Release 5 Snapshot #1
Clinical ReasoningThis page is part of the FHIR Specification (v5.0.0-snapshot1: Release 5 Snapshot #1). The current version which supercedes this version is 5.0.0. For a full list of available versions, see the Directory of published versions 
| Clinical Decision Support Work Group | Maturity Level: N/A | Standards Status: Informative | Compartments: Not linked to any defined compartments |
Raw XML (canonical form + also see XML Format Specification)
Systematic Meta Review (id = "citation-example-systematic-meta-review")
<?xml version="1.0" encoding="UTF-8"?> <Citation xmlns="http://hl7.org/fhir"> <id value="citation-example-systematic-meta-review"/> <text> <status value="generated"/> <div xmlns="http://www.w3.org/1999/xhtml"><p> <b> Generated Narrative</b> </p> <div> <p> Resource "citation-example-systematic-meta-review" </p> </div> <p> <b> url</b> : <code> http://hl7.org/fhir/Citation/citation-example-systematic-meta-review</code> </p> <p> <b> identifier</b> : FEvIR Object Identifier: 27121</p> <p> <b> title</b> : SMR Sterne JAC JAMA 32876694</p> <p> <b> status</b> : active</p> <p> <b> description</b> : A systematic review included in the Steroids SMR Project</p> <p> <b> copyright</b> : https://creativecommons.org/licenses/by-nc-sa/4.0/</p> <p> <b> author</b> : Brian S. Alper: </p> <h3> Summaries</h3> <table> <tr> <td> -</td> <td> <b> Style</b> </td> <td> <b> Text</b> </td> </tr> <tr> <td> *</td> <td> Computable Publishing <span> (citation-summary-style#comppub)</span> </td> <td> Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19: A Meta-analysis [Journal Article]. Contributors: The WHO Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working Group Authors and Members of the Writing Committee: Jonathan A. C. Sterne, MA, MSc, PhD; Srinivas Murthy, MD, MSc; Janet V. Diaz, MD; Arthur S. Slutsky, CM, MD; Jesús Villar, MD, PhD; Derek C. Angus, MD, MPH; Djillali Annane, MD, PhD; Luciano Cesar Pontes Azevedo, MD, PhD; Otavio Berwanger, MD, PhD; Alexandre B. Cavalcanti, MD, PhD; Pierre-Francois Dequin, MD, PhD; Bin Du, MD; Jonathan Emberson, PhD; David Fisher, MSc; Bruno Giraudeau, PhD; Anthony C. Gordon, MBBS, MD; Anders Granholm, MD; Cameron Green, MSc; Richard Haynes, DM; Nicholas Heming, MD, PhD; Julian P. T. Higgins, BA, PhD; Peter Horby, PhD; Peter Jüni, MD; Martin J. Landray, PhD; Amelie Le Gouge, MSc; Marie Leclerc, MSc; Wei Shen Lim, BMedSci, BMBS, DM; Flávia R. Machado, MD, PhD; Colin McArthur, MBChB; Ferhat Meziani, MD, PhD; Morten Hylander Møller, MD, PhD; Anders Perner, MD, PhD; Marie Warrer Petersen, MD; Jelena Savović, BPharm, MSc, PhD; Bruno Tomazini, MD; Viviane C. Veiga, MD, PhD; Steve Webb, MBBS, MPH, PhD; John C. Marshall, MD. In: JAMA, PMID 32876694. Accessed February 15, 2021. Available at: http://doi.org/10.1 001/jama.2020.17023.</td> </tr> </table> <h3> Classifications</h3> <table> <tr> <td> -</td> <td> <b> Type</b> </td> <td> <b> Classifier</b> </td> </tr> <tr> <td> *</td> <td> FEvIR Platform Use <span> (<a> CitationClassificationType</a> #fevir-platform-use)</span> </td> <td> Project Specific <span> (<a> CitationArtifactClassifier</a> #project-specific)</span> </td> </tr> </table> <blockquote> <p> <b> statusDate</b> </p> <p> <b> activity</b> : ROB assessment <span> ()</span> </p> <p> <b> actual</b> : true</p> <p> <b> period</b> : ?? --> 2021-06-07</p> </blockquote> <blockquote> <p> <b> statusDate</b> </p> <p> <b> activity</b> : Author contact <span> ()</span> </p> <p> <b> actual</b> : true</p> <p> <b> period</b> : 2021-06-07 --> (ongoing)</p> </blockquote> <blockquote> <p> <b> citedArtifact</b> </p> <p> <b> identifier</b> : id: 32876694, pii: 2770279, id: 10.1001/jama.2020.17023, id: PMC7489434</p> <p> <b> relatedIdentifier</b> : id: CRD42020197242</p> <p> <b> dateAccessed</b> : 2021-02-15</p> <h3> Titles</h3> <table> <tr> <td> -</td> <td> <b> Type</b> </td> <td> <b> Language</b> </td> <td> <b> Text</b> </td> </tr> <tr> <td> *</td> <td> primary-human-use <span> ()</span> </td> <td> English <span> (<a> Tags for the Identification of Languages</a> #en)</span> </td> <td> Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19: A Meta-analysis.</td> </tr> </table> <h3> Abstracts</h3> <table> <tr> <td> -</td> <td> <b> Type</b> </td> <td> <b> Text</b> </td> </tr> <tr> <td> *</td> <td> Primary human use <span> (<a> CitedArtifactAbstractType</a> #primary-human-use)</span> </td> <td> <AbstractText Label="Importance">Effective therapies for patients with coronavirus disease 2019 (COVID-19) are needed, and clinical trial data have demonstrated that low-dose dexamethasone reduced mortality in hospitalized patients with COVID-19 who required respiratory support.</AbstractText><AbstractText Label="Objective">To estimate the association between administration of corticosteroids compared with usual care or placebo and 28-day all-cause mortality.</AbstractText><AbstractText Label="Des ign, Setting, and Participants">Prospective meta-analysis that pooled data from 7 randomized clinical trials that evaluated the efficacy of corticosteroids in 1703 critically ill patients with COVID-19. The trials were conducted in 12 countries from February 26, 2020, to June 9, 2020, and the date of final follow-up was July 6, 2020. Pooled data were aggregated from the individual trials, overall, and in predefined subgroups. Risk of bias was assessed using the Cochrane Risk of Bias Assessment Tool. Inconsistency among trial results was assessed using the I2 statistic. The primary analysis was an inverse variance-weighted fixed-effect meta-analysis of overall mortality, with the association between the intervention and mortality quantified using odds ratios (ORs). Random-effects meta-analyses also were conducted (with the Paule-Mandel estimate of heterogeneity and the Hartung-Knapp adjustment) and an inverse variance-weighted fixed-effect analysis using risk ratios.</AbstractText><Ab stractText Label="Exposures">Patients had been randomized to receive systemic dexamethasone, hydrocortisone, or methylprednisolone (678 patients) or to receive usual care or placebo (1025 patients).</AbstractText><AbstractText Label="Main Outcomes and Measures">The primary outcome measure was all-cause mortality at 28 days after randomization. A secondary outcome was investigator-defined serious adverse events.</AbstractText><AbstractText Label="Results">A total of 1703 patients (median age, 60 years [interquartile range, 52-68 years]; 488 [29%] women) were included in the analysis. Risk of bias was assessed as "low" for 6 of the 7 mortality results and as "some concerns" in 1 trial because of the randomization method. Five trials reported mortality at 28 days, 1 trial at 21 days, and 1 trial at 30 days. There were 222 deaths among the 678 patients randomized to corticosteroids and 425 deaths among the 1025 patients randomized to usual care or placebo (summary OR, 0.66 [95% CI, 0.53-0.82]; P < .001 based on a fixed-effect meta-analysis). There was little inconsistency between the trial results (I2 = 15.6%; P = .31 for heterogeneity) and the summary OR was 0.70 (95% CI, 0.48-1.01; P = .053) based on the random-effects meta-analysis. The fixed-effect summary OR for the association with mortality was 0.64 (95% CI, 0.50-0.82; P < .001) for dexamethasone compared with usual care or placebo (3 trials, 1282 patients, and 527 deaths), the OR was 0.69 (95% CI, 0.43-1.12; P = .13) for hydrocortisone (3 trials, 374 patients, and 94 deaths), and the OR was 0.91 (95% CI, 0.29-2.87; P = .87) for methylprednisolon e (1 trial, 47 patients, and 26 deaths). Among the 6 trials that reported serious adverse events, 64 events occurred among 354 patients randomized to corticosteroids and 80 events occurred among 342 patients randomized to usual care or placebo.