<?xml version="1.0" encoding="UTF-8"?><MedicationRequest xmlns="http://hl7.org/fhir">
    <id value="medrx0317"/>
    <text><status value="generated"/><div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: MedicationRequest</b><a name="medrx0317"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource MedicationRequest &quot;medrx0317&quot; </p></div><p><b>identifier</b>: id: 12345689 (use: OFFICIAL)</p><p><b>status</b>: completed</p><p><b>intent</b>: order</p><h3>Medications</h3><table class="grid"><tr><td>-</td><td><b>Reference</b></td></tr><tr><td>*</td><td><a name="med0303"> </a><blockquote><p/><p><a name="med0303"> </a></p><p><b>code</b>: Alemtuzumab 10mg/ml (Lemtrada) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.1.0/CodeSystem-v3-rxNorm.html">RxNorm</a>#1594660)</span></p></blockquote></td></tr></table><p><b>subject</b>: <a href="patient-example-a.html">Patient/pat1: Donald Duck</a> &quot;Donald DUCK&quot;</p><p><b>authoredOn</b>: 2015-01-15</p><p><b>requester</b>: <a href="practitioner-example-f007-sh.html">Practitioner/f007: Patrick Pump</a> &quot;Simone HEPS&quot;</p><h3>Reasons</h3><table class="grid"><tr><td>-</td><td><b>Concept</b></td></tr><tr><td>*</td><td>Chronic Lymphoid Leukemia (disorder) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://browser.ihtsdotools.org/">SNOMED CT</a>#92814006)</span></td></tr></table><blockquote><p><b>dosageInstruction</b></p><p><b>sequence</b>: 1</p><p><b>text</b>: Rapid daily-dose escalation, until tolerated, from 3 mg/d, and then 10 mg/d, to the recommended maintenance dose of 30 mg IV over 120 min, 3 times per wk on alternate days for up to 12 wk</p><p><b>additionalInstruction</b>: Rapidly increase dose until tolerated <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span>, Administer on alternate days <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></p><p><b>timing</b>: Duration 12weeks, 3 per 1 weeks</p><p><b>route</b>: Intravenous route (qualifier value) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://browser.ihtsdotools.org/">SNOMED CT</a>#47625008)</span></p><p><b>method</b>: Inject - dosing instruction imperative (qualifier value) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://browser.ihtsdotools.org/">SNOMED CT</a>#422145002)</span></p><blockquote><p><b>doseAndRate</b></p></blockquote></blockquote><blockquote><p><b>dosageInstruction</b></p><p><b>sequence</b>: 2</p><p><b>text</b>: Rapid daily-dose escalation, until tolerated, from 3 mg/d, and then 10 mg/d, to the recommended maintenance dose of 30 mg IV over 120 min, 3 times per wk on alternate days for up to 12 wk</p><p><b>additionalInstruction</b>: Rapidly increase dose until tolerated <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span>, Administer on alternate days <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></p><p><b>timing</b>: Duration 12weeks, 3 per 1 weeks</p><p><b>route</b>: Intravenous route (qualifier value) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://browser.ihtsdotools.org/">SNOMED CT</a>#47625008)</span></p><p><b>method</b>: Inject - dosing instruction imperative (qualifier value) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://browser.ihtsdotools.org/">SNOMED CT</a>#422145002)</span></p><blockquote><p><b>doseAndRate</b></p></blockquote></blockquote><blockquote><p><b>dosageInstruction</b></p><p><b>sequence</b>: 3</p><p><b>text</b>: Rapid daily-dose escalation, until tolerated, from 3 mg/d, and then 10 mg/d, to the recommended maintenance dose of 30 mg IV over 120 min, 3 times per wk on alternate days for up to 12 wk</p><p><b>additionalInstruction</b>: Rapidly increase dose until tolerated <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span>, Administer on alternate days <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></p><p><b>timing</b>: Duration 12weeks, 3 per 1 weeks</p><p><b>route</b>: Intravenous route (qualifier value) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://browser.ihtsdotools.org/">SNOMED CT</a>#47625008)</span></p><p><b>method</b>: Inject - dosing instruction imperative (qualifier value) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://browser.ihtsdotools.org/">SNOMED CT</a>#422145002)</span></p><blockquote><p><b>doseAndRate</b></p></blockquote></blockquote></div></text><contained>
        <Medication>
            <id value="med0303"/>
            <code>
                <coding>
                    <system value="http://www.nlm.nih.gov/research/umls/rxnorm"/>
                    <code value="1594660"/>
                    <display value="Alemtuzumab 10mg/ml (Lemtrada)"/>
                </coding>
            </code>
        </Medication>
    </contained>
    <identifier>
        <use value="official"/>
        <system value="http://www.bmc.nl/portal/prescriptions"/>
        <value value="12345689"/>
    </identifier>
    <status value="completed"/>
    <intent value="order"/>
    <medication>
    <reference>
        <reference value="#med0303"/>
    </reference>
    </medication>
    <subject>
            <!--   Linked to the resource patient who needs the medication   -->
        <reference value="Patient/pat1"/>
        <display value="Donald Duck"/>
    </subject>
    <authoredOn value="2015-01-15"/>
    <requester>
        <reference value="Practitioner/f007"/>
        <display value="Patrick Pump"/>
    </requester>
    <reason>
      <concept>
        <coding>
            <system value="http://snomed.info/sct"/>
            <code value="92814006"/>
            <display value="Chronic Lymphoid Leukemia (disorder)"/>
        </coding>
      </concept>
    </reason>
    
