"Risk of fatal ICH with alteplase for stroke" is a univariate risk estimate.

<status value="draft"/><publisher value="HL7 International / Clinical Decision Support"/><contact><telecom><system value="url"/></telecom></contact><relatedArtifact><type value="citation"/><label value="Emberson 2014"/><display value="Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials."/><citation value="Emberson J, Lees KR, Lyden P, Blackwell L, Albers G, Bluhmki E, et al;Stroke Thrombolysis Trialists' Collaborative Group. Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials. Lancet 2014 Nov 29;384(9958):1929-35 PMID 25106063"/><document><url value="https://doi.org/10.1016/S0140-6736(14)60584-5"/></document></relatedArtifact><description value="2.7% incidence of fatal intracranial hemorrhage within 7 days with alteplase in patients with acute ischemic stroke"/><variableDefinition><variableRole value="population"/><observed><reference value="Group/Emberson-2014-IPD-MA-Alteplase-Cohort"/><type value="Group"/><display value="Emberson 2014 IPD-MA Alteplase Cohort"/></observed><intended><reference value="Group/AcuteIschemicStrokeTreatedWithAlteplase"/><type value="Group"/><display value="adults with acute ischemic stroke treated with alteplase"/></intended></variableDefinition><variableDefinition><variableRole value="outcome"/><observed><reference value="EvidenceVariable/example-fatal-ICH-in-7-days"/><type value="EvidenceVariable"/><display value="fatal ICH"/></observed><intended><reference value="EvidenceVariable/example-fatal-ICH-in-7-days"/><type value="EvidenceVariable"/><display value="fatal ICH"/></intended></variableDefinition><synthesisType><coding><system value="http://terminology.hl7.org/CodeSystem/synthesis-type"/><code value="IPD-MA"/><display value="individual patient data meta-analysis"/></coding></synthesisType><studyDesign><coding><system value="http://hl7.org/fhir/study-design"/><code value="SEVCO:01003"/><display value="randomized assignment"/></coding></studyDesign><statistic><statisticType><coding><system value="http://terminology.hl7.org/CodeSystem/statistic-type"/><code value="C44256"/><display value="Proportion"/></coding></statisticType><quantity><value value="0.026835741669"/></quantity><numberOfEvents value="91"/><sampleSize><numberOfStudies value="9"/><numberOfParticipants value="3391"/></sampleSize></statistic></Evidence>