</AbstractText><AbstractTex t Label="Conclusions and Relevance">In this prospective meta-analysis of clinical trials of critically ill patients with COVID-19, administration of systemic corticosteroids, compared with usual care or placebo, was associated with lower 28-day all-cause mortality.</Abstr actText></td> </tr> </table> <blockquote> <p> <b> publicationForm</b> </p> <h3> PublishedIns</h3> <table> <tr> <td> -</td> <td> <b> Type</b> </td> <td> <b> Identifier</b> </td> <td> <b> Title</b> </td> <td> <b> PublisherLocation</b> </td> </tr> <tr> <td> *</td> <td> Periodical <span> (<a> PublishedInType</a> #D020492)</span> </td> <td> ISSN Type: 1538-3598, ISOAbbreviation: JAMA, ISSN Linking: 0098-7484, Medline Title Abbreviation: JAMA, NLM Unique ID: 7501160</td> <td> JAMA</td> <td> United States</td> </tr> </table> <blockquote> <p> <b> periodicRelease</b> </p> <p> <b> citedMedium</b> : Internet <span> (journal-issue-medium#Internet)</span> </p> <p> <b> volume</b> : 324</p> <p> <b> issue</b> : 13</p> <h3> DateOfPublications</h3> <table> <tr> <td> -</td> <td> <b> Date</b> </td> <td> <b> Year</b> </td> <td> <b> Month</b> </td> <td> <b> Day</b> </td> </tr> <tr> <td> *</td> <td> 2020-10-06</td> <td> 2020</td> <td> 10</td> <td> 06</td> </tr> </table> </blockquote> <p> <b> language</b> : English <span> (<a> Tags for the Identification of Languages</a> #en)</span> </p> <p> <b> pageString</b> : 1330-1341</p> </blockquote> <blockquote> <p> <b> webLocation</b> </p> <p> <b> classifier</b> : DOI Based <span> (<a> ArtifactUrlClassifier</a> #doi-based)</span> </p> <p> <b> url</b> : <a> http://doi.org/10.1001/jama.2020.17023</a> </p> </blockquote> <blockquote> <p> <b> webLocation</b> </p> <p> <b> classifier</b> : on PubMed <span> (<a> ArtifactUrlClassifier[5.0.0-snapshot1]</a> #abstract "Abstract")</span> </p> <p> <b> url</b> : <a> https://pubmed.ncbi.nlm.nih.gov/32876694/</a> </p> </blockquote> <blockquote> <p> <b> webLocation</b> </p> <p> <b> classifier</b> : on JAMA <span> (<a> ArtifactUrlClassifier[5.0.0-snapshot1]</a> #full-text "Full-Text")</span> </p> <p> <b> url</b> : <a> https://jamanetwork.com/journals/jama/fullarticle/2770279</a> </p> </blockquote> <blockquote> <p> <b> classification</b> </p> <p> <b> type</b> : Steroids SMR project use <span> ()</span> </p> <p> <b> classifier</b> : primary article <span> ()</span> , Unclear risk of bias <span> ()</span> </p> <h3> WhoClassifieds</h3> <table> <tr> <td> -</td> <td> <b> Person</b> </td> <td> <b> FreeToShare</b> </td> </tr> <tr> <td> *</td> <td> <span> : Brian S. Alper</span> </td> <td> false</td> </tr> </table> </blockquote> <blockquote> <p> <b> classification</b> </p> <p> <b> type</b> : UC Description <span> ()</span> </p> <p> <b> classifier</b> : To assess systemic corticosteroids on 28-day mortality in critically ill patients with COVID-19 <span> ()</span> </p> <h3> WhoClassifieds</h3> <table> <tr> <td> -</td> <td> <b> Person</b> </td> <td> <b> Organization</b> </td> <td> <b> FreeToShare</b> </td> </tr> <tr> <td> *</td> <td> <span> : Dr. Ethan Molitch</span> </td> <td> <span> : University of Chicago</span> </td> <td> true</td> </tr> </table> </blockquote> <blockquote> <p> <b> classification</b> </p> <p> <b> type</b> : Knowledge Artifact Type <span> (<a> CitedArtifactClassificationType</a> #knowledge-artifact-type)</span> </p> <p> <b> classifier</b> : Journal Article <span> (<a> CitationArtifactClassifier</a> #D016428)</span> </p> <h3> WhoClassifieds</h3> <table> <tr> <td> -</td> <td> <b> Publisher</b> </td> <td> <b> ClassifierCopyright</b> </td> <td> <b> FreeToShare</b> </td> </tr> <tr> <td> *</td> <td> <span> : Computable Publishing LLC</span> </td> <td> https://creativecommons.org/licenses/by-nc-sa/4.0</td> <td> true</td> </tr> </table> </blockquote> <blockquote> <p> <b> classification</b> </p> <p> <b> type</b> : Publishing Model <span> (<a> CitedArtifactClassificationType</a> #publishing-model)</span> </p> <p> <b> classifier</b> : Print <span> (<a> CitationArtifactClassifier</a> #Print)</span> </p> </blockquote> <blockquote> <p> <b> classification</b> </p> <p> <b> type</b> : Chemical <span> (<a> CitedArtifactClassificationType</a> #chemical)</span> </p> <p> <b> classifier</b> : Adrenal Cortex Hormones <span> (chemical-substances#0; #D000305)</span> , Glucocorticoids <span> (chemical-substances#0; #D005938)</span> , Dexamethasone <span> (chemical-substances#7S5I7G3JQL; #D003907)</span> , Hydrocortisone <span> (chemical-substances#WI4X0X7BPJ; #D006854)</span> , Methylprednisolone <span> (chemical-substances#X4W7ZR7023; #D008775)</span> </p> </blockquote> <blockquote> <p> <b> classification</b> </p> <p> <b> type</b> : MeSH heading <span> (<a> CitedArtifactClassificationType</a> #mesh-heading)</span> </p> <p> <b> classifier</b> : Adrenal Cortex Hormones <span> (#D000305; #Q000627 "therapeutic use"; [not stated]#Y)</span> , Betacoronavirus <span> (#D000073640)</span> , COVID-19 <span> (#D000086382)</span> , Cause of Death <span> (#D002423)</span> , Coronavirus Infections <span> (#D018352; #Q000188 "drug therapy"; [not stated]#Y; #Q000401 "mortality"; [not stated]#N)</span> , Critical Illness <span> (#D016638)</span> , Dexamethasone <span> (#D003907; #Q000627 "therapeutic use"; [not stated]#N)</span> , Glucocorticoids <span> (#D005938; #Q000627 "therapeutic use"; [not stated]#Y)</span> , Humans <span> (#D006801)</span> , Hydrocortisone <span> (#D006854; #Q000627 "therapeutic use"; [not stated]#N)</span> , Methylprednisolone <span> (#D008775; #Q000627 "therapeutic use"; [not stated]#N)</span> , Pandemics <span> (#D058873)</span> , Pneumonia, Viral <span> (#D011024; #Q000188 "drug therapy"; [not stated]#Y; #Q000401 "mortality"; [not stated]#N)</span> , Randomized Controlled Trials as Topic <span> (#D016032)</span> , SARS-CoV-2 <span> (#D000086402)</span> </p> </blockquote> <blockquote> <p> <b> classification</b> </p> <p> <b> type</b> : Publication type <span> (<a> CitedArtifactClassificationType</a> #publication-type)</span> </p> <p> <b> classifier</b> : Journal Article <span> (#D016428)</span> , Meta-Analysis <span> (#D017418)</span> , Research Support, Non-U.S. Gov't <span> (#D013485)</span> </p> </blockquote> <blockquote> <p> <b> classification</b> </p> <p> <b> type</b> : Supplemental MeSH for Protocol <span> (<a> CitedArtifactClassificationType</a> #supplemental-mesh-protocol)</span> </p> <p> <b> classifier</b> : COVID-19 drug treatment <span> (#C000705127)</span> </p> </blockquote> <blockquote> <p> <b> classification</b> </p> <p> <b> type</b> : Citation subset <span> (<a> CitedArtifactClassificationType</a> #citation-subset)</span> </p> <p> <b> classifier</b> : AIM <span> (elements_descriptions.html#citationsubset#AIM)</span> , IM <span> (elements_descriptions.html#citationsubset#IM)</span> </p> </blockquote> <blockquote> <p> <b> classification</b> </p> <p> <b> type</b> : Funding <span> ()</span> </p> <p> <b> classifier</b> : The World Health Organization (Conflict of interest statements included notes on several fundings for co-investigators as well, albeit not directly funding this meta-analysis) <span> ()</span> </p> <h3> WhoClassifieds</h3> <table> <tr> <td> -</td> <td> <b> Person</b> </td> <td> <b> Organization</b> </td> <td> <b> FreeToShare</b> </td> </tr> <tr> <td> *</td> <td> <span> : Erfan Shamsoddin</span> </td> <td> <span> : COVID-19 Knowledge Accelerator</span> </td> <td> true</td> </tr> </table> </blockquote> <blockquote> <p> <b> contributorship</b> </p> <p> <b> complete</b> : true</p> <blockquote> <p> <b> entry</b> </p> <p> <b> collectiveName</b> : WHO Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working Group</p> </blockquote> <blockquote> <p> <b> entry</b> </p> <p> <b> name</b> : Jonathan A C Sterne </p> <p> <b> initials</b> : JAC</p> <blockquote> <p> <b> affiliationInfo</b> </p> <p> <b> affiliation</b> : Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, England.