Risk of fatal ICH with alteplase for stroke

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  "id" : "example-stroke-alteplase-fatalICH",
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    "value" : "urn:oid:2.16.840.1.113883.4.642.10.1"
  }],
  "name" : "RiskOfFatalICHWithAlteplaseForStroke",
  "title" : "Risk of fatal ICH with alteplase for stroke",
  "status" : "draft",
  "publisher" : "HL7 International / Clinical Decision Support",
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  "relatedArtifact" : [{
    "type" : "citation",
    "label" : "Emberson 2014",
    "display" : "Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials.",
    "citation" : "Emberson J, Lees KR, Lyden P, Blackwell L, Albers G, Bluhmki E, et al;Stroke Thrombolysis Trialists' Collaborative Group. Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials. Lancet 2014 Nov 29;384(9958):1929-35 PMID 25106063",
    "document" : {
      "url" : "https://doi.org/10.1016/S0140-6736(14)60584-5"
    }
  }],
  "description" : "2.7% incidence of fatal intracranial hemorrhage within 7 days with alteplase in patients with acute ischemic stroke",
  "variableDefinition" : [{
    "variableRole" : "population",
    "observed" : {
      "reference" : "Group/Emberson-2014-IPD-MA-Alteplase-Cohort",
      "type" : "Group",
      "display" : "Emberson 2014 IPD-MA Alteplase Cohort"
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    "intended" : {
      "reference" : "Group/AcuteIschemicStrokeTreatedWithAlteplase",
      "type" : "Group",
      "display" : "adults with acute ischemic stroke treated with alteplase"
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  },
  {
    "variableRole" : "outcome",
    "observed" : {
      "reference" : "EvidenceVariable/example-fatal-ICH-in-7-days",
      "type" : "EvidenceVariable",
      "display" : "fatal ICH"
    },
    "intended" : {
      "reference" : "EvidenceVariable/example-fatal-ICH-in-7-days",
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    },
    "quantity" : {
      "value" : 0.026835741669
    },
    "numberOfEvents" : 91,
    "sampleSize" : {
      "numberOfStudies" : 9,
      "numberOfParticipants" : 3391
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}