| Version 5.0.1 | Current Build | Difference | Union | Intersection | Notes | 
| CodeSystems | 
| US Core CarePlan Category Extension Codes | US Core CarePlan Category Extension Codes | Comparison | Union | Intersection | 1 Breaking Change, 0 Changes, 3 Notes | 
| US Core Condition Category Extension Codes | US Core Condition Category Extension Codes | Comparison | Union | Intersection | 1 Breaking Change, 0 Changes, 5 Notes | 
|  | US Core Category | Added |  | 
| US Core DocumentReferences Category Codes | US Core DocumentReferences Category Codes | Comparison | Union | Intersection | 1 Breaking Change, 0 Changes, 2 Notes | 
| US Core Observation Category Extension Codes |  | Removed |  | 
| US Core Provenance Participant Type Extension Codes | US Core Provenance Participant Type Extension Codes | Comparison | Union | Intersection | 1 Breaking Change, 0 Changes, 3 Notes | 
| US Core Tags CodeSystem |  | Removed |  | 
| ValueSets | 
| Condition/Problem/Diagnosis Codes | US Core Condition Codes | Comparison | Union | Intersection | 2 Breaking Changes, 0 Changes, 14 Notes | 
| DocumentReference Format Code Set | HL7 ValueSet of Format Codes for use with Document Sharing | Comparison | Union | Intersection | 2 Breaking Changes, 0 Changes, 11 Notes | 
| LOINC Codes | US Core Laboratory Test Codes | Comparison | Union | Intersection | 3 Breaking Changes, 0 Changes, 8 Notes | 
| Procedure Reason Codes | US Core Condition Codes | Comparison | Union | Intersection | 2 Breaking Changes, 0 Changes, 14 Notes | 
| Birth Sex | Birth Sex | Comparison | Union | Intersection | 2 Breaking Changes, 0 Changes, 6 Notes | 
| Birth Sex |  | Removed |  | 
| Detailed ethnicity | Detailed ethnicity | Comparison | Union | Intersection | 1 Breaking Change, 0 Changes, 4 Notes | 
| Detailed Race | Detailed Race | Comparison | Union | Intersection | 1 Breaking Change, 0 Changes, 4 Notes | 
| OMB Ethnicity Categories | OMB Ethnicity Categories | Comparison | Union | Intersection | 1 Breaking Change, 0 Changes, 3 Notes | 
| OMB Race Categories | OMB Race Categories | Comparison | Union | Intersection | 1 Breaking Change, 0 Changes, 3 Notes | 
| Language codes with language and optionally a region modifier | Language codes with language and optionally a region modifier | Comparison | Union | Intersection | 1 Breaking Change, 0 Changes, 3 Notes | 
| US Core Clinical Note Type | US Core Clinical Note Type | Comparison | Union | Intersection | 6 Breaking Changes, 0 Changes, 8 Notes | 
|  | US Core Clinical Result Observation Category | Added |  | 
| US Core Clinical Test Codes |  | Removed |  | 
| US Core Common SDOH Assessments |  | Removed |  | 
| US Core Condition Codes | US Core Condition Codes | Comparison | Union | Intersection | 1 Breaking Change, 0 Changes, 6 Notes | 
| US Core Diagnostic Report Category Codes | US Core Diagnostic Report Category Codes | Comparison | Union | Intersection | 1 Breaking Change, 0 Changes, 3 Notes | 
| US Core Diagnostic Report Laboratory Codes |  | Removed |  | 
| US Core Diagnostic Report Laboratory Codes | US Core Laboratory Test Codes | Comparison | Union | Intersection | 2 Breaking Changes, 0 Changes, 6 Notes | 
| US Core Non Laboratory Codes | US Core Non Laboratory Codes | Comparison | Union | Intersection | 1 Breaking Change, 0 Changes, 3 Notes | 
| US Core Discharge Disposition |  | Removed |  | 
| US Core Discharge Disposition | USEncounterDischargeDisposition | Comparison | Union | Intersection | 2 Breaking Changes, 0 Changes, 8 Notes | 
| US Core DocumentReference Category | US Core DocumentReference Category | Comparison | Union | Intersection | 1 Breaking Change, 0 Changes, 3 Notes | 
| US Core DocumentReference Type | US Core DocumentReference Type | Comparison | Union | Intersection | 1 Breaking Change, 0 Changes, 5 Notes | 
