minimal Common Oncology Data Elements (mCODE) Implementation Guide
4.0.0-ballot - STU4 Ballot
minimal Common Oncology Data Elements (mCODE) Implementation Guide
4.0.0-ballot - STU4 Ballot
This page is part of the HL7 FHIR Implementation Guide: minimal Common Oncology Data Elements (mCODE) Release 1 - US Realm | STU1 (v4.0.0-ballot: STU4 Ballot 1) based on FHIR (HL7® FHIR® Standard) R4. The current version which supersedes this version is 3.0.0. For a full list of available versions, see the Directory of published versions
@prefix fhir: <http://hl7.org/fhir/> . @prefix loinc: <https://loinc.org/rdf/> . @prefix owl: <http://www.w3.org/2002/07/owl#> . @prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> . @prefix sct: <http://snomed.info/id/> . @prefix xsd: <http://www.w3.org/2001/XMLSchema#> . # - resource ------------------------------------------------------------------- a fhir:Bundle ; fhir:nodeRole fhir:treeRoot ; fhir:id [ fhir:v "gx-genomic-bundle-adam-anyperson"] ; # fhir:type [ fhir:v "collection"] ; # fhir:entry ( [ fhir:fullUrl [ fhir:v "http://example.org/fhir/Patient/gx-cancer-patient-adam-anyperson"^^xsd:anyURI ] ; ( fhir:resource <http://example.org/fhir/Patient/gx-cancer-patient-adam-anyperson> ) ] [ fhir:fullUrl [ fhir:v "http://example.org/fhir/DiagnosticReport/gx-genomics-report-adam-anyperson"^^xsd:anyURI ] ; ( fhir:resource <http://example.org/fhir/DiagnosticReport/gx-genomics-report-adam-anyperson> ) ] [ fhir:fullUrl [ fhir:v "http://example.org/fhir/ServiceRequest/gx-order-tumornormal-gensop-inc"^^xsd:anyURI ] ; ( fhir:resource <http://example.org/fhir/ServiceRequest/gx-order-tumornormal-gensop-inc> ) ] [ fhir:fullUrl [ fhir:v "http://example.org/fhir/Practitioner/gx-practitioner-test-pathologist"^^xsd:anyURI ] ; ( fhir:resource <http://example.org/fhir/Practitioner/gx-practitioner-test-pathologist> ) ] [ fhir:fullUrl [ fhir:v "http://example.org/fhir/Specimen/gx-genomic-specimen-tumornormal-tumor"^^xsd:anyURI ] ; ( fhir:resource <http://example.org/fhir/Specimen/gx-genomic-specimen-tumornormal-tumor> ) ] [ fhir:fullUrl [ fhir:v "http://example.org/fhir/Specimen/gx-genomic-specimen-tumornormal-normal"^^xsd:anyURI ] ; ( fhir:resource <http://example.org/fhir/Specimen/gx-genomic-specimen-tumornormal-normal> ) ] [ fhir:fullUrl [ fhir:v "http://example.org/fhir/Observation/gx-genomic-variant-somatic-bap1-indel"^^xsd:anyURI ] ; ( fhir:resource <http://example.org/fhir/Observation/gx-genomic-variant-somatic-bap1-indel> ) ] [ fhir:fullUrl [ fhir:v "http://example.org/fhir/Observation/gx-genomic-variant-somatic-cdkn2a-cnv"^^xsd:anyURI ] ; ( fhir:resource <http://example.org/fhir/Observation/gx-genomic-variant-somatic-cdkn2a-cnv> ) ] [ fhir:fullUrl [ fhir:v "http://example.org/fhir/Observation/gx-genomic-variant-somatic-cdkn2b-cnv"^^xsd:anyURI ] ; ( fhir:resource <http://example.org/fhir/Observation/gx-genomic-variant-somatic-cdkn2b-cnv> ) ] [ fhir:fullUrl [ fhir:v "http://example.org/fhir/Observation/gx-genomic-variant-somatic-kdm5d"^^xsd:anyURI ] ; ( fhir:resource <http://example.org/fhir/Observation/gx-genomic-variant-somatic-kdm5d> ) ] [ fhir:fullUrl [ fhir:v "http://example.org/fhir/Observation/gx-genomic-variant-somatic-mtap"^^xsd:anyURI ] ; ( fhir:resource <http://example.org/fhir/Observation/gx-genomic-variant-somatic-mtap> ) ] [ fhir:fullUrl [ fhir:v "http://example.org/fhir/Observation/gx-genomic-variant-somatic-mycn"^^xsd:anyURI ] ; ( fhir:resource <http://example.org/fhir/Observation/gx-genomic-variant-somatic-mycn> ) ] [ fhir:fullUrl [ fhir:v "http://example.org/fhir/Observation/gx-genomic-variant-somatic-pof1b"^^xsd:anyURI ] ; ( fhir:resource <http://example.org/fhir/Observation/gx-genomic-variant-somatic-pof1b> ) ] [ fhir:fullUrl [ fhir:v "http://example.org/fhir/Observation/gx-genomic-variant-somatic-polrmt"^^xsd:anyURI ] ; ( fhir:resource <http://example.org/fhir/Observation/gx-genomic-variant-somatic-polrmt> ) ] [ fhir:fullUrl [ fhir:v "http://example.org/fhir/Observation/gx-genomic-diagnostic-implication-bap1"^^xsd:anyURI ] ; ( fhir:resource <http://example.org/fhir/Observation/gx-genomic-diagnostic-implication-bap1> ) ] [ fhir:fullUrl [ fhir:v "http://example.org/fhir/Observation/gx-genomic-diagnostic-implication-pof1b"^^xsd:anyURI ] ; ( fhir:resource <http://example.org/fhir/Observation/gx-genomic-diagnostic-implication-pof1b> ) ] [ fhir:fullUrl [ fhir:v "http://example.org/fhir/Observation/gx-genomic-diagnostic-implication-polrmt"^^xsd:anyURI ] ; ( fhir:resource <http://example.org/fhir/Observation/gx-genomic-diagnostic-implication-polrmt> ) ] [ fhir:fullUrl [ fhir:v "http://example.org/fhir/Observation/gx-genomic-variant-fusion-met-alk"^^xsd:anyURI ] ; ( fhir:resource <http://example.org/fhir/Observation/gx-genomic-variant-fusion-met-alk> ) ] [ fhir:fullUrl [ fhir:v "http://example.org/fhir/Observation/gx-genomic-variant-pertinent-negative-nras-kit-braf"^^xsd:anyURI ] ; ( fhir:resource <http://example.org/fhir/Observation/gx-genomic-variant-pertinent-negative-nras-kit-braf> ) ] [ fhir:fullUrl [ fhir:v "http://example.org/fhir/Observation/gx-genomic-tmb"^^xsd:anyURI ] ; ( fhir:resource <http://example.org/fhir/Observation/gx-genomic-tmb> ) ] [ fhir:fullUrl [ fhir:v "http://example.org/fhir/Observation/gx-genomic-therapeutic-implication-alectinib"^^xsd:anyURI ] ; ( fhir:resource <http://example.org/fhir/Observation/gx-genomic-therapeutic-implication-alectinib> ) ] [ fhir:fullUrl [ fhir:v "http://example.org/fhir/Observation/gx-genomic-therapeutic-implication-brigatinib"^^xsd:anyURI ] ; ( fhir:resource <http://example.org/fhir/Observation/gx-genomic-therapeutic-implication-brigatinib> ) ] [ fhir:fullUrl [ fhir:v "http://example.org/fhir/Observation/gx-genomic-therapeutic-implication-ceritinib"^^xsd:anyURI ] ; ( fhir:resource <http://example.org/fhir/Observation/gx-genomic-therapeutic-implication-ceritinib> ) ] [ fhir:fullUrl [ fhir:v "http://example.org/fhir/Observation/gx-genomic-therapeutic-implication-crizotinib"^^xsd:anyURI ] ; ( fhir:resource <http://example.org/fhir/Observation/gx-genomic-therapeutic-implication-crizotinib> ) ] [ fhir:fullUrl [ fhir:v "http://example.org/fhir/Observation/gx-genomic-therapeutic-implication-lorlatinib"^^xsd:anyURI ] ; ( fhir:resource <http://example.org/fhir/Observation/gx-genomic-therapeutic-implication-lorlatinib> ) ] ) . # <http://example.org/fhir/Patient/gx-cancer-patient-adam-anyperson> a fhir:Patient ; fhir:id [ fhir:v "gx-cancer-patient-adam-anyperson"] ; # fhir:meta [ ( fhir:profile [ fhir:v "http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-cancer-patient"^^xsd:anyURI ; fhir:link <http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-cancer-patient> ] ) ] ; # fhir:text [ fhir:status [ fhir:v "extensions" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Patient_gx-cancer-patient-adam-anyperson\"> </a><p><b>Generated Narrative: Patient</b><a name=\"gx-cancer-patient-adam-anyperson\"> </a><a name=\"hcgx-cancer-patient-adam-anyperson\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Patient "gx-cancer-patient-adam-anyperson" </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-mcode-cancer-patient.html\">Cancer Patient Profile</a></p></div><p><b>US Core Birth Sex Extension</b>: M</p><p><b>identifier</b>: Patient external identifier/22ea1d1b-03a5-47d6-81e0-b9b4cbb15ccf (use: usual), Medical Record Number/123456789</p><p><b>name</b>: Adam Anyperson </p><p><b>gender</b>: male</p><p><b>birthDate</b>: 1990-01-01</p><p><b>address</b>: 987 Main St Anytown 12345 US </p></div>" ] ; # fhir:extension ( [ fhir:url [ fhir:v "http://hl7.org/fhir/us/core/StructureDefinition/us-core-birthsex"^^xsd:anyURI ] ; fhir:value [ fhir:v "M" ] ] ) ; # fhir:identifier ( [ fhir:use [ fhir:v "usual" ] ; fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v2-0203"^^xsd:anyURI ] ; fhir:code [ fhir:v "PT" ] ; fhir:display [ fhir:v "Patient external identifier" ] ] ) ] ; fhir:system [ fhir:v "https://www.gensop.com"^^xsd:anyURI ] ; fhir:value [ fhir:v "22ea1d1b-03a5-47d6-81e0-b9b4cbb15ccf" ] ] [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v2-0203"^^xsd:anyURI ] ; fhir:code [ fhir:v "MR" ] ; fhir:display [ fhir:v "Medical Record Number" ] ] ) ] ; fhir:system [ fhir:v "http://hospital.example.org"^^xsd:anyURI ] ; fhir:value [ fhir:v "123456789" ] ] ) ; # fhir:name ( [ fhir:family [ fhir:v "Anyperson" ] ; ( fhir:given [ fhir:v "Adam" ] ) ] ) ; # fhir:gender [ fhir:v "male"] ; # fhir:birthDate [ fhir:v "1990-01-01"^^xsd:date] ; # fhir:address ( [ ( fhir:line [ fhir:v "987 Main St" ] ) ; fhir:city [ fhir:v "Anytown" ] ; fhir:postalCode [ fhir:v "12345" ] ; fhir:country [ fhir:v "US" ] ] ) . # <http://example.org/fhir/DiagnosticReport/gx-genomics-report-adam-anyperson> a fhir:DiagnosticReport ; fhir:id [ fhir:v "gx-genomics-report-adam-anyperson"] ; # fhir:meta [ ( fhir:profile [ fhir:v "http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-genomics-report"^^xsd:anyURI ; fhir:link <http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-genomics-report> ] ) ] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"DiagnosticReport_gx-genomics-report-adam-anyperson\"> </a><p><b>Generated Narrative: DiagnosticReport</b><a name=\"gx-genomics-report-adam-anyperson\"> </a><a name=\"hcgx-genomics-report-adam-anyperson\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource DiagnosticReport "gx-genomics-report-adam-anyperson" </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-mcode-genomics-report.html\">Genomics Report Profile</a></p></div><p><b>basedOn</b>: See on this page: ServiceRequest/gx-order-tumornormal-gensop-inc</p><p><b>status</b>: final</p><p><b>category</b>: Genetics <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-v2-0074.html\">diagnosticServiceSectionId</a>#GE)</span></p><p><b>code</b>: Genetic analysis report <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#51969-4)</span></p><p><b>subject</b>: See on this page: Patient/gx-cancer-patient-adam-anyperson</p><p><b>effective</b>: 2022-02-15 19:28:58+0500</p><p><b>performer</b>: <a href=\"Organization-gx-us-core-organization-gensop-inc.html\">Organization/gx-us-core-organization-gensop-inc</a> "Gensop Labs, Inc."</p><p><b>resultsInterpreter</b>: See on this page: Practitioner/gx-practitioner-test-pathologist</p><p><b>specimen</b>: </p><ul><li>See on this page: Specimen/gx-genomic-specimen-tumornormal-tumor</li><li>See on this page: Specimen/gx-genomic-specimen-tumornormal-normal</li></ul><p><b>result</b>: </p><ul><li>See on this page: Observation/gx-genomic-variant-somatic-bap1-indel</li><li>See on this page: Observation/gx-genomic-variant-somatic-cdkn2a-cnv</li><li>See on this page: Observation/gx-genomic-variant-somatic-cdkn2b-cnv</li><li>See on this page: Observation/gx-genomic-variant-somatic-kdm5d</li><li>See on this page: Observation/gx-genomic-variant-somatic-mtap</li><li>See on this page: Observation/gx-genomic-variant-somatic-mycn</li><li>See on this page: Observation/gx-genomic-variant-somatic-pof1b</li><li>See on this page: Observation/gx-genomic-variant-somatic-polrmt</li><li>See on this page: Observation/gx-genomic-diagnostic-implication-bap1</li><li>See on this page: Observation/gx-genomic-diagnostic-implication-pof1b</li><li>See on this page: Observation/gx-genomic-diagnostic-implication-polrmt</li><li>See on this page: Observation/gx-genomic-variant-fusion-met-alk</li><li>See on this page: Observation/gx-genomic-variant-pertinent-negative-nras-kit-braf</li><li>See on this page: Observation/gx-genomic-tmb</li><li><a href=\"Observation-gx-genomic-msi.html\">Observation/gx-genomic-msi</a></li><li>See on this page: Observation/gx-genomic-therapeutic-implication-alectinib</li><li>See on this page: Observation/gx-genomic-therapeutic-implication-brigatinib</li><li>See on this page: Observation/gx-genomic-therapeutic-implication-ceritinib</li><li>See on this page: Observation/gx-genomic-therapeutic-implication-crizotinib</li><li>See on this page: Observation/gx-genomic-therapeutic-implication-lorlatinib</li></ul></div>" ] ; # fhir:basedOn ( [ fhir:reference [ fhir:v "ServiceRequest/gx-order-tumornormal-gensop-inc" ] ] ) ; # fhir:status [ fhir:v "final"] ; # fhir:category ( [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v2-0074"^^xsd:anyURI ] ; fhir:code [ fhir:v "GE" ] ] ) ] ) ; # fhir:code [ ( fhir:coding [ a loinc:51969-4 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "51969-4" ] ; fhir:display [ fhir:v "Genetic analysis report" ] ] ) ] ; # fhir:subject [ fhir:reference [ fhir:v "Patient/gx-cancer-patient-adam-anyperson" ] ] ; # fhir:effective [ fhir:v "2022-02-15T19:28:58+05:00"^^xsd:dateTime] ; # fhir:performer ( [ fhir:reference [ fhir:v "Organization/gx-us-core-organization-gensop-inc" ] ] ) ; # fhir:resultsInterpreter ( [ fhir:reference [ fhir:v "Practitioner/gx-practitioner-test-pathologist" ] ] ) ; # fhir:specimen ( [ fhir:reference [ fhir:v "Specimen/gx-genomic-specimen-tumornormal-tumor" ] ] [ fhir:reference [ fhir:v "Specimen/gx-genomic-specimen-tumornormal-normal" ] ] ) ; # fhir:result ( [ fhir:reference [ fhir:v "Observation/gx-genomic-variant-somatic-bap1-indel" ] ] [ fhir:reference [ fhir:v "Observation/gx-genomic-variant-somatic-cdkn2a-cnv" ] ] [ fhir:reference [ fhir:v "Observation/gx-genomic-variant-somatic-cdkn2b-cnv" ] ] [ fhir:reference [ fhir:v "Observation/gx-genomic-variant-somatic-kdm5d" ] ] [ fhir:reference [ fhir:v "Observation/gx-genomic-variant-somatic-mtap" ] ] [ fhir:reference [ fhir:v "Observation/gx-genomic-variant-somatic-mycn" ] ] [ fhir:reference [ fhir:v "Observation/gx-genomic-variant-somatic-pof1b" ] ] [ fhir:reference [ fhir:v "Observation/gx-genomic-variant-somatic-polrmt" ] ] [ fhir:reference [ fhir:v "Observation/gx-genomic-diagnostic-implication-bap1" ] ] [ fhir:reference [ fhir:v "Observation/gx-genomic-diagnostic-implication-pof1b" ] ] [ fhir:reference [ fhir:v "Observation/gx-genomic-diagnostic-implication-polrmt" ] ] [ fhir:reference [ fhir:v "Observation/gx-genomic-variant-fusion-met-alk" ] ] [ fhir:reference [ fhir:v "Observation/gx-genomic-variant-pertinent-negative-nras-kit-braf" ] ] [ fhir:reference [ fhir:v "Observation/gx-genomic-tmb" ] ] [ fhir:reference [ fhir:v "Observation/gx-genomic-msi" ] ] [ fhir:reference [ fhir:v "Observation/gx-genomic-therapeutic-implication-alectinib" ] ] [ fhir:reference [ fhir:v "Observation/gx-genomic-therapeutic-implication-brigatinib" ] ] [ fhir:reference [ fhir:v "Observation/gx-genomic-therapeutic-implication-ceritinib" ] ] [ fhir:reference [ fhir:v "Observation/gx-genomic-therapeutic-implication-crizotinib" ] ] [ fhir:reference [ fhir:v "Observation/gx-genomic-therapeutic-implication-lorlatinib" ] ] ) . # <http://example.org/fhir/ServiceRequest/gx-order-tumornormal-gensop-inc> a fhir:ServiceRequest ; fhir:id [ fhir:v "gx-order-tumornormal-gensop-inc"] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"ServiceRequest_gx-order-tumornormal-gensop-inc\"> </a><p><b>Generated Narrative: ServiceRequest</b><a name=\"gx-order-tumornormal-gensop-inc\"> </a><a name=\"hcgx-order-tumornormal-gensop-inc\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource ServiceRequest "gx-order-tumornormal-gensop-inc" </p></div><p><b>identifier</b>: Filler Identifier/22howe</p><p><b>status</b>: completed</p><p><b>intent</b>: order</p><p><b>code</b>: xT - 648 gene panel <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (www.gensop.com#XT.V4)</span></p><p><b>subject</b>: See on this page: Patient/gx-cancer-patient-adam-anyperson</p><p><b>reasonCode</b>: Malignant neoplasm of unspecified part of bronchus or lung <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-icd10CM.html\">International Classification of Diseases, 10th Revision, Clinical Modification (ICD-10-CM)</a>#C34.9; <a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-icd-o-3.html\">International Classification of Diseases for Oncology, version 3.</a>#C34.9 8140/3 "Lung adenocarcinoma")</span></p></div>" ] ; # fhir:identifier ( [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v2-0203"^^xsd:anyURI ] ; fhir:code [ fhir:v "FILL" ] ; fhir:display [ fhir:v "Filler Identifier" ] ] ) ] ; fhir:system [ fhir:v "https://www.gensop.com"^^xsd:anyURI ] ; fhir:value [ fhir:v "22howe" ] ] ) ; # fhir:status [ fhir:v "completed"] ; # fhir:intent [ fhir:v "order"] ; # fhir:code [ ( fhir:coding [ fhir:system [ fhir:v "https://www.gensop.com"^^xsd:anyURI ] ; fhir:code [ fhir:v "XT.V4" ] ; fhir:display [ fhir:v "xT - 648 gene panel" ] ] ) ] ; # fhir:subject [ fhir:reference [ fhir:v "Patient/gx-cancer-patient-adam-anyperson" ] ] ; # fhir:reasonCode ( [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/sid/icd-10-cm"^^xsd:anyURI ] ; fhir:code [ fhir:v "C34.9" ] ; fhir:display [ fhir:v "Malignant neoplasm of unspecified part of bronchus or lung" ] ] [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/icd-o-3"^^xsd:anyURI ] ; fhir:code [ fhir:v "C34.9 8140/3" ] ; fhir:display [ fhir:v "Lung adenocarcinoma" ] ] ) ] ) . # <http://example.org/fhir/Practitioner/gx-practitioner-test-pathologist> a fhir:Practitioner ; fhir:id [ fhir:v "gx-practitioner-test-pathologist"] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Practitioner_gx-practitioner-test-pathologist\"> </a><p><b>Generated Narrative: Practitioner</b><a name=\"gx-practitioner-test-pathologist\"> </a><a name=\"hcgx-practitioner-test-pathologist\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Practitioner "gx-practitioner-test-pathologist" </p></div><p><b>name</b>: Test Pathologist, MD</p></div>" ] ; # fhir:name ( [ fhir:text [ fhir:v "Test Pathologist, MD" ] ] ) . # <http://example.org/fhir/Specimen/gx-genomic-specimen-tumornormal-tumor> a fhir:Specimen ; fhir:id [ fhir:v "gx-genomic-specimen-tumornormal-tumor"] ; # fhir:meta [ ( fhir:profile [ fhir:v "http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-human-specimen"^^xsd:anyURI ; fhir:link <http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-human-specimen> ] ) ] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Specimen_gx-genomic-specimen-tumornormal-tumor\"> </a><p><b>Generated Narrative: Specimen</b><a name=\"gx-genomic-specimen-tumornormal-tumor\"> </a><a name=\"hcgx-genomic-specimen-tumornormal-tumor\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Specimen "gx-genomic-specimen-tumornormal-tumor" </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-mcode-human-specimen.html\">Human Specimen Profile</a></p></div><p><b>status</b>: available</p><p><b>type</b>: Tumor <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-v2-0487.html\">specimenType</a>#TUMOR)</span></p><p><b>subject</b>: See on this page: Patient/gx-cancer-patient-adam-anyperson</p><p><b>receivedTime</b>: 2021-02-09 21:30:50+0500</p><h3>Collections</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Collected[x]</b></td><td><b>BodySite</b></td></tr><tr><td style=\"display: none\">*</td><td>2021-02-06 17:15:00+0500</td><td>Left lung structure (body structure) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://browser.ihtsdotools.org/\">SNOMED CT</a>#44029006)</span></td></tr></table></div>" ] ; # fhir:status [ fhir:v "available"] ; # fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v2-0487"^^xsd:anyURI ] ; fhir:code [ fhir:v "TUMOR" ] ; fhir:display [ fhir:v "Tumor" ] ] ) ] ; # fhir:subject [ fhir:reference [ fhir:v "Patient/gx-cancer-patient-adam-anyperson" ] ] ; # fhir:receivedTime [ fhir:v "2021-02-09T21:30:50+05:00"^^xsd:dateTime] ; # fhir:collection [ fhir:collected [ fhir:v "2021-02-06T17:15:00+05:00"^^xsd:dateTime ] ; fhir:bodySite [ ( fhir:coding [ a sct:44029006 ; fhir:system [ fhir:v "http://snomed.info/sct"^^xsd:anyURI ] ; fhir:code [ fhir:v "44029006" ] ; fhir:display [ fhir:v "Left lung structure (body structure)" ] ] ) ] ] . # <http://example.org/fhir/Specimen/gx-genomic-specimen-tumornormal-normal> a fhir:Specimen ; fhir:id [ fhir:v "gx-genomic-specimen-tumornormal-normal"] ; # fhir:meta [ ( fhir:profile [ fhir:v "http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-human-specimen"^^xsd:anyURI ; fhir:link <http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-human-specimen> ] ) ] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Specimen_gx-genomic-specimen-tumornormal-normal\"> </a><p><b>Generated Narrative: Specimen</b><a name=\"gx-genomic-specimen-tumornormal-normal\"> </a><a name=\"hcgx-genomic-specimen-tumornormal-normal\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Specimen "gx-genomic-specimen-tumornormal-normal" </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-mcode-human-specimen.html\">Human Specimen Profile</a></p></div><p><b>status</b>: available</p><p><b>type</b>: Whole Blood <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-v2-0487.html\">specimenType</a>#BLD)</span></p><p><b>subject</b>: See on this page: Patient/gx-cancer-patient-adam-anyperson</p><p><b>receivedTime</b>: 2021-02-09 21:30:50+0500</p><h3>Collections</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Collected[x]</b></td></tr><tr><td style=\"display: none\">*</td><td>2021-02-06 17:15:00+0500</td></tr></table></div>" ] ; # fhir:status [ fhir:v "available"] ; # fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v2-0487"^^xsd:anyURI ] ; fhir:code [ fhir:v "BLD" ] ; fhir:display [ fhir:v "Whole Blood" ] ] ) ] ; # fhir:subject [ fhir:reference [ fhir:v "Patient/gx-cancer-patient-adam-anyperson" ] ] ; # fhir:receivedTime [ fhir:v "2021-02-09T21:30:50+05:00"^^xsd:dateTime] ; # fhir:collection [ fhir:collected [ fhir:v "2021-02-06T17:15:00+05:00"^^xsd:dateTime ] ] . # <http://example.org/fhir/Observation/gx-genomic-variant-somatic-bap1-indel> a fhir:Observation ; fhir:id [ fhir:v "gx-genomic-variant-somatic-bap1-indel"] ; # fhir:meta [ ( fhir:profile [ fhir:v "http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-genomic-variant"^^xsd:anyURI ; fhir:link <http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-genomic-variant> ] ) ] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_gx-genomic-variant-somatic-bap1-indel\"> </a><p><b>Generated Narrative: Observation</b><a name=\"gx-genomic-variant-somatic-bap1-indel\"> </a><a name=\"hcgx-genomic-variant-somatic-bap1-indel\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "gx-genomic-variant-somatic-bap1-indel" </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-mcode-genomic-variant.html\">Genomic Variant Profile</a></p></div><p><b>status</b>: final</p><p><b>category</b>: Laboratory <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-observation-category.html\">Observation Category Codes</a>#laboratory)</span></p><p><b>code</b>: Genetic var assess <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#69548-6)</span></p><p><b>subject</b>: See on this page: Patient/gx-cancer-patient-adam-anyperson</p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href=\"Practitioner-us-core-practitioner-owen-oncologist.html\">Practitioner/us-core-practitioner-owen-oncologist</a> " ONCOLOGIST"</p><p><b>value</b>: Present <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#LA9633-4)</span></p><p><b>method</b>: Sequencing <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#LA26398-0)</span></p><blockquote><p><b>component</b></p><p><b>code</b>: Gene studied ID <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#48018-6)</span></p><p><b>value</b>: BAP1 <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-v3-hgnc.html\">HUGO Gene Nomenclature Committee Genes</a>#HGNC:950; gene#3815)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Transcript ref sequence ID <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#51958-7)</span></p><p><b>value</b>: NM_004656.4 <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-v3-refSeq.html\">Gene Reference Sequence Collection</a>#NM_004656)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: DNA change <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#48004-6)</span></p><p><b>value</b>: NM_004656.4:c.1768C>T <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-v3-hgvs.html\">Human Genome Variation Society nomenclature</a>#NM_004656.4:c.1768C>T)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Amino acid change <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#48005-3)</span></p><p><b>value</b>: NP_004647.1:p.(Gln590Ter) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-v3-hgvs.html\">Human Genome Variation Society nomenclature</a>#NP_004647.1:p.(Gln590Ter))</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Genomic source class <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#48002-0)</span></p><p><b>value</b>: Somatic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#LA6684-0)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Sample VAF <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#81258-6)</span></p><p><b>value</b>: 57.4 %<span style=\"background: LightGoldenRodYellow\"> (Details: UCUM code % = '%')</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Molecular Consequence <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/uv/genomics-reporting/STU2/CodeSystem-tbd-codes-cs.html\">To Be Determined Codes</a>#molecular-consequence)</span></p><p><b>value</b>: stop_gained <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#SO:0001587)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Human ref seq assembly+build <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#62374-4)</span></p><p><b>value</b>: GRCh37 <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#LA14029-5)</span></p></blockquote></div>" ] ; # fhir:status [ fhir:v "final"] ; # fhir:category ( [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/observation-category"^^xsd:anyURI ] ; fhir:code [ fhir:v "laboratory" ] ] ) ] ) ; # fhir:code [ ( fhir:coding [ a loinc:69548-6 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "69548-6" ] ] ) ] ; # fhir:subject [ fhir:reference [ fhir:v "Patient/gx-cancer-patient-adam-anyperson" ] ] ; # fhir:effective [ fhir:v "2019-04-01"^^xsd:date] ; # fhir:performer ( [ fhir:reference [ fhir:v "Practitioner/us-core-practitioner-owen-oncologist" ] ] ) ; # fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA9633-4 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA9633-4" ] ; fhir:display [ fhir:v "Present" ] ] ) ] ; # fhir:method [ ( fhir:coding [ a loinc:LA26398-0 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA26398-0" ] ; fhir:display [ fhir:v "Sequencing" ] ] ) ] ; # fhir:component ( [ fhir:code [ ( fhir:coding [ a loinc:48018-6 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "48018-6" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://www.genenames.