</p> </blockquote> <blockquote> <p> <b> affiliationInfo</b> </p> <p> <b> affiliation</b> : NIHR Bristol Biomedical Research Centre, Bristol, England.</p> </blockquote> <p> <b> telecom</b> : <a> jonathan.sterne@bristol.ac.uk</a> </p> <p> <b> correspondingContact</b> : true</p> </blockquote> <blockquote> <p> <b> entry</b> </p> <p> <b> name</b> : Srinivas Murthy </p> <p> <b> initials</b> : S</p> <h3> AffiliationInfos</h3> <table> <tr> <td> -</td> <td> <b> Affiliation</b> </td> </tr> <tr> <td> *</td> <td> Department of Pediatrics, University of British Columbia, Vancouver, Canada.</td> </tr> </table> </blockquote> <blockquote> <p> <b> entry</b> </p> <p> <b> name</b> : Janet V Diaz </p> <p> <b> initials</b> : JV</p> <h3> AffiliationInfos</h3> <table> <tr> <td> -</td> <td> <b> Affiliation</b> </td> </tr> <tr> <td> *</td> <td> Clinical Unit, Health Emergencies Programme, World Health Organization, Geneva, Switzerland.</td> </tr> </table> </blockquote> <blockquote> <p> <b> entry</b> </p> <p> <b> name</b> : Arthur S Slutsky </p> <p> <b> initials</b> : AS</p> <h3> AffiliationInfos</h3> <table> <tr> <td> -</td> <td> <b> Affiliation</b> </td> </tr> <tr> <td> *</td> <td> Applied Health Research Centre, Li Ka Shing Knowledge Institute of St Michael's Hospital, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.</td> </tr> </table> </blockquote> <blockquote> <p> <b> entry</b> </p> <p> <b> name</b> : Jesús Villar </p> <p> <b> initials</b> : J</p> <blockquote> <p> <b> affiliationInfo</b> </p> <p> <b> affiliation</b> : Research Unit, Hospital Universitario Dr Negrín, Las Palmas de Gran Canaria, Spain.</p> </blockquote> <blockquote> <p> <b> affiliationInfo</b> </p> <p> <b> affiliation</b> : CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain.</p> </blockquote> </blockquote> <blockquote> <p> <b> entry</b> </p> <p> <b> name</b> : Derek C Angus </p> <p> <b> initials</b> : DC</p> <h3> AffiliationInfos</h3> <table> <tr> <td> -</td> <td> <b> Affiliation</b> </td> </tr> <tr> <td> *</td> <td> Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.</td> </tr> </table> </blockquote> <blockquote> <p> <b> entry</b> </p> <p> <b> name</b> : Djillali Annane </p> <p> <b> initials</b> : D</p> <h3> AffiliationInfos</h3> <table> <tr> <td> -</td> <td> <b> Affiliation</b> </td> </tr> <tr> <td> *</td> <td> Department of Intensive Care, Raymond Poincaré Hospital (APHP), School of Medicine Simone Veil, University Paris Saclay-UVSQ, Paris, France.</td> </tr> </table> </blockquote> <blockquote> <p> <b> entry</b> </p> <p> <b> name</b> : Luciano Cesar Pontes Azevedo </p> <p> <b> initials</b> : LCP</p> <blockquote> <p> <b> affiliationInfo</b> </p> <p> <b> affiliation</b> : Hospital Sírio-Libanês, São Paulo, Brazil.</p> </blockquote> <blockquote> <p> <b> affiliationInfo</b> </p> <p> <b> affiliation</b> : Emergency Medicine Department, University of São Paulo School of Medicine, São Paulo, Brazil.</p> </blockquote> </blockquote> <blockquote> <p> <b> entry</b> </p> <p> <b> name</b> : Otavio Berwanger </p> <p> <b> initials</b> : O</p> <h3> AffiliationInfos</h3> <table> <tr> <td> -</td> <td> <b> Affiliation</b> </td> </tr> <tr> <td> *</td> <td> Academic Research Organization, Hospital Israelita Albert Einstein, São Paulo, Brazil.</td> </tr> </table> </blockquote> <blockquote> <p> <b> entry</b> </p> <p> <b> name</b> : Alexandre B Cavalcanti </p> <p> <b> initials</b> : AB</p> <h3> AffiliationInfos</h3> <table> <tr> <td> -</td> <td> <b> Affiliation</b> </td> </tr> <tr> <td> *</td> <td> HCor Research Insitute, São Paulo, Brazil.</td> </tr> </table> </blockquote> <blockquote> <p> <b> entry</b> </p> <p> <b> name</b> : Pierre-Francois Dequin </p> <p> <b> initials</b> : PF</p> <blockquote> <p> <b> affiliationInfo</b> </p> <p> <b> affiliation</b> : Médecine Intensive-Réanimation, INSERM CIC1415, CHRU de Tours, Tours, France.</p> </blockquote> <blockquote> <p> <b> affiliationInfo</b> </p> <p> <b> affiliation</b> : CRICS-TriGGERSep Network, Centre d'Etude des Pathologies Respiratoires, Université de Tours, Tours, France.</p> </blockquote> </blockquote> <blockquote> <p> <b> entry</b> </p> <p> <b> name</b> : Bin Du </p> <p> <b> initials</b> : B</p> <h3> AffiliationInfos</h3> <table> <tr> <td> -</td> <td> <b> Affiliation</b> </td> </tr> <tr> <td> *</td> <td> Peking Union Medical College Hospital, Beijing, China.</td> </tr> </table> </blockquote> <blockquote> <p> <b> entry</b> </p> <p> <b> name</b> : Jonathan Emberson </p> <p> <b> initials</b> : J</p> <blockquote> <p> <b> affiliationInfo</b> </p> <p> <b> affiliation</b> : Nuffield Department of Population Health, University of Oxford, Oxford, England.</p> </blockquote> <blockquote> <p> <b> affiliationInfo</b> </p> <p> <b> affiliation</b> : MRC Population Health Research Unit, University of Oxford, Oxford, England.</p> </blockquote> </blockquote> <blockquote> <p> <b> entry</b> </p> <p> <b> name</b> : David Fisher </p> <p> <b> initials</b> : D</p> <h3> AffiliationInfos</h3> <table> <tr> <td> -</td> <td> <b> Affiliation</b> </td> </tr> <tr> <td> *</td> <td> MRC Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, Faculty of Population Health Sciences, University College London, London, England.</td> </tr> </table> </blockquote> <blockquote> <p> <b> entry</b> </p> <p> <b> name</b> : Bruno Giraudeau </p> <p> <b> initials</b> : B</p> <h3> AffiliationInfos</h3> <table> <tr> <td> -</td> <td> <b> Affiliation</b> </td> </tr> <tr> <td> *</td> <td> CIC INSERM 1415-CHRU de Tours, Tours, France.</td> </tr> </table> </blockquote> <blockquote> <p> <b> entry</b> </p> <p> <b> name</b> : Anthony C Gordon </p> <p> <b> initials</b> : AC</p> <h3> AffiliationInfos</h3> <table> <tr> <td> -</td> <td> <b> Affiliation</b> </td> </tr> <tr> <td> *</td> <td> Division of Anaesthetics, Pain Medicine and Intensive Care, Imperial College London, London, England.</td> </tr> </table> </blockquote> <blockquote> <p> <b> entry</b> </p> <p> <b> name</b> : Anders Granholm </p> <p> <b> initials</b> : A</p> <h3> AffiliationInfos</h3> <table> <tr> <td> -</td> <td> <b> Affiliation</b> </td> </tr> <tr> <td> *</td> <td> Department of Intensive Care, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.</td> </tr> </table> </blockquote> <blockquote> <p> <b> entry</b> </p> <p> <b> name</b> : Cameron Green </p> <p> <b> initials</b> : C</p> <h3> AffiliationInfos</h3> <table> <tr> <td> -</td> <td> <b> Affiliation</b> </td> </tr> <tr> <td> *</td> <td> Australian and New Zealand Intensive Care Research Centre, School of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia.</td> </tr> </table> </blockquote> <blockquote> <p> <b> entry</b> </p> <p> <b> name</b> : Richard Haynes </p> <p> <b> initials</b> : R</p> <blockquote> <p> <b> affiliationInfo</b> </p> <p> <b> affiliation</b> : Nuffield Department of Population Health, University of Oxford, Oxford, England.</p> </blockquote> <blockquote> <p> <b> affiliationInfo</b> </p> <p> <b> affiliation</b> : MRC Population Health Research Unit, University of Oxford, Oxford, England.</p> </blockquote> </blockquote> <blockquote> <p> <b> entry</b> </p> <p> <b> name</b> : Nicholas Heming </p> <p> <b> initials</b> : N</p> <h3> AffiliationInfos</h3> <table> <tr> <td> -</td> <td> <b> Affiliation</b> </td> </tr> <tr> <td> *</td> <td> Department of Intensive Care, Raymond Poincaré Hospital (APHP), School of Medicine Simone Veil, University Paris Saclay-UVSQ, Paris, France.</td> </tr> </table> </blockquote> <blockquote> <p> <b> entry</b> </p> <p> <b> name</b> : Julian P T Higgins </p> <p> <b> initials</b> : JPT</p> <blockquote> <p> <b> affiliationInfo</b> </p> <p> <b> affiliation</b> : Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, England.