| US Core Encounter Type | Encounter Type | Comparison | Union | Intersection | 2 Breaking Changes, 0 Changes, 11 Notes | 
| US Core Encounter Type |  | Removed |  | 
| US Core Goal Codes | US Core Goal Codes | Comparison | Union | Intersection | 1 Breaking Change, 0 Changes, 5 Notes | 
|  | US Core Laboratory Test Codes | Added |  | 
|  | US Core Location Type | Added |  | 
| US Core Narrative Status | US Core Narrative Status | Comparison | Union | Intersection | 1 Breaking Change, 0 Changes, 4 Notes | 
| US Core Observation Category |  | Removed |  | 
| US Core Status for Smoking Status Observation | US Core Status for Smoking Status Observation | Comparison | Union | Intersection | 1 Breaking Change, 0 Changes, 5 Notes | 
| US Core Smoking Status Max-Binding |  | Removed |  | 
| US Core Observation Value Codes (SNOMED-CT) |  | Removed |  | 
| US Core Problem or Health Concern | US Core Problem or Health Concern | Comparison | Union | Intersection | 1 Breaking Change, 0 Changes, 5 Notes | 
| US Core Procedure Codes | US Core Procedure Codes | Comparison | Union | Intersection | 1 Breaking Change, 0 Changes, 6 Notes | 
| US Core Provenance Participant Type Codes | US Core Provenance Participant Type Codes | Comparison | Union | Intersection | 1 Breaking Change, 0 Changes, 5 Notes | 
| US Core Provider Role (NUCC) | Care Team Member Function | Comparison | Union | Intersection | 2 Breaking Changes, 0 Changes, 10 Notes | 
| US Core Provider Role (NUCC) |  | Removed |  | 
|  | US Core Screening Assessment Condition Category | Added |  | 
|  | US Core Screening Assessment Observation Category | Added |  | 
|  | US Core Screening Assessment Observation Maximum Category | Added |  | 
| US Core ServiceRequest Category Codes | US Core ServiceRequest Category Codes | Comparison | Union | Intersection | 1 Breaking Change, 0 Changes, 5 Notes | 
| US Core Sexual Orientation |  | Removed |  | 
|  | US Core Simple Observation Category | Added |  | 
| US Core Smoking Status Observation Codes | Smoking Status Type | Comparison | Union | Intersection | 2 Breaking Changes, 0 Changes, 10 Notes | 
| US Core Smoking Status Observation Codes |  | Removed |  | 
|  | US Core Specimen Condition | Added |  | 
| US Core Survey Codes |  | Removed |  | 
| US Core Tags ValueSet |  | Removed |  | 
| USPS Two Letter Alphabetic Codes | USPS Two Letter Alphabetic Codes | Comparison | Union | Intersection | 1 Breaking Change, 0 Changes, 3 Notes | 
| US Core Vital Signs ValueSet | Vital Sign Result Type | Comparison | Union | Intersection | 17 Breaking Changes, 0 Changes, 15 Notes | 
| US Core Vital Signs ValueSet |  | Removed |  | 
| ServiceDeliveryLocationRoleType | US Core Location Type | Comparison | Union | Intersection | 2 Breaking Changes, 0 Changes, 11 Notes | 
| StructureDefinitions | 
| SimpleQuantity | SimpleQuantity | Comparison | Union | Intersection | 0 Breaking Changes, 0 Changes, 0 Notes | 
| US Core Pediatric Head Occipital-frontal Circumference Percentile Profile | US Core Pediatric Head Occipital Frontal Circumference Percentile Profile | Comparison | Union | Intersection | 1 Breaking Change, 1 Change, 4 Notes | 
| US Core Pediatric BMI for Age Observation Profile | US Core Pediatric BMI for Age Observation Profile | Comparison | Union | Intersection | 1 Breaking Change, 1 Change, 3 Notes | 
| US Core Pediatric Weight for Height Observation Profile | US Core Pediatric Weight for Height Observation Profile | Comparison | Union | Intersection | 1 Breaking Change, 1 Change, 3 Notes | 
|  | US Core ADI DocumentReference Profile | Added |  | 
| US Core AllergyIntolerance Profile | US Core AllergyIntolerance Profile | Comparison | Union | Intersection | 1 Breaking Change, 0 Changes, 3 Notes | 
|  | US Core Authentication Time Extension | Added |  | 
|  | US Core Average Blood Pressure Profile | Added |  | 
