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Clinical Decision Support Work Group | Maturity Level: N/A | Standards Status: Informative | Compartments: No defined compartments |
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Certainty Rating of all-cause mortality in meta-analysis of RCTs of heparin for moderately ill patients with COVID-19
{ "resourceType" : "ArtifactAssessment", "id" : "example-certainty-rating", "text" : { "status" : "generated", "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: ArtifactAssessment</b><a name=\"example-certainty-rating\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource ArtifactAssessment "example-certainty-rating" </p></div><p><b>identifier</b>: FEvIR Object Identifier:\u00a027756</p><p><b>date</b>: 2021-11-02T14:48:59.89Z</p><p><b>copyright</b>: https://creativecommons.org/licenses/by-nc-sa/4.0/</p><p><b>artifact</b>: <a href=\"broken-link.html\">Evidence/18812: Critically appraised summary of all-cause mortality in meta-analysis of RCTs of heparin for moderately ill patients with COVID-19</a></p><blockquote><p><b>content</b></p><p><b>informationType</b>: rating</p><p><b>summary</b>: serious concerns with risk of bias, inconsistency, and imprecision</p><p><b>type</b>: Overall certainty <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"codesystem-certainty-type.html\">Evidence Certainty Type</a>#Overall)</span></p><p><b>classifier</b>: Very low quality <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"codesystem-certainty-rating.html\">Evidence Certainty Rating</a>#very-low)</span></p><p><b>author</b>: <span>: Brian S. Alper</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td>-</td><td><b>InformationType</b></td><td><b>Summary</b></td><td><b>Type</b></td><td><b>Classifier</b></td><td><b>Author</b></td></tr><tr><td>*</td><td>rating</td><td>risk of bias in both included trials</td><td>Risk of bias <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"codesystem-certainty-type.html\">Evidence Certainty Type</a>#RiskOfBias)</span></td><td>serious concern <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"codesystem-certainty-rating.html\">Evidence Certainty Rating</a>#serious-concern)</span></td><td><span>: Brian S. Alper</span></td></tr><tr><td>*</td><td>rating</td><td>high degree of heterogeneity (I-squared 80.7%) with confidence intervals of 2 trial effect estimates barely overlapping</td><td>Inconsistency <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"codesystem-certainty-type.html\">Evidence Certainty Type</a>#Inconsistency)</span></td><td>serious concern <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"codesystem-certainty-rating.html\">Evidence Certainty Rating</a>#serious-concern)</span></td><td><span>: Brian S. Alper</span></td></tr><tr><td>*</td><td>rating</td><td> </td><td>Indirectness <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"codesystem-certainty-type.html\">Evidence Certainty Type</a>#Indirectness)</span></td><td>no serious concern <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"codesystem-certainty-rating.html\">Evidence Certainty Rating</a>#no-concern)</span></td><td><span>: Brian S. Alper</span></td></tr><tr><td>*</td><td>rating</td><td>95% confidence interval includes both large effects and no effects</td><td>Imprecision <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"codesystem-certainty-type.html\">Evidence Certainty Type</a>#Imprecision)</span></td><td>serious concern <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"codesystem-certainty-rating.html\">Evidence Certainty Rating</a>#serious-concern)</span></td><td><span>: Brian S. Alper</span></td></tr><tr><td>*</td><td>rating</td><td> </td><td>Publication bias <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"codesystem-certainty-type.html\">Evidence Certainty Type</a>#PublicationBias)</span></td><td>no serious concern <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"codesystem-certainty-rating.html\">Evidence Certainty Rating</a>#no-concern)</span></td><td><span>: Brian S. Alper</span></td></tr></table></blockquote></div>" }, "identifier" : [{ "type" : { "text" : "FEvIR Object Identifier" }, "system" : "https://fevir.net", "value" : "27756", "assigner" : { "display" : "Computable Publishing LLC" } }], "date" : "2021-11-02T14:48:59.890Z", "copyright" : "https://creativecommons.org/licenses/by-nc-sa/4.0/", "artifactReference" : { "reference" : "Evidence/18812", "type" : "Evidence", "display" : "Critically appraised summary of all-cause mortality in meta-analysis of RCTs of heparin for moderately ill patients with COVID-19" }, "content" : [{ "informationType" : "rating", "summary" : "serious concerns with risk of bias, inconsistency, and imprecision", "type" : { "coding" : [{ "system" : "http://hl7.org/fhir/certainty-type", "code" : "Overall", "display" : "Overall certainty" }] }, "classifier" : [{ "coding" : [{ "system" : "http://hl7.org/fhir/certainty-rating", "code" : "very-low", "display" : "Very low quality" }] }], "author" : { "display" : "Brian S. Alper" }, "freeToShare" : true, "component" : [{ "informationType" : "rating", "summary" : "risk of bias in both included trials", "type" : { "coding" : [{ "system" : "http://hl7.org/fhir/certainty-type", "code" : "RiskOfBias", "display" : "Risk of bias" }] }, "classifier" : [{ "coding" : [{ "system" : "http://hl7.org/fhir/certainty-rating", "code" : "serious-concern", "display" : "serious concern" }] }], "author" : { "display" : "Brian S. Alper" } }, { "informationType" : "rating", "summary" : "high degree of heterogeneity (I-squared 80.7%) with confidence intervals of 2 trial effect estimates barely overlapping", "type" : { "coding" : [{ "system" : "http://hl7.org/fhir/certainty-type", "code" : "Inconsistency", "display" : "Inconsistency" }] }, "classifier" : [{ "coding" : [{ "system" : "http://hl7.org/fhir/certainty-rating", "code" : "serious-concern", "display" : "serious concern" }] }], "author" : { "display" : "Brian S. Alper" } }, { "informationType" : "rating", "type" : { "coding" : [{ "system" : "http://hl7.org/fhir/certainty-type", "code" : "Indirectness", "display" : "Indirectness" }] }, "classifier" : [{ "coding" : [{ "system" : "http://hl7.org/fhir/certainty-rating", "code" : "no-concern", "display" : "no serious concern" }] }], "author" : { "display" : "Brian S. Alper" } }, { "informationType" : "rating", "summary" : "95% confidence interval includes both large effects and no effects", "type" : { "coding" : [{ "system" : "http://hl7.org/fhir/certainty-type", "code" : "Imprecision", "display" : "Imprecision" }] }, "classifier" : [{ "coding" : [{ "system" : "http://hl7.org/fhir/certainty-rating", "code" : "serious-concern", "display" : "serious concern" }] }], "author" : { "display" : "Brian S. Alper" } }, { "informationType" : "rating", "type" : { "coding" : [{ "system" : "http://hl7.org/fhir/certainty-type", "code" : "PublicationBias", "display" : "Publication bias" }] }, "classifier" : [{ "coding" : [{ "system" : "http://hl7.org/fhir/certainty-rating", "code" : "no-concern", "display" : "no serious concern" }] }], "author" : { "display" : "Brian S. Alper" } }] }] }
Usage note: every effort has been made to ensure that the examples are correct and useful, but they are not a normative part of the specification.
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