</p> </blockquote> <blockquote> <p> <b> affiliationInfo</b> </p> <p> <b> affiliation</b> : NIHR Bristol Biomedical Research Centre, Bristol, England.</p> </blockquote> <blockquote> <p> <b> affiliationInfo</b> </p> <p> <b> affiliation</b> : NIHR Applied Research Collaboration West, University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, England.</p> </blockquote> </blockquote> <blockquote> <p> <b> entry</b> </p> <p> <b> name</b> : Peter Horby </p> <p> <b> initials</b> : P</p> <h3> AffiliationInfos</h3> <table> <tr> <td> -</td> <td> <b> Affiliation</b> </td> </tr> <tr> <td> *</td> <td> Nuffield Department of Medicine, University of Oxford, Oxford, England.</td> </tr> </table> </blockquote> <blockquote> <p> <b> entry</b> </p> <p> <b> name</b> : Peter Jüni </p> <p> <b> initials</b> : P</p> <h3> AffiliationInfos</h3> <table> <tr> <td> -</td> <td> <b> Affiliation</b> </td> </tr> <tr> <td> *</td> <td> Applied Health Research Centre, Li Ka Shing Knowledge Institute of St Michael's Hospital, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.</td> </tr> </table> </blockquote> <blockquote> <p> <b> entry</b> </p> <p> <b> name</b> : Martin J Landray </p> <p> <b> initials</b> : MJ</p> <blockquote> <p> <b> affiliationInfo</b> </p> <p> <b> affiliation</b> : Nuffield Department of Population Health, University of Oxford, Oxford, England.</p> </blockquote> <blockquote> <p> <b> affiliationInfo</b> </p> <p> <b> affiliation</b> : MRC Population Health Research Unit, University of Oxford, Oxford, England.</p> </blockquote> <blockquote> <p> <b> affiliationInfo</b> </p> <p> <b> affiliation</b> : NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, England.</p> </blockquote> </blockquote> <blockquote> <p> <b> entry</b> </p> <p> <b> name</b> : Amelie Le Gouge </p> <p> <b> initials</b> : A</p> <h3> AffiliationInfos</h3> <table> <tr> <td> -</td> <td> <b> Affiliation</b> </td> </tr> <tr> <td> *</td> <td> CIC INSERM 1415-CHRU de Tours, Tours, France.</td> </tr> </table> </blockquote> <blockquote> <p> <b> entry</b> </p> <p> <b> name</b> : Marie Leclerc </p> <p> <b> initials</b> : M</p> <h3> AffiliationInfos</h3> <table> <tr> <td> -</td> <td> <b> Affiliation</b> </td> </tr> <tr> <td> *</td> <td> CIC INSERM 1415-CHRU de Tours, Tours, France.</td> </tr> </table> </blockquote> <blockquote> <p> <b> entry</b> </p> <p> <b> name</b> : Wei Shen Lim </p> <p> <b> initials</b> : WS</p> <h3> AffiliationInfos</h3> <table> <tr> <td> -</td> <td> <b> Affiliation</b> </td> </tr> <tr> <td> *</td> <td> Respiratory Medicine Department, Nottingham University Hospitals NHS Trust, Nottingham, England.</td> </tr> </table> </blockquote> <blockquote> <p> <b> entry</b> </p> <p> <b> name</b> : Flávia R Machado </p> <p> <b> initials</b> : FR</p> <h3> AffiliationInfos</h3> <table> <tr> <td> -</td> <td> <b> Affiliation</b> </td> </tr> <tr> <td> *</td> <td> Anesthesiology, Pain, and Intensive Care Department, Federal University of São Paulo, São Paulo, Brazil.</td> </tr> </table> </blockquote> <blockquote> <p> <b> entry</b> </p> <p> <b> name</b> : Colin McArthur </p> <p> <b> initials</b> : C</p> <blockquote> <p> <b> affiliationInfo</b> </p> <p> <b> affiliation</b> : Australian and New Zealand Intensive Care Research Centre, School of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia.</p> </blockquote> <blockquote> <p> <b> affiliationInfo</b> </p> <p> <b> affiliation</b> : Department of Critical Care Medicine, Auckland City Hospital, Auckland, New Zealand.</p> </blockquote> </blockquote> <blockquote> <p> <b> entry</b> </p> <p> <b> name</b> : Ferhat Meziani </p> <p> <b> initials</b> : F</p> <blockquote> <p> <b> affiliationInfo</b> </p> <p> <b> affiliation</b> : Hôpitaux Universitaires de Strasbourg, Service de Médecine Intensive Réanimation, Nouvel Hôpital Civil, Strasbourg, France.</p> </blockquote> <blockquote> <p> <b> affiliationInfo</b> </p> <p> <b> affiliation</b> : INSERM UMR 1260, Regenerative Nanomedicine, FMTS, Strasbourg, France.</p> </blockquote> </blockquote> <blockquote> <p> <b> entry</b> </p> <p> <b> name</b> : Morten Hylander Møller </p> <p> <b> initials</b> : MH</p> <h3> AffiliationInfos</h3> <table> <tr> <td> -</td> <td> <b> Affiliation</b> </td> </tr> <tr> <td> *</td> <td> Department of Intensive Care, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.</td> </tr> </table> </blockquote> <blockquote> <p> <b> entry</b> </p> <p> <b> name</b> : Anders Perner </p> <p> <b> initials</b> : A</p> <h3> AffiliationInfos</h3> <table> <tr> <td> -</td> <td> <b> Affiliation</b> </td> </tr> <tr> <td> *</td> <td> Department of Intensive Care, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.</td> </tr> </table> </blockquote> <blockquote> <p> <b> entry</b> </p> <p> <b> name</b> : Marie Warrer Petersen </p> <p> <b> initials</b> : MW</p> <h3> AffiliationInfos</h3> <table> <tr> <td> -</td> <td> <b> Affiliation</b> </td> </tr> <tr> <td> *</td> <td> Department of Intensive Care, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.</td> </tr> </table> </blockquote> <blockquote> <p> <b> entry</b> </p> <p> <b> name</b> : Jelena Savovic </p> <p> <b> initials</b> : J</p> <blockquote> <p> <b> affiliationInfo</b> </p> <p> <b> affiliation</b> : Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, England.</p> </blockquote> <blockquote> <p> <b> affiliationInfo</b> </p> <p> <b> affiliation</b> : NIHR Applied Research Collaboration West, University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, England.</p> </blockquote> </blockquote> <blockquote> <p> <b> entry</b> </p> <p> <b> name</b> : Bruno Tomazini </p> <p> <b> initials</b> : B</p> <blockquote> <p> <b> affiliationInfo</b> </p> <p> <b> affiliation</b> : Hospital Sírio-Libanês, São Paulo, Brazil.</p> </blockquote> <blockquote> <p> <b> affiliationInfo</b> </p> <p> <b> affiliation</b> : Department of Surgery, School of Medicine, University of São Paulo, São Paulo, Brazil.</p> </blockquote> </blockquote> <blockquote> <p> <b> entry</b> </p> <p> <b> name</b> : Viviane C Veiga </p> <p> <b> initials</b> : VC</p> <h3> AffiliationInfos</h3> <table> <tr> <td> -</td> <td> <b> Affiliation</b> </td> </tr> <tr> <td> *</td> <td> BP-A Beneficência Portuguesa de São Paulo, São Paulo, Brazil.</td> </tr> </table> </blockquote> <blockquote> <p> <b> entry</b> </p> <p> <b> name</b> : Steve Webb </p> <p> <b> initials</b> : S</p> <blockquote> <p> <b> affiliationInfo</b> </p> <p> <b> affiliation</b> : Australian and New Zealand Intensive Care Research Centre, School of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia.</p> </blockquote> <blockquote> <p> <b> affiliationInfo</b> </p> <p> <b> affiliation</b> : St John of God Healthcare, Subiaco, Australia.</p> </blockquote> </blockquote> <blockquote> <p> <b> entry</b> </p> <p> <b> name</b> : John C Marshall </p> <p> <b> initials</b> : JC</p> <h3> AffiliationInfos</h3> <table> <tr> <td> -</td> <td> <b> Affiliation</b> </td> </tr> <tr> <td> *</td> <td> Li Ka Shing Knowledge Institute, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.