Evidence Based Medicine on FHIR Implementation Guide
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This page is part of the Evidence Based Medicine on FHIR Implementation Guide (v1.0.0-ballot2: STU1 Ballot 2) based on FHIR (HL7® FHIR® Standard) v6.0.0. No current official version has been published yet. For a full list of available versions, see the Directory of published versions

Example ArtifactAssessment: Certainty of Evidence Rating of 14-day mortality remdesivir vs placebo meta-analysis (ACTT-1, Wang et al, WHO SOLIDARITY)

Page standards status: Informative

Generated Narrative: ArtifactAssessment 179693

version: 7; Last updated: 2024-12-12 13:06:16+0000

Profile: CertaintyOfEvidence

Artifact URL: https://fevir.net/resources/ArtifactAssessment/179693

Artifact Description:

This example of a CertaintyOfEvidence Profile shows a recursive pattern of component elements with type/classifier paired values for different aspects of rating the certainty of evidence.

identifier: FEvIR Object Identifier/https://fevir.net/FOI/179693

title: Certainty of Evidence Rating of 14-day mortality remdesivir vs placebo meta-analysis (ACTT-1, Wang et al, WHO SOLIDARITY)

artifact: 14-day mortality remdesivir vs placebo meta-analysis (ACTT-1, Wang et al, WHO SOLIDARITY)

content

summary:

Low certainty due to inconsistency and risk of bias

type: Overall certainty

classifier: Low quality

component

type: Publication bias

classifier: no serious concern

component

summary:

There is a high degree of heterogeneity (I-squared = 73%). There is also inconsistency in findings between the fixed-effect and random-effects statistical models.

type: Inconsistency

classifier: serious concern

component

summary:

Although the random-effects analysis finds an estimate without statistical significance, this imprecision is explained by the inconsistency (heterogeneity) and thus not further downrated in certainty assessment.

type: Imprecision

classifier: no serious concern

component

type: Indirectness

classifier: no serious concern

component

type: Risk of bias

classifier: serious concern

Components

-SummaryTypeClassifier
*

No blinding (no placebo control) in the largest trial

Lack of blindingpresent