Order for as needed (PRN) dosage - Vicodin - completed with dosageInstruction with additionalInstruction (coded) and as needed with reason, dispenseRequest and substitution

{
  "resourceType" : "MedicationRequest",
  "id" : "medrx0308",
  "text" : {
    "status" : "generated",
    "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: MedicationRequest</b><a name=\"medrx0308\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource MedicationRequest &quot;medrx0308&quot; </p></div><p><b>identifier</b>: id: 12345689 (use: OFFICIAL)</p><p><b>status</b>: completed</p><p><b>intent</b>: order</p><h3>Medications</h3><table class=\"grid\"><tr><td>-</td><td><b>Concept</b></td></tr><tr><td>*</td><td>Vicodin 5/500 Oral Tablet <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/4.0.0/CodeSystem-v3-rxNorm.html\">RxNorm</a>#856907)</span></td></tr></table><p><b>subject</b>: <a href=\"patient-example-a.html\">Patient/pat1: Donald Duck</a> &quot;Donald DUCK&quot;</p><p><b>encounter</b>: <a href=\"encounter-example-f001-heart.html\">Encounter/f001: encounter who leads to this prescription</a></p><p><b>authoredOn</b>: 2015-01-15</p><p><b>requester</b>: <a href=\"practitioner-example-f007-sh.html\">Practitioner/f007: Patrick Pump</a> &quot;Simone HEPS&quot;</p><p><b>recorder</b>: <a href=\"practitioner-example-f204-ce.html\">Practitioner/f204: Carla Espinoza</a> &quot;Carla Espinosa&quot;</p><blockquote><p><b>dose</b></p><blockquote><p><b>dosageInstruction</b></p><p><b>sequence</b>: 1</p><p><b>text</b>: 1 tablet every four hours as needed for pain</p><p><b>additionalInstruction</b>: Warning. May cause drowsiness. If affected do not drive or operate machinery. Avoid alcoholic drink (qualifier value) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://browser.ihtsdotools.org/\">SNOMED CT</a>#418914006)</span></p><p><b>timing</b>: Once per 4 hours</p><p><b>asNeededFor</b>: Fibromyalgia (disorder) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://browser.ihtsdotools.org/\">SNOMED CT</a>#203082005)</span></p><p><b>route</b>: Oral Route <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://browser.ihtsdotools.org/\">SNOMED CT</a>#26643006)</span></p></blockquote></blockquote><blockquote><p><b>dispenseRequest</b></p><p><b>validityPeriod</b>: 2015-01-15 --&gt; 2016-01-15</p><p><b>quantity</b>: 30 TAB<span style=\"background: LightGoldenRodYellow\"> (Details: http://terminology.hl7.org/CodeSystem/v3-orderableDrugForm code TAB = 'Tablet')</span></p><h3>ExpectedSupplyDurations</h3><table class=\"grid\"><tr><td>-</td><td><b>Value</b></td><td><b>Unit</b></td><td><b>System</b></td><td><b>Code</b></td></tr><tr><td>*</td><td>10</td><td>days</td><td><a href=\"http://terminology.hl7.org/4.0.0/CodeSystem-v3-ucum.html\">Unified Code for Units of Measure (UCUM)</a></td><td>d</td></tr></table></blockquote><h3>Substitutions</h3><table class=\"grid\"><tr><td>-</td><td><b>Allowed[x]</b></td><td><b>Reason</b></td></tr><tr><td>*</td><td>false</td><td>formulary policy <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/4.0.0/CodeSystem-v3-ActReason.html\">ActReason</a>#FP)</span></td></tr></table></div>"
  },
  "identifier" : [{
    "use" : "official",
    "system" : "http://www.bmc.nl/portal/prescriptions",
    "value" : "12345689"
  }],
  "status" : "completed",
  "intent" : "order",
  "medication" : {
    "concept" : {
      "coding" : [{
        "system" : "http://www.nlm.nih.gov/research/umls/rxnorm",
        "code" : "856907",
        "display" : "Vicodin 5/500 Oral Tablet"
      }]
    }
  },
  "subject" : {
    "reference" : "Patient/pat1",
    "display" : "Donald Duck"
  },
  "encounter" : {
    "reference" : "Encounter/f001",
    "display" : "encounter who leads to this prescription"
  },
  "authoredOn" : "2015-01-15",
  "requester" : {
    "reference" : "Practitioner/f007",
    "display" : "Patrick Pump"
  },
  "recorder" : {
    "reference" : "Practitioner/f204",
    "display" : "Carla Espinoza"
  },
  "dose" : {
    "dosageInstruction" : [{
      "sequence" : 1,
      "text" : "1 tablet every four hours as needed for pain",
      "additionalInstruction" : [{
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "418914006",
          "display" : "Warning. May cause drowsiness. If affected do not drive or operate machinery. Avoid alcoholic drink (qualifier value)"
        }]
      }],
      "timing" : {
        "repeat" : {
          "frequency" : 1,
          "period" : 4,
          "periodUnit" : "h"
        }
      },
      "asNeededFor" : [{
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "203082005",
          "display" : "Fibromyalgia (disorder)"
        }]
      }],
      "route" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "26643006",
          "display" : "Oral Route"
        }]
      },
      "doseAndRate" : [{
        "type" : {
          "coding" : [{
            "system" : "http://terminology.hl7.org/CodeSystem/dose-rate-type",
            "code" : "ordered",
            "display" : "Ordered"
          }]
        },
        "doseQuantity" : {
          "value" : 1,
          "unit" : "TAB",
          "system" : "http://terminology.hl7.org/CodeSystem/v3-orderableDrugForm",
          "code" : "TAB"
        }
      }]
    }]
  },
  "dispenseRequest" : {
    "validityPeriod" : {
      "start" : "2015-01-15",
      "end" : "2016-01-15"
    },
    "quantity" : {
      "value" : 30,
      "unit" : "TAB",
      "system" : "http://terminology.hl7.org/CodeSystem/v3-orderableDrugForm",
      "code" : "TAB"
    },
    "expectedSupplyDuration" : {
      "value" : 10,
      "unit" : "days",
      "system" : "http://unitsofmeasure.org",
      "code" : "d"
    }
  },
  "substitution" : {
    "allowedBoolean" : false,
    "reason" : {
      "coding" : [{
        "system" : "http://terminology.hl7.org/CodeSystem/v3-ActReason",
        "code" : "FP",
        "display" : "formulary policy"
      }]
    }
  }
}