Request referencing Medication Resource for Eye Drops - Timoptic - active - with link to encounter, dispenseRequest and substitution flag

{
  "resourceType" : "MedicationRequest",
  "id" : "medrx0330",
  "contained" : [{
    "resourceType" : "Medication",
    "id" : "med0305",
    "code" : {
      "coding" : [{
        "system" : "http://hl7.org/fhir/sid/ndc",
        "code" : "24208-813-10",
        "display" : "Timoptic, 1 BOTTLE, DISPENSING in 1 CARTON (24208-813-10) > 10 mL in 1 BOTTLE, DISPENSING (package)"
      }],
      "text" : "Timoptic 5mg/ml solution"
    }
  }],
  "identifier" : [{
    "use" : "official",
    "system" : "http://www.bmc.nl/portal/prescriptions",
    "value" : "12345689"
  }],
  "status" : "active",
  "intent" : "order",
  "medication" : {
    "reference" : {
      "reference" : "#med0305"
    }
  },
  "subject" : {
    "reference" : "Patient/pat1",
    "display" : "Donald Duck"
  },
  "encounter" : {
    "reference" : "Encounter/f002",
    "display" : "encounter who leads to this prescription"
  },
  "authoredOn" : "2015-01-15",
  "requester" : {
    "reference" : "Practitioner/f007",
    "display" : "Patrick Pump"
  },
  "dosageInstruction" : [{
    "sequence" : 1,
    "text" : "Instil one drop in each eye twice daily",
    "timing" : {
      "repeat" : {
        "frequency" : 2,
        "period" : 1,
        "periodUnit" : "d"
      }
    },
    "route" : {
      "coding" : [{
        "system" : "http://snomed.info/sct",
        "code" : "54485002",
        "display" : "Ophthalmic route (qualifier value)"
      }]
    },
    "method" : {
      "coding" : [{
        "system" : "http://snomed.info/sct",
        "code" : "421538008",
        "display" : "Instill - dosing instruction imperative (qualifier value)"
      }]
    },
    "doseAndRate" : [{
      "type" : {
        "coding" : [{
          "system" : "http://terminology.hl7.org/CodeSystem/dose-rate-type",
          "code" : "ordered",
          "display" : "Ordered"
        }]
      },
      "doseQuantity" : {
        "value" : 1,
        "unit" : "OPDROP",
        "system" : "http://terminology.hl7.org/CodeSystem/v3-orderableDrugForm",
        "code" : "OPDROP"
      }
    }]
  }],
  "dispenseRequest" : {
    "validityPeriod" : {
      "start" : "2015-01-15",
      "end" : "2016-01-15"
    },
    "numberOfRepeatsAllowed" : 1,
    "quantity" : {
      "value" : 10,
      "unit" : "mL",
      "system" : "http://unitsofmeasure.org",
      "code" : "mL"
    },
    "expectedSupplyDuration" : {
      "value" : 30,
      "unit" : "days",
      "system" : "http://unitsofmeasure.org",
      "code" : "d"
    }
  },
  "substitution" : {
    "allowedBoolean" : false,
    "reason" : {
      "coding" : [{
        "system" : "http://terminology.hl7.org/CodeSystem/v3-ActReason",
        "code" : "FP",
        "display" : "formulary policy"
      }]
    }
  }
}