library "KawasakiDisease" version '0.0.0' using FHIR version '4.0.0' include "FHIRHelpers" version '4.0.0' called FHIRHelpers codesystem "ICD-10-CM": 'http://hl7.org/fhir/sid/icd-10-cm' codesystem "CVX": 'http://hl7.org/fhir/sid/cvx' codesystem "RxNorm": 'http://www.nlm.nih.gov/research/umls/rxnorm' codesystem "NDC": 'http://hl7.org/fhir/sid/ndc' codesystem "CPT": 'http://www.ama-assn.org/go/cpt' codesystem "SNOMED": 'http://snomed.info/sct' define "Covid Vaccine Drug Exposure": Concept { Code '207' from "CVX", Code '208' from "CVX", Code '210' from "CVX", Code '212' from "CVX", Code '213' from "CVX", Code '213' from "CVX", Code '2470234' from "RxNorm", Code '2468235' from "RxNorm", Code '59267100003' from "NDC", Code '59267100002' from "NDC", Code '80777027310' from "NDC", Code '80777027399' from "NDC", Code '59676058005' from "NDC", Code '00310122210' from "NDC", Code '59676058015' from "NDC", Code '59267100001' from "NDC" } define "Covid Vaccine Procedure": Concept { Code '0002A' from "CPT", Code '0001A' from "CPT", Code '91300' from "CPT", Code '0012A' from "CPT", Code '0011A' from "CPT", Code '90301' from "CPT", Code '0022A' from "CPT", Code '0021A' from "CPT", Code '91302' from "CPT" } define "KawasakiDisease": Concept{ Code 'M30.3' from "ICD-10-CM", Code '75053002' from"SNOMED" } context Patient define "KawasakiCondition": ConditionLookBack([Condition: "KawasakiDisease"], 365 days) define "CovidImmunization": [Immunization: "Covid Vaccine Drug Exposure"] define "CovidProcedure": [Procedure: "Covid Vaccine Procedure"] define "MostRecentCovidI": MostRecentImmunizationDT("CovidImmunization") define "MostRecentCovidP": MostRecentProcedureDT("CovidProcedure") define "LastCovidInstanceDT": case when not exists("MostRecentCovidI") then "MostRecentCovidP" when not exists("MostRecentCovidP") then "MostRecentCovidI" when "MostRecentCovidI" after "MostRecentCovidP" then "MostRecentCovidI" else "MostRecentCovidP" end define "RiskPeriod": Interval[ Last("LastCovidInstanceDT") + 1 day, Last("LastCovidInstanceDT") + 28 days] define "CleanPeriod": Interval[ Last("LastCovidInstanceDT") - 365 days, Last("LastCovidInstanceDT")] define "KawasakiinRiskPeriod": "KawasakiCondition" cond where (cond.onset as FHIR.dateTime).value in "RiskPeriod" or PeriodToInterval(cond.onset as FHIR.Period) overlaps "RiskPeriod" define "KawasakiinCleanPeriod": "KawasakiCondition" cond where (cond.onset as FHIR.dateTime).value in "CleanPeriod" or PeriodToInterval(cond.onset as FHIR.Period) overlaps "CleanPeriod" define "InPopulation": exists(KawasakiinRiskPeriod) and not exists(KawasakiinCleanPeriod) define function MostRecentImmunizationDT(ImmunizationList List): from ImmunizationList I let result: Last(ImmunizationList I sort by (occurrence as FHIR.dateTime).value) return (result.occurrence as FHIR.dateTime).value define function MostRecentProcedureDT(ProcedureList List): from ProcedureList P let result:Last(ProcedureList P sort by (performed as FHIR.dateTime).value) return (result.performed as FHIR.dateTime).value define function ConditionLookBack(CondList List, LookBack System.Quantity): CondList C let LookBackInterval: Interval[Now() - LookBack, Now()] where ((C.onset as FHIR.dateTime).value in LookBackInterval or PeriodToInterval(C.onset as FHIR.Period) overlaps LookBackInterval) and Last(C.verificationStatus.coding.code.value) = 'confirmed' define function PeriodToInterval(period FHIR.Period): if period is null then null else Interval[period."start".value, period."end".value]