Certainty Rating of all-cause mortality in meta-analysis of RCTs of heparin for moderately ill patients with COVID-19
{
"resourceType" : "ArtifactAssessment",
"id" : "example-certainty-rating",
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: ArtifactAssessment</b><a name=\"example-certainty-rating\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource ArtifactAssessment "example-certainty-rating" </p></div><p><b>identifier</b>: FEvIR Object Identifier: 27756</p><p><b>date</b>: 2021-11-02T14:48:59.89Z</p><p><b>copyright</b>: https://creativecommons.org/licenses/by-nc-sa/4.0/</p><p><b>artifact</b>: <a href=\"broken-link.html\">Evidence/18812: Critically appraised summary of all-cause mortality in meta-analysis of RCTs of heparin for moderately ill patients with COVID-19</a></p><blockquote><p><b>content</b></p><p><b>informationType</b>: rating</p><p><b>summary</b>: serious concerns with risk of bias, inconsistency, and imprecision</p><p><b>type</b>: Overall certainty <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"codesystem-certainty-type.html\">EvidenceCertaintyType</a>#Overall)</span></p><p><b>classifier</b>: Very low quality <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"codesystem-certainty-rating.html\">EvidenceCertaintyRating</a>#very-low)</span></p><p><b>author</b>: <span>: Brian S. Alper</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td>-</td><td><b>InformationType</b></td><td><b>Summary</b></td><td><b>Type</b></td><td><b>Classifier</b></td><td><b>Author</b></td></tr><tr><td>*</td><td>rating</td><td>risk of bias in both included trials</td><td>Risk of bias <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"codesystem-certainty-type.html\">EvidenceCertaintyType</a>#RiskOfBias)</span></td><td>serious concern <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"codesystem-certainty-rating.html\">EvidenceCertaintyRating</a>#serious-concern)</span></td><td><span>: Brian S. Alper</span></td></tr><tr><td>*</td><td>rating</td><td>high degree of heterogeneity (I-squared 80.7%) with confidence intervals of 2 trial effect estimates barely overlapping</td><td>Inconsistency <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"codesystem-certainty-type.html\">EvidenceCertaintyType</a>#Inconsistency)</span></td><td>serious concern <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"codesystem-certainty-rating.html\">EvidenceCertaintyRating</a>#serious-concern)</span></td><td><span>: Brian S. Alper</span></td></tr><tr><td>*</td><td>rating</td><td> </td><td>Indirectness <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"codesystem-certainty-type.html\">EvidenceCertaintyType</a>#Indirectness)</span></td><td>no serious concern <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"codesystem-certainty-rating.html\">EvidenceCertaintyRating</a>#no-concern)</span></td><td><span>: Brian S. Alper</span></td></tr><tr><td>*</td><td>rating</td><td>95% confidence interval includes both large effects and no effects</td><td>Imprecision <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"codesystem-certainty-type.html\">EvidenceCertaintyType</a>#Imprecision)</span></td><td>serious concern <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"codesystem-certainty-rating.html\">EvidenceCertaintyRating</a>#serious-concern)</span></td><td><span>: Brian S. Alper</span></td></tr><tr><td>*</td><td>rating</td><td> </td><td>Publication bias <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"codesystem-certainty-type.html\">EvidenceCertaintyType</a>#PublicationBias)</span></td><td>no serious concern <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"codesystem-certainty-rating.html\">EvidenceCertaintyRating</a>#no-concern)</span></td><td><span>: Brian S. Alper</span></td></tr></table></blockquote></div>"
},
"identifier" : [{
"type" : {
"text" : "FEvIR Object Identifier"
},
"system" : "https://fevir.net",
"value" : "27756",
"assigner" : {
"display" : "Computable Publishing LLC"
}
}],
"date" : "2021-11-02T14:48:59.890Z",
"copyright" : "https://creativecommons.org/licenses/by-nc-sa/4.0/",
"artifactReference" : {
"reference" : "Evidence/18812",
"type" : "Evidence",
"display" : "Critically appraised summary of all-cause mortality in meta-analysis of RCTs of heparin for moderately ill patients with COVID-19"
},
"content" : [{
"informationType" : "rating",
"summary" : "serious concerns with risk of bias, inconsistency, and imprecision",
"type" : {
"coding" : [{
"system" : "http://hl7.org/fhir/certainty-type",
"code" : "Overall",
"display" : "Overall certainty"
}]
},
"classifier" : [{
"coding" : [{
"system" : "http://terminology.hl7.org/CodeSystem/certainty-rating",
"code" : "very-low",
"display" : "Very low quality"
}]
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"author" : {
"display" : "Brian S. Alper"
},
"freeToShare" : true,
"component" : [{
"informationType" : "rating",
"summary" : "risk of bias in both included trials",
"type" : {
"coding" : [{
"system" : "http://hl7.org/fhir/certainty-type",
"code" : "RiskOfBias",
"display" : "Risk of bias"
}]
},
"classifier" : [{
"coding" : [{
"system" : "http://terminology.hl7.org/CodeSystem/certainty-rating",
"code" : "serious-concern",
"display" : "serious concern"
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"author" : {
"display" : "Brian S. Alper"
}
},
{
"informationType" : "rating",
"summary" : "high degree of heterogeneity (I-squared 80.7%) with confidence intervals of 2 trial effect estimates barely overlapping",
"type" : {
"coding" : [{
"system" : "http://hl7.org/fhir/certainty-type",
"code" : "Inconsistency",
"display" : "Inconsistency"
}]
},
"classifier" : [{
"coding" : [{
"system" : "http://terminology.hl7.org/CodeSystem/certainty-rating",
"code" : "serious-concern",
"display" : "serious concern"
}]
}],
"author" : {
"display" : "Brian S. Alper"
}
},
{
"informationType" : "rating",
"type" : {
"coding" : [{
"system" : "http://hl7.org/fhir/certainty-type",
"code" : "Indirectness",
"display" : "Indirectness"
}]
},
"classifier" : [{
"coding" : [{
"system" : "http://terminology.hl7.org/CodeSystem/certainty-rating",
"code" : "no-concern",
"display" : "no serious concern"
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}],
"author" : {
"display" : "Brian S. Alper"
}
},
{
"informationType" : "rating",
"summary" : "95% confidence interval includes both large effects and no effects",
"type" : {
"coding" : [{
"system" : "http://hl7.org/fhir/certainty-type",
"code" : "Imprecision",
"display" : "Imprecision"
}]
},
"classifier" : [{
"coding" : [{
"system" : "http://terminology.hl7.org/CodeSystem/certainty-rating",
"code" : "serious-concern",
"display" : "serious concern"
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}],
"author" : {
"display" : "Brian S. Alper"
}
},
{
"informationType" : "rating",
"type" : {
"coding" : [{
"system" : "http://hl7.org/fhir/certainty-type",
"code" : "PublicationBias",
"display" : "Publication bias"
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},
"classifier" : [{
"coding" : [{
"system" : "http://terminology.hl7.org/CodeSystem/certainty-rating",
"code" : "no-concern",
"display" : "no serious concern"
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"author" : {
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}]
}]
}
Usage note: every effort has been made to ensure that the
examples are correct and useful, but they are not a normative part
of the specification.
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