</td> </tr> </table> </blockquote> <h3> Summaries</h3> <table> <tr> <td> -</td> <td> <b> Type</b> </td> <td> <b> Source</b> </td> <td> <b> Value</b> </td> </tr> <tr> <td> *</td> <td> Author string <span> (<a> ContributorSummaryType[5.0.0-snapshot1]</a> #author-string)</span> </td> <td> articleCopy <span> ()</span> </td> <td> The WHO Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working Group Authors and Members of the Writing Committee: Jonathan A. C. Sterne, MA, MSc, PhD; Srinivas Murthy, MD, MSc; Janet V. Diaz, MD; Arthur S. Slutsky, CM, MD; Jesús Villar, MD, PhD; Derek C. Angus, MD, MPH; Djillali Annane, MD, PhD; Luciano Cesar Pontes Azevedo, MD, PhD; Otavio Berwanger, MD, PhD; Alexandre B. Cavalcanti, MD, PhD; Pierre-Francois Dequin, MD, PhD; Bin Du, MD; Jonathan Emberson, PhD; David Fisher, MSc; Bruno Giraudeau, PhD; Anthony C. Gordon, MBBS, MD; Anders Granholm, MD; Cameron Green, MSc; Richard Haynes, DM; Nicholas Heming, MD, PhD; Julian P. T. Higgins, BA, PhD; Peter Horby, PhD; Peter Jüni, MD; Martin J. Landray, PhD; Amelie Le Gouge, MSc; Marie Leclerc, MSc; Wei Shen Lim, BMedSci, BMBS, DM; Flávia R. Machado, MD, PhD; Colin McArthur, MBChB; Ferhat Meziani, MD, PhD; Morten Hylander Møller, MD, PhD; Anders Perner, MD, PhD; Marie Warrer Petersen, MD; Jelena Savović, BPharm, MSc, PhD; Bruno Tomazini, MD; Viviane C. Veiga, MD, PhD; Steve Webb, MBBS, MPH, PhD; John C. Marshall, MD.</td> </tr> </table> </blockquote> </blockquote> </div> </text> <url value="http://hl7.org/fhir/Citation/citation-example-systematic-meta-review"/> <identifier> <type> <text value="FEvIR Object Identifier"/> </type> <system value="https://fevir.net"/> <value value="27121"/> <assigner> <display value="Computable Publishing LLC"/> </assigner> </identifier> <title value="SMR Sterne JAC JAMA 32876694"/> <status value="active"/> <description value="A systematic review included in the Steroids SMR Project"/> <useContext> <code> <system value="http://terminology.hl7.org/CodeSystem/usage-context-type"/> <code value="program"/> <display value="Program"/> </code> <valueCodeableConcept> <text value="Steroids SMR Project"/> </valueCodeableConcept> </useContext> <copyright value="https://creativecommons.org/licenses/by-nc-sa/4.0/"/> <author> <name value="Brian S. Alper"/> </author> <summary> <style> <coding> <system value="http://terminology.hl7.org/ValueSet/citation-summary-style"/> <code value="comppub"/> <display value="Computable Publishing"/> </coding> </style> <text value="Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19: A Meta-analysis [Journal Article]. Contributors: The WHO Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working Group Authors and Members of the Writing Committee: Jonathan A. C. Sterne, MA, MSc, PhD; Srinivas Murthy, MD, MSc; Janet V. Diaz, MD; Arthur S. Slutsky, CM, MD; Jesús Villar, MD, PhD; Derek C. Angus, MD, MPH; Djillali Annane, MD, PhD; Luciano Cesar Pontes Azevedo, MD, PhD; Otavio Berwanger, MD, PhD; Alexandre B. Cavalcanti, MD, PhD; Pierre-Francois Dequin, MD, PhD; Bin Du, MD; Jonathan Emberson, PhD; David Fisher, MSc; Bruno Giraudeau, PhD; Anthony C. Gordon, MBBS, MD; Anders Granholm, MD; Cameron Green, MSc; Richard Haynes, DM; Nicholas Heming, MD, PhD; Julian P. T. Higgins, BA, PhD; Peter Horby, PhD; Peter Jüni, MD; Martin J. Landray, PhD; Amelie Le Gouge, MSc; Marie Leclerc, MSc; Wei Shen Lim, BMedSci, BMBS, DM; Flávia R. Machado, MD, PhD; Colin McArthur, MBChB; Ferhat Meziani, MD, PhD; Morten Hylander Møller, MD, PhD; Anders Perner, MD, PhD; Marie Warrer Petersen, MD; Jelena Savović, BPharm, MSc, PhD; Bruno Tomazini, MD; Viviane C. Veiga, MD, PhD; Steve Webb, MBBS, MPH, PhD; John C. Marshall, MD. In: JAMA, PMID 32876694. Accessed February 15, 2021. Available at: http://doi.org/10.1 001/jama.2020.17023."/> </summary> <classification> <type> <coding> <system value="http://terminology.hl7.org/CodeSystem/citation-classification-type"/> <code value="fevir-platform-use"/> <display value="FEvIR Platform Use"/> </coding> </type> <classifier> <coding> <system value="http://terminology.hl7.org/CodeSystem/citation-artifact-classifier"/> <code value="project-specific"/> <display value="Project Specific"/> </coding> </classifier> </classification> <statusDate> <activity> <text value="ROB assessment"/> </activity> <actual value="true"/> <period> <end value="2021-06-07"/> </period> </statusDate> <statusDate> <activity> <text value="Author contact"/> </activity> <actual value="true"/> <period> <start value="2021-06-07"/> </period> </statusDate> <relatedArtifact> <type value="derived-from"/> <classifier> <coding> <system value="http://terminology.hl7.org/CodeSystem/citation-artifact-classifier"/> <code value="fhir-resource"/> <display value="FHIR Resource"/> </coding> </classifier> <resourceReference> <reference value="Citation/87"/> <type value="Citation"/> <identifier> <system value="https://fevir.net"/> <value value="87"/> <assigner> <display value="FEvIR ID"/> </assigner> </identifier> <display value="32876694 Medline Base"/> </resourceReference> </relatedArtifact> <citedArtifact> <identifier> <system value="https://pubmed.ncbi.nlm.nih.gov"/> <value value="32876694"/> <assigner> <display value="NLM"/> </assigner> </identifier> <identifier> <type> <text value="pii"/> </type> <value value="2770279"/> </identifier> <identifier> <system value="https://doi.org"/> <value value="10.1001/jama.2020.17023"/> </identifier> <identifier> <system value="https://www.ncbi.nlm.nih.gov/pmc/"/> <value value="PMC7489434"/> <assigner> <display value="NLM"/> </assigner> </identifier> <relatedIdentifier> <system value="https://www.crd.york.ac.uk/prospero"/> <value value="CRD42020197242"/> <assigner> <display value="PROSPERO"/> </assigner> </relatedIdentifier> <dateAccessed value="2021-02-15"/> <title> <type> <text value="primary-human-use"/> </type> <language> <coding> <system value="urn:ietf:bcp:47"/> <code value="en"/> <display value="English"/> </coding> </language> <text value="Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19: A Meta-analysis."/> </title> <abstract> <type> <coding> <system value="http://terminology.hl7.org/CodeSystem/cited-artifact-abstract-type"/> <code value="primary-human-use"/> <display value="Primary human use"/> </coding> </type> <text value="<AbstractText Label="Importance">Effective therapies for patients with coronavirus disease 2019 (COVID-19) are needed, and clinical trial data have demonstrated that low-dose dexamethasone reduced mortality in hospitalized patients with COVID-19 who required respiratory support.</AbstractText><AbstractText Label="Objective">To estimate the association between administration of corticosteroids compared with usual care or placebo and 28-day all-cause mortality.</AbstractText><AbstractText Label="Des ign, Setting, and Participants">Prospective meta-analysis that pooled data from 7 randomized clinical trials that evaluated the efficacy of corticosteroids in 1703 critically ill patients with COVID-19. The trials were conducted in 12 countries from February 26, 2020, to June 9, 2020, and the date of final follow-up was July 6, 2020. Pooled data were aggregated from the individual trials, overall, and in predefined subgroups. Risk of bias was assessed using the Cochrane Risk of Bias Assessment Tool. Inconsistency among trial results was assessed using the I2 statistic. The primary analysis was an inverse variance-weighted fixed-effect meta-analysis of overall mortality, with the association between the intervention and mortality quantified using odds ratios (ORs). Random-effects meta-analyses also were conducted (with the Paule-Mandel estimate of heterogeneity and the Hartung-Knapp adjustment) and an inverse variance-weighted fixed-effect analysis using risk ratios.</AbstractText><Ab stractText Label="Exposures">Patients had been randomized to receive systemic dexamethasone, hydrocortisone, or methylprednisolone (678 patients) or to receive usual care or placebo (1025 patients).</AbstractText><AbstractText Label="Main Outcomes and Measures">The primary outcome measure was all-cause mortality at 28 days after randomization. A secondary outcome was investigator-defined serious adverse events.