Evidence Based Medicine on FHIR Implementation Guide
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This page is part of the Evidence Based Medicine on FHIR Implementation Guide (v1.0.0-ballot: STU1 Ballot 1) based on FHIR (HL7® FHIR® Standard) v5.0.0. . For a full list of available versions, see the Directory of published versions

: 23604530 A phase II trial of androgen deprivation therapy (ADT) plus chemotherapy as initial treatment for local failures or advanced prostate cancer. - TTL Representation

Active as of 2023-12-17

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@prefix fhir: <http://hl7.org/fhir/> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

# - resource -------------------------------------------------------------------

 a fhir:Citation ;
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  fhir:id [ fhir:v "179629"] ; # 
  fhir:meta [
fhir:versionId [ fhir:v "1" ] ;
fhir:lastUpdated [ fhir:v "2023-11-26T22:35:28.730Z"^^xsd:dateTime ]
  ] ; # 
  fhir:text [
fhir:status [ fhir:v "extensions" ] ;
fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Citation</b><a name=\"179629\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Citation &quot;179629&quot; Version &quot;1&quot; Updated &quot;2023-11-26 22:35:28+0000&quot; </p></div><p><b>StructureDefinition Work Group</b>: cds</p><p><b>url</b>: <code>https://fevir.net/resources/Citation/179629</code></p><p><b>identifier</b>: FEvIR Object Identifier: 179629, id: 23604530</p><p><b>version</b>: 1.0.0-ballot</p><p><b>title</b>: 23604530 A phase II trial of androgen deprivation therapy (ADT) plus chemotherapy as initial treatment for local failures or advanced prostate cancer.</p><p><b>status</b>: active</p><p><b>date</b>: 2023-12-17 16:55:23+0000</p><p><b>publisher</b>: HL7 International / Clinical Decision Support</p><p><b>contact</b>: HL7 International / Clinical Decision Support: <a href=\"http://www.hl7.org/Special/committees/dss\">http://www.hl7.org/Special/committees/dss</a></p><p><b>description</b>: This Citation Resource is referenced in an example for the EBMonFHIR Implementation Guide.</p><h3>UseContexts</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td>FEvIR Platform Use (Details: http://hl7.org/fhir/citation-classification-type code fevir-platform-use = 'FEvIR Platform Use', stated as 'FEvIR Platform Use')</td><td>Medline Base <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-citation-artifact-classifier.html\">Citation Artifact Classifier</a>#medline-base)</span></td></tr></table><p><b>jurisdiction</b>: World <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (m49.htm#001)</span></p><p><b>copyright</b>: https://creativecommons.org/licenses/by-nc-sa/4.0/</p><p><b>approvalDate</b>: 2013-08-01</p><p><b>lastReviewDate</b>: 2021-11-22</p><p><b>author</b>: Computable Publishing®: MEDLINE-to-FEvIR Converter: </p><blockquote><p><b>classification</b></p><p><b>type</b>: Citation Source <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-citation-classification-type.html\">Citation Classification Type</a>#citation-source)</span></p><p><b>classifier</b>: MEDLINE <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: MEDLINE Citation Owner <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-citation-classification-type.html\">Citation Classification Type</a>#medline-owner)</span></p><p><b>classifier</b>: National Library of Medicine, Index Section <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (elements_descriptions.html#owner_value#NLM)</span></p></blockquote><p><b>currentState</b>: Medline Citation Status of Medline <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-citation-status-type.html\">Citation Status Type</a>#medline-medline)</span>, PubMed PublicationStatus of ppublish <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-citation-status-type.html\">Citation Status Type</a>#pubmed-publication-status-ppublish)</span></p><blockquote><p><b>statusDate</b></p><p><b>activity</b>: PubMed Pubstatus of Received <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-citation-status-type.html\">Citation Status Type</a>#pubmed-pubstatus-received)</span></p><p><b>period</b>: ?? --&gt; 2013-02-14</p></blockquote><blockquote><p><b>statusDate</b></p><p><b>activity</b>: PubMed Pubstatus of Accepted <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-citation-status-type.html\">Citation Status Type</a>#pubmed-pubstatus-accepted)</span></p><p><b>period</b>: ?? --&gt; 2013-04-08</p></blockquote><blockquote><p><b>statusDate</b></p><p><b>activity</b>: PubMed Pubstatus of Entrez <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-citation-status-type.html\">Citation Status Type</a>#pubmed-pubstatus-entrez)</span></p><p><b>period</b>: ?? --&gt; 2013-04-23 06:00:00+0000</p></blockquote><blockquote><p><b>statusDate</b></p><p><b>activity</b>: PubMed Pubstatus of Pubmed <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-citation-status-type.html\">Citation Status Type</a>#pubmed-pubstatus-pubmed)</span></p><p><b>period</b>: ?? --&gt; 2013-04-23 06:00:00+0000</p></blockquote><blockquote><p><b>statusDate</b></p><p><b>activity</b>: PubMed Pubstatus of Medline <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-citation-status-type.html\">Citation Status Type</a>#pubmed-pubstatus-medline)</span></p><p><b>period</b>: ?? --&gt; 2013-08-02 06:00:00+0000</p></blockquote><blockquote><p><b>citedArtifact</b></p><p><b>identifier</b>: id: 23604530, id: 10.1007/s00280-013-2163-4</p><h3>Titles</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Language</b></td><td><b>Text</b></td></tr><tr><td style=\"display: none\">*</td><td>Primary title <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-title-type.html\">Title Type</a>#primary)</span></td><td>English <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-v3-ietf3066.html\">Tags for the Identification of Languages</a>#en)</span></td><td>A phase II trial of androgen deprivation therapy (ADT) plus chemotherapy as initial treatment for local failures or advanced prostate cancer.</td></tr></table><h3>Abstracts</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Text</b></td></tr><tr><td style=\"display: none\">*</td><td>**PURPOSE:** Long-term hormonal ablation in prostate cancer is associated with decreased overall health and quality of life. Few reports emphasized the role of chemotherapy in the management of early stage prostate cancer. This study analyzed the safety and efficacy of androgen deprivation therapy (ADT) plus chemotherapy as initial treatment for patients identified as local failures or not eligible for prostatectomy or radiation therapy due to advanced disease presentation.\n**METHODS:** Enrolled patients received ADT in the form of leuprolide every 12 weeks for 24 months with bicalutamide initiating after the completion of chemotherapy. Chemotherapy consisted of ketoconazole and doxorubicin for weeks 1, 3, and 5 and estramustine and docetaxel and for weeks 2, 4 and 6. During weeks 7 and 8, no treatment was received.\n**RESULTS:** Forty-six patients were enrolled, and forty-five patients were evaluable. Median progression-free survival (PFS) was 23.4 months. Median overall survival (OS) was 53.7 months. Out of 45 patients with measurable disease, 22 patients had an objective response: 9 patients achieved a complete response; 2 patients achieved a partial response; 10 patients achieved stable disease. Frequent grade 3 adverse events included elevated ALT (17 %), hypokalemia (13 %), and hypophosphatemia (13 %). Grade 4 adverse events were rare and included low bicarbonate (2 %), hypokalemia (2 %), leukocytopenia (2 %), and neutropenia (2 %).\n**CONCLUSIONS:** The treatment demonstrated clinical benefit in all patient subsets with minimal reversible treatment-related adverse events. Subgroup analysis suggests that having prior local therapy resulted in greater PFS and OS.</td></tr></table><blockquote><p><b>publicationForm</b></p><h3>PublishedIns</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Identifier</b></td><td><b>Title</b></td><td><b>PublisherLocation</b></td></tr><tr><td style=\"display: none\">*</td><td>Periodical <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-published-in-type.html\">Published In Type</a>#D020492)</span></td><td>Electronic ISSN Type: 1432-0843, ISOAbbreviation: Cancer Chemother Pharmacol, ISSN Linking: 0344-5704, Medline Title Abbreviation: Cancer Chemother Pharmacol, NLM Unique ID: 7806519</td><td>Cancer chemotherapy and pharmacology</td><td>Germany</td></tr></table><p><b>citedMedium</b>: Internet <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-medium.html\">Cited Medium</a>#internet)</span></p><p><b>volume</b>: 71</p><p><b>issue</b>: 6</p><p><b>articleDate</b>: 2013-06</p><p><b>publicationDateText</b>: 2013-Jun</p><p><b>language</b>: English <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-v3-ietf3066.html\">Tags for the Identification of Languages</a>#en)</span></p><p><b>pageString</b>: 1629-34</p></blockquote><blockquote><p><b>publicationForm</b></p><p><b>citedMedium</b>: Internet without issue <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-medium.html\">Cited Medium</a>#internet-without-issue)</span></p><p><b>articleDate</b>: 2013-04-21</p></blockquote><blockquote><p><b>webLocation</b></p><p><b>classifier</b>: Abstract <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-artifact-url-classifier.html\">Artifact Url Classifier</a>#abstract)</span></p><p><b>url</b>: <a href=\"https://pubmed.ncbi.nlm.nih.gov/23604530/\">https://pubmed.ncbi.nlm.nih.gov/23604530/</a></p></blockquote><blockquote><p><b>webLocation</b></p><p><b>classifier</b>: DOI Based <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-artifact-url-classifier.html\">Artifact Url Classifier</a>#doi-based)</span></p><p><b>url</b>: <a href=\"https://doi.org/10.1007/s00280-013-2163-4\">https://doi.org/10.1007/s00280-013-2163-4</a></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: Publishing Model <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#publishing-model)</span></p><p><b>classifier</b>: Print Electronic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-citation-artifact-classifier.html\">Citation Artifact Classifier</a>#Print-Electronic)</span></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: Chemical <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#chemical)</span></p><p><b>classifier</b>: Androgen Antagonists <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D000726)</span>, Anilides <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D000813)</span>, Antineoplastic Agents, Hormonal <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D018931)</span>, Nitriles <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D009570)</span>, Tosyl Compounds <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D014105)</span>, bicalutamide <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (chemical-substances#A0Z3NAU9DP; #C053541)</span>, KLK3 protein, human <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (chemical-substances#EC 3.4.21.