{"authorizingPrescription":[{"reference":"MedicationRequest/medrx0317"}],"contained":[{"code":{"coding":[{"code":"1594660","display":"alemtuzumab 10 MG/ML [Lemtrada]","system":"http://www.nlm.nih.gov/research/umls/rxnorm"}]},"id":"med0303","resourceType":"Medication"}],"daysSupply":{"code":"d","system":"http://unitsofmeasure.org","unit":"Day","value":7},"dosageInstruction":[{"additionalInstruction":[{"text":"Rapidly increase dose until tolerated"},{"text":"Administer on alternate days"}],"doseAndRate":[{"doseQuantity":{"code":"mg","system":"http://unitsofmeasure.org","unit":"mg","value":3},"type":{"coding":[{"code":"calculated","display":"Calculated","system":"http://terminology.hl7.org/CodeSystem/dose-rate-type"}]}}],"method":{"coding":[{"code":"422145002","display":"Inject - dosing instruction imperative (qualifier value)","system":"http://snomed.info/sct"}]},"route":{"coding":[{"code":"47625008","display":"Intravenous route (qualifier value)","system":"http://snomed.info/sct"}]},"sequence":1,"text":"Rapid daily-dose escalation, until tolerated, from 3 mg/d, and then 10 mg/d, to the recommended maintenance dose of 30 mg IV over 120 min, 3 times per wk on alternate days for up to 12 wk","timing":{"repeat":{"duration":12,"durationUnit":"wk","frequency":3,"period":1,"periodUnit":"wk"}}},{"additionalInstruction":[{"text":"Rapidly increase dose until tolerated"},{"text":"Administer on alternate days"}],"doseAndRate":[{"doseQuantity":{"code":"mg","system":"http://unitsofmeasure.org","unit":"mg","value":10},"type":{"coding":[{"code":"calculated","display":"Calculated","system":"http://terminology.hl7.org/CodeSystem/dose-rate-type"}]}}],"method":{"coding":[{"code":"422145002","display":"Inject - dosing instruction imperative (qualifier value)","system":"http://snomed.info/sct"}]},"route":{"coding":[{"code":"47625008","display":"Intravenous route (qualifier value)","system":"http://snomed.info/sct"}]},"sequence":2,"text":"Rapid daily-dose escalation, until tolerated, from 3 mg/d, and then 10 mg/d, to the recommended maintenance dose of 30 mg IV over 120 min, 3 times per wk on alternate days for up to 12 wk","timing":{"repeat":{"duration":12,"durationUnit":"wk","frequency":3,"period":1,"periodUnit":"wk"}}},{"additionalInstruction":[{"text":"Rapidly increase dose until tolerated"},{"text":"Administer on alternate days"}],"doseAndRate":[{"doseQuantity":{"code":"mg","system":"http://unitsofmeasure.org","unit":"mg","value":30},"type":{"coding":[{"code":"calculated","display":"Calculated","system":"http://terminology.hl7.org/CodeSystem/dose-rate-type"}]}}],"method":{"coding":[{"code":"422145002","display":"Inject - dosing instruction imperative (qualifier value)","system":"http://snomed.info/sct"}]},"route":{"coding":[{"code":"47625008","display":"Intravenous route (qualifier value)","system":"http://snomed.info/sct"}]},"sequence":3,"text":"Rapid daily-dose escalation, until tolerated, from 3 mg/d, and then 10 mg/d, to the recommended maintenance dose of 30 mg IV over 120 min, 3 times per wk on alternate days for up to 12 wk","timing":{"repeat":{"duration":12,"durationUnit":"wk","frequency":3,"period":1,"periodUnit":"wk"}}}],"id":"meddisp0306","medication":{"reference":{"display":"alemtuzumab 10 MG/ML [Lemtrada]","reference":"#med0303"}},"performer":[{"actor":{"reference":"Practitioner/f006"}}],"quantity":{"code":"415818006","system":"http://snomed.info/sct","value":5},"resourceType":"MedicationDispense","status":"in-progress","subject":{"display":"Donald Duck","reference":"Patient/pat1"},"text":{"div":"

Generated Narrative: MedicationDispense

Resource MedicationDispense "meddisp0306"

status: in-progress

Medications

-Reference
*

code: alemtuzumab 10 MG/ML [Lemtrada] (RxNorm#1594660)

subject: Patient/pat1: Donald Duck "Donald DUCK"

Performers

-Actor
*Practitioner/f006 "Rob VAN DEN BERK"

authorizingPrescription: MedicationRequest/medrx0317

type: Daily Fill (ActCode#DF)

quantity: 5(unit 415818006 from http://snomed.info/sct) (Details: SNOMED CT code 415818006 = 'Vial')

daysSupply: 7 Day (Details: UCUM code d = 'd')

whenPrepared: 2015-01-15T10:20:00Z

dosageInstruction

sequence: 1

text: Rapid daily-dose escalation, until tolerated, from 3 mg/d, and then 10 mg/d, to the recommended maintenance dose of 30 mg IV over 120 min, 3 times per wk on alternate days for up to 12 wk

additionalInstruction: Rapidly increase dose until tolerated (), Administer on alternate days ()

timing: Duration 12weeks, 3 per 1 weeks

route: Intravenous route (qualifier value) (SNOMED CT#47625008)

method: Inject - dosing instruction imperative (qualifier value) (SNOMED CT#422145002)

doseAndRate

dosageInstruction

sequence: 2

text: Rapid daily-dose escalation, until tolerated, from 3 mg/d, and then 10 mg/d, to the recommended maintenance dose of 30 mg IV over 120 min, 3 times per wk on alternate days for up to 12 wk

additionalInstruction: Rapidly increase dose until tolerated (), Administer on alternate days ()

timing: Duration 12weeks, 3 per 1 weeks

route: Intravenous route (qualifier value) (SNOMED CT#47625008)

method: Inject - dosing instruction imperative (qualifier value) (SNOMED CT#422145002)

doseAndRate

dosageInstruction

sequence: 3

text: Rapid daily-dose escalation, until tolerated, from 3 mg/d, and then 10 mg/d, to the recommended maintenance dose of 30 mg IV over 120 min, 3 times per wk on alternate days for up to 12 wk

additionalInstruction: Rapidly increase dose until tolerated (), Administer on alternate days ()

timing: Duration 12weeks, 3 per 1 weeks

route: Intravenous route (qualifier value) (SNOMED CT#47625008)

method: Inject - dosing instruction imperative (qualifier value) (SNOMED CT#422145002)

doseAndRate

","status":"generated"},"type":{"coding":[{"code":"DF","display":"Daily Fill","system":"http://terminology.hl7.org/CodeSystem/v3-ActCode"}]},"whenPrepared":"2015-01-15T10:20:00Z"}