenameInitials [ fhir:v "J" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "Hull & East Yorkshire Hospitals NHS Trust, Hull, UK." ] ] ) ] [ fhir:contributor [ fhir:reference [ fhir:v "#contributor7" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ; fhir:display [ fhir:v "Hoskin PJ" ] ] ; fhir:forenameInitials [ fhir:v "PJ" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "Mount Vernon Hospital, Northwood, Middlesex, UK." ] ] ) ] [ fhir:contributor [ fhir:reference [ fhir:v "#contributor8" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ; fhir:display [ fhir:v "Jones RJ" ] ] ; fhir:forenameInitials [ fhir:v "RJ" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "University of Glasgow, Beatson West of Scotland Cancer Centre, Glasgow, UK." ] ] ) ] [ fhir:contributor [ fhir:reference [ fhir:v "#contributor9" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ; fhir:display [ fhir:v "Laing R" ] ] ; fhir:forenameInitials [ fhir:v "R" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "Royal Surrey County Hospital, Guildford, UK." ] ] ) ] [ fhir:contributor [ fhir:reference [ fhir:v "#contributor10" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ; fhir:display [ fhir:v "Lester JF" ] ] ; fhir:forenameInitials [ fhir:v "JF" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "Velindre Hospital, Cardiff, UK." ] ] ) ] [ fhir:contributor [ fhir:reference [ fhir:v "#contributor11" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ; fhir:display [ fhir:v "McLaren D" ] ] ; fhir:forenameInitials [ fhir:v "D" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "Western General Hospital, Edinburgh, UK." ] ] ) ] [ fhir:contributor [ fhir:reference [ fhir:v "#contributor12" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ; fhir:display [ fhir:v "Parker CC" ] ] ; fhir:forenameInitials [ fhir:v "CC" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "Institute of Cancer Research, London, UK; The Royal Marsden NHS Foundation Trust, London and Sutton, UK." ] ] ) ] [ fhir:contributor [ fhir:reference [ fhir:v "#contributor13" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ; fhir:display [ fhir:v "Parmar MKB" ] ] ; fhir:forenameInitials [ fhir:v "MKB" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "Medical Research Council Clinical Trials Unit at University College London, London, UK." ] ] ) ] [ fhir:contributor [ fhir:reference [ fhir:v "#contributor14" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ; fhir:display [ fhir:v "Ritchie AWS" ] ] ; fhir:forenameInitials [ fhir:v "AWS" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "Medical Research Council Clinical Trials Unit at University College London, London, UK." ] ] ) ] [ fhir:contributor [ fhir:reference [ fhir:v "#contributor15" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ; fhir:display [ fhir:v "Russell JM" ] ] ; fhir:forenameInitials [ fhir:v "JM" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "Institute of Cancer Sciences, University of Glasgow, Glasgow, UK." ] ] ) ] [ fhir:contributor [ fhir:reference [ fhir:v "#contributor16" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ; fhir:display [ fhir:v "Strebel RT" ] ] ; fhir:forenameInitials [ fhir:v "RT" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "Kantonsspital Graübunden, Chur, Switzerland." ] ] ) ] [ fhir:contributor [ fhir:reference [ fhir:v "#contributor17" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ; fhir:display [ fhir:v "Thalmann GN" ] ] ; fhir:forenameInitials [ fhir:v "GN" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "Department of Urology, University Hospital, Bern, Switzerland." ] ] ) ] [ fhir:contributor [ fhir:reference [ fhir:v "#contributor18" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ; fhir:display [ fhir:v "Mason MD" ] ] ; fhir:forenameInitials [ fhir:v "MD" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "Velindre Hospital, Cardiff, UK." ] ] ) ] [ fhir:contributor [ fhir:reference [ fhir:v "#contributor19" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ; fhir:display [ fhir:v "Sydes MR" ] ] ; fhir:forenameInitials [ fhir:v "MR" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "Medical Research Council Clinical Trials Unit at University College London, London, UK." ] ] ) ] ) ] ] . #
IG © 2024+ HL7 International / Clinical Decision Support. Package hl7.fhir.uv.ebm#1.0.0-ballot2 based on FHIR 6.0.0-ballot2. Generated 2025-03-28
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