-; #C549870)</span>, Kallikreins <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (chemical-substances#EC 3.4.21.-; #D007610)</span>, Prostate-Specific Antigen <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (chemical-substances#EC 3.4.21.77; #D017430)</span>, Leuprolide <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (chemical-substances#EFY6W0M8TG; #D016729)</span></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: MeSH Heading <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#mesh-heading)</span></p><p><b>artifactAssessment</b>: <a name=\"meshHeading0\"> </a></p><blockquote><p/><p><a name=\"meshHeading0\"> </a></p><p><b>artifact</b>: <a href=\"#\">#</a></p><blockquote><p><b>content</b></p><p><b>informationType</b>: classifier</p><p><b>type</b>: components (if present) include qualifier codings <span style=\"background: LightGoldenRodYellow; 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margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: metabolism <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#Q000378)</span></p><blockquote><p><b>component</b></p></blockquote></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: pathology <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#Q000473)</span></p><blockquote><p><b>component</b></p></blockquote></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: classifier</p><p><b>type</b>: components (if present) include qualifier codings <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#mesh-heading &quot;MeSH heading&quot;)</span></p><p><b>classifier</b>: Aged <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D000368)</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td>qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td>is not a major topic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: classifier</p><p><b>type</b>: components (if present) include qualifier codings <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#mesh-heading &quot;MeSH heading&quot;)</span></p><p><b>classifier</b>: Aged, 80 and over <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D000369)</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td>qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td>is not a major topic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: classifier</p><p><b>type</b>: components (if present) include qualifier codings <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#mesh-heading &quot;MeSH heading&quot;)</span></p><p><b>classifier</b>: Androgen Antagonists <span style=\"background: LightGoldenRodYellow; 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margin: 4px; border: 1px solid khaki\"> (#Q000627)</span></p><blockquote><p><b>component</b></p></blockquote></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: classifier</p><p><b>type</b>: components (if present) include qualifier codings <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#mesh-heading &quot;MeSH heading&quot;)</span></p><p><b>classifier</b>: Anilides <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D000813)</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: is not a major topic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: administration &amp; dosage <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#Q000008)</span></p><blockquote><p><b>component</b></p></blockquote></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: therapeutic use <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#Q000627)</span></p><blockquote><p><b>component</b></p></blockquote></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: classifier</p><p><b>type</b>: components (if present) include qualifier codings <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#mesh-heading &quot;MeSH heading&quot;)</span></p><p><b>classifier</b>: Antineoplastic Agents, Hormonal <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D018931)</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: is not a major topic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: administration &amp; dosage <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#Q000008)</span></p><blockquote><p><b>component</b></p></blockquote></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: therapeutic use <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#Q000627)</span></p><blockquote><p><b>component</b></p></blockquote></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: classifier</p><p><b>type</b>: components (if present) include qualifier codings <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#mesh-heading &quot;MeSH heading&quot;)</span></p><p><b>classifier</b>: Antineoplastic Combined Chemotherapy Protocols <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D000971)</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: is not a major topic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: administration &amp; dosage <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#Q000008)</span></p><blockquote><p><b>component</b></p></blockquote></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: therapeutic use <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#Q000627)</span></p><blockquote><p><b>component</b></p></blockquote></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: classifier</p><p><b>type</b>: components (if present) include qualifier codings <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#mesh-heading &quot;MeSH heading&quot;)</span></p><p><b>classifier</b>: Disease-Free Survival <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D018572)</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td>qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td>is not a major topic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: classifier</p><p><b>type</b>: components (if present) include qualifier codings <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#mesh-heading &quot;MeSH heading&quot;)</span></p><p><b>classifier</b>: Humans <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D006801)</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td>qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td>is not a major topic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: classifier</p><p><b>type</b>: components (if present) include qualifier codings <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#mesh-heading &quot;MeSH heading&quot;)</span></p><p><b>classifier</b>: Kallikreins <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D007610)</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: is not a major topic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: blood <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#Q000097)</span></p><blockquote><p><b>component</b></p></blockquote></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: classifier</p><p><b>type</b>: components (if present) include qualifier codings <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#mesh-heading &quot;MeSH heading&quot;)</span></p><p><b>classifier</b>: Leuprolide <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D016729)</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: is not a major topic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: administration &amp; dosage <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#Q000008)</span></p><blockquote><p><b>component</b></p></blockquote></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: therapeutic use <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#Q000627)</span></p><blockquote><p><b>component</b></p></blockquote></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: classifier</p><p><b>type</b>: components (if present) include qualifier codings <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#mesh-heading &quot;MeSH heading&quot;)</span></p><p><b>classifier</b>: Male <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D008297)</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td>qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td>is not a major topic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: classifier</p><p><b>type</b>: components (if present) include qualifier codings <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#mesh-heading &quot;MeSH heading&quot;)</span></p><p><b>classifier</b>: Middle Aged <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D008875)</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td>qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td>is not a major topic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: classifier</p><p><b>type</b>: components (if present) include qualifier codings <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#mesh-heading &quot;MeSH heading&quot;)</span></p><p><b>classifier</b>: Neoplasm Grading <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D060787)</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td>qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td>is not a major topic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: classifier</p><p><b>type</b>: components (if present) include qualifier codings <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#mesh-heading &quot;MeSH heading&quot;)</span></p><p><b>classifier</b>: Nitriles <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D009570)</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: is not a major topic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: administration &amp; dosage <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#Q000008)</span></p><blockquote><p><b>component</b></p></blockquote></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: therapeutic use <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#Q000627)</span></p><blockquote><p><b>component</b></p></blockquote></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: classifier</p><p><b>type</b>: components (if present) include qualifier codings <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#mesh-heading &quot;MeSH heading&quot;)</span></p><p><b>classifier</b>: Prostate-Specific Antigen <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D017430)</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: is not a major topic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: blood <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#Q000097)</span></p><blockquote><p><b>component</b></p></blockquote></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: classifier</p><p><b>type</b>: components (if present) include qualifier codings <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#mesh-heading &quot;MeSH heading&quot;)</span></p><p><b>classifier</b>: Prostatectomy <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D011468)</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td>qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td>is not a major topic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: classifier</p><p><b>type</b>: components (if present) include qualifier codings <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#mesh-heading &quot;MeSH heading&quot;)</span></p><p><b>classifier</b>: Prostatic Neoplasms <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D011471)</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: is not a major topic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: drug therapy <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#Q000188)</span></p><blockquote><p><b>component</b></p></blockquote></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: metabolism <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#Q000378)</span></p><blockquote><p><b>component</b></p></blockquote></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: pathology <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#Q000473)</span></p><blockquote><p><b>component</b></p></blockquote></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: classifier</p><p><b>type</b>: components (if present) include qualifier codings <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#mesh-heading &quot;MeSH heading&quot;)</span></p><p><b>classifier</b>: Radiotherapy <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D011878)</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td>qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td>is not a major topic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: classifier</p><p><b>type</b>: components (if present) include qualifier codings <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#mesh-heading &quot;MeSH heading&quot;)</span></p><p><b>classifier</b>: Tosyl Compounds <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D014105)</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: is not a major topic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: administration &amp; dosage <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#Q000008)</span></p><blockquote><p><b>component</b></p></blockquote></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: therapeutic use <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#Q000627)</span></p><blockquote><p><b>component</b></p></blockquote></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: classifier</p><p><b>type</b>: components (if present) include qualifier codings <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#mesh-heading &quot;MeSH heading&quot;)</span></p><p><b>classifier</b>: Treatment Failure <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D017211)</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td>qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td>is not a major topic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td></tr></table></blockquote></blockquote></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: Publication Type <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#publication-type)</span></p><p><b>classifier</b>: Clinical Trial, Phase II <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D017427)</span>, Journal Article <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D016428)</span></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: Knowledge Artifact Type <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#knowledge-artifact-type)</span></p><p><b>classifier</b>: Journal Article <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-citation-artifact-classifier.html\">Citation Artifact Classifier</a>#D016428)</span></p><p><b>artifactAssessment</b>: <span>: Classifier added by Computable Publishing LLC</span></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: Citation Subset <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#citation-subset)</span></p><p><b>classifier</b>: IM <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (elements_descriptions.html#citationsubset#IM)</span></p></blockquote><blockquote><p><b>contributorship</b></p><p><b>complete</b>: true</p><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a name=\"author0\"> </a></p><blockquote><p/><p><a name=\"author0\"> </a></p><p><b>name</b>: Robert Amato </p></blockquote><p><b>forenameInitials</b>: R</p><p><b>affiliation</b>: <span>: Division of Oncology, Department of Internal Medicine, University of Texas Health Science Center at Houston (Medical School)/Memorial Hermann Cancer Center, 6410 Fannin St., Suite 830, Houston, TX 77030, USA. robert.amato@uth.tmc.edu</span></p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a name=\"author1\"> </a></p><blockquote><p/><p><a name=\"author1\"> </a></p><p><b>name</b>: Mika Stepankiw </p></blockquote><p><b>forenameInitials</b>: M</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a name=\"author2\"> </a></p><blockquote><p/><p><a name=\"author2\"> </a></p><p><b>name</b>: Patricia Gonzales </p></blockquote><p><b>forenameInitials</b>: P</p></blockquote></blockquote></blockquote><hr/><blockquote><p><b>Generated Narrative: Practitioner #author0</b><a name=\"author0\"> </a></p><p><b>name</b>: Robert Amato </p></blockquote><hr/><blockquote><p><b>Generated Narrative: Practitioner #author1</b><a name=\"author1\"> </a></p><p><b>name</b>: Mika Stepankiw </p></blockquote><hr/><blockquote><p><b>Generated Narrative: Practitioner #author2</b><a name=\"author2\"> </a></p><p><b>name</b>: Patricia Gonzales </p></blockquote><hr/><blockquote><p><b>Generated Narrative: ArtifactAssessment #meshHeading0</b><a name=\"meshHeading0\"> </a></p><p><b>artifact</b>: <a href=\"#\">#</a></p><blockquote><p><b>content</b></p><p><b>informationType</b>: classifier</p><p><b>type</b>: components (if present) include qualifier codings <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#mesh-heading &quot;MeSH heading&quot;)</span></p><p><b>classifier</b>: Adenocarcinoma <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D000230)</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: is not a major topic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: drug therapy <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#Q000188)</span></p><blockquote><p><b>component</b></p></blockquote></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: metabolism <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#Q000378)</span></p><blockquote><p><b>component</b></p></blockquote></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: pathology <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#Q000473)</span></p><blockquote><p><b>component</b></p></blockquote></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: classifier</p><p><b>type</b>: components (if present) include qualifier codings <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#mesh-heading &quot;MeSH heading&quot;)</span></p><p><b>classifier</b>: Aged <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D000368)</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td>qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td>is not a major topic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: classifier</p><p><b>type</b>: components (if present) include qualifier codings <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#mesh-heading &quot;MeSH heading&quot;)</span></p><p><b>classifier</b>: Aged, 80 and over <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D000369)</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td>qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td>is not a major topic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: classifier</p><p><b>type</b>: components (if present) include qualifier codings <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#mesh-heading &quot;MeSH heading&quot;)</span></p><p><b>classifier</b>: Androgen Antagonists <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D000726)</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: is not a major topic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: administration &amp; dosage <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#Q000008)</span></p><blockquote><p><b>component</b></p></blockquote></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: therapeutic use <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#Q000627)</span></p><blockquote><p><b>component</b></p></blockquote></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: classifier</p><p><b>type</b>: components (if present) include qualifier codings <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#mesh-heading &quot;MeSH heading&quot;)</span></p><p><b>classifier</b>: Anilides <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D000813)</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: is not a major topic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: administration &amp; dosage <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#Q000008)</span></p><blockquote><p><b>component</b></p></blockquote></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: therapeutic use <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#Q000627)</span></p><blockquote><p><b>component</b></p></blockquote></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: classifier</p><p><b>type</b>: components (if present) include qualifier codings <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#mesh-heading &quot;MeSH heading&quot;)</span></p><p><b>classifier</b>: Antineoplastic Agents, Hormonal <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D018931)</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: is not a major topic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: administration &amp; dosage <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#Q000008)</span></p><blockquote><p><b>component</b></p></blockquote></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: therapeutic use <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#Q000627)</span></p><blockquote><p><b>component</b></p></blockquote></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: classifier</p><p><b>type</b>: components (if present) include qualifier codings <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#mesh-heading &quot;MeSH heading&quot;)</span></p><p><b>classifier</b>: Antineoplastic Combined Chemotherapy Protocols <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D000971)</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: is not a major topic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: administration &amp; dosage <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#Q000008)</span></p><blockquote><p><b>component</b></p></blockquote></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: therapeutic use <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#Q000627)</span></p><blockquote><p><b>component</b></p></blockquote></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: classifier</p><p><b>type</b>: components (if present) include qualifier codings <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#mesh-heading &quot;MeSH heading&quot;)</span></p><p><b>classifier</b>: Disease-Free Survival <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D018572)</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td>qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td>is not a major topic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: classifier</p><p><b>type</b>: components (if present) include qualifier codings <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#mesh-heading &quot;MeSH heading&quot;)</span></p><p><b>classifier</b>: Humans <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D006801)</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td>qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td>is not a major topic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: classifier</p><p><b>type</b>: components (if present) include qualifier codings <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#mesh-heading &quot;MeSH heading&quot;)</span></p><p><b>classifier</b>: Kallikreins <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D007610)</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: is not a major topic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: blood <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#Q000097)</span></p><blockquote><p><b>component</b></p></blockquote></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: classifier</p><p><b>type</b>: components (if present) include qualifier codings <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#mesh-heading &quot;MeSH heading&quot;)</span></p><p><b>classifier</b>: Leuprolide <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D016729)</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: is not a major topic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: administration &amp; dosage <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#Q000008)</span></p><blockquote><p><b>component</b></p></blockquote></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: therapeutic use <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#Q000627)</span></p><blockquote><p><b>component</b></p></blockquote></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: classifier</p><p><b>type</b>: components (if present) include qualifier codings <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#mesh-heading &quot;MeSH heading&quot;)</span></p><p><b>classifier</b>: Male <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D008297)</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td>qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td>is not a major topic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: classifier</p><p><b>type</b>: components (if present) include qualifier codings <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#mesh-heading &quot;MeSH heading&quot;)</span></p><p><b>classifier</b>: Middle Aged <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D008875)</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td>qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td>is not a major topic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: classifier</p><p><b>type</b>: components (if present) include qualifier codings <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#mesh-heading &quot;MeSH heading&quot;)</span></p><p><b>classifier</b>: Neoplasm Grading <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D060787)</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td>qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td>is not a major topic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: classifier</p><p><b>type</b>: components (if present) include qualifier codings <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#mesh-heading &quot;MeSH heading&quot;)</span></p><p><b>classifier</b>: Nitriles <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D009570)</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: is not a major topic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: administration &amp; dosage <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#Q000008)</span></p><blockquote><p><b>component</b></p></blockquote></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: therapeutic use <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#Q000627)</span></p><blockquote><p><b>component</b></p></blockquote></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: classifier</p><p><b>type</b>: components (if present) include qualifier codings <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#mesh-heading &quot;MeSH heading&quot;)</span></p><p><b>classifier</b>: Prostate-Specific Antigen <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D017430)</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: is not a major topic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: blood <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#Q000097)</span></p><blockquote><p><b>component</b></p></blockquote></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: classifier</p><p><b>type</b>: components (if present) include qualifier codings <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#mesh-heading &quot;MeSH heading&quot;)</span></p><p><b>classifier</b>: Prostatectomy <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D011468)</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td>qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td>is not a major topic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: classifier</p><p><b>type</b>: components (if present) include qualifier codings <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#mesh-heading &quot;MeSH heading&quot;)</span></p><p><b>classifier</b>: Prostatic Neoplasms <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D011471)</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: is not a major topic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: drug therapy <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#Q000188)</span></p><blockquote><p><b>component</b></p></blockquote></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: metabolism <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#Q000378)</span></p><blockquote><p><b>component</b></p></blockquote></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: pathology <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#Q000473)</span></p><blockquote><p><b>component</b></p></blockquote></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: classifier</p><p><b>type</b>: components (if present) include qualifier codings <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#mesh-heading &quot;MeSH heading&quot;)</span></p><p><b>classifier</b>: Radiotherapy <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D011878)</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td>qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td>is not a major topic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: classifier</p><p><b>type</b>: components (if present) include qualifier codings <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#mesh-heading &quot;MeSH heading&quot;)</span></p><p><b>classifier</b>: Tosyl Compounds <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D014105)</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: is not a major topic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: administration &amp; dosage <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#Q000008)</span></p><blockquote><p><b>component</b></p></blockquote></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: therapeutic use <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#Q000627)</span></p><blockquote><p><b>component</b></p></blockquote></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: classifier</p><p><b>type</b>: components (if present) include qualifier codings <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#mesh-heading &quot;MeSH heading&quot;)</span></p><p><b>classifier</b>: Treatment Failure <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D017211)</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td>qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td>is not a major topic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td></tr></table></blockquote></blockquote></div>"
  ] ; # 
  fhir:contained ( [
a fhir:Practitioner ;
fhir:id [ fhir:v "author0" ] ;
    ( fhir:name [
fhir:family [ fhir:v "Amato" ] ;
      ( fhir:given [ fhir:v "Robert" ] )     ] )
  ] [
a fhir:Practitioner ;
fhir:id [ fhir:v "author1" ] ;
    ( fhir:name [
fhir:family [ fhir:v "Stepankiw" ] ;
      ( fhir:given [ fhir:v "Mika" ] )     ] )
  ] [
a fhir:Practitioner ;
fhir:id [ fhir:v "author2" ] ;
    ( fhir:name [
fhir:family [ fhir:v "Gonzales" ] ;
      ( fhir:given [ fhir:v "Patricia" ] )     ] )
  ] [
a fhir:ArtifactAssessment ;
fhir:id [ fhir:v "meshHeading0" ] ;
fhir:artifact [
a fhir:Reference ;
fhir:reference [ fhir:v "#" ] ;
fhir:type [ fhir:v "Citation"^^xsd:anyURI ]     ] ;
    ( fhir:content [
fhir:informationType [ fhir:v "classifier" ] ;
fhir:type [
        ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ;
fhir:code [ fhir:v "mesh-heading" ] ;
fhir:display [ fhir:v "MeSH heading" ]         ] ) ;
fhir:text [ fhir:v "components (if present) include qualifier codings" ]       ] ;
      ( fhir:classifier [
        ( fhir:coding [
fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ;
fhir:code [ fhir:v "D000230" ] ;
fhir:display [ fhir:v "Adenocarcinoma" ] ;
fhir:userSelected [ fhir:v "false"^^xsd:boolean ]         ] )       ] ) ;
fhir:freeToShare [ fhir:v "true"^^xsd:boolean ] ;
      ( fhir:component [
fhir:type [
fhir:text [ fhir:v "qualifier" ]         ] ;
        ( fhir:classifier [
fhir:text [ fhir:v "is not a major topic" ]         ] )       ] [
fhir:type [
fhir:text [ fhir:v "qualifier" ]         ] ;
        ( fhir:classifier [
          ( fhir:coding [
fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ;
fhir:code [ fhir:v "Q000188" ] ;
fhir:display [ fhir:v "drug therapy" ]           ] )         ] ) ;
        ( fhir:component [
fhir:type [
fhir:text [ fhir:v "is Major topic" ]           ] ;
          ( fhir:classifier [
            ( fhir:coding [
fhir:system [ fhir:v "https://ncithesaurus.nci.nih.gov/ncitbrowser"^^xsd:anyURI ] ;
fhir:code [ fhir:v "C49488" ] ;
fhir:display [ fhir:v "Yes" ]             ] )           ] )         ] )       ] [
fhir:type [
fhir:text [ fhir:v "qualifier" ]         ] ;
        ( fhir:classifier [
          ( fhir:coding [
fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ;
fhir:code [ fhir:v "Q000378" ] ;
fhir:display [ fhir:v "metabolism" ]           ] )         ] ) ;
        ( fhir:component [
fhir:type [
fhir:text [ fhir:v "is Major topic" ]           ] ;
          ( fhir:classifier [
            ( fhir:coding [
fhir:system [ fhir:v "https://ncithesaurus.nci.nih.gov/ncitbrowser"^^xsd:anyURI ] ;
fhir:code [ fhir:v "C49487" ] ;
fhir:display [ fhir:v "No" ]             ] )           ] )         ] )       ] [
fhir:type [
fhir:text [ fhir:v "qualifier" ]         ] ;
        ( fhir:classifier [
          ( fhir:coding [
fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ;
fhir:code [ fhir:v "Q000473" ] ;
fhir:display [ fhir:v "pathology" ]           ] )         ] ) ;
        ( fhir:component [
fhir:type [
fhir:text [ fhir:v "is Major topic" ]           ] ;
          ( fhir:classifier [
            ( fhir:coding [
fhir:system [ fhir:v "https://ncithesaurus.nci.nih.gov/ncitbrowser"^^xsd:anyURI ] ;
fhir:code [ fhir:v "C49487" ] ;
fhir:display [ fhir:v "No" ]             ] )           ] )         ] )       ] )     ] [
fhir:informationType [ fhir:v "classifier" ] ;
fhir:type [
        ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ;
fhir:code [ fhir:v "mesh-heading" ] ;
fhir:display [ fhir:v "MeSH heading" ]         ] ) ;
fhir:text [ fhir:v "components (if present) include qualifier codings" ]       ] ;
      ( fhir:classifier [
        ( fhir:coding [
fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ;
fhir:code [ fhir:v "D000368" ] ;
fhir:display [ fhir:v "Aged" ] ;
fhir:userSelected [ fhir:v "false"^^xsd:boolean ]         ] )       ] ) ;
fhir:freeToShare [ fhir:v "true"^^xsd:boolean ] ;
      ( fhir:component [
fhir:type [
fhir:text [ fhir:v "qualifier" ]         ] ;
        ( fhir:classifier [
fhir:text [ fhir:v "is not a major topic" ]         ] )       ] )     ] [
fhir:informationType [ fhir:v "classifier" ] ;
fhir:type [
        ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ;
fhir:code [ fhir:v "mesh-heading" ] ;
fhir:display [ fhir:v "MeSH heading" ]         ] ) ;
fhir:text [ fhir:v "components (if present) include qualifier codings" ]       ] ;
      ( fhir:classifier [
        ( fhir:coding [
fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ;
fhir:code [ fhir:v "D000369" ] ;
fhir:display [ fhir:v "Aged, 80 and over" ] ;
fhir:userSelected [ fhir:v "false"^^xsd:boolean ]         ] )       ] ) ;
fhir:freeToShare [ fhir:v "true"^^xsd:boolean ] ;
      ( fhir:component [
fhir:type [
fhir:text [ fhir:v "qualifier" ]         ] ;
        ( fhir:classifier [
fhir:text [ fhir:v "is not a major topic" ]         ] )       ] )     ] [
fhir:informationType [ fhir:v "classifier" ] ;
fhir:type [
        ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ;
fhir:code [ fhir:v "mesh-heading" ] ;
fhir:display [ fhir:v "MeSH heading" ]         ] ) ;
fhir:text [ fhir:v "components (if present) include qualifier codings" ]       ] ;
      ( fhir:classifier [
        ( fhir:coding [
fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ;
fhir:code [ fhir:v "D000726" ] ;
fhir:display [ fhir:v "Androgen Antagonists" ] ;
fhir:userSelected [ fhir:v "false"^^xsd:boolean ]         ] )       ] ) ;
fhir:freeToShare [ fhir:v "true"^^xsd:boolean ] ;
      ( fhir:component [
fhir:type [
fhir:text [ fhir:v "qualifier" ]         ] ;
        ( fhir:classifier [
fhir:text [ fhir:v "is not a major topic" ]         ] )       ] [
fhir:type [
fhir:text [ fhir:v "qualifier" ]         ] ;
        ( fhir:classifier [
          ( fhir:coding [
fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ;
fhir:code [ fhir:v "Q000008" ] ;
fhir:display [ fhir:v "administration & dosage" ]           ] )         ] ) ;
        ( fhir:component [
fhir:type [
fhir:text [ fhir:v "is Major topic" ]           ] ;
          ( fhir:classifier [
            ( fhir:coding [
fhir:system [ fhir:v "https://ncithesaurus.nci.nih.gov/ncitbrowser"^^xsd:anyURI ] ;
fhir:code [ fhir:v "C49487" ] ;
fhir:display [ fhir:v "No" ]             ] )           ] )         ] )       ] [
fhir:type [
fhir:text [ fhir:v "qualifier" ]         ] ;
        ( fhir:classifier [
          ( fhir:coding [
fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ;
fhir:code [ fhir:v "Q000627" ] ;
fhir:display [ fhir:v "therapeutic use" ]           ] )         ] ) ;
        ( fhir:component [
fhir:type [
fhir:text [ fhir:v "is Major topic" ]           ] ;
          ( fhir:classifier [
            ( fhir:coding [
fhir:system [ fhir:v "https://ncithesaurus.nci.nih.gov/ncitbrowser"^^xsd:anyURI ] ;
fhir:code [ fhir:v "C49488" ] ;
fhir:display [ fhir:v "Yes" ]             ] )           ] )         ] )       ] )     ] [
fhir:informationType [ fhir:v "classifier" ] ;
fhir:type [
        ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ;
fhir:code [ fhir:v "mesh-heading" ] ;
fhir:display [ fhir:v "MeSH heading" ]         ] ) ;
fhir:text [ fhir:v "components (if present) include qualifier codings" ]       ] ;
      ( fhir:classifier [
        ( fhir:coding [
fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ;
fhir:code [ fhir:v "D000813" ] ;
fhir:display [ fhir:v "Anilides" ] ;
fhir:userSelected [ fhir:v "false"^^xsd:boolean ]         ] )       ] ) ;
fhir:freeToShare [ fhir:v "true"^^xsd:boolean ] ;
      ( fhir:component [
fhir:type [
fhir:text [ fhir:v "qualifier" ]         ] ;
        ( fhir:classifier [
fhir:text [ fhir:v "is not a major topic" ]         ] )       ] [
fhir:type [
fhir:text [ fhir:v "qualifier" ]         ] ;
        ( fhir:classifier [
          ( fhir:coding [
fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ;
fhir:code [ fhir:v "Q000008" ] ;
fhir:display [ fhir:v "administration & dosage" ]           ] )         ] ) ;
        ( fhir:component [
fhir:type [
fhir:text [ fhir:v "is Major topic" ]           ] ;
          ( fhir:classifier [
            ( fhir:coding [
fhir:system [ fhir:v "https://ncithesaurus.nci.nih.gov/ncitbrowser"^^xsd:anyURI ] ;
fhir:code [ fhir:v "C49487" ] ;
fhir:display [ fhir:v "No" ]             ] )           ] )         ] )       ] [
fhir:type [