</AbstractText><AbstractText Label="Results">A total of 1703 patients (median age, 60 years [interquartile range, 52-68 years]; 488 [29%] women) were included in the analysis. Risk of bias was assessed as "low" for 6 of the 7 mortality results and as "some concerns" in 1 trial because of the randomization method. Five trials reported mortality at 28 days, 1 trial at 21 days, and 1 trial at 30 days. There were 222 deaths among the 678 patients randomized to corticosteroids and 425 deaths among the 1025 patients randomized to usual care or placebo (summary OR, 0.66 [95% CI, 0.53-0.82]; P < .001 based on a fixed-effect meta-analysis). There was little inconsistency between the trial results (I2 = 15.6%; P = .31 for heterogeneity) and the summary OR was 0.70 (95% CI, 0.48-1.01; P = .053) based on the random-effects meta-analysis. The fixed-effect summary OR for the association with mortality was 0.64 (95% CI, 0.50-0.82; P < .001) for dexamethasone compared with usual care or placebo (3 trials, 1282 patients, and 527 deaths), the OR was 0.69 (95% CI, 0.43-1.12; P = .13) for hydrocortisone (3 trials, 374 patients, and 94 deaths), and the OR was 0.91 (95% CI, 0.29-2.87; P = .87) for methylprednisolon e (1 trial, 47 patients, and 26 deaths). Among the 6 trials that reported serious adverse events, 64 events occurred among 354 patients randomized to corticosteroids and 80 events occurred among 342 patients randomized to usual care or placebo.</AbstractText><AbstractTex t Label="Conclusions and Relevance">In this prospective meta-analysis of clinical trials of critically ill patients with COVID-19, administration of systemic corticosteroids, compared with usual care or placebo, was associated with lower 28-day all-cause mortality.</Abstr actText>"/> </abstract> <relatesTo> <type value="cites"/> <classifier> <coding> <system value="http://terminology.hl7.org/CodeSystem/citation-artifact-classifier"/> <code value="D016428"/> <display value="Journal Article"/> </coding> </classifier> <citation value="JAMA. 2020 Oct 6;324(13):1307-1316"/> <document> <url value="https://pubmed.ncbi.nlm.nih.gov/32876695/"/> </document> <resourceReference> <identifier> <system value="https://pubmed.ncbi.nlm.nih.gov"/> <value value="32876695"/> <assigner> <display value="NLM"/> </assigner> </identifier> </resourceReference> </relatesTo> <relatesTo> <type value="cites"/> <classifier> <coding> <system value="http://terminology.hl7.org/CodeSystem/citation-artifact-classifier"/> <code value="D016428"/> <display value="Journal Article"/> </coding> </classifier> <citation value="Res Synth Methods. 2017 Jun;8(2):181-198"/> <document> <url value="https://pubmed.ncbi.nlm.nih.gov/27060925/"/> </document> <resourceReference> <identifier> <system value="https://pubmed.ncbi.nlm.nih.gov"/> <value value="27060925"/> <assigner> <display value="NLM"/> </assigner> </identifier> </resourceReference> </relatesTo> <relatesTo> <type value="cites"/> <classifier> <coding> <system value="http://terminology.hl7.org/CodeSystem/citation-artifact-classifier"/> <code value="D016428"/> <display value="Journal Article"/> </coding> </classifier> <citation value="Trials. 2020 Aug 24;21(1):734"/> <document> <url value="https://pubmed.ncbi.nlm.nih.gov/32831155/"/> </document> <resourceReference> <identifier> <system value="https://pubmed.ncbi.nlm.nih.gov"/> <value value="32831155"/> <assigner> <display value="NLM"/> </assigner> </identifier> </resourceReference> </relatesTo> <relatesTo> <type value="cites"/> <classifier> <coding> <system value="http://terminology.hl7.org/CodeSystem/citation-artifact-classifier"/> <code value="D016428"/> <display value="Journal Article"/> </coding> </classifier> <citation value="Clin Infect Dis. 2020 Aug 12;:"/> <document> <url value="https://pubmed.ncbi.nlm.nih.gov/32785710/"/> </document> <resourceReference> <identifier> <system value="https://pubmed.ncbi.nlm.nih.gov"/> <value value="32785710"/> <assigner> <display value="NLM"/> </assigner> </identifier> </resourceReference> </relatesTo> <relatesTo> <type value="cites"/> <classifier> <coding> <system value="http://terminology.hl7.org/CodeSystem/citation-artifact-classifier"/> <code value="D016428"/> <display value="Journal Article"/> </coding> </classifier> <citation value="Stat Med. 2001 Dec 30;20(24):3875-89"/> <document> <url value="https://pubmed.ncbi.nlm.nih.gov/11782040/"/> </document> <resourceReference> <identifier> <system value="https://pubmed.ncbi.nlm.nih.gov"/> <value value="11782040"/> <assigner> <display value="NLM"/> </assigner> </identifier> </resourceReference> </relatesTo> <relatesTo> <type value="cites"/> <classifier> <coding> <system value="http://terminology.hl7.org/CodeSystem/citation-artifact-classifier"/> <code value="D016428"/> <display value="Journal Article"/> </coding> </classifier> <citation value="JAMA. 2020 Oct 6;324(13):1298-1306"/> <document> <url value="https://pubmed.ncbi.nlm.nih.gov/32876689/"/> </document> <resourceReference> <identifier> <system value="https://pubmed.ncbi.nlm.nih.gov"/> <value value="32876689"/> <assigner> <display value="NLM"/> </assigner> </identifier> </resourceReference> </relatesTo> <relatesTo> <type value="cites"/> <classifier> <coding> <system value="http://terminology.hl7.org/CodeSystem/citation-artifact-classifier"/> <code value="D016428"/> <display value="Journal Article"/> </coding> </classifier> <citation value="N Engl J Med. 2020 Jul 17;:"/> <document> <url value="https://pubmed.ncbi.nlm.nih.gov/32678530/"/> </document> <resourceReference> <identifier> <system value="https://pubmed.ncbi.nlm.nih.gov"/> <value value="32678530"/> <assigner> <display value="NLM"/> </assigner> </identifier> </resourceReference> </relatesTo> <relatesTo> <type value="cites"/> <classifier> <coding> <system value="http://terminology.hl7.org/CodeSystem/citation-artifact-classifier"/> <code value="D016428"/> <display value="Journal Article"/> </coding> </classifier> <citation value="BMJ. 2020 May 22;369:m1985"/> <document> <url value="https://pubmed.ncbi.nlm.nih.gov/32444460/"/> </document> <resourceReference> <identifier> <system value="https://pubmed.ncbi.nlm.nih.gov"/> <value value="32444460"/> <assigner> <display value="NLM"/> </assigner> </identifier> </resourceReference> </relatesTo> <relatesTo> <type value="cites"/> <classifier> <coding> <system value="http://terminology.hl7.org/CodeSystem/citation-artifact-classifier"/> <code value="D016428"/> <display value="Journal Article"/> </coding> </classifier> <citation value="Cochrane Database Syst Rev. 2019 Dec 6;12:CD002243"/> <document> <url value="https://pubmed.ncbi.nlm.nih.gov/31808551/"/> </document> <resourceReference> <identifier> <system value="https://pubmed.ncbi.nlm.nih.gov"/> <value value="31808551"/> <assigner> <display value="NLM"/> </assigner> </identifier> </resourceReference> </relatesTo> <relatesTo> <type value="cites"/> <classifier> <coding> <system value="http://terminology.hl7.org/CodeSystem/citation-artifact-classifier"/> <code value="D016428"/> <display value="Journal Article"/> </coding> </classifier> <citation value="Intensive Care Med. 2017 Dec;43(12):1751-1763"/> <document> <url value="https://pubmed.ncbi.nlm.nih.gov/28940011/"/> </document> <resourceReference> <identifier> <system value="https://pubmed.ncbi.nlm.nih.gov"/> <value value="28940011"/> <assigner> <display value="NLM"/> </assigner> </identifier> </resourceReference> </relatesTo> <relatesTo> <type value="cites"/> <classifier> <coding> <system value="http://terminology.hl7.org/CodeSystem/citation-artifact-classifier"/> <code value="D016428"/> <display value="Journal Article"/> </coding> </classifier> <citation value="BMJ. 2008 Apr 26;336(7650):924-6"/> <document> <url value="https://pubmed.ncbi.nlm.nih.gov/18436948/"/> </document> <resourceReference> <identifier> <system value="https://pubmed.ncbi.nlm.nih.gov"/> <value value="18436948"/> <assigner> <display value="NLM"/> </assigner> </identifier> </resourceReference> </relatesTo> <relatesTo> <type value="cites"/> <classifier> <coding> <system value="http://terminology.hl7.org/CodeSystem/citation-artifact-classifier"/> <code value="D016428"/> <display value="Journal Article"/> </coding> </classifier> <citation value="BMJ. 2017 Mar 3;356:j573"/> <document> <url value="https://pubmed.ncbi.nlm.nih.gov/28258124/"/> </document> <resourceReference> <identifier> <system value="https://pubmed.ncbi.nlm.nih.gov"/> <value value="28258124"/> <assigner> <display value="NLM"/> </assigner> </identifier> </resourceReference> </relatesTo> <relatesTo> <type value="cites"/> <classifier> <coding> <system value="http://terminology.hl7.org/CodeSystem/citation-artifact-classifier"/> <code value="D016428"/> <display value="Journal Article"/> </coding> </classifier> <citation value="Crit Care Explor. 