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "HGNC:950" ] ; fhir:display [ fhir:v "BAP1" ] ] [ fhir:system [ fhir:v "https://www.ncbi.nlm.nih.gov/gene"^^xsd:anyURI ] ; fhir:code [ fhir:v "3815" ] ; fhir:display [ fhir:v "BAP1" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:51958-7 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "51958-7" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://www.ncbi.nlm.nih.gov/refseq"^^xsd:anyURI ] ; fhir:code [ fhir:v "NM_004656" ] ; fhir:display [ fhir:v "NM_004656.4" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:48004-6 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "48004-6" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://varnomen.hgvs.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "NM_004656.4:c.1768C>T" ] ; fhir:display [ fhir:v "NM_004656.4:c.1768C>T" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:48005-3 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "48005-3" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://varnomen.hgvs.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "NP_004647.1:p.(Gln590Ter)" ] ; fhir:display [ fhir:v "NP_004647.1:p.(Gln590Ter)" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:48002-0 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "48002-0" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA6684-0 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA6684-0" ] ; fhir:display [ fhir:v "Somatic" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:81258-6 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "81258-6" ] ] ) ] ; fhir:value [ a fhir:Quantity ; fhir:value [ fhir:v "57.4"^^xsd:decimal ] ; fhir:unit [ fhir:v "%" ] ; fhir:system [ fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "%" ] ] ] [ fhir:code [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"^^xsd:anyURI ] ; fhir:code [ fhir:v "molecular-consequence" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://www.sequenceontology.org/"^^xsd:anyURI ] ; fhir:code [ fhir:v "SO:0001587" ] ; fhir:display [ fhir:v "stop_gained" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:62374-4 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "62374-4" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA14029-5 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA14029-5" ] ; fhir:display [ fhir:v "GRCh37" ] ] ) ] ] ) . # <http://example.org/fhir/Observation/gx-genomic-variant-somatic-cdkn2a-cnv> a fhir:Observation ; fhir:id [ fhir:v "gx-genomic-variant-somatic-cdkn2a-cnv"] ; # fhir:meta [ ( fhir:profile [ fhir:v "http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-genomic-variant"^^xsd:anyURI ; fhir:link <http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-genomic-variant> ] ) ] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_gx-genomic-variant-somatic-cdkn2a-cnv\"> </a><p><b>Generated Narrative: Observation</b><a name=\"gx-genomic-variant-somatic-cdkn2a-cnv\"> </a><a name=\"hcgx-genomic-variant-somatic-cdkn2a-cnv\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "gx-genomic-variant-somatic-cdkn2a-cnv" </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-mcode-genomic-variant.html\">Genomic Variant Profile</a></p></div><p><b>status</b>: final</p><p><b>category</b>: Laboratory <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-observation-category.html\">Observation Category Codes</a>#laboratory)</span></p><p><b>code</b>: Genetic var assess <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#69548-6)</span></p><p><b>subject</b>: See on this page: Patient/gx-cancer-patient-adam-anyperson</p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href=\"Practitioner-us-core-practitioner-owen-oncologist.html\">Practitioner/us-core-practitioner-owen-oncologist</a> " ONCOLOGIST"</p><p><b>value</b>: Present <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#LA9633-4)</span></p><p><b>method</b>: Sequencing <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#LA26398-0)</span></p><blockquote><p><b>component</b></p><p><b>code</b>: Gene studied ID <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#48018-6)</span></p><p><b>value</b>: CDKN2A <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-v3-hgnc.html\">HUGO Gene Nomenclature Committee Genes</a>#HGNC:1787; gene#1029)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Genomic source class <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#48002-0)</span></p><p><b>value</b>: Somatic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#LA6684-0)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Molecular Consequence <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/uv/genomics-reporting/STU2/CodeSystem-tbd-codes-cs.html\">To Be Determined Codes</a>#molecular-consequence)</span></p><p><b>value</b>: copy_number_loss <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#SO:0001743)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Human ref seq assembly+build <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#62374-4)</span></p><p><b>value</b>: GRCh37 <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#LA14029-5)</span></p></blockquote></div>" ] ; # fhir:status [ fhir:v "final"] ; # fhir:category ( [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/observation-category"^^xsd:anyURI ] ; fhir:code [ fhir:v "laboratory" ] ] ) ] ) ; # fhir:code [ ( fhir:coding [ a loinc:69548-6 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "69548-6" ] ] ) ] ; # fhir:subject [ fhir:reference [ fhir:v "Patient/gx-cancer-patient-adam-anyperson" ] ] ; # fhir:effective [ fhir:v "2019-04-01"^^xsd:date] ; # fhir:performer ( [ fhir:reference [ fhir:v "Practitioner/us-core-practitioner-owen-oncologist" ] ] ) ; # fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA9633-4 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA9633-4" ] ; fhir:display [ fhir:v "Present" ] ] ) ] ; # fhir:method [ ( fhir:coding [ a loinc:LA26398-0 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA26398-0" ] ; fhir:display [ fhir:v "Sequencing" ] ] ) ] ; # fhir:component ( [ fhir:code [ ( fhir:coding [ a loinc:48018-6 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "48018-6" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://www.genenames.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "HGNC:1787" ] ; fhir:display [ fhir:v "CDKN2A" ] ] [ fhir:system [ fhir:v "https://www.ncbi.nlm.nih.gov/gene"^^xsd:anyURI ] ; fhir:code [ fhir:v "1029" ] ; fhir:display [ fhir:v "CDKN2A" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:48002-0 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "48002-0" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA6684-0 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA6684-0" ] ; fhir:display [ fhir:v "Somatic" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"^^xsd:anyURI ] ; fhir:code [ fhir:v "molecular-consequence" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://www.sequenceontology.org/"^^xsd:anyURI ] ; fhir:code [ fhir:v "SO:0001743" ] ; fhir:display [ fhir:v "copy_number_loss" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:62374-4 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "62374-4" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA14029-5 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA14029-5" ] ; fhir:display [ fhir:v "GRCh37" ] ] ) ] ] ) . # <http://example.org/fhir/Observation/gx-genomic-variant-somatic-cdkn2b-cnv> a fhir:Observation ; fhir:id [ fhir:v "gx-genomic-variant-somatic-cdkn2b-cnv"] ; # fhir:meta [ ( fhir:profile [ fhir:v "http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-genomic-variant"^^xsd:anyURI ; fhir:link <http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-genomic-variant> ] ) ] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_gx-genomic-variant-somatic-cdkn2b-cnv\"> </a><p><b>Generated Narrative: Observation</b><a name=\"gx-genomic-variant-somatic-cdkn2b-cnv\"> </a><a name=\"hcgx-genomic-variant-somatic-cdkn2b-cnv\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "gx-genomic-variant-somatic-cdkn2b-cnv" </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-mcode-genomic-variant.html\">Genomic Variant Profile</a></p></div><p><b>status</b>: final</p><p><b>category</b>: Laboratory <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-observation-category.html\">Observation Category Codes</a>#laboratory)</span></p><p><b>code</b>: Genetic var assess <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#69548-6)</span></p><p><b>subject</b>: See on this page: Patient/gx-cancer-patient-adam-anyperson</p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href=\"Practitioner-us-core-practitioner-owen-oncologist.html\">Practitioner/us-core-practitioner-owen-oncologist</a> " ONCOLOGIST"</p><p><b>value</b>: Present <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#LA9633-4)</span></p><p><b>method</b>: Sequencing <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#LA26398-0)</span></p><blockquote><p><b>component</b></p><p><b>code</b>: Gene studied ID <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#48018-6)</span></p><p><b>value</b>: CDKN2B <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-v3-hgnc.html\">HUGO Gene Nomenclature Committee Genes</a>#HGNC:1788; gene#1030)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Genomic source class <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#48002-0)</span></p><p><b>value</b>: Somatic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#LA6684-0)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Molecular Consequence <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/uv/genomics-reporting/STU2/CodeSystem-tbd-codes-cs.html\">To Be Determined Codes</a>#molecular-consequence)</span></p><p><b>value</b>: copy_number_loss <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#SO:0001743)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Human ref seq assembly+build <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#62374-4)</span></p><p><b>value</b>: GRCh37 <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#LA14029-5)</span></p></blockquote></div>" ] ; # fhir:status [ fhir:v "final"] ; # fhir:category ( [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/observation-category"^^xsd:anyURI ] ; fhir:code [ fhir:v "laboratory" ] ] ) ] ) ; # fhir:code [ ( fhir:coding [ a loinc:69548-6 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "69548-6" ] ] ) ] ; # fhir:subject [ fhir:reference [ fhir:v "Patient/gx-cancer-patient-adam-anyperson" ] ] ; # fhir:effective [ fhir:v "2019-04-01"^^xsd:date] ; # fhir:performer ( [ fhir:reference [ fhir:v "Practitioner/us-core-practitioner-owen-oncologist" ] ] ) ; # fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA9633-4 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA9633-4" ] ; fhir:display [ fhir:v "Present" ] ] ) ] ; # fhir:method [ ( fhir:coding [ a loinc:LA26398-0 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA26398-0" ] ; fhir:display [ fhir:v "Sequencing" ] ] ) ] ; # fhir:component ( [ fhir:code [ ( fhir:coding [ a loinc:48018-6 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "48018-6" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://www.genenames.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "HGNC:1788" ] ; fhir:display [ fhir:v "CDKN2B" ] ] [ fhir:system [ fhir:v "https://www.ncbi.nlm.nih.gov/gene"^^xsd:anyURI ] ; fhir:code [ fhir:v "1030" ] ; fhir:display [ fhir:v "CDKN2B" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:48002-0 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "48002-0" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA6684-0 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA6684-0" ] ; fhir:display [ fhir:v "Somatic" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"^^xsd:anyURI ] ; fhir:code [ fhir:v "molecular-consequence" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://www.sequenceontology.org/"^^xsd:anyURI ] ; fhir:code [ fhir:v "SO:0001743" ] ; fhir:display [ fhir:v "copy_number_loss" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:62374-4 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "62374-4" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA14029-5 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA14029-5" ] ; fhir:display [ fhir:v "GRCh37" ] ] ) ] ] ) . # <http://example.org/fhir/Observation/gx-genomic-variant-somatic-kdm5d> a fhir:Observation ; fhir:id [ fhir:v "gx-genomic-variant-somatic-kdm5d"] ; # fhir:meta [ ( fhir:profile [ fhir:v "http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-genomic-variant"^^xsd:anyURI ; fhir:link <http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-genomic-variant> ] ) ] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_gx-genomic-variant-somatic-kdm5d\"> </a><p><b>Generated Narrative: Observation</b><a name=\"gx-genomic-variant-somatic-kdm5d\"> </a><a name=\"hcgx-genomic-variant-somatic-kdm5d\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "gx-genomic-variant-somatic-kdm5d" </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-mcode-genomic-variant.html\">Genomic Variant Profile</a></p></div><p><b>status</b>: final</p><p><b>category</b>: Laboratory <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-observation-category.html\">Observation Category Codes</a>#laboratory)</span></p><p><b>code</b>: Genetic var assess <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#69548-6)</span></p><p><b>subject</b>: See on this page: Patient/gx-cancer-patient-adam-anyperson</p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href=\"Practitioner-us-core-practitioner-owen-oncologist.html\">Practitioner/us-core-practitioner-owen-oncologist</a> " ONCOLOGIST"</p><p><b>value</b>: Present <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#LA9633-4)</span></p><p><b>method</b>: Sequencing <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#LA26398-0)</span></p><blockquote><p><b>component</b></p><p><b>code</b>: Gene studied ID <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#48018-6)</span></p><p><b>value</b>: KDM5D <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-v3-hgnc.html\">HUGO Gene Nomenclature Committee Genes</a>#HGNC:11115; gene#8284)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Genomic source class <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#48002-0)</span></p><p><b>value</b>: Somatic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#LA6684-0)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Molecular Consequence <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/uv/genomics-reporting/STU2/CodeSystem-tbd-codes-cs.html\">To Be Determined Codes</a>#molecular-consequence)</span></p><p><b>value</b>: copy_number_loss <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#SO:0001743)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Human ref seq assembly+build <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#62374-4)</span></p><p><b>value</b>: GRCh37 <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#LA14029-5)</span></p></blockquote></div>" ] ; # fhir:status [ fhir:v "final"] ; # fhir:category ( [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/observation-category"^^xsd:anyURI ] ; fhir:code [ fhir:v "laboratory" ] ] ) ] ) ; # fhir:code [ ( fhir:coding [ a loinc:69548-6 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "69548-6" ] ] ) ] ; # fhir:subject [ fhir:reference [ fhir:v "Patient/gx-cancer-patient-adam-anyperson" ] ] ; # fhir:effective [ fhir:v "2019-04-01"^^xsd:date] ; # fhir:performer ( [ fhir:reference [ fhir:v "Practitioner/us-core-practitioner-owen-oncologist" ] ] ) ; # fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA9633-4 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA9633-4" ] ; fhir:display [ fhir:v "Present" ] ] ) ] ; # fhir:method [ ( fhir:coding [ a loinc:LA26398-0 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA26398-0" ] ; fhir:display [ fhir:v "Sequencing" ] ] ) ] ; # fhir:component ( [ fhir:code [ ( fhir:coding [ a loinc:48018-6 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "48018-6" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://www.genenames.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "HGNC:11115" ] ; fhir:display [ fhir:v "KDM5D" ] ] [ fhir:system [ fhir:v "https://www.ncbi.nlm.nih.gov/gene"^^xsd:anyURI ] ; fhir:code [ fhir:v "8284" ] ; fhir:display [ fhir:v "KDM5D" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:48002-0 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "48002-0" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA6684-0 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA6684-0" ] ; fhir:display [ fhir:v "Somatic" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"^^xsd:anyURI ] ; fhir:code [ fhir:v "molecular-consequence" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://www.sequenceontology.org/"^^xsd:anyURI ] ; fhir:code [ fhir:v "SO:0001743" ] ; fhir:display [ fhir:v "copy_number_loss" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:62374-4 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "62374-4" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA14029-5 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA14029-5" ] ; fhir:display [ fhir:v "GRCh37" ] ] ) ] ] ) . # <http://example.org/fhir/Observation/gx-genomic-variant-somatic-mtap> a fhir:Observation ; fhir:id [ fhir:v "gx-genomic-variant-somatic-mtap"] ; # fhir:meta [ ( fhir:profile [ fhir:v "http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-genomic-variant"^^xsd:anyURI ; fhir:link <http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-genomic-variant> ] ) ] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_gx-genomic-variant-somatic-mtap\"> </a><p><b>Generated Narrative: Observation</b><a name=\"gx-genomic-variant-somatic-mtap\"> </a><a name=\"hcgx-genomic-variant-somatic-mtap\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "gx-genomic-variant-somatic-mtap" </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-mcode-genomic-variant.html\">Genomic Variant Profile</a></p></div><p><b>status</b>: final</p><p><b>category</b>: Laboratory <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-observation-category.html\">Observation Category Codes</a>#laboratory)</span></p><p><b>code</b>: Genetic var assess <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#69548-6)</span></p><p><b>subject</b>: See on this page: Patient/gx-cancer-patient-adam-anyperson</p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href=\"Practitioner-us-core-practitioner-owen-oncologist.html\">Practitioner/us-core-practitioner-owen-oncologist</a> " ONCOLOGIST"</p><p><b>value</b>: Present <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#LA9633-4)</span></p><p><b>method</b>: Sequencing <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#LA26398-0)</span></p><blockquote><p><b>component</b></p><p><b>code</b>: Gene studied ID <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#48018-6)</span></p><p><b>value</b>: MTAP <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-v3-hgnc.html\">HUGO Gene Nomenclature Committee Genes</a>#HGNC:7413; gene#4507)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Genomic source class <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#48002-0)</span></p><p><b>value</b>: Somatic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#LA6684-0)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Molecular Consequence <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/uv/genomics-reporting/STU2/CodeSystem-tbd-codes-cs.html\">To Be Determined Codes</a>#molecular-consequence)</span></p><p><b>value</b>: copy_number_loss <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#SO:0001743)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Human ref seq assembly+build <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#62374-4)</span></p><p><b>value</b>: GRCh37 <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#LA14029-5)</span></p></blockquote></div>" ] ; # fhir:status [ fhir:v "final"] ; # fhir:category ( [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/observation-category"^^xsd:anyURI ] ; fhir:code [ fhir:v "laboratory" ] ] ) ] ) ; # fhir:code [ ( fhir:coding [ a loinc:69548-6 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "69548-6" ] ] ) ] ; # fhir:subject [ fhir:reference [ fhir:v "Patient/gx-cancer-patient-adam-anyperson" ] ] ; # fhir:effective [ fhir:v "2019-04-01"^^xsd:date] ; # fhir:performer ( [ fhir:reference [ fhir:v "Practitioner/us-core-practitioner-owen-oncologist" ] ] ) ; # fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA9633-4 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA9633-4" ] ; fhir:display [ fhir:v "Present" ] ] ) ] ; # fhir:method [ ( fhir:coding [ a loinc:LA26398-0 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA26398-0" ] ; fhir:display [ fhir:v "Sequencing" ] ] ) ] ; # fhir:component ( [ fhir:code [ ( fhir:coding [ a loinc:48018-6 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "48018-6" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://www.genenames.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "HGNC:7413" ] ; fhir:display [ fhir:v "MTAP" ] ] [ fhir:system [ fhir:v "https://www.ncbi.nlm.nih.gov/gene"^^xsd:anyURI ] ; fhir:code [ fhir:v "4507" ] ; fhir:display [ fhir:v "MTAP" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:48002-0 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "48002-0" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA6684-0 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA6684-0" ] ; fhir:display [ fhir:v "Somatic" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"^^xsd:anyURI ] ; fhir:code [ fhir:v "molecular-consequence" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://www.sequenceontology.org/"^^xsd:anyURI ] ; fhir:code [ fhir:v "SO:0001743" ] ; fhir:display [ fhir:v "copy_number_loss" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:62374-4 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "62374-4" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA14029-5 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA14029-5" ] ; fhir:display [ fhir:v "GRCh37" ] ] ) ] ] ) . # <http://example.org/fhir/Observation/gx-genomic-variant-somatic-mycn> a fhir:Observation ; fhir:id [ fhir:v "gx-genomic-variant-somatic-mycn"] ; # fhir:meta [ ( fhir:profile [ fhir:v "http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-genomic-variant"^^xsd:anyURI ; fhir:link <http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-genomic-variant> ] ) ] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_gx-genomic-variant-somatic-mycn\"> </a><p><b>Generated Narrative: Observation</b><a name=\"gx-genomic-variant-somatic-mycn\"> </a><a name=\"hcgx-genomic-variant-somatic-mycn\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "gx-genomic-variant-somatic-mycn" </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-mcode-genomic-variant.html\">Genomic Variant Profile</a></p></div><p><b>status</b>: final</p><p><b>category</b>: Laboratory <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-observation-category.html\">Observation Category Codes</a>#laboratory)</span></p><p><b>code</b>: Genetic var assess <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#69548-6)</span></p><p><b>subject</b>: See on this page: Patient/gx-cancer-patient-adam-anyperson</p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href=\"Practitioner-us-core-practitioner-owen-oncologist.html\">Practitioner/us-core-practitioner-owen-oncologist</a> " ONCOLOGIST"</p><p><b>value</b>: Present <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#LA9633-4)</span></p><p><b>method</b>: Sequencing <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#LA26398-0)</span></p><blockquote><p><b>component</b></p><p><b>code</b>: Gene studied ID <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#48018-6)</span></p><p><b>value</b>: MYCN <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-v3-hgnc.html\">HUGO Gene Nomenclature Committee Genes</a>#HGNC:7559; gene#4613)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Genomic source class <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#48002-0)</span></p><p><b>value</b>: Somatic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#LA6684-0)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Molecular Consequence <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/uv/genomics-reporting/STU2/CodeSystem-tbd-codes-cs.html\">To Be Determined Codes</a>#molecular-consequence)</span></p><p><b>value</b>: copy_number_gain <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#SO:0001742)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Human ref seq assembly+build <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#62374-4)</span></p><p><b>value</b>: GRCh37 <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#LA14029-5)</span></p></blockquote></div>" ] ; # fhir:status [ fhir:v "final"] ; # fhir:category ( [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/observation-category"^^xsd:anyURI ] ; fhir:code [ fhir:v "laboratory" ] ] ) ] ) ; # fhir:code [ ( fhir:coding [ a loinc:69548-6 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "69548-6" ] ] ) ] ; # fhir:subject [ fhir:reference [ fhir:v "Patient/gx-cancer-patient-adam-anyperson" ] ] ; # fhir:effective [ fhir:v "2019-04-01"^^xsd:date] ; # fhir:performer ( [ fhir:reference [ fhir:v "Practitioner/us-core-practitioner-owen-oncologist" ] ] ) ; # fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA9633-4 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA9633-4" ] ; fhir:display [ fhir:v "Present" ] ] ) ] ; # fhir:method [ ( fhir:coding [ a loinc:LA26398-0 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA26398-0" ] ; fhir:display [ fhir:v "Sequencing" ] ] ) ] ; # fhir:component ( [ fhir:code [ ( fhir:coding [ a loinc:48018-6 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "48018-6" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://www.genenames.