fhir:text [ fhir:v "qualifier" ]         ] ;
        ( fhir:classifier [
          ( fhir:coding [
fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ;
fhir:code [ fhir:v "Q000627" ] ;
fhir:display [ fhir:v "therapeutic use" ]           ] )         ] ) ;
        ( fhir:component [
fhir:type [
fhir:text [ fhir:v "is Major topic" ]           ] ;
          ( fhir:classifier [
            ( fhir:coding [
fhir:system [ fhir:v "https://ncithesaurus.nci.nih.gov/ncitbrowser"^^xsd:anyURI ] ;
fhir:code [ fhir:v "C49487" ] ;
fhir:display [ fhir:v "No" ]             ] )           ] )         ] )       ] )     ] [
fhir:informationType [ fhir:v "classifier" ] ;
fhir:type [
        ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ;
fhir:code [ fhir:v "mesh-heading" ] ;
fhir:display [ fhir:v "MeSH heading" ]         ] ) ;
fhir:text [ fhir:v "components (if present) include qualifier codings" ]       ] ;
      ( fhir:classifier [
        ( fhir:coding [
fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ;
fhir:code [ fhir:v "D018931" ] ;
fhir:display [ fhir:v "Antineoplastic Agents, Hormonal" ] ;
fhir:userSelected [ fhir:v "false"^^xsd:boolean ]         ] )       ] ) ;
fhir:freeToShare [ fhir:v "true"^^xsd:boolean ] ;
      ( fhir:component [
fhir:type [
fhir:text [ fhir:v "qualifier" ]         ] ;
        ( fhir:classifier [
fhir:text [ fhir:v "is not a major topic" ]         ] )       ] [
fhir:type [
fhir:text [ fhir:v "qualifier" ]         ] ;
        ( fhir:classifier [
          ( fhir:coding [
fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ;
fhir:code [ fhir:v "Q000008" ] ;
fhir:display [ fhir:v "administration & dosage" ]           ] )         ] ) ;
        ( fhir:component [
fhir:type [
fhir:text [ fhir:v "is Major topic" ]           ] ;
          ( fhir:classifier [
            ( fhir:coding [
fhir:system [ fhir:v "https://ncithesaurus.nci.nih.gov/ncitbrowser"^^xsd:anyURI ] ;
fhir:code [ fhir:v "C49487" ] ;
fhir:display [ fhir:v "No" ]             ] )           ] )         ] )       ] [
fhir:type [
fhir:text [ fhir:v "qualifier" ]         ] ;
        ( fhir:classifier [
          ( fhir:coding [
fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ;
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fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ;
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fhir:display [ fhir:v "MeSH heading" ]         ] ) ;
fhir:text [ fhir:v "components (if present) include qualifier codings" ]       ] ;
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fhir:freeToShare [ fhir:v "true"^^xsd:boolean ] ;
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fhir:type [
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fhir:text [ fhir:v "qualifier" ]         ] ;
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fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ;
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fhir:type [
fhir:text [ fhir:v "is Major topic" ]           ] ;
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fhir:system [ fhir:v "https://ncithesaurus.nci.nih.gov/ncitbrowser"^^xsd:anyURI ] ;
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fhir:text [ fhir:v "qualifier" ]         ] ;
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fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ;
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fhir:display [ fhir:v "therapeutic use" ]           ] )         ] ) ;
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fhir:system [ fhir:v "https://ncithesaurus.nci.nih.gov/ncitbrowser"^^xsd:anyURI ] ;
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fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ;
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fhir:display [ fhir:v "MeSH heading" ]         ] ) ;
fhir:text [ fhir:v "components (if present) include qualifier codings" ]       ] ;
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fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ;
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fhir:freeToShare [ fhir:v "true"^^xsd:boolean ] ;
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fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ;
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fhir:text [ fhir:v "components (if present) include qualifier codings" ]       ] ;
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fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ;
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fhir:freeToShare [ fhir:v "true"^^xsd:boolean ] ;
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fhir:type [
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fhir:type [
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fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ;
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fhir:display [ fhir:v "MeSH heading" ]         ] ) ;
fhir:text [ fhir:v "components (if present) include qualifier codings" ]       ] ;
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fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ;
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fhir:freeToShare [ fhir:v "true"^^xsd:boolean ] ;
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fhir:type [
fhir:text [ fhir:v "qualifier" ]         ] ;
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fhir:text [ fhir:v "qualifier" ]         ] ;
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fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ;
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fhir:type [
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fhir:system [ fhir:v "https://ncithesaurus.nci.nih.gov/ncitbrowser"^^xsd:anyURI ] ;
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fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ;
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fhir:text [ fhir:v "components (if present) include qualifier codings" ]       ] ;
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fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ;
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fhir:freeToShare [ fhir:v "true"^^xsd:boolean ] ;
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fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ;
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fhir:text [ fhir:v "is Major topic" ]           ] ;
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fhir:system [ fhir:v "https://ncithesaurus.nci.nih.gov/ncitbrowser"^^xsd:anyURI ] ;
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fhir:text [ fhir:v "qualifier" ]         ] ;
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fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ;
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fhir:display [ fhir:v "therapeutic use" ]           ] )         ] ) ;
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fhir:text [ fhir:v "is Major topic" ]           ] ;
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fhir:system [ fhir:v "https://ncithesaurus.nci.nih.gov/ncitbrowser"^^xsd:anyURI ] ;
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fhir:type [
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fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ;
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fhir:text [ fhir:v "components (if present) include qualifier codings" ]       ] ;
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fhir:freeToShare [ fhir:v "true"^^xsd:boolean ] ;
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fhir:type [
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fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ;
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fhir:text [ fhir:v "components (if present) include qualifier codings" ]       ] ;
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fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ;
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fhir:freeToShare [ fhir:v "true"^^xsd:boolean ] ;
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fhir:type [
fhir:text [ fhir:v "qualifier" ]         ] ;
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fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ;
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fhir:display [ fhir:v "MeSH heading" ]         ] ) ;
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fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ;
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fhir:freeToShare [ fhir:v "true"^^xsd:boolean ] ;
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fhir:text [ fhir:v "components (if present) include qualifier codings" ]       ] ;
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fhir:freeToShare [ fhir:v "true"^^xsd:boolean ] ;
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          ( fhir:coding [
fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ;
fhir:code [ fhir:v "Q000627" ] ;
fhir:display [ fhir:v "therapeutic use" ]           ] )         ] ) ;
        ( fhir:component [
fhir:type [
fhir:text [ fhir:v "is Major topic" ]           ] ;
          ( fhir:classifier [
            ( fhir:coding [
fhir:system [ fhir:v "https://ncithesaurus.nci.nih.gov/ncitbrowser"^^xsd:anyURI ] ;
fhir:code [ fhir:v "C49487" ] ;
fhir:display [ fhir:v "No" ]             ] )           ] )         ] )       ] )     ] [
fhir:informationType [ fhir:v "classifier" ] ;
fhir:type [
        ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ;
fhir:code [ fhir:v "mesh-heading" ] ;
fhir:display [ fhir:v "MeSH heading" ]         ] ) ;
fhir:text [ fhir:v "components (if present) include qualifier codings" ]       ] ;
      ( fhir:classifier [
        ( fhir:coding [
fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ;
fhir:code [ fhir:v "D017211" ] ;
fhir:display [ fhir:v "Treatment Failure" ] ;
fhir:userSelected [ fhir:v "false"^^xsd:boolean ]         ] )       ] ) ;