2020 Apr 29;2(4):e0111"/> <document> <url value="https://pubmed.ncbi.nlm.nih.gov/32426753/"/> </document> <resourceReference> <identifier> <system value="https://pubmed.ncbi.nlm.nih.gov"/> <value value="32426753"/> <assigner> <display value="NLM"/> </assigner> </identifier> </resourceReference> </relatesTo> <relatesTo> <type value="cites"/> <classifier> <coding> <system value="http://terminology.hl7.org/CodeSystem/citation-artifact-classifier"/> <code value="D016428"/> <display value="Journal Article"/> </coding> </classifier> <citation value="JAMA. 2020 Oct 6;324(13):1317-1329"/> <document> <url value="https://pubmed.ncbi.nlm.nih.gov/32876697/"/> </document> <resourceReference> <identifier> <system value="https://pubmed.ncbi.nlm.nih.gov"/> <value value="32876697"/> <assigner> <display value="NLM"/> </assigner> </identifier> </resourceReference> </relatesTo> <relatesTo> <type value="cites"/> <classifier> <coding> <system value="http://terminology.hl7.org/CodeSystem/citation-artifact-classifier"/> <code value="D016428"/> <display value="Journal Article"/> </coding> </classifier> <citation value="BMJ. 2019 Aug 28;366:l4898"/> <document> <url value="https://pubmed.ncbi.nlm.nih.gov/31462531/"/> </document> <resourceReference> <identifier> <system value="https://pubmed.ncbi.nlm.nih.gov"/> <value value="31462531"/> <assigner> <display value="NLM"/> </assigner> </identifier> </resourceReference> </relatesTo> <relatesTo> <type value="cites"/> <classifier> <coding> <system value="http://terminology.hl7.org/CodeSystem/citation-artifact-classifier"/> <code value="D016428"/> <display value="Journal Article"/> </coding> </classifier> <citation value="BMC Med Res Methodol. 2014 Feb 18;14:25"/> <document> <url value="https://pubmed.ncbi.nlm.nih.gov/24548571/"/> </document> <resourceReference> <identifier> <system value="https://pubmed.ncbi.nlm.nih.gov"/> <value value="24548571"/> <assigner> <display value="NLM"/> </assigner> </identifier> </resourceReference> </relatesTo> <relatesTo> <type value="cites"/> <classifier> <coding> <system value="http://terminology.hl7.org/CodeSystem/citation-artifact-classifier"/> <code value="D016428"/> <display value="Journal Article"/> </coding> </classifier> <citation value="JAMA. 2012 Jun 20;307(23):2526-33"/> <document> <url value="https://pubmed.ncbi.nlm.nih.gov/22797452/"/> </document> <resourceReference> <identifier> <system value="https://pubmed.ncbi.nlm.nih.gov"/> <value value="22797452"/> <assigner> <display value="NLM"/> </assigner> </identifier> </resourceReference> </relatesTo> <relatesTo> <type value="cites"/> <classifier> <coding> <system value="http://terminology.hl7.org/CodeSystem/citation-artifact-classifier"/> <code value="D016428"/> <display value="Journal Article"/> </coding> </classifier> <citation value="Ann Am Thorac Soc. 2020 Jul;17(7):879-891"/> <document> <url value="https://pubmed.ncbi.nlm.nih.gov/32267771/"/> </document> <resourceReference> <identifier> <system value="https://pubmed.ncbi.nlm.nih.gov"/> <value value="32267771"/> <assigner> <display value="NLM"/> </assigner> </identifier> </resourceReference> </relatesTo> <relatesTo> <type value="cites"/> <classifier> <coding> <system value="http://terminology.hl7.org/CodeSystem/citation-artifact-classifier"/> <code value="D016428"/> <display value="Journal Article"/> </coding> </classifier> <citation value="JAMA. 2009 Jun 10;301(22):2362-75"/> <document> <url value="https://pubmed.ncbi.nlm.nih.gov/19509383/"/> </document> <resourceReference> <identifier> <system value="https://pubmed.ncbi.nlm.nih.gov"/> <value value="19509383"/> <assigner> <display value="NLM"/> </assigner> </identifier> </resourceReference> </relatesTo> <relatesTo> <type value="cites"/> <classifier> <coding> <system value="http://terminology.hl7.org/CodeSystem/citation-artifact-classifier"/> <code value="D016428"/> <display value="Journal Article"/> </coding> </classifier> <citation value="Lancet. 2020 Feb 15;395(10223):473-475"/> <document> <url value="https://pubmed.ncbi.nlm.nih.gov/32043983/"/> </document> <resourceReference> <identifier> <system value="https://pubmed.ncbi.nlm.nih.gov"/> <value value="32043983"/> <assigner> <display value="NLM"/> </assigner> </identifier> </resourceReference> </relatesTo> <relatesTo> <type value="cites"/> <classifier> <coding> <system value="http://terminology.hl7.org/CodeSystem/citation-artifact-classifier"/> <code value="D016428"/> <display value="Journal Article"/> </coding> </classifier> <citation value="Crit Care Med. 2020 Feb;48(2):e98-e106"/> <document> <url value="https://pubmed.ncbi.nlm.nih.gov/31939808/"/> </document> <resourceReference> <identifier> <system value="https://pubmed.ncbi.nlm.nih.gov"/> <value value="31939808"/> <assigner> <display value="NLM"/> </assigner> </identifier> </resourceReference> </relatesTo> <relatesTo> <type value="cites"/> <classifier> <coding> <system value="http://terminology.hl7.org/CodeSystem/citation-artifact-classifier"/> <code value="D016428"/> <display value="Journal Article"/> </coding> </classifier> <citation value="PLoS One. 2020 Jul 10;15(7):e0235653"/> <document> <url value="https://pubmed.ncbi.nlm.nih.gov/32649661/"/> </document> <resourceReference> <identifier> <system value="https://pubmed.ncbi.nlm.nih.gov"/> <value value="32649661"/> <assigner> <display value="NLM"/> </assigner> </identifier> </resourceReference> </relatesTo> <relatesTo> <type value="cites"/> <classifier> <coding> <system value="http://terminology.hl7.org/CodeSystem/citation-artifact-classifier"/> <code value="D016428"/> <display value="Journal Article"/> </coding> </classifier> <citation value="Med Clin North Am. 1973 Sep;57(5):1277-87"/> <document> <url value="https://pubmed.ncbi.nlm.nih.gov/4593200/"/> </document> <resourceReference> <identifier> <system value="https://pubmed.ncbi.nlm.nih.gov"/> <value value="4593200"/> <assigner> <display value="NLM"/> </assigner> </identifier> </resourceReference> </relatesTo> <relatesTo> <type value="comment-in"/> <classifier> <coding> <system value="http://terminology.hl7.org/CodeSystem/citation-artifact-classifier"/> <code value="D016420"/> <display value="Comment"/> <userSelected value="false"/> </coding> </classifier> <citation value="CJEM. 2021 Mar;23(2):162-163"/> <document> <url value="https://pubmed.ncbi.nlm.nih.gov/33709361/"/> </document> <resourceReference> <identifier> <system value="https://pubmed.ncbi.nlm.nih.gov"/> <value value="33709361"/> <assigner> <display value="NLM"/> </assigner> </identifier> </resourceReference> </relatesTo> <relatesTo> <type value="comment-in"/> <classifier> <coding> <system value="http://terminology.hl7.org/CodeSystem/citation-artifact-classifier"/> <code value="D016420"/> <display value="Comment"/> <userSelected value="false"/> </coding> </classifier> <citation value="Rev Chilena Infectol. 