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "HGNC:7559" ] ; fhir:display [ fhir:v "MYCN" ] ] [ fhir:system [ fhir:v "https://www.ncbi.nlm.nih.gov/gene"^^xsd:anyURI ] ; fhir:code [ fhir:v "4613" ] ; fhir:display [ fhir:v "MYCN" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:48002-0 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "48002-0" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA6684-0 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA6684-0" ] ; fhir:display [ fhir:v "Somatic" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"^^xsd:anyURI ] ; fhir:code [ fhir:v "molecular-consequence" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://www.sequenceontology.org/"^^xsd:anyURI ] ; fhir:code [ fhir:v "SO:0001742" ] ; fhir:display [ fhir:v "copy_number_gain" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:62374-4 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "62374-4" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA14029-5 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA14029-5" ] ; fhir:display [ fhir:v "GRCh37" ] ] ) ] ] ) . # <http://example.org/fhir/Observation/gx-genomic-variant-somatic-pof1b> a fhir:Observation ; fhir:id [ fhir:v "gx-genomic-variant-somatic-pof1b"] ; # fhir:meta [ ( fhir:profile [ fhir:v "http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-genomic-variant"^^xsd:anyURI ; fhir:link <http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-genomic-variant> ] ) ] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_gx-genomic-variant-somatic-pof1b\"> </a><p><b>Generated Narrative: Observation</b><a name=\"gx-genomic-variant-somatic-pof1b\"> </a><a name=\"hcgx-genomic-variant-somatic-pof1b\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "gx-genomic-variant-somatic-pof1b" </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-mcode-genomic-variant.html\">Genomic Variant Profile</a></p></div><p><b>status</b>: final</p><p><b>category</b>: Laboratory <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-observation-category.html\">Observation Category Codes</a>#laboratory)</span></p><p><b>code</b>: Genetic var assess <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#69548-6)</span></p><p><b>subject</b>: See on this page: Patient/gx-cancer-patient-adam-anyperson</p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href=\"Practitioner-us-core-practitioner-owen-oncologist.html\">Practitioner/us-core-practitioner-owen-oncologist</a> " ONCOLOGIST"</p><p><b>value</b>: Present <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#LA9633-4)</span></p><p><b>method</b>: Sequencing <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#LA26398-0)</span></p><blockquote><p><b>component</b></p><p><b>code</b>: Gene studied ID <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#48018-6)</span></p><p><b>value</b>: POF1B <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-v3-hgnc.html\">HUGO Gene Nomenclature Committee Genes</a>#HGNC:13711; gene#79983)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Genomic source class <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#48002-0)</span></p><p><b>value</b>: Somatic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#LA6684-0)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Molecular Consequence <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/uv/genomics-reporting/STU2/CodeSystem-tbd-codes-cs.html\">To Be Determined Codes</a>#molecular-consequence)</span></p><p><b>value</b>: missense_variant <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#SO:0001583)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Transcript ref sequence ID <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#51958-7)</span></p><p><b>value</b>: NM_004656 <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-v3-refSeq.html\">Gene Reference Sequence Collection</a>#NM_004656)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: DNA change <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#48004-6)</span></p><p><b>value</b>: NM_001307940.2:c.430C>T <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-v3-hgvs.html\">Human Genome Variation Society nomenclature</a>#NM_001307940.2:c.430C>T)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Amino acid change <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#48005-3)</span></p><p><b>value</b>: NP_001294869.1:p.(Pro144Ser) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-v3-hgvs.html\">Human Genome Variation Society nomenclature</a>#NP_001294869.1:p.(Pro144Ser))</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Sample VAF <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#81258-6)</span></p><p><b>value</b>: 78.6 %<span style=\"background: LightGoldenRodYellow\"> (Details: UCUM code % = '%')</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Human ref seq assembly+build <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#62374-4)</span></p><p><b>value</b>: GRCh37 <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#LA14029-5)</span></p></blockquote></div>" ] ; # fhir:status [ fhir:v "final"] ; # fhir:category ( [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/observation-category"^^xsd:anyURI ] ; fhir:code [ fhir:v "laboratory" ] ] ) ] ) ; # fhir:code [ ( fhir:coding [ a loinc:69548-6 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "69548-6" ] ] ) ] ; # fhir:subject [ fhir:reference [ fhir:v "Patient/gx-cancer-patient-adam-anyperson" ] ] ; # fhir:effective [ fhir:v "2019-04-01"^^xsd:date] ; # fhir:performer ( [ fhir:reference [ fhir:v "Practitioner/us-core-practitioner-owen-oncologist" ] ] ) ; # fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA9633-4 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA9633-4" ] ; fhir:display [ fhir:v "Present" ] ] ) ] ; # fhir:method [ ( fhir:coding [ a loinc:LA26398-0 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA26398-0" ] ; fhir:display [ fhir:v "Sequencing" ] ] ) ] ; # fhir:component ( [ fhir:code [ ( fhir:coding [ a loinc:48018-6 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "48018-6" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://www.genenames.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "HGNC:13711" ] ; fhir:display [ fhir:v "POF1B" ] ] [ fhir:system [ fhir:v "https://www.ncbi.nlm.nih.gov/gene"^^xsd:anyURI ] ; fhir:code [ fhir:v "79983" ] ; fhir:display [ fhir:v "POF1B" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:48002-0 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "48002-0" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA6684-0 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA6684-0" ] ; fhir:display [ fhir:v "Somatic" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"^^xsd:anyURI ] ; fhir:code [ fhir:v "molecular-consequence" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://www.sequenceontology.org/"^^xsd:anyURI ] ; fhir:code [ fhir:v "SO:0001583" ] ; fhir:display [ fhir:v "missense_variant" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:51958-7 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "51958-7" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://www.ncbi.nlm.nih.gov/refseq"^^xsd:anyURI ] ; fhir:code [ fhir:v "NM_004656" ] ; fhir:display [ fhir:v "NM_004656" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:48004-6 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "48004-6" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://varnomen.hgvs.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "NM_001307940.2:c.430C>T" ] ; fhir:display [ fhir:v "NM_001307940.2:c.430C>T" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:48005-3 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "48005-3" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://varnomen.hgvs.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "NP_001294869.1:p.(Pro144Ser)" ] ; fhir:display [ fhir:v "NP_001294869.1:p.(Pro144Ser)" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:81258-6 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "81258-6" ] ] ) ] ; fhir:value [ a fhir:Quantity ; fhir:value [ fhir:v "78.6"^^xsd:decimal ] ; fhir:unit [ fhir:v "%" ] ; fhir:system [ fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "%" ] ] ] [ fhir:code [ ( fhir:coding [ a loinc:62374-4 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "62374-4" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA14029-5 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA14029-5" ] ; fhir:display [ fhir:v "GRCh37" ] ] ) ] ] ) . # <http://example.org/fhir/Observation/gx-genomic-variant-somatic-polrmt> a fhir:Observation ; fhir:id [ fhir:v "gx-genomic-variant-somatic-polrmt"] ; # fhir:meta [ ( fhir:profile [ fhir:v "http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-genomic-variant"^^xsd:anyURI ; fhir:link <http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-genomic-variant> ] ) ] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_gx-genomic-variant-somatic-polrmt\"> </a><p><b>Generated Narrative: Observation</b><a name=\"gx-genomic-variant-somatic-polrmt\"> </a><a name=\"hcgx-genomic-variant-somatic-polrmt\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "gx-genomic-variant-somatic-polrmt" </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-mcode-genomic-variant.html\">Genomic Variant Profile</a></p></div><p><b>status</b>: final</p><p><b>category</b>: Laboratory <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-observation-category.html\">Observation Category Codes</a>#laboratory)</span></p><p><b>code</b>: Genetic var assess <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#69548-6)</span></p><p><b>subject</b>: See on this page: Patient/gx-cancer-patient-adam-anyperson</p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href=\"Practitioner-us-core-practitioner-owen-oncologist.html\">Practitioner/us-core-practitioner-owen-oncologist</a> " ONCOLOGIST"</p><p><b>value</b>: Present <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#LA9633-4)</span></p><p><b>method</b>: Sequencing <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#LA26398-0)</span></p><blockquote><p><b>component</b></p><p><b>code</b>: Gene studied ID <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#48018-6)</span></p><p><b>value</b>: POLRMT <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (gene#5442)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Genomic source class <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#48002-0)</span></p><p><b>value</b>: Somatic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#LA6684-0)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Molecular Consequence <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/uv/genomics-reporting/STU2/CodeSystem-tbd-codes-cs.html\">To Be Determined Codes</a>#molecular-consequence)</span></p><p><b>value</b>: missense_variant <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#SO:0001583)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Transcript ref sequence ID <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#51958-7)</span></p><p><b>value</b>: NM_005035 <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-v3-refSeq.html\">Gene Reference Sequence Collection</a>#NM_004656)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: DNA change <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#48004-6)</span></p><p><b>value</b>: NM_005035.4:c.598G>A <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-v3-hgvs.html\">Human Genome Variation Society nomenclature</a>#NM_005035.4:c.598G>A)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Amino acid change <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#48005-3)</span></p><p><b>value</b>: NP_005026.3:p.(Gly200Arg) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-v3-hgvs.html\">Human Genome Variation Society nomenclature</a>#NP_005026.3:p.(Gly200Arg))</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Sample VAF <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#81258-6)</span></p><p><b>value</b>: 75.6 %<span style=\"background: LightGoldenRodYellow\"> (Details: UCUM code % = '%')</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Human ref seq assembly+build <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#62374-4)</span></p><p><b>value</b>: GRCh37 <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#LA14029-5)</span></p></blockquote></div>" ] ; # fhir:status [ fhir:v "final"] ; # fhir:category ( [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/observation-category"^^xsd:anyURI ] ; fhir:code [ fhir:v "laboratory" ] ] ) ] ) ; # fhir:code [ ( fhir:coding [ a loinc:69548-6 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "69548-6" ] ] ) ] ; # fhir:subject [ fhir:reference [ fhir:v "Patient/gx-cancer-patient-adam-anyperson" ] ] ; # fhir:effective [ fhir:v "2019-04-01"^^xsd:date] ; # fhir:performer ( [ fhir:reference [ fhir:v "Practitioner/us-core-practitioner-owen-oncologist" ] ] ) ; # fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA9633-4 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA9633-4" ] ; fhir:display [ fhir:v "Present" ] ] ) ] ; # fhir:method [ ( fhir:coding [ a loinc:LA26398-0 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA26398-0" ] ; fhir:display [ fhir:v "Sequencing" ] ] ) ] ; # fhir:component ( [ fhir:code [ ( fhir:coding [ a loinc:48018-6 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "48018-6" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "https://www.ncbi.nlm.nih.gov/gene"^^xsd:anyURI ] ; fhir:code [ fhir:v "5442" ] ; fhir:display [ fhir:v "POLRMT" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:48002-0 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "48002-0" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA6684-0 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA6684-0" ] ; fhir:display [ fhir:v "Somatic" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"^^xsd:anyURI ] ; fhir:code [ fhir:v "molecular-consequence" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://www.sequenceontology.org/"^^xsd:anyURI ] ; fhir:code [ fhir:v "SO:0001583" ] ; fhir:display [ fhir:v "missense_variant" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:51958-7 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "51958-7" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://www.ncbi.nlm.nih.gov/refseq"^^xsd:anyURI ] ; fhir:code [ fhir:v "NM_004656" ] ; fhir:display [ fhir:v "NM_005035" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:48004-6 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "48004-6" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://varnomen.hgvs.