| US Core Birth Sex Extension | US Core Birth Sex Extension | Comparison | Union | Intersection | 1 Breaking Change, 0 Changes, 3 Notes | 
| US Core Blood Pressure Profile | US Core Blood Pressure Profile | Comparison | Union | Intersection | 1 Breaking Change, 1 Change, 3 Notes | 
| US Core BMI Profile | US Core BMI Profile | Comparison | Union | Intersection | 1 Breaking Change, 1 Change, 3 Notes | 
| US Core Body Height Profile | US Core Body Height Profile | Comparison | Union | Intersection | 1 Breaking Change, 1 Change, 3 Notes | 
| US Core Body Temperature Profile | US Core Body Temperature Profile | Comparison | Union | Intersection | 1 Breaking Change, 1 Change, 3 Notes | 
| US Core Body Weight Profile | US Core Body Weight Profile | Comparison | Union | Intersection | 1 Breaking Change, 1 Change, 3 Notes | 
|  | US Core Care Experience Preference Profile | Added |  | 
| US Core CarePlan Profile | US Core CarePlan Profile | Comparison | Union | Intersection | 1 Breaking Change, 0 Changes, 4 Notes | 
| US Core CareTeam Profile | US Core CareTeam Profile | Comparison | Union | Intersection | 1 Breaking Change, 0 Changes, 3 Notes | 
| US Core Condition Encounter Diagnosis Profile | US Core Condition Encounter Diagnosis Profile | Comparison | Union | Intersection | 1 Breaking Change, 0 Changes, 3 Notes | 
| US Core Condition Problems and Health Concerns Profile | US Core Condition Problems and Health Concerns Profile | Comparison | Union | Intersection | 1 Breaking Change, 1 Change, 11 Notes | 
|  | US Core Coverage Profile | Added |  | 
| US Core DiagnosticReport Profile for Laboratory Results Reporting | US Core DiagnosticReport Profile for Laboratory Results Reporting | Comparison | Union | Intersection | 1 Breaking Change, 3 Changes, 11 Notes | 
| US Core DiagnosticReport Profile for Report and Note Exchange | US Core DiagnosticReport Profile for Report and Note Exchange | Comparison | Union | Intersection | 1 Breaking Change, 3 Changes, 3 Notes | 
| US Core Direct email Extension | US Core Direct email Extension | Comparison | Union | Intersection | 1 Breaking Change, 0 Changes, 3 Notes | 
| US Core DocumentReference Profile | US Core DocumentReference Profile | Comparison | Union | Intersection | 1 Breaking Change, 0 Changes, 3 Notes | 
| US Core Encounter Profile | US Core Encounter Profile | Comparison | Union | Intersection | 1 Breaking Change, 1 Change, 12 Notes | 
| US Core Ethnicity Extension | US Core Ethnicity Extension | Comparison | Union | Intersection | 1 Breaking Change, 0 Changes, 3 Notes | 
| US Core Extension Questionnaire URI | US Core Extension Questionnaire URI | Comparison | Union | Intersection | 1 Breaking Change, 0 Changes, 2 Notes | 
| US Core Gender Identity Extension | US Core Gender Identity Extension | Comparison | Union | Intersection | 2 Breaking Changes, 0 Changes, 7 Notes | 
| US Core Goal Profile | US Core Goal Profile | Comparison | Union | Intersection | 2 Breaking Changes, 2 Changes, 3 Notes | 
| US Core Head Circumference Profile | US Core Head Circumference Profile | Comparison | Union | Intersection | 1 Breaking Change, 1 Change, 3 Notes | 
| US Core Heart Rate Profile | US Core Heart Rate Profile | Comparison | Union | Intersection | 1 Breaking Change, 1 Change, 3 Notes | 
| US Core Immunization Profile | US Core Immunization Profile | Comparison | Union | Intersection | 1 Breaking Change, 5 Changes, 4 Notes | 
| US Core Implantable Device Profile | US Core Implantable Device Profile | Comparison | Union | Intersection | 1 Breaking Change, 0 Changes, 3 Notes | 
|  | US Core Interpreter Needed Extension | Added |  | 
|  | US Core Jurisdiction Extension | Added |  | 
| US Core Location Profile | US Core Location Profile | Comparison | Union | Intersection | 1 Breaking Change, 2 Changes, 4 Notes | 
|  | US Core Medication Adherence Extension | Added |  | 
