@prefix fhir: <http://hl7.org/fhir/> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix sct: <http://snomed.info/id/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

# - resource -------------------------------------------------------------------

<http://hl7.org/fhir/uv/ae-research-backport-ig/MedicationRequest/medicationrequest-for-bresentrik> a fhir:MedicationRequest ;
  fhir:nodeRole fhir:treeRoot ;
  fhir:id [ fhir:v "medicationrequest-for-bresentrik"] ; # 
  fhir:text [
     fhir:status [ fhir:v "generated" ] ;
     fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: MedicationRequest</b><a name=\"medicationrequest-for-bresentrik\"> </a><a name=\"hcmedicationrequest-for-bresentrik\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource MedicationRequest &quot;medicationrequest-for-bresentrik&quot; </p></div><p><b>identifier</b>: <code>http://www.bmc.nl/portal/medstatements</code>/1234568900-studyDrug (use: official)</p><p><b>status</b>: active</p><p><b>intent</b>: order</p><p><b>medication</b>: <a href=\"Medication-bresentrik.html\">Medication/bresentrik: bresentrik 2mg tablet</a></p><p><b>subject</b>: <a href=\"Patient-JanetPatient.html\">Patient/JanetPatient: Janet</a> &quot; CLINICAL TRIAL PATIENT&quot;</p><p><b>supportingInformation</b>: <a href=\"ResearchStudy-BreastCancerTrial.html\">ResearchStudy/BreastCancerTrial</a></p><p><b>authoredOn</b>: 2023-04-05</p><p><b>requester</b>: <span>: Could be reference to inline contained profile such as Reference(practitioner-1) Ronald Bone, MD</span></p><p><b>reasonCode</b>: Breast Cancer <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://browser.ihtsdotools.org/\">SNOMED CT</a>#254837009)</span></p><p><b>instantiatesCanonical</b>: <a href=\"http://baseUrlOfHospitalHolding/PlanDefinition/protocol-for-the-ResearchStudy\">http://baseUrlOfHospitalHolding/PlanDefinition/protocol-for-the-ResearchStudy</a></p><blockquote><p><b>dosageInstruction</b></p><p><b>sequence</b>: 1</p><p><b>text</b>: 6 mg PO daily for remission induction; adjust dosage to white blood cell (WBC) count.  With hold treatment if WBC is less than 15,000/µL; resume when WBC is greater than 50,000/µL</p><p><b>timing</b>: Once per 1 days</p><p><b>route</b>: Oral route (qualifier value) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://browser.ihtsdotools.org/\">SNOMED CT</a>#26643006)</span></p><blockquote><p><b>doseAndRate</b></p></blockquote></blockquote><blockquote><p><b>dispenseRequest</b></p><p><b>numberOfRepeatsAllowed</b>: 1</p><p><b>quantity</b>: 600 mg<span style=\"background: LightGoldenRodYellow\"> (Details: UCUM code mg = 'mg')</span></p><h3>ExpectedSupplyDurations</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Value</b></td><td><b>Unit</b></td><td><b>System</b></td><td><b>Code</b></td></tr><tr><td style=\"display: none\">*</td><td>30</td><td>days</td><td><a href=\"http://terminology.hl7.org/5.5.0/CodeSystem-v3-ucum.html\">Unified Code for Units of Measure (UCUM)</a></td><td>d</td></tr></table></blockquote></div>"
  ] ; # 
  fhir:identifier ( [
     fhir:use [ fhir:v "official" ] ;
     fhir:system [ fhir:v "http://www.bmc.nl/portal/medstatements"^^xsd:anyURI ] ;
     fhir:value [ fhir:v "1234568900-studyDrug" ]
  ] ) ; # 
  fhir:status [ fhir:v "active"] ; # 
  fhir:intent [ fhir:v "order"] ; # 
  fhir:medication [
     a fhir:Reference ;
     fhir:link <http://hl7.org/fhir/uv/ae-research-backport-ig/Medication/bresentrik> ;
