<?xml version="1.0" encoding="UTF-8"?><Observation xmlns="http://hl7.org/fhir"><id value="genetics-example1-somatic"/><text><status value="generated"/><div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative with Details</b></p><p><b>id</b>: genetics-example1-somatic</p><p><b>contained</b>: </p><p><b>status</b>: final</p><p><b>code</b>: Genetic analysis master panel ­Blood or Tissue by Molecular genetics method <span>(Details : {LOINC code &#39;55233-1&#39; = &#39;Genetic analysis master panel - Blood or Tissue by Molecular genetics method&#39;, given as &#39;Genetic analysis master panel ­Blood or Tissue by Molecular genetics method&#39;})</span></p><p><b>subject</b>: <a>Molecular Lab Patient ID: HOSP-23456</a></p><p><b>performer</b>: <a>Molecular Diagnostic Laboratory</a></p><p><b>interpretation</b>: positive <span>(Details : {http://hl7.org/fhir/v2/0078 code &#39;POS&#39; = &#39;Positive)</span></p><p><b>comments</b>: The EGFR p.L858R mutation has been associated with response to anti-EGFR therapy</p><p><b>specimen</b>: <a>Molecular Specimen ID: MLD45-Z4-1234</a></p></div></text><contained><Condition><id value="c1"/><patient><reference value="Patient/p1"/></patient><code><coding><system value="http://snomed.info/sct"/><code value="254626006"/></coding><text value="Adenocarcinoma of lung "/></code><category><coding><system value="http://hl7.org/fhir/condition-category"/><code value="finding"/><display value="Finding"/></coding></category><verificationStatus value="provisional"/></Condition></contained><extension url="http://hl7.org/fhir/StructureDefinition/geneticsGenomeBuild"><valueString value="GRCh 37"/></extension><extension url="http://hl7.org/fhir/StructureDefinition/geneticsChromosome"><valueCodeableConcept><coding><system value="http://www.ncbi.nlm.nih.gov/gene"/><code value="NC_000007"/></coding><text value="Homo sapiens chromosome 7"/></valueCodeableConcept></extension><extension url="http://hl7.org/fhir/StructureDefinition/geneticsGenomicStart"><valueInteger value="55259515"/></extension><extension url="http://hl7.org/fhir/StructureDefinition/geneticsGenomicStop"><valueInteger value="55259516"/></extension><extension url="http://hl7.org/fhir/StructureDefinition/geneticsSpecies"><valueCodeableConcept><coding><system value="http://snomed.info/sct"/><code value="337915000"/></coding><text value="Homo sapiens"/></valueCodeableConcept></extension><extension url="http://hl7.org/fhir/StructureDefinition/geneticsCIGAR"><valueString value="1M"/></extension><extension url="http://hl7.org/fhir/StructureDefinition/geneticsAssessedCondition"><valueReference><reference value="#c1"/></valueReference></extension><extension url="http://hl7.org/fhir/StructureDefinition/geneticsReferenceAllele"><valueString value="T"/></extension><extension url="http://hl7.org/fhir/StructureDefinition/geneticsObservedAllele"><valueString value="G"/></extension><extension url="http://hl7.org/fhir/StructureDefinition/geneticsGene"><valueCodeableConcept><coding><system value="http://www.genenames.org"/><code value="3236"/><display value="EGFR"/></coding></valueCodeableConcept></extension><extension url="http://hl7.org/fhir/StructureDefinition/geneticsTranscriptReferenceSequenceId"><valueCodeableConcept><coding><system value="http://www.ensembl.org"/><code value="ENSESTT00000085772.1"/></coding></valueCodeableConcept></extension><extension url="http://hl7.org/fhir/StructureDefinition/geneticsDNASequenceVariation"><valueString value="c.2573T&gt;G"/></extension><extension url="http://hl7.org/fhir/StructureDefinition/geneticsDNASequenceVariationType"><valueCodeableConcept><coding><system value="http://loinc.org"/><code value="LA6690-7"/><display value="Substitution"/></coding></valueCodeableConcept></extension><extension url="http://hl7.org/fhir/StructureDefinition/geneticsAminoAcidChange"><valueString value="p.Leu858Arg"/></extension><extension url="http://hl7.org/fhir/StructureDefinition/geneticsAlleleName"><valueString value="p.L858R"/></extension><extension url="http://hl7.org/fhir/StructureDefinition/geneticsGenomicSourceClass"><valueCodeableConcept><coding><system value="http://loinc.org"/><code value="LA6684-0"/><display value="Somatic"/></coding></valueCodeableConcept></extension><status value="final"/><code><coding><system value="http://loinc.org"/><code value="55233-1"/><display value="Genetic analysis master panel ­Blood or Tissue by Molecular genetics method"/></coding></code><subject><reference value="Patient/genetics-example1-somatic"/><display value="Molecular Lab Patient ID: HOSP-23456"/></subject><performer><reference value="Practitioner/genetics-example1-somatic"/><display value="Molecular Diagnostic Laboratory"/></performer><interpretation><coding><system value="http://hl7.org/fhir/v2/0078"/><code value="POS"/></coding><text value="positive"/></interpretation><comments value="The EGFR p.L858R mutation has been associated with response to anti-EGFR therapy"/><specimen><reference value="Specimen/genetics-example1-somatic"/><display value="Molecular Specimen ID: MLD45-Z4-1234"/></specimen></Observation>