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "NM_005035.4:c.598G>A" ] ; fhir:display [ fhir:v "NM_005035.4:c.598G>A" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:48005-3 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "48005-3" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://varnomen.hgvs.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "NP_005026.3:p.(Gly200Arg)" ] ; fhir:display [ fhir:v "NP_005026.3:p.(Gly200Arg)" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:81258-6 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "81258-6" ] ] ) ] ; fhir:value [ a fhir:Quantity ; fhir:value [ fhir:v "75.6"^^xsd:decimal ] ; fhir:unit [ fhir:v "%" ] ; fhir:system [ fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "%" ] ] ] [ fhir:code [ ( fhir:coding [ a loinc:62374-4 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "62374-4" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA14029-5 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA14029-5" ] ; fhir:display [ fhir:v "GRCh37" ] ] ) ] ] ) . # <http://example.org/fhir/Observation/gx-genomic-diagnostic-implication-bap1> a fhir:Observation ; fhir:id [ fhir:v "gx-genomic-diagnostic-implication-bap1"] ; # fhir:meta [ ( fhir:profile [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/diagnostic-implication"^^xsd:anyURI ; fhir:link <http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/diagnostic-implication> ] ) ] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_gx-genomic-diagnostic-implication-bap1\"> </a><p><b>Generated Narrative: Observation</b><a name=\"gx-genomic-diagnostic-implication-bap1\"> </a><a name=\"hcgx-genomic-diagnostic-implication-bap1\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "gx-genomic-diagnostic-implication-bap1" </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"http://hl7.org/fhir/uv/genomics-reporting/STU2/StructureDefinition-diagnostic-implication.html\">Diagnostic Implication</a></p></div><p><b>status</b>: final</p><p><b>category</b>: Laboratory <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-observation-category.html\">Observation Category Codes</a>#laboratory)</span></p><p><b>code</b>: Diagnostic Implication <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/uv/genomics-reporting/STU2/CodeSystem-tbd-codes-cs.html\">To Be Determined Codes</a>#diagnostic-implication)</span></p><p><b>subject</b>: See on this page: Patient/gx-cancer-patient-adam-anyperson</p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href=\"Practitioner-us-core-practitioner-owen-oncologist.html\">Practitioner/us-core-practitioner-owen-oncologist</a> " ONCOLOGIST"</p><p><b>derivedFrom</b>: See on this page: Observation/gx-genomic-variant-somatic-bap1-indel</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td>Functional Effect <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/uv/genomics-reporting/STU2/CodeSystem-tbd-codes-cs.html\">To Be Determined Codes</a>#functional-effect)</span></td><td>loss of function variant <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#SO:0002054)</span></td></tr></table></div>" ] ; # fhir:status [ fhir:v "final"] ; # fhir:category ( [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/observation-category"^^xsd:anyURI ] ; fhir:code [ fhir:v "laboratory" ] ] ) ] ) ; # fhir:code [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"^^xsd:anyURI ] ; fhir:code [ fhir:v "diagnostic-implication" ] ] ) ] ; # fhir:subject [ fhir:reference [ fhir:v "Patient/gx-cancer-patient-adam-anyperson" ] ] ; # fhir:effective [ fhir:v "2019-04-01"^^xsd:date] ; # fhir:performer ( [ fhir:reference [ fhir:v "Practitioner/us-core-practitioner-owen-oncologist" ] ] ) ; # fhir:derivedFrom ( [ fhir:reference [ fhir:v "Observation/gx-genomic-variant-somatic-bap1-indel" ] ] ) ; # fhir:component ( [ fhir:code [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"^^xsd:anyURI ] ; fhir:code [ fhir:v "functional-effect" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://www.sequenceontology.org/"^^xsd:anyURI ] ; fhir:code [ fhir:v "SO:0002054" ] ; fhir:display [ fhir:v "loss of function variant" ] ] ) ] ] ) . # <http://example.org/fhir/Observation/gx-genomic-diagnostic-implication-pof1b> a fhir:Observation ; fhir:id [ fhir:v "gx-genomic-diagnostic-implication-pof1b"] ; # fhir:meta [ ( fhir:profile [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/diagnostic-implication"^^xsd:anyURI ; fhir:link <http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/diagnostic-implication> ] ) ] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_gx-genomic-diagnostic-implication-pof1b\"> </a><p><b>Generated Narrative: Observation</b><a name=\"gx-genomic-diagnostic-implication-pof1b\"> </a><a name=\"hcgx-genomic-diagnostic-implication-pof1b\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "gx-genomic-diagnostic-implication-pof1b" </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"http://hl7.org/fhir/uv/genomics-reporting/STU2/StructureDefinition-diagnostic-implication.html\">Diagnostic Implication</a></p></div><p><b>status</b>: final</p><p><b>category</b>: Laboratory <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-observation-category.html\">Observation Category Codes</a>#laboratory)</span></p><p><b>code</b>: Diagnostic Implication <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/uv/genomics-reporting/STU2/CodeSystem-tbd-codes-cs.html\">To Be Determined Codes</a>#diagnostic-implication)</span></p><p><b>subject</b>: See on this page: Patient/gx-cancer-patient-adam-anyperson</p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href=\"Practitioner-us-core-practitioner-owen-oncologist.html\">Practitioner/us-core-practitioner-owen-oncologist</a> " ONCOLOGIST"</p><p><b>derivedFrom</b>: See on this page: Observation/gx-genomic-variant-somatic-pof1b</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td>Gene dis seq var interp-Imp <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#53037-8)</span></td><td>Uncertain significance <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#LA26333-7)</span></td></tr></table></div>" ] ; # fhir:status [ fhir:v "final"] ; # fhir:category ( [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/observation-category"^^xsd:anyURI ] ; fhir:code [ fhir:v "laboratory" ] ] ) ] ) ; # fhir:code [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"^^xsd:anyURI ] ; fhir:code [ fhir:v "diagnostic-implication" ] ] ) ] ; # fhir:subject [ fhir:reference [ fhir:v "Patient/gx-cancer-patient-adam-anyperson" ] ] ; # fhir:effective [ fhir:v "2019-04-01"^^xsd:date] ; # fhir:performer ( [ fhir:reference [ fhir:v "Practitioner/us-core-practitioner-owen-oncologist" ] ] ) ; # fhir:derivedFrom ( [ fhir:reference [ fhir:v "Observation/gx-genomic-variant-somatic-pof1b" ] ] ) ; # fhir:component ( [ fhir:code [ ( fhir:coding [ a loinc:53037-8 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "53037-8" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA26333-7 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA26333-7" ] ; fhir:display [ fhir:v "Uncertain significance" ] ] ) ] ] ) . # <http://example.org/fhir/Observation/gx-genomic-diagnostic-implication-polrmt> a fhir:Observation ; fhir:id [ fhir:v "gx-genomic-diagnostic-implication-polrmt"] ; # fhir:meta [ ( fhir:profile [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/diagnostic-implication"^^xsd:anyURI ; fhir:link <http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/diagnostic-implication> ] ) ] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_gx-genomic-diagnostic-implication-polrmt\"> </a><p><b>Generated Narrative: Observation</b><a name=\"gx-genomic-diagnostic-implication-polrmt\"> </a><a name=\"hcgx-genomic-diagnostic-implication-polrmt\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "gx-genomic-diagnostic-implication-polrmt" </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"http://hl7.org/fhir/uv/genomics-reporting/STU2/StructureDefinition-diagnostic-implication.html\">Diagnostic Implication</a></p></div><p><b>status</b>: final</p><p><b>category</b>: Laboratory <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-observation-category.html\">Observation Category Codes</a>#laboratory)</span></p><p><b>code</b>: Diagnostic Implication <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/uv/genomics-reporting/STU2/CodeSystem-tbd-codes-cs.html\">To Be Determined Codes</a>#diagnostic-implication)</span></p><p><b>subject</b>: See on this page: Patient/gx-cancer-patient-adam-anyperson</p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href=\"Practitioner-us-core-practitioner-owen-oncologist.html\">Practitioner/us-core-practitioner-owen-oncologist</a> " ONCOLOGIST"</p><p><b>derivedFrom</b>: See on this page: Observation/gx-genomic-variant-somatic-polrmt</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td>Gene dis seq var interp-Imp <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#53037-8)</span></td><td>Uncertain significance <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#LA26333-7)</span></td></tr></table></div>" ] ; # fhir:status [ fhir:v "final"] ; # fhir:category ( [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/observation-category"^^xsd:anyURI ] ; fhir:code [ fhir:v "laboratory" ] ] ) ] ) ; # fhir:code [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"^^xsd:anyURI ] ; fhir:code [ fhir:v "diagnostic-implication" ] ] ) ] ; # fhir:subject [ fhir:reference [ fhir:v "Patient/gx-cancer-patient-adam-anyperson" ] ] ; # fhir:effective [ fhir:v "2019-04-01"^^xsd:date] ; # fhir:performer ( [ fhir:reference [ fhir:v "Practitioner/us-core-practitioner-owen-oncologist" ] ] ) ; # fhir:derivedFrom ( [ fhir:reference [ fhir:v "Observation/gx-genomic-variant-somatic-polrmt" ] ] ) ; # fhir:component ( [ fhir:code [ ( fhir:coding [ a loinc:53037-8 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "53037-8" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA26333-7 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA26333-7" ] ; fhir:display [ fhir:v "Uncertain significance" ] ] ) ] ] ) . # <http://example.org/fhir/Observation/gx-genomic-variant-fusion-met-alk> a fhir:Observation ; fhir:id [ fhir:v "gx-genomic-variant-fusion-met-alk"] ; # fhir:meta [ ( fhir:profile [ fhir:v "http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-genomic-variant"^^xsd:anyURI ; fhir:link <http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-genomic-variant> ] ) ] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_gx-genomic-variant-fusion-met-alk\"> </a><p><b>Generated Narrative: Observation</b><a name=\"gx-genomic-variant-fusion-met-alk\"> </a><a name=\"hcgx-genomic-variant-fusion-met-alk\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "gx-genomic-variant-fusion-met-alk" </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-mcode-genomic-variant.html\">Genomic Variant Profile</a></p></div><p><b>status</b>: final</p><p><b>category</b>: Laboratory <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-observation-category.html\">Observation Category Codes</a>#laboratory)</span></p><p><b>code</b>: Genetic var assess <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#69548-6)</span></p><p><b>subject</b>: See on this page: Patient/gx-cancer-patient-adam-anyperson</p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href=\"Practitioner-us-core-practitioner-owen-oncologist.html\">Practitioner/us-core-practitioner-owen-oncologist</a> " ONCOLOGIST"</p><p><b>value</b>: Present <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#LA9633-4)</span></p><p><b>method</b>: Sequencing <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#LA26398-0)</span></p><blockquote><p><b>component</b></p><p><b>code</b>: Gene studied ID <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#48018-6)</span></p><p><b>value</b>: MET <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-v3-hgnc.html\">HUGO Gene Nomenclature Committee Genes</a>#HGNC:7029; gene#4233)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Gene studied ID <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#48018-6)</span></p><p><b>value</b>: ALK <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-v3-hgnc.html\">HUGO Gene Nomenclature Committee Genes</a>#HGNC:427; gene#238)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: DNA Change Type <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#48019-4)</span></p><p><b>value</b>: complex chromosomal rearrangement <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#SO:0002062)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Genomic source class <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#48002-0)</span></p><p><b>value</b>: Somatic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#LA6684-0)</span></p></blockquote></div>" ] ; # fhir:status [ fhir:v "final"] ; # fhir:category ( [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/observation-category"^^xsd:anyURI ] ; fhir:code [ fhir:v "laboratory" ] ] ) ] ) ; # fhir:code [ ( fhir:coding [ a loinc:69548-6 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "69548-6" ] ] ) ] ; # fhir:subject [ fhir:reference [ fhir:v "Patient/gx-cancer-patient-adam-anyperson" ] ] ; # fhir:effective [ fhir:v "2019-04-01"^^xsd:date] ; # fhir:performer ( [ fhir:reference [ fhir:v "Practitioner/us-core-practitioner-owen-oncologist" ] ] ) ; # fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA9633-4 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA9633-4" ] ; fhir:display [ fhir:v "Present" ] ] ) ] ; # fhir:method [ ( fhir:coding [ a loinc:LA26398-0 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA26398-0" ] ; fhir:display [ fhir:v "Sequencing" ] ] ) ] ; # fhir:component ( [ fhir:code [ ( fhir:coding [ a loinc:48018-6 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "48018-6" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://www.genenames.