fhir:freeToShare [ fhir:v "true"^^xsd:boolean ] ;
      ( fhir:component [
fhir:type [
fhir:text [ fhir:v "qualifier" ]         ] ;
        ( fhir:classifier [
fhir:text [ fhir:v "is not a major topic" ]         ] )       ] )     ] )
  ] ) ; # 
  fhir:extension ( [
fhir:url [ fhir:v "http://hl7.org/fhir/StructureDefinition/structuredefinition-wg"^^xsd:anyURI ] ;
fhir:value [ fhir:v "cds" ]
  ] ) ; # 
  fhir:url [ fhir:v "https://fevir.net/resources/Citation/179629"^^xsd:anyURI] ; # 
  fhir:identifier ( [
fhir:type [
      ( fhir:coding [
fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v2-0203"^^xsd:anyURI ] ;
fhir:code [ fhir:v "ACSN" ] ;
fhir:display [ fhir:v "Accession ID" ]       ] ) ;
fhir:text [ fhir:v "FEvIR Object Identifier" ]     ] ;
fhir:system [ fhir:v "https://fevir.net"^^xsd:anyURI ] ;
fhir:value [ fhir:v "179629" ] ;
fhir:assigner [
fhir:display [ fhir:v "Computable Publishing LLC" ]     ]
  ] [
fhir:system [ fhir:v "https://pubmed.ncbi.nlm.nih.gov"^^xsd:anyURI ] ;
fhir:value [ fhir:v "23604530" ]
  ] ) ; # 
  fhir:version [ fhir:v "1.0.0-ballot"] ; # 
  fhir:title [ fhir:v "23604530 A phase II trial of androgen deprivation therapy (ADT) plus chemotherapy as initial treatment for local failures or advanced prostate cancer."] ; # 
  fhir:status [ fhir:v "active"] ; # 
  fhir:date [ fhir:v "2023-12-17T16:55:23+00:00"^^xsd:dateTime] ; # 
  fhir:publisher [ fhir:v "HL7 International / Clinical Decision Support"] ; # 
  fhir:contact ( [
fhir:name [ fhir:v "HL7 International / Clinical Decision Support" ] ;
    ( fhir:telecom [
fhir:system [ fhir:v "url" ] ;
fhir:value [ fhir:v "http://www.hl7.org/Special/committees/dss" ]     ] )
  ] ) ; # 
  fhir:description [ fhir:v "This Citation Resource is referenced in an example for the EBMonFHIR Implementation Guide."] ; # 
  fhir:useContext ( [
fhir:code [
fhir:system [ fhir:v "http://hl7.org/fhir/citation-classification-type"^^xsd:anyURI ] ;
fhir:code [ fhir:v "fevir-platform-use" ] ;
fhir:display [ fhir:v "FEvIR Platform Use" ]     ] ;
fhir:value [
a fhir:CodeableConcept ;
      ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/citation-artifact-classifier"^^xsd:anyURI ] ;
fhir:code [ fhir:v "medline-base" ] ;
fhir:display [ fhir:v "Medline Base" ] ;
fhir:userSelected [ fhir:v "false"^^xsd:boolean ]       ] )     ]
  ] ) ; # 
  fhir:jurisdiction ( [
    ( fhir:coding [
fhir:system [ fhir:v "http://unstats.un.org/unsd/methods/m49/m49.htm"^^xsd:anyURI ] ;
fhir:code [ fhir:v "001" ] ;
fhir:display [ fhir:v "World" ]     ] )
  ] ) ; # 
  fhir:copyright [ fhir:v "https://creativecommons.org/licenses/by-nc-sa/4.0/"] ; # 
  fhir:approvalDate [ fhir:v "2013-08-01"^^xsd:date] ; # 
  fhir:lastReviewDate [ fhir:v "2021-11-22"^^xsd:date] ; # 
  fhir:author ( [
fhir:name [ fhir:v "Computable Publishing®: MEDLINE-to-FEvIR Converter" ]
  ] ) ; # 
  fhir:classification ( [
fhir:type [
      ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/citation-classification-type"^^xsd:anyURI ] ;
fhir:code [ fhir:v "citation-source" ] ;
fhir:display [ fhir:v "Citation Source" ]       ] )     ] ;
    ( fhir:classifier [
fhir:text [ fhir:v "MEDLINE" ]     ] )
  ] [
fhir:type [
      ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/citation-classification-type"^^xsd:anyURI ] ;
fhir:code [ fhir:v "medline-owner" ] ;
fhir:display [ fhir:v "MEDLINE Citation Owner" ]       ] )     ] ;
    ( fhir:classifier [
      ( fhir:coding [
fhir:system [ fhir:v "https://www.nlm.nih.gov/bsd/licensee/elements_descriptions.html#owner_value"^^xsd:anyURI ] ;
fhir:code [ fhir:v "NLM" ] ;
fhir:display [ fhir:v "National Library of Medicine, Index Section" ] ;
fhir:userSelected [ fhir:v "false"^^xsd:boolean ]       ] )     ] )
  ] ) ; # 
  fhir:currentState ( [
    ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/citation-status-type"^^xsd:anyURI ] ;
fhir:code [ fhir:v "medline-medline" ] ;
fhir:display [ fhir:v "Medline Citation Status of Medline" ]     ] )
  ] [
    ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/citation-status-type"^^xsd:anyURI ] ;
fhir:code [ fhir:v "pubmed-publication-status-ppublish" ] ;
fhir:display [ fhir:v "PubMed PublicationStatus of ppublish" ]     ] )
  ] ) ; # 
  fhir:statusDate ( [
fhir:activity [
      ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/citation-status-type"^^xsd:anyURI ] ;
fhir:code [ fhir:v "pubmed-pubstatus-received" ] ;
fhir:display [ fhir:v "PubMed Pubstatus of Received" ]       ] )     ] ;
fhir:period [
fhir:end [ fhir:v "2013-02-14"^^xsd:date ]     ]
  ] [
fhir:activity [
      ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/citation-status-type"^^xsd:anyURI ] ;
fhir:code [ fhir:v "pubmed-pubstatus-accepted" ] ;
fhir:display [ fhir:v "PubMed Pubstatus of Accepted" ]       ] )     ] ;
fhir:period [
fhir:end [ fhir:v "2013-04-08"^^xsd:date ]     ]
  ] [
fhir:activity [
      ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/citation-status-type"^^xsd:anyURI ] ;
fhir:code [ fhir:v "pubmed-pubstatus-entrez" ] ;
fhir:display [ fhir:v "PubMed Pubstatus of Entrez" ]       ] )     ] ;
fhir:period [
fhir:end [ fhir:v "2013-04-23T06:00:00.000Z"^^xsd:dateTime ]     ]
  ] [
fhir:activity [
      ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/citation-status-type"^^xsd:anyURI ] ;
fhir:code [ fhir:v "pubmed-pubstatus-pubmed" ] ;
fhir:display [ fhir:v "PubMed Pubstatus of Pubmed" ]       ] )     ] ;
fhir:period [
fhir:end [ fhir:v "2013-04-23T06:00:00.000Z"^^xsd:dateTime ]     ]
  ] [
fhir:activity [
      ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/citation-status-type"^^xsd:anyURI ] ;
fhir:code [ fhir:v "pubmed-pubstatus-medline" ] ;
fhir:display [ fhir:v "PubMed Pubstatus of Medline" ]       ] )     ] ;
fhir:period [
fhir:end [ fhir:v "2013-08-02T06:00:00.000Z"^^xsd:dateTime ]     ]
  ] ) ; # 
  fhir:citedArtifact [
    ( fhir:identifier [
fhir:system [ fhir:v "https://pubmed.ncbi.nlm.nih.gov"^^xsd:anyURI ] ;
fhir:value [ fhir:v "23604530" ]     ] [
fhir:system [ fhir:v "https://doi.org"^^xsd:anyURI ] ;
fhir:value [ fhir:v "10.1007/s00280-013-2163-4" ]     ] ) ;
    ( fhir:title [
      ( fhir:type [
        ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/title-type"^^xsd:anyURI ] ;
fhir:code [ fhir:v "primary" ] ;
fhir:display [ fhir:v "Primary title" ]         ] )       ] ) ;
fhir:language [
        ( fhir:coding [
fhir:system [ fhir:v "urn:ietf:bcp:47"^^xsd:anyURI ] ;
fhir:code [ fhir:v "en" ] ;
fhir:display [ fhir:v "English" ]         ] )       ] ;
fhir:text [ fhir:v "A phase II trial of androgen deprivation therapy (ADT) plus chemotherapy as initial treatment for local failures or advanced prostate cancer." ]     ] ) ;
    ( fhir:abstract [
fhir:text [ fhir:v "**PURPOSE:** Long-term hormonal ablation in prostate cancer is associated with decreased overall health and quality of life. Few reports emphasized the role of chemotherapy in the management of early stage prostate cancer. This study analyzed the safety and efficacy of androgen deprivation therapy (ADT) plus chemotherapy as initial treatment for patients identified as local failures or not eligible for prostatectomy or radiation therapy due to advanced disease presentation.\n**METHODS:** Enrolled patients received ADT in the form of leuprolide every 12 weeks for 24 months with bicalutamide initiating after the completion of chemotherapy. Chemotherapy consisted of ketoconazole and doxorubicin for weeks 1, 3, and 5 and estramustine and docetaxel and for weeks 2, 4 and 6. During weeks 7 and 8, no treatment was received.\n**RESULTS:** Forty-six patients were enrolled, and forty-five patients were evaluable. Median progression-free survival (PFS) was 23.4 months. Median overall survival (OS) was 53.7 months. Out of 45 patients with measurable disease, 22 patients had an objective response: 9 patients achieved a complete response; 2 patients achieved a partial response; 10 patients achieved stable disease. Frequent grade 3 adverse events included elevated ALT (17 %), hypokalemia (13 %), and hypophosphatemia (13 %). Grade 4 adverse events were rare and included low bicarbonate (2 %), hypokalemia (2 %), leukocytopenia (2 %), and neutropenia (2 %).\n**CONCLUSIONS:** The treatment demonstrated clinical benefit in all patient subsets with minimal reversible treatment-related adverse events. Subgroup analysis suggests that having prior local therapy resulted in greater PFS and OS." ]     ] ) ;
    ( fhir:publicationForm [
fhir:publishedIn [
fhir:type [
          ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/published-in-type"^^xsd:anyURI ] ;
fhir:code [ fhir:v "D020492" ] ;
fhir:display [ fhir:v "Periodical" ]           ] )         ] ;
        ( fhir:identifier [
fhir:type [
            ( fhir:coding [
fhir:system [ fhir:v "https://www.nlm.nih.gov/bsd/licensee/elements_descriptions.html#issn"^^xsd:anyURI ] ;
fhir:code [ fhir:v "Electronic" ] ;
fhir:display [ fhir:v "Electronic" ]             ] ) ;
fhir:text [ fhir:v "Electronic ISSN Type" ]           ] ;
fhir:system [ fhir:v "https://portal.issn.org"^^xsd:anyURI ] ;
fhir:value [ fhir:v "1432-0843" ]         ] [
fhir:type [
            ( fhir:coding [
fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v2-0203"^^xsd:anyURI ] ;
fhir:code [ fhir:v "XX" ] ;
fhir:display [ fhir:v "Organization identifier" ]             ] ) ;
fhir:text [ fhir:v "ISOAbbreviation" ]           ] ;
fhir:system [ fhir:v "https://www.issn.org/services/online-services/access-to-the-ltwa/"^^xsd:anyURI ] ;
fhir:value [ fhir:v "Cancer Chemother Pharmacol" ]         ] [
fhir:type [
            ( fhir:coding [
fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v2-0203"^^xsd:anyURI ] ;
fhir:code [ fhir:v "XX" ] ;
fhir:display [ fhir:v "Organization identifier" ]             ] ) ;
fhir:text [ fhir:v "ISSN Linking" ]           ] ;
fhir:system [ fhir:v "https://www.issn.org/understanding-the-issn/assignment-rules/the-issn-l-for-publications-on-multiple-media/"^^xsd:anyURI ] ;