|  | US Core MedicationDispense Profile | Added |  | 
| US Core MedicationRequest Profile | US Core MedicationRequest Profile | Comparison | Union | Intersection | 1 Breaking Change, 7 Changes, 4 Notes | 
| US Core Medication Profile | US Core Medication Profile | Comparison | Union | Intersection | 1 Breaking Change, 0 Changes, 3 Notes | 
|  | US Core Observation ADI Documentation Profile | Added |  | 
|  | US Core Observation Clinical Result Profile | Added |  | 
| US Core Observation Clinical Test Result Profile |  | Removed |  | 
| US Core Observation Imaging Result Profile |  | Removed |  | 
| US Core Laboratory Result Observation Profile | US Core Laboratory Result Observation Profile | Comparison | Union | Intersection | 2 Breaking Changes, 6 Changes, 11 Notes | 
|  | US Core Observation Occupation Profile | Added |  | 
|  | US Core Observation Pregnancy Intent Profile | Added |  | 
|  | US Core Observation Pregnancy Status Profile | Added |  | 
|  | US Core Observation Screening Assessment Profile | Added |  | 
| US Core Observation SDOH Assessment Profile |  | Removed |  | 
| US Core Observation Sexual Orientation Profile | US Core Observation Sexual Orientation Profile | Comparison | Union | Intersection | 1 Breaking Change, 0 Changes, 3 Notes | 
| US Core Observation Social History Profile |  | Removed |  | 
| US Core Observation Survey Profile |  | Removed |  | 
| US Core Organization Profile | US Core Organization Profile | Comparison | Union | Intersection | 1 Breaking Change, 0 Changes, 2 Notes | 
| US Core Patient Profile | US Core Patient Profile | Comparison | Union | Intersection | 1 Breaking Change, 1 Change, 3 Notes | 
| US Core PractitionerRole Profile | US Core PractitionerRole Profile | Comparison | Union | Intersection | 1 Breaking Change, 0 Changes, 2 Notes | 
| US Core Practitioner Profile | US Core Practitioner Profile | Comparison | Union | Intersection | 1 Breaking Change, 0 Changes, 2 Notes | 
| US Core Procedure Profile | US Core Procedure Profile | Comparison | Union | Intersection | 1 Breaking Change, 1 Change, 3 Notes | 
| US Core Provenance Profile | US Core Provenance Profile | Comparison | Union | Intersection | 1 Breaking Change, 0 Changes, 3 Notes | 
| US Core Pulse Oximetry Profile | US Core Pulse Oximetry Profile | Comparison | Union | Intersection | 1 Breaking Change, 1 Change, 4 Notes | 
| US Core QuestionnaireResponse Profile | US Core QuestionnaireResponse Profile | Comparison | Union | Intersection | 1 Breaking Change, 1 Change, 11 Notes | 
| US Core Race Extension | US Core Race Extension | Comparison | Union | Intersection | 1 Breaking Change, 0 Changes, 4 Notes | 
| US Core RelatedPerson Profile | US Core RelatedPerson Profile | Comparison | Union | Intersection | 1 Breaking Change, 0 Changes, 3 Notes | 
| US Core Respiratory Rate Profile | US Core Respiratory Rate Profile | Comparison | Union | Intersection | 1 Breaking Change, 1 Change, 3 Notes | 
| US Core ServiceRequest Profile | US Core ServiceRequest Profile | Comparison | Union | Intersection | 1 Breaking Change, 1 Change, 4 Notes | 
|  | US Core Sex Extension | Added |  | 
|  | US Core Simple Observation Profile | Added |  | 
| US Core Smoking Status Observation Profile | US Core Smoking Status Observation Profile | Comparison | Union | Intersection | 1 Breaking Change, 3 Changes, 3 Notes | 
|  | US Core Specimen Profile | Added |  | 
|  | US Core Treatment Intervention Preference Profile | Added |  | 
|  | US Core Tribal Affiliation Extension | Added |  | 
| US Core Vital Signs Profile | US Core Vital Signs Profile | Comparison | Union | Intersection | 1 Breaking Change, 1 Change, 3 Notes | 
|  | US Core USCDI Requirement Extension | Added |  | 
| CapabilityStatements | 
|  | US Core Client CapabilityStatement | Added |  | 
|  | US Core Server CapabilityStatement | Added |  |