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "HGNC:7029" ] ; fhir:display [ fhir:v "MET" ] ] [ fhir:system [ fhir:v "https://www.ncbi.nlm.nih.gov/gene"^^xsd:anyURI ] ; fhir:code [ fhir:v "4233" ] ; fhir:display [ fhir:v "MET" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:48018-6 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "48018-6" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://www.genenames.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "HGNC:427" ] ; fhir:display [ fhir:v "ALK" ] ] [ fhir:system [ fhir:v "https://www.ncbi.nlm.nih.gov/gene"^^xsd:anyURI ] ; fhir:code [ fhir:v "238" ] ; fhir:display [ fhir:v "ALK" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:48019-4 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "48019-4" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://www.sequenceontology.org/"^^xsd:anyURI ] ; fhir:code [ fhir:v "SO:0002062" ] ; fhir:display [ fhir:v "complex chromosomal rearrangement" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:48002-0 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "48002-0" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA6684-0 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA6684-0" ] ; fhir:display [ fhir:v "Somatic" ] ] ) ] ] ) . # <http://example.org/fhir/Observation/gx-genomic-variant-pertinent-negative-nras-kit-braf> a fhir:Observation ; fhir:id [ fhir:v "gx-genomic-variant-pertinent-negative-nras-kit-braf"] ; # fhir:meta [ ( fhir:profile [ fhir:v "http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-genomic-variant"^^xsd:anyURI ; fhir:link <http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-genomic-variant> ] ) ] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_gx-genomic-variant-pertinent-negative-nras-kit-braf\"> </a><p><b>Generated Narrative: Observation</b><a name=\"gx-genomic-variant-pertinent-negative-nras-kit-braf\"> </a><a name=\"hcgx-genomic-variant-pertinent-negative-nras-kit-braf\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "gx-genomic-variant-pertinent-negative-nras-kit-braf" </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-mcode-genomic-variant.html\">Genomic Variant Profile</a></p></div><p><b>status</b>: final</p><p><b>category</b>: Laboratory <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-observation-category.html\">Observation Category Codes</a>#laboratory)</span></p><p><b>code</b>: Genetic var assess <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#69548-6)</span></p><p><b>subject</b>: See on this page: Patient/gx-cancer-patient-adam-anyperson</p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href=\"Practitioner-us-core-practitioner-owen-oncologist.html\">Practitioner/us-core-practitioner-owen-oncologist</a> " ONCOLOGIST"</p><p><b>value</b>: Absent <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#LA9634-2)</span></p><p><b>method</b>: Sequencing <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#LA26398-0)</span></p><blockquote><p><b>component</b></p><p><b>code</b>: Gene studied ID <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#48018-6)</span></p><p><b>value</b>: NRAS <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-v3-hgnc.html\">HUGO Gene Nomenclature Committee Genes</a>#HGNC:6342)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Gene studied ID <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#48018-6)</span></p><p><b>value</b>: KIT <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-v3-hgnc.html\">HUGO Gene Nomenclature Committee Genes</a>#HGNC:7989)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Gene studied ID <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#48018-6)</span></p><p><b>value</b>: BRAF <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-v3-hgnc.html\">HUGO Gene Nomenclature Committee Genes</a>#HGNC:1097)</span></p></blockquote></div>" ] ; # fhir:status [ fhir:v "final"] ; # fhir:category ( [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/observation-category"^^xsd:anyURI ] ; fhir:code [ fhir:v "laboratory" ] ] ) ] ) ; # fhir:code [ ( fhir:coding [ a loinc:69548-6 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "69548-6" ] ] ) ] ; # fhir:subject [ fhir:reference [ fhir:v "Patient/gx-cancer-patient-adam-anyperson" ] ] ; # fhir:effective [ fhir:v "2019-04-01"^^xsd:date] ; # fhir:performer ( [ fhir:reference [ fhir:v "Practitioner/us-core-practitioner-owen-oncologist" ] ] ) ; # fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA9634-2 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA9634-2" ] ; fhir:display [ fhir:v "Absent" ] ] ) ] ; # fhir:method [ ( fhir:coding [ a loinc:LA26398-0 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA26398-0" ] ; fhir:display [ fhir:v "Sequencing" ] ] ) ] ; # fhir:component ( [ fhir:code [ ( fhir:coding [ a loinc:48018-6 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "48018-6" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://www.genenames.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "HGNC:6342" ] ; fhir:display [ fhir:v "NRAS" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:48018-6 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "48018-6" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://www.genenames.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "HGNC:7989" ] ; fhir:display [ fhir:v "KIT" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:48018-6 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "48018-6" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://www.genenames.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "HGNC:1097" ] ; fhir:display [ fhir:v "BRAF" ] ] ) ] ] ) . # <http://example.org/fhir/Observation/gx-genomic-tmb> a fhir:Observation ; fhir:id [ fhir:v "gx-genomic-tmb"] ; # fhir:meta [ ( fhir:profile [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/tmb"^^xsd:anyURI ; fhir:link <http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/tmb> ] ) ] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_gx-genomic-tmb\"> </a><p><b>Generated Narrative: Observation</b><a name=\"gx-genomic-tmb\"> </a><a name=\"hcgx-genomic-tmb\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "gx-genomic-tmb" </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"http://hl7.org/fhir/uv/genomics-reporting/STU2/StructureDefinition-tmb.html\">Tumor Mutation Burden</a></p></div><p><b>status</b>: final</p><p><b>category</b>: Laboratory <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-observation-category.html\">Observation Category Codes</a>#laboratory)</span></p><p><b>code</b>: Muts/Mb Tumor <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#94076-7)</span></p><p><b>subject</b>: See on this page: Patient/gx-cancer-patient-adam-anyperson</p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href=\"Practitioner-us-core-practitioner-owen-oncologist.html\">Practitioner/us-core-practitioner-owen-oncologist</a> " ONCOLOGIST"</p><p><b>value</b>: 57.1 1/1000000{Base}<span style=\"background: LightGoldenRodYellow\"> (Details: UCUM code 1/1000000{Base} = '1/1000000{Base}')</span></p></div>" ] ; # fhir:status [ fhir:v "final"] ; # fhir:category ( [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/observation-category"^^xsd:anyURI ] ; fhir:code [ fhir:v "laboratory" ] ] ) ] ) ; # fhir:code [ ( fhir:coding [ a loinc:94076-7 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "94076-7" ] ] ) ] ; # fhir:subject [ fhir:reference [ fhir:v "Patient/gx-cancer-patient-adam-anyperson" ] ] ; # fhir:effective [ fhir:v "2019-04-01"^^xsd:date] ; # fhir:performer ( [ fhir:reference [ fhir:v "Practitioner/us-core-practitioner-owen-oncologist" ] ] ) ; # fhir:value [ a fhir:Quantity ; fhir:value [ fhir:v "57.1"^^xsd:decimal ] ; fhir:system [ fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "1/1000000{Base}" ] ] . # <http://example.org/fhir/Observation/gx-genomic-therapeutic-implication-alectinib> a fhir:Observation ; fhir:id [ fhir:v "gx-genomic-therapeutic-implication-alectinib"] ; # fhir:meta [ ( fhir:profile [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication"^^xsd:anyURI ; fhir:link <http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication> ] ) ] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_gx-genomic-therapeutic-implication-alectinib\"> </a><p><b>Generated Narrative: Observation</b><a name=\"gx-genomic-therapeutic-implication-alectinib\"> </a><a name=\"hcgx-genomic-therapeutic-implication-alectinib\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "gx-genomic-therapeutic-implication-alectinib" </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"http://hl7.org/fhir/uv/genomics-reporting/STU2/StructureDefinition-therapeutic-implication.html\">Therapeutic Implication</a></p></div><p><b>status</b>: final</p><p><b>category</b>: Laboratory <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-observation-category.html\">Observation Category Codes</a>#laboratory)</span></p><p><b>code</b>: Therapeutic Implication <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/uv/genomics-reporting/STU2/CodeSystem-tbd-codes-cs.html\">To Be Determined Codes</a>#therapeutic-implication)</span></p><p><b>subject</b>: See on this page: Patient/gx-cancer-patient-adam-anyperson</p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href=\"Practitioner-us-core-practitioner-owen-oncologist.html\">Practitioner/us-core-practitioner-owen-oncologist</a> " ONCOLOGIST"</p><p><b>derivedFrom</b>: See on this page: Observation/gx-genomic-variant-fusion-met-alk</p><blockquote><p><b>component</b></p><p><b>code</b>: Medication assessed <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#51963-7)</span></p><p><b>value</b>: alectinib <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-v3-rxNorm.html\">RxNorm</a>#1727455)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Predicted Therapeutic Implication <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/uv/genomics-reporting/STU2/CodeSystem-tbd-codes-cs.html\">To Be Determined Codes</a>#predicted-therapeutic-implication)</span></p><p><b>value</b>: Presumed responsive <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#LA9661-5)</span></p></blockquote></div>" ] ; # fhir:status [ fhir:v "final"] ; # fhir:category ( [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/observation-category"^^xsd:anyURI ] ; fhir:code [ fhir:v "laboratory" ] ] ) ] ) ; # fhir:code [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"^^xsd:anyURI ] ; fhir:code [ fhir:v "therapeutic-implication" ] ] ) ] ; # fhir:subject [ fhir:reference [ fhir:v "Patient/gx-cancer-patient-adam-anyperson" ] ] ; # fhir:effective [ fhir:v "2019-04-01"^^xsd:date] ; # fhir:performer ( [ fhir:reference [ fhir:v "Practitioner/us-core-practitioner-owen-oncologist" ] ] ) ; # fhir:derivedFrom ( [ fhir:reference [ fhir:v "Observation/gx-genomic-variant-fusion-met-alk" ] ] ) ; # fhir:component ( [ fhir:code [ ( fhir:coding [ a loinc:51963-7 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "51963-7" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://www.nlm.nih.gov/research/umls/rxnorm"^^xsd:anyURI ] ; fhir:code [ fhir:v "1727455" ] ; fhir:display [ fhir:v "alectinib" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"^^xsd:anyURI ] ; fhir:code [ fhir:v "predicted-therapeutic-implication" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA9661-5 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA9661-5" ] ; fhir:display [ fhir:v "Presumed responsive" ] ] ) ] ] ) . # <http://example.org/fhir/Observation/gx-genomic-therapeutic-implication-brigatinib> a fhir:Observation ; fhir:id [ fhir:v "gx-genomic-therapeutic-implication-brigatinib"] ; # fhir:meta [ ( fhir:profile [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication"^^xsd:anyURI ; fhir:link <http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication> ] ) ] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_gx-genomic-therapeutic-implication-brigatinib\"> </a><p><b>Generated Narrative: Observation</b><a name=\"gx-genomic-therapeutic-implication-brigatinib\"> </a><a name=\"hcgx-genomic-therapeutic-implication-brigatinib\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "gx-genomic-therapeutic-implication-brigatinib" </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"http://hl7.org/fhir/uv/genomics-reporting/STU2/StructureDefinition-therapeutic-implication.html\">Therapeutic Implication</a></p></div><p><b>status</b>: final</p><p><b>category</b>: Laboratory <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-observation-category.html\">Observation Category Codes</a>#laboratory)</span></p><p><b>code</b>: Therapeutic Implication <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/uv/genomics-reporting/STU2/CodeSystem-tbd-codes-cs.html\">To Be Determined Codes</a>#therapeutic-implication)</span></p><p><b>subject</b>: See on this page: Patient/gx-cancer-patient-adam-anyperson</p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href=\"Practitioner-us-core-practitioner-owen-oncologist.html\">Practitioner/us-core-practitioner-owen-oncologist</a> " ONCOLOGIST"</p><p><b>derivedFrom</b>: See on this page: Observation/gx-genomic-variant-fusion-met-alk</p><blockquote><p><b>component</b></p><p><b>code</b>: Medication assessed <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#51963-7)</span></p><p><b>value</b>: brigatinib <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-v3-rxNorm.html\">RxNorm</a>#1921217)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Predicted Therapeutic Implication <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/uv/genomics-reporting/STU2/CodeSystem-tbd-codes-cs.html\">To Be Determined Codes</a>#predicted-therapeutic-implication)</span></p><p><b>value</b>: Presumed responsive <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#LA9661-5)</span></p></blockquote></div>" ] ; # fhir:status [ fhir:v "final"] ; # fhir:category ( [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/observation-category"^^xsd:anyURI ] ; fhir:code [ fhir:v "laboratory" ] ] ) ] ) ; # fhir:code [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"^^xsd:anyURI ] ; fhir:code [ fhir:v "therapeutic-implication" ] ] ) ] ; # fhir:subject [ fhir:reference [ fhir:v "Patient/gx-cancer-patient-adam-anyperson" ] ] ; # fhir:effective [ fhir:v "2019-04-01"^^xsd:date] ; # fhir:performer ( [ fhir:reference [ fhir:v "Practitioner/us-core-practitioner-owen-oncologist" ] ] ) ; # fhir:derivedFrom ( [ fhir:reference [ fhir:v "Observation/gx-genomic-variant-fusion-met-alk" ] ] ) ; # fhir:component ( [ fhir:code [ ( fhir:coding [ a loinc:51963-7 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "51963-7" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://www.nlm.nih.gov/research/umls/rxnorm"^^xsd:anyURI ] ; fhir:code [ fhir:v "1921217" ] ; fhir:display [ fhir:v "brigatinib" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"^^xsd:anyURI ] ; fhir:code [ fhir:v "predicted-therapeutic-implication" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA9661-5 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA9661-5" ] ; fhir:display [ fhir:v "Presumed responsive" ] ] ) ] ] ) . # <http://example.org/fhir/Observation/gx-genomic-therapeutic-implication-ceritinib> a fhir:Observation ; fhir:id [ fhir:v "gx-genomic-therapeutic-implication-ceritinib"] ; # fhir:meta [ ( fhir:profile [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication"^^xsd:anyURI ; fhir:link <http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication> ] ) ] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_gx-genomic-therapeutic-implication-ceritinib\"> </a><p><b>Generated Narrative: Observation</b><a name=\"gx-genomic-therapeutic-implication-ceritinib\"> </a><a name=\"hcgx-genomic-therapeutic-implication-ceritinib\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "gx-genomic-therapeutic-implication-ceritinib" </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"http://hl7.org/fhir/uv/genomics-reporting/STU2/StructureDefinition-therapeutic-implication.html\">Therapeutic Implication</a></p></div><p><b>status</b>: final</p><p><b>category</b>: Laboratory <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-observation-category.html\">Observation Category Codes</a>#laboratory)</span></p><p><b>code</b>: Therapeutic Implication <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/uv/genomics-reporting/STU2/CodeSystem-tbd-codes-cs.html\">To Be Determined Codes</a>#therapeutic-implication)</span></p><p><b>subject</b>: See on this page: Patient/gx-cancer-patient-adam-anyperson</p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href=\"Practitioner-us-core-practitioner-owen-oncologist.html\">Practitioner/us-core-practitioner-owen-oncologist</a> " ONCOLOGIST"</p><p><b>derivedFrom</b>: See on this page: Observation/gx-genomic-variant-fusion-met-alk</p><blockquote><p><b>component</b></p><p><b>code</b>: Medication assessed <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#51963-7)</span></p><p><b>value</b>: ceritinib <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-v3-rxNorm.html\">RxNorm</a>#1535457)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Predicted Therapeutic Implication <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/uv/genomics-reporting/STU2/CodeSystem-tbd-codes-cs.html\">To Be Determined Codes</a>#predicted-therapeutic-implication)</span></p><p><b>value</b>: Presumed responsive <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#LA9661-5)</span></p></blockquote></div>" ] ; # fhir:status [ fhir:v "final"] ; # fhir:category ( [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/observation-category"^^xsd:anyURI ] ; fhir:code [ fhir:v "laboratory" ] ] ) ] ) ; # fhir:code [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"^^xsd:anyURI ] ; fhir:code [ fhir:v "therapeutic-implication" ] ] ) ] ; # fhir:subject [ fhir:reference [ fhir:v "Patient/gx-cancer-patient-adam-anyperson" ] ] ; # fhir:effective [ fhir:v "2019-04-01"^^xsd:date] ; # fhir:performer ( [ fhir:reference [ fhir:v "Practitioner/us-core-practitioner-owen-oncologist" ] ] ) ; # fhir:derivedFrom ( [ fhir:reference [ fhir:v "Observation/gx-genomic-variant-fusion-met-alk" ] ] ) ; # fhir:component ( [ fhir:code [ ( fhir:coding [ a loinc:51963-7 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "51963-7" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://www.nlm.nih.gov/research/umls/rxnorm"^^xsd:anyURI ] ; fhir:code [ fhir:v "1535457" ] ; fhir:display [ fhir:v "ceritinib" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"^^xsd:anyURI ] ; fhir:code [ fhir:v "predicted-therapeutic-implication" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA9661-5 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA9661-5" ] ; fhir:display [ fhir:v "Presumed responsive" ] ] ) ] ] ) . # <http://example.org/fhir/Observation/gx-genomic-therapeutic-implication-crizotinib> a fhir:Observation ; fhir:id [ fhir:v "gx-genomic-therapeutic-implication-crizotinib"] ; # fhir:meta [ ( fhir:profile [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication"^^xsd:anyURI ; fhir:link <http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication> ] ) ] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_gx-genomic-therapeutic-implication-crizotinib\"> </a><p><b>Generated Narrative: Observation</b><a name=\"gx-genomic-therapeutic-implication-crizotinib\"> </a><a name=\"hcgx-genomic-therapeutic-implication-crizotinib\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "gx-genomic-therapeutic-implication-crizotinib" </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"http://hl7.org/fhir/uv/genomics-reporting/STU2/StructureDefinition-therapeutic-implication.html\">Therapeutic Implication</a></p></div><p><b>status</b>: final</p><p><b>category</b>: Laboratory <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-observation-category.html\">Observation Category Codes</a>#laboratory)</span></p><p><b>code</b>: Therapeutic Implication <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/uv/genomics-reporting/STU2/CodeSystem-tbd-codes-cs.html\">To Be Determined Codes</a>#therapeutic-implication)</span></p><p><b>subject</b>: See on this page: Patient/gx-cancer-patient-adam-anyperson</p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href=\"Practitioner-us-core-practitioner-owen-oncologist.html\">Practitioner/us-core-practitioner-owen-oncologist</a> " ONCOLOGIST"</p><p><b>derivedFrom</b>: See on this page: Observation/gx-genomic-variant-fusion-met-alk</p><blockquote><p><b>component</b></p><p><b>code</b>: Medication assessed <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#51963-7)</span></p><p><b>value</b>: crizotinib <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-v3-rxNorm.html\">RxNorm</a>#1148495)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Predicted Therapeutic Implication <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/uv/genomics-reporting/STU2/CodeSystem-tbd-codes-cs.html\">To Be Determined Codes</a>#predicted-therapeutic-implication)</span></p><p><b>value</b>: Presumed responsive <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#LA9661-5)</span></p></blockquote></div>" ] ; # fhir:status [ fhir:v "final"] ; # fhir:category ( [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/observation-category"^^xsd:anyURI ] ; fhir:code [ fhir:v "laboratory" ] ] ) ] ) ; # fhir:code [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"^^xsd:anyURI ] ; fhir:code [ fhir:v "therapeutic-implication" ] ] ) ] ; # fhir:subject [ fhir:reference [ fhir:v "Patient/gx-cancer-patient-adam-anyperson" ] ] ; # fhir:effective [ fhir:v "2019-04-01"^^xsd:date] ; # fhir:performer ( [ fhir:reference [ fhir:v "Practitioner/us-core-practitioner-owen-oncologist" ] ] ) ; # fhir:derivedFrom ( [ fhir:reference [ fhir:v "Observation/gx-genomic-variant-fusion-met-alk" ] ] ) ; # fhir:component ( [ fhir:code [ ( fhir:coding [ a loinc:51963-7 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "51963-7" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://www.nlm.nih.gov/research/umls/rxnorm"^^xsd:anyURI ] ; fhir:code [ fhir:v "1148495" ] ; fhir:display [ fhir:v "crizotinib" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"^^xsd:anyURI ] ; fhir:code [ fhir:v "predicted-therapeutic-implication" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA9661-5 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA9661-5" ] ; fhir:display [ fhir:v "Presumed responsive" ] ] ) ] ] ) . # <http://example.org/fhir/Observation/gx-genomic-therapeutic-implication-lorlatinib> a fhir:Observation ; fhir:id [ fhir:v "gx-genomic-therapeutic-implication-lorlatinib"] ; # fhir:meta [ ( fhir:profile [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication"^^xsd:anyURI ; fhir:link <http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication> ] ) ] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_gx-genomic-therapeutic-implication-lorlatinib\"> </a><p><b>Generated Narrative: Observation</b><a name=\"gx-genomic-therapeutic-implication-lorlatinib\"> </a><a name=\"hcgx-genomic-therapeutic-implication-lorlatinib\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "gx-genomic-therapeutic-implication-lorlatinib" </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"http://hl7.org/fhir/uv/genomics-reporting/STU2/StructureDefinition-therapeutic-implication.html\">Therapeutic Implication</a></p></div><p><b>status</b>: final</p><p><b>category</b>: Laboratory <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-observation-category.html\">Observation Category Codes</a>#laboratory)</span></p><p><b>code</b>: Therapeutic Implication <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/uv/genomics-reporting/STU2/CodeSystem-tbd-codes-cs.html\">To Be Determined Codes</a>#therapeutic-implication)</span></p><p><b>subject</b>: See on this page: Patient/gx-cancer-patient-adam-anyperson</p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href=\"Practitioner-us-core-practitioner-owen-oncologist.html\">Practitioner/us-core-practitioner-owen-oncologist</a> " ONCOLOGIST"</p><p><b>derivedFrom</b>: See on this page: Observation/gx-genomic-variant-fusion-met-alk</p><blockquote><p><b>component</b></p><p><b>code</b>: Medication assessed <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#51963-7)</span></p><p><b>value</b>: lorlatinib <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-v3-rxNorm.html\">RxNorm</a>#2103164)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Predicted Therapeutic Implication <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/uv/genomics-reporting/STU2/CodeSystem-tbd-codes-cs.html\">To Be Determined Codes</a>#predicted-therapeutic-implication)</span></p><p><b>value</b>: Presumed responsive <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#LA9661-5)</span></p></blockquote></div>" ] ; # fhir:status [ fhir:v "final"] ; # fhir:category ( [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/observation-category"^^xsd:anyURI ] ; fhir:code [ fhir:v "laboratory" ] ] ) ] ) ; # fhir:code [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"^^xsd:anyURI ] ; fhir:code [ fhir:v "therapeutic-implication" ] ] ) ] ; # fhir:subject [ fhir:reference [ fhir:v "Patient/gx-cancer-patient-adam-anyperson" ] ] ; # fhir:effective [ fhir:v "2019-04-01"^^xsd:date] ; # fhir:performer ( [ fhir:reference [ fhir:v "Practitioner/us-core-practitioner-owen-oncologist" ] ] ) ; # fhir:derivedFrom ( [ fhir:reference [ fhir:v "Observation/gx-genomic-variant-fusion-met-alk" ] ] ) ; # fhir:component ( [ fhir:code [ ( fhir:coding [ a loinc:51963-7 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "51963-7" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://www.nlm.nih.gov/research/umls/rxnorm"^^xsd:anyURI ] ; fhir:code [ fhir:v "2103164" ] ; fhir:display [ fhir:v "lorlatinib" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"^^xsd:anyURI ] ; fhir:code [ fhir:v "predicted-therapeutic-implication" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA9661-5 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA9661-5" ] ; fhir:display [ fhir:v "Presumed responsive" ] ] ) ] ] ) . #
IG © 2019+ HL7 International / Clinical Interoperability Council. Package hl7.fhir.us.mcode#4.0.0-ballot based on FHIR 4.0.1. Generated 2024-04-10
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