fhir:value [ fhir:v "0344-5704" ]         ] [
fhir:type [
            ( fhir:coding [
fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v2-0203"^^xsd:anyURI ] ;
fhir:code [ fhir:v "XX" ] ;
fhir:display [ fhir:v "Organization identifier" ]             ] ) ;
fhir:text [ fhir:v "Medline Title Abbreviation" ]           ] ;
fhir:system [ fhir:v "https://www.nlm.nih.gov/tsd/cataloging/contructitleabbre.html"^^xsd:anyURI ] ;
fhir:value [ fhir:v "Cancer Chemother Pharmacol" ]         ] [
fhir:type [
            ( fhir:coding [
fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v2-0203"^^xsd:anyURI ] ;
fhir:code [ fhir:v "XX" ] ;
fhir:display [ fhir:v "Organization identifier" ]             ] ) ;
fhir:text [ fhir:v "NLM Unique ID" ]           ] ;
fhir:system [ fhir:v "https://locatorplus.gov/cgi-bin/Pwebrecon.cgi?DB=local"^^xsd:anyURI ] ;
fhir:value [ fhir:v "7806519" ]         ] ) ;
fhir:title [ fhir:v "Cancer chemotherapy and pharmacology" ] ;
fhir:publisherLocation [ fhir:v "Germany" ]       ] ;
fhir:citedMedium [
        ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/cited-medium"^^xsd:anyURI ] ;
fhir:code [ fhir:v "internet" ] ;
fhir:display [ fhir:v "Internet" ]         ] )       ] ;
fhir:volume [ fhir:v "71" ] ;
fhir:issue [ fhir:v "6" ] ;
fhir:articleDate [ fhir:v "2013-06"^^xsd:gYearMonth ] ;
fhir:publicationDateText [ fhir:v "2013-Jun" ] ;
      ( fhir:language [
        ( fhir:coding [
fhir:system [ fhir:v "urn:ietf:bcp:47"^^xsd:anyURI ] ;
fhir:code [ fhir:v "en" ] ;
fhir:display [ fhir:v "English" ]         ] )       ] ) ;
fhir:pageString [ fhir:v "1629-34" ]     ] [
fhir:citedMedium [
        ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/cited-medium"^^xsd:anyURI ] ;
fhir:code [ fhir:v "internet-without-issue" ] ;
fhir:display [ fhir:v "Internet without issue" ]         ] )       ] ;
fhir:articleDate [ fhir:v "2013-04-21"^^xsd:date ]     ] ) ;
    ( fhir:webLocation [
      ( fhir:classifier [
        ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/artifact-url-classifier"^^xsd:anyURI ] ;
fhir:code [ fhir:v "abstract" ] ;
fhir:display [ fhir:v "Abstract" ]         ] )       ] ) ;
fhir:url [ fhir:v "https://pubmed.ncbi.nlm.nih.gov/23604530/"^^xsd:anyURI ]     ] [
      ( fhir:classifier [
        ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/artifact-url-classifier"^^xsd:anyURI ] ;
fhir:code [ fhir:v "doi-based" ] ;
fhir:display [ fhir:v "DOI Based" ]         ] )       ] ) ;
fhir:url [ fhir:v "https://doi.org/10.1007/s00280-013-2163-4"^^xsd:anyURI ]     ] ) ;
    ( fhir:classification [
fhir:type [
        ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ;
fhir:code [ fhir:v "publishing-model" ] ;
fhir:display [ fhir:v "Publishing Model" ] ;
fhir:userSelected [ fhir:v "false"^^xsd:boolean ]         ] )       ] ;
      ( fhir:classifier [
        ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/citation-artifact-classifier"^^xsd:anyURI ] ;
fhir:code [ fhir:v "Print-Electronic" ] ;
fhir:display [ fhir:v "Print Electronic" ] ;
fhir:userSelected [ fhir:v "false"^^xsd:boolean ]         ] )       ] )     ] [
fhir:type [
        ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ;
fhir:code [ fhir:v "chemical" ] ;
fhir:display [ fhir:v "Chemical" ] ;
fhir:userSelected [ fhir:v "false"^^xsd:boolean ]         ] )       ] ;
      ( fhir:classifier [
        ( fhir:coding [
fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ;
fhir:code [ fhir:v "D000726" ] ;
fhir:display [ fhir:v "Androgen Antagonists" ] ;
fhir:userSelected [ fhir:v "false"^^xsd:boolean ]         ] )       ] [
        ( fhir:coding [
fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ;
fhir:code [ fhir:v "D000813" ] ;
fhir:display [ fhir:v "Anilides" ] ;
fhir:userSelected [ fhir:v "false"^^xsd:boolean ]         ] )       ] [
        ( fhir:coding [
fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ;
fhir:code [ fhir:v "D018931" ] ;
fhir:display [ fhir:v "Antineoplastic Agents, Hormonal" ] ;
fhir:userSelected [ fhir:v "false"^^xsd:boolean ]         ] )       ] [
        ( fhir:coding [
fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ;
fhir:code [ fhir:v "D009570" ] ;
fhir:display [ fhir:v "Nitriles" ] ;
fhir:userSelected [ fhir:v "false"^^xsd:boolean ]         ] )       ] [
        ( fhir:coding [
fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ;
fhir:code [ fhir:v "D014105" ] ;
fhir:display [ fhir:v "Tosyl Compounds" ] ;
fhir:userSelected [ fhir:v "false"^^xsd:boolean ]         ] )       ] [
        ( fhir:coding [
fhir:system [ fhir:v "https://www.cas.org/support/documentation/chemical-substances"^^xsd:anyURI ] ;
fhir:code [ fhir:v "A0Z3NAU9DP" ] ;
fhir:userSelected [ fhir:v "false"^^xsd:boolean ]         ] [
fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ;
fhir:code [ fhir:v "C053541" ] ;
fhir:display [ fhir:v "bicalutamide" ] ;
fhir:userSelected [ fhir:v "false"^^xsd:boolean ]         ] )       ] [
        ( fhir:coding [
fhir:system [ fhir:v "https://www.cas.org/support/documentation/chemical-substances"^^xsd:anyURI ] ;
fhir:code [ fhir:v "EC 3.4.21.-" ] ;
fhir:userSelected [ fhir:v "false"^^xsd:boolean ]         ] [
fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ;
fhir:code [ fhir:v "C549870" ] ;
fhir:display [ fhir:v "KLK3 protein, human" ] ;
fhir:userSelected [ fhir:v "false"^^xsd:boolean ]         ] )       ] [
        ( fhir:coding [
fhir:system [ fhir:v "https://www.cas.org/support/documentation/chemical-substances"^^xsd:anyURI ] ;
fhir:code [ fhir:v "EC 3.4.21.-" ] ;
fhir:userSelected [ fhir:v "false"^^xsd:boolean ]         ] [
fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ;
fhir:code [ fhir:v "D007610" ] ;
fhir:display [ fhir:v "Kallikreins" ] ;
fhir:userSelected [ fhir:v "false"^^xsd:boolean ]         ] )       ] [
        ( fhir:coding [
fhir:system [ fhir:v "https://www.cas.org/support/documentation/chemical-substances"^^xsd:anyURI ] ;
fhir:code [ fhir:v "EC 3.4.21.77" ] ;
fhir:userSelected [ fhir:v "false"^^xsd:boolean ]         ] [
fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ;
fhir:code [ fhir:v "D017430" ] ;
fhir:display [ fhir:v "Prostate-Specific Antigen" ] ;
fhir:userSelected [ fhir:v "false"^^xsd:boolean ]         ] )       ] [
        ( fhir:coding [
fhir:system [ fhir:v "https://www.cas.org/support/documentation/chemical-substances"^^xsd:anyURI ] ;
fhir:code [ fhir:v "EFY6W0M8TG" ] ;
fhir:userSelected [ fhir:v "false"^^xsd:boolean ]         ] [
fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ;
fhir:code [ fhir:v "D016729" ] ;
fhir:display [ fhir:v "Leuprolide" ] ;
fhir:userSelected [ fhir:v "false"^^xsd:boolean ]         ] )       ] )     ] [
fhir:type [
        ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ;
fhir:code [ fhir:v "mesh-heading" ] ;
fhir:display [ fhir:v "MeSH Heading" ]         ] )       ] ;
      ( fhir:artifactAssessment [
fhir:reference [ fhir:v "#meshHeading0" ] ;
fhir:type [ fhir:v "ArtifactAssessment"^^xsd:anyURI ]       ] )     ] [
fhir:type [
        ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ;
fhir:code [ fhir:v "publication-type" ] ;
fhir:display [ fhir:v "Publication Type" ]         ] )       ] ;
      ( fhir:classifier [
        ( fhir:coding [
fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ;
fhir:code [ fhir:v "D017427" ] ;
fhir:display [ fhir:v "Clinical Trial, Phase II" ] ;
fhir:userSelected [ fhir:v "false"^^xsd:boolean ]         ] )       ] [
        ( fhir:coding [
fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ;
fhir:code [ fhir:v "D016428" ] ;
fhir:display [ fhir:v "Journal Article" ] ;
fhir:userSelected [ fhir:v "false"^^xsd:boolean ]         ] )       ] )     ] [
fhir:type [
        ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ;
fhir:code [ fhir:v "knowledge-artifact-type" ] ;
fhir:display [ fhir:v "Knowledge Artifact Type" ] ;
fhir:userSelected [ fhir:v "false"^^xsd:boolean ]         ] )       ] ;
      ( fhir:classifier [
        ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/citation-artifact-classifier"^^xsd:anyURI ] ;
fhir:code [ fhir:v "D016428" ] ;
fhir:display [ fhir:v "Journal Article" ] ;
fhir:userSelected [ fhir:v "false"^^xsd:boolean ]         ] )       ] ) ;
      ( fhir:artifactAssessment [
fhir:display [ fhir:v "Classifier added by Computable Publishing LLC" ]       ] )     ] [
fhir:type [
        ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ;
fhir:code [ fhir:v "citation-subset" ] ;
fhir:display [ fhir:v "Citation Subset" ] ;
fhir:userSelected [ fhir:v "false"^^xsd:boolean ]         ] )       ] ;
      ( fhir:classifier [
        ( fhir:coding [
fhir:system [ fhir:v "https://www.nlm.nih.gov/bsd/licensee/elements_descriptions.html#citationsubset"^^xsd:anyURI ] ;
fhir:code [ fhir:v "IM" ] ;
fhir:display [ fhir:v "IM" ] ;
fhir:userSelected [ fhir:v "false"^^xsd:boolean ]         ] )       ] )     ] ) ;
fhir:contributorship [
fhir:complete [ fhir:v "true"^^xsd:boolean ] ;
      ( fhir:entry [
fhir:contributor [
fhir:reference [ fhir:v "#author0" ] ;
fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ;
fhir:display [ fhir:v "Amato R" ]         ] ;
fhir:forenameInitials [ fhir:v "R" ] ;
        ( fhir:affiliation [
fhir:display [ fhir:v "Division of Oncology, Department of Internal Medicine, University of Texas Health Science Center at Houston (Medical School)/Memorial Hermann Cancer Center, 6410 Fannin St., Suite 830, Houston, TX 77030, USA. robert.amato@uth.tmc.edu" ]         ] )       ] [
fhir:contributor [
fhir:reference [ fhir:v "#author1" ] ;
fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ;
fhir:display [ fhir:v "Stepankiw M" ]         ] ;
fhir:forenameInitials [ fhir:v "M" ]       ] [
fhir:contributor [
fhir:reference [ fhir:v "#author2" ] ;
fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ;
fhir:display [ fhir:v "Gonzales P" ]         ] ;
fhir:forenameInitials [ fhir:v "P" ]       ] )     ]
  ] . #