    <dosageInstruction>
        <sequence value="1"/>
        <text value="Rapid daily-dose escalation, until tolerated, from 3 mg/d, and then 10 mg/d, to the recommended maintenance dose of 30 mg IV over 120 min, 3 times per wk on alternate days for up to 12 wk"/>
        <additionalInstruction>
            <text value="Rapidly increase dose until tolerated"/>
        </additionalInstruction>
        <additionalInstruction>
            <text value="Administer on alternate days"/>
        </additionalInstruction>
        <timing>
            <repeat>
                <duration value="12"/>
                <durationUnit value="wk"/>
                <frequency value="3"/>
                <period value="1"/>
                <periodUnit value="wk"/>
            </repeat>
        </timing>
        <route>
            <coding>
                <system value="http://snomed.info/sct"/>
                <code value="47625008"/>
                <display value="Intravenous route (qualifier value)"/>
            </coding>
        </route>
        <method>
            <coding>
                <system value="http://snomed.info/sct"/>
                <code value="422145002"/>
                <display value="Inject - dosing instruction imperative (qualifier value)"/>
            </coding>
        </method>
        <doseAndRate>
            <type>
                <coding>
                    <system value="http://terminology.hl7.org/CodeSystem/dose-rate-type"/>
                    <code value="ordered"/>
                    <display value="Ordered"/>
                </coding>
            </type>
            <doseQuantity>
                <value value="3"/>
                <unit value="mg"/>
                <system value="http://unitsofmeasure.org"/>
                <code value="mg"/>
            </doseQuantity>
        </doseAndRate>
        
    </dosageInstruction>
    <dosageInstruction>
        <sequence value="2"/>
        <text value="Rapid daily-dose escalation, until tolerated, from 3 mg/d, and then 10 mg/d, to the recommended maintenance dose of 30 mg IV over 120 min, 3 times per wk on alternate days for up to 12 wk"/>
        <additionalInstruction>
            <text value="Rapidly increase dose until tolerated"/>
        </additionalInstruction>
        <additionalInstruction>
        <text value="Administer on alternate days"/>
        </additionalInstruction>
        <timing>
            <repeat>
                <duration value="12"/>
                <durationUnit value="wk"/>
                <frequency value="3"/>
                <period value="1"/>
                <periodUnit value="wk"/>
            </repeat>
        </timing>
        <route>
            <coding>
                <system value="http://snomed.info/sct"/>
                <code value="47625008"/>
                <display value="Intravenous route (qualifier value)"/>
            </coding>
        </route>
        <method>
            <coding>
                <system value="http://snomed.info/sct"/>
                <code value="422145002"/>
                <display value="Inject - dosing instruction imperative (qualifier value)"/>
            </coding>
        </method>
        <doseAndRate>
            <type>
                <coding>
                    <system value="http://terminology.hl7.org/CodeSystem/dose-rate-type"/>
                    <code value="ordered"/>
                    <display value="Ordered"/>
                </coding>
            </type>
            <doseQuantity>
                <value value="10"/>
                <unit value="mg"/>
                <system value="http://unitsofmeasure.org"/>
                <code value="mg"/>
            </doseQuantity>
        </doseAndRate>
        
    </dosageInstruction>  
    <dosageInstruction>
        <sequence value="3"/>
        <text value="Rapid daily-dose escalation, until tolerated, from 3 mg/d, and then 10 mg/d, to the recommended maintenance dose of 30 mg IV over 120 min, 3 times per wk on alternate days for up to 12 wk"/>
        <additionalInstruction>
            <text value="Rapidly increase dose until tolerated"/>
        </additionalInstruction>
        <additionalInstruction>
        <text value="Administer on alternate days"/>
        </additionalInstruction>
        <timing>
            <repeat>
                <duration value="12"/>
                <durationUnit value="wk"/>
                <frequency value="3"/>
                <period value="1"/>
                <periodUnit value="wk"/>
            </repeat>
        </timing>
        <route>
            <coding>
                <system value="http://snomed.info/sct"/>
                <code value="47625008"/>
                <display value="Intravenous route (qualifier value)"/>
            </coding>
        </route>
        <method>
            <coding>
                <system value="http://snomed.info/sct"/>
                <code value="422145002"/>
                <display value="Inject - dosing instruction imperative (qualifier value)"/>
            </coding>
        </method>
        <doseAndRate>
            <type>
                <coding>
                    <system value="http://terminology.hl7.org/CodeSystem/dose-rate-type"/>
                    <code value="ordered"/>
                    <display value="Ordered"/>
                </coding>
            </type>
            <doseQuantity>
                <value value="30"/>
                <unit value="mg"/>
                <system value="http://unitsofmeasure.org"/>
                <code value="mg"/>
            </doseQuantity>
        </doseAndRate>

    </dosageInstruction>
    
</MedicationRequest>