     fhir:reference [ fhir:v "Medication/bresentrik" ] ;
     fhir:display [ fhir:v "bresentrik 2mg tablet" ]
  ] ; # 
  fhir:subject [
     fhir:link <http://hl7.org/fhir/uv/ae-research-backport-ig/Patient/JanetPatient> ;
     fhir:reference [ fhir:v "Patient/JanetPatient" ] ;
     fhir:display [ fhir:v "Janet" ]
  ] ; # 
  fhir:supportingInformation ( [
     fhir:link <http://hl7.org/fhir/uv/ae-research-backport-ig/ResearchStudy/BreastCancerTrial> ;
     fhir:reference [ fhir:v "ResearchStudy/BreastCancerTrial" ]
  ] ) ; # 
  fhir:authoredOn [ fhir:v "2023-04-05"^^xsd:date] ; # 
  fhir:requester [
     fhir:display [ fhir:v "Could be reference to inline contained profile such as Reference(practitioner-1) Ronald Bone, MD" ]
  ] ; # 
  fhir:reasonCode ( [
     fhir:coding ( [
       a sct:254837009 ;
       fhir:system [ fhir:v "http://snomed.info/sct"^^xsd:anyURI ] ;
       fhir:code [ fhir:v "254837009" ] ;
       fhir:display [ fhir:v "Breast Cancer" ]
     ] )
  ] ) ; # 
  fhir:instantiatesCanonical ( [
     fhir:v "http://baseUrlOfHospitalHolding/PlanDefinition/protocol-for-the-ResearchStudy"^^xsd:anyURI ;
     fhir:link <http://baseUrlOfHospitalHolding/PlanDefinition/protocol-for-the-ResearchStudy>
  ] ) ; # 
  fhir:dosageInstruction ( [
     fhir:sequence [ fhir:v "1"^^xsd:integer ] ;
     fhir:text [ fhir:v "6 mg PO daily for remission induction; adjust dosage to white blood cell (WBC) count.  With hold treatment if WBC is less than 15,000/µL; resume when WBC is greater than 50,000/µL" ] ;
     fhir:timing [
       fhir:repeat [
         fhir:frequency [ fhir:v "1"^^xsd:positiveInteger ] ;
         fhir:period [ fhir:v "1"^^xsd:decimal ] ;
         fhir:periodUnit [ fhir:v "d" ]
       ]
     ] ;
     fhir:route [
       fhir:coding ( [
         a sct:26643006 ;
         fhir:system [ fhir:v "http://snomed.info/sct"^^xsd:anyURI ] ;
         fhir:code [ fhir:v "26643006" ] ;
         fhir:display [ fhir:v "Oral route (qualifier value)" ]
       ] )
     ] ;
     fhir:doseAndRate ( [
       fhir:type [
         fhir:coding ( [
           fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/dose-rate-type"^^xsd:anyURI ] ;
           fhir:code [ fhir:v "ordered" ] ;
           fhir:display [ fhir:v "Ordered" ]
         ] )
       ] ;
       fhir:dose [
         a fhir:Quantity ;
         fhir:value [ fhir:v "6"^^xsd:decimal ] ;
         fhir:unit [ fhir:v "mg" ] ;
         fhir:system [ fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ] ;
         fhir:code [ fhir:v "mg" ]
       ]
     ] )
  ] ) ; # 
  fhir:dispenseRequest [
     fhir:numberOfRepeatsAllowed [ fhir:v "1"^^xsd:nonNegativeInteger ] ;
     fhir:quantity [
       fhir:value [ fhir:v "600"^^xsd:decimal ] ;
       fhir:unit [ fhir:v "mg" ] ;
       fhir:system [ fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ] ;
       fhir:code [ fhir:v "mg" ]
     ] ;
     fhir:expectedSupplyDuration [
       fhir:value [ fhir:v "30"^^xsd:decimal ] ;
       fhir:unit [ fhir:v "days" ] ;
       fhir:system [ fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ] ;
       fhir:code [ fhir:v "d" ]
     ]
  ] . # 

<http://hl7.org/fhir/uv/ae-research-backport-ig/Medication/bresentrik> a fhir:uv .

<http://hl7.org/fhir/uv/ae-research-backport-ig/Patient/JanetPatient> a fhir:uv .

<http://hl7.org/fhir/uv/ae-research-backport-ig/ResearchStudy/BreastCancerTrial> a fhir:uv .

# -------------------------------------------------------------------------------------