2020 Dec;37(6):646-666"/> <document> <url value="https://pubmed.ncbi.nlm.nih.gov/33844805/"/> </document> <resourceReference> <identifier> <system value="https://pubmed.ncbi.nlm.nih.gov"/> <value value="33844805"/> <assigner> <display value="NLM"/> </assigner> </identifier> </resourceReference> </relatesTo> <publicationForm> <publishedIn> <type> <coding> <system value="http://terminology.hl7.org/CodeSystem/published-in-type"/> <code value="D020492"/> <display value="Periodical"/> </coding> </type> <identifier> <type> <coding> <system value="https://www.nlm.nih.gov/bsd/licensee/elements_descriptions.html#issn"/> <code value="Electronic"/> <display value="Electronic"/> </coding> <text value="ISSN Type"/> </type> <system value="https://portal.issn.org"/> <value value="1538-3598"/> </identifier> <identifier> <type> <text value="ISOAbbreviation"/> </type> <system value="https://www.issn.org/services/online-services/access-to-the-ltwa/"/> <value value="JAMA"/> </identifier> <identifier> <type> <text value="ISSN Linking"/> </type> <system value="https://www.issn.org/understanding-the-issn/assignment-rules/the-issn-l-for-publications-on-multiple -media/"/> <value value="0098-7484"/> </identifier> <identifier> <type> <text value="Medline Title Abbreviation"/> </type> <system value="https://www.nlm.nih.gov/tsd/cataloging/contructitleabbre.html"/> <value value="JAMA"/> </identifier> <identifier> <type> <text value="NLM Unique ID"/> </type> <system value="https://locatorplus.gov/cgi-bin/Pwebrecon.cgi?DB=local"/> <value value="7501160"/> </identifier> <title value="JAMA"/> <publisherLocation value="United States"/> </publishedIn> <periodicRelease> <citedMedium> <coding> <system value="http://terminology.hl7.org/CodeSystem/journal-issue-medium"/> <code value="Internet"/> <display value="Internet"/> </coding> </citedMedium> <volume value="324"/> <issue value="13"/> <dateOfPublication> <date value="2020-10-06"/> <year value="2020"/> <month value="10"/> <day value="06"/> </dateOfPublication> </periodicRelease> <language> <coding> <system value="urn:ietf:bcp:47"/> <code value="en"/> <display value="English"/> </coding> </language> <pageString value="1330-1341"/> </publicationForm> <webLocation> <classifier> <coding> <system value="http://terminology.hl7.org/CodeSystem/artifact-url-classifier"/> <code value="doi-based"/> <display value="DOI Based"/> </coding> </classifier> <url value="http://doi.org/10.1001/jama.2020.17023"/> </webLocation> <webLocation> <classifier> <coding> <system value="http://terminology.hl7.org/CodeSystem/artifact-url-classifier"/> <version value="5.0.0-snapshot1"/> <code value="abstract"/> <display value="Abstract"/> <userSelected value="true"/> </coding> <text value="on PubMed"/> </classifier> <url value="https://pubmed.ncbi.nlm.nih.gov/32876694/"/> </webLocation> <webLocation> <classifier> <coding> <system value="http://terminology.hl7.org/CodeSystem/artifact-url-classifier"/> <version value="5.0.0-snapshot1"/> <code value="full-text"/> <display value="Full-Text"/> <userSelected value="true"/> </coding> <text value="on JAMA"/> </classifier> <url value="https://jamanetwork.com/journals/jama/fullarticle/2770279"/> </webLocation> <classification> <type> <text value="Steroids SMR project use"/> </type> <classifier> <text value="primary article"/> </classifier> <classifier> <text value="Unclear risk of bias"/> </classifier> <whoClassified> <person> <display value="Brian S. Alper"/> </person> <freeToShare value="false"/> </whoClassified> </classification> <classification> <type> <text value="UC Description"/> </type> <classifier> <text value="To assess systemic corticosteroids on 28-day mortality in critically ill patients with COVID-19"/> </classifier> <whoClassified> <person> <display value="Dr. Ethan Molitch"/> </person> <organization> <display value="University of Chicago"/> </organization> <freeToShare value="true"/> </whoClassified> </classification> <classification> <type> <coding> <system value="http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type"/> <code value="knowledge-artifact-type"/> <display value="Knowledge Artifact Type"/> </coding> </type> <classifier> <coding> <system value="http://terminology.hl7.org/CodeSystem/citation-artifact-classifier"/> <code value="D016428"/> <display value="Journal Article"/> </coding> </classifier> <whoClassified> <publisher> <display value="Computable Publishing LLC"/> </publisher> <classifierCopyright value="https://creativecommons.org/licenses/by-nc-sa/4.0"/> <freeToShare value="true"/> </whoClassified> </classification> <classification> <type> <coding> <system value="http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type"/> <code value="publishing-model"/> <display value="Publishing Model"/> </coding> </type> <classifier> <coding> <system value="http://terminology.hl7.org/CodeSystem/citation-artifact-classifier"/> <code value="Print"/> <display value="Print"/> </coding> </classifier> </classification> <classification> <type> <coding> <system value="http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type"/> <code value="chemical"/> <display value="Chemical"/> </coding> </type> <classifier> <coding> <system value="https://www.cas.org/support/documentation/chemical-substances"/> <code value="0"/> </coding> <coding> <system value="https://meshb.nlm.nih.gov/"/> <code value="D000305"/> <display value="Adrenal Cortex Hormones"/> </coding> </classifier> <classifier> <coding> <system value="https://www.cas.org/support/documentation/chemical-substances"/> <code value="0"/> </coding> <coding> <system value="https://meshb.nlm.nih.gov/"/> <code value="D005938"/> <display value="Glucocorticoids"/> </coding> </classifier> <classifier> <coding> <system value="https://www.cas.org/support/documentation/chemical-substances"/> <code value="7S5I7G3JQL"/> </coding> <coding> <system value="https://meshb.nlm.nih.gov/"/> <code value="D003907"/> <display value="Dexamethasone"/> </coding> </classifier> <classifier> <coding> <system value="https://www.cas.org/support/documentation/chemical-substances"/> <code value="WI4X0X7BPJ"/> </coding> <coding> <system value="https://meshb.nlm.nih.gov/"/> <code value="D006854"/> <display value="Hydrocortisone"/> </coding> </classifier> <classifier> <coding> <system value="https://www.cas.org/support/documentation/chemical-substances"/> <code value="X4W7ZR7023"/> </coding> <coding> <system value="https://meshb.nlm.nih.gov/"/> <code value="D008775"/> <display value="Methylprednisolone"/> </coding> </classifier> </classification> <classification> <type> <coding> <system value="http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type"/> <code value="mesh-heading"/> <display value="MeSH heading"/> </coding> </type> <classifier> <coding> <system value="https://meshb.nlm.nih.gov/"/> <code value="D000305"/> <display value="Adrenal Cortex Hormones"/> </coding> <coding> <system value="https://meshb.nlm.nih.gov/"/> <code value="Q000627"/> <display value="therapeutic use"/> </coding> <coding> <code value="Y"/> </coding> </classifier> <classifier> <coding> <system value="https://meshb.nlm.nih.gov/"/> <code value="D000073640"/> <display value="Betacoronavirus"/> </coding> </classifier> <classifier> <coding> <system value="https://meshb.nlm.nih.gov/"/> <code value="D000086382"/> <display value="COVID-19"/> </coding> </classifier> <classifier> <coding> <system value="https://meshb.nlm.nih.gov/"/> <code value="D002423"/> <display value="Cause of Death"/> </coding> </classifier> <classifier> <coding> <system value="https://meshb.nlm.nih.gov/"/> <code value="D018352"/> <display value="Coronavirus Infections"/> </coding> <coding> <system value="https://meshb.nlm.nih.gov/"/> <code value="Q000188"/> <display value="drug therapy"/> </coding> <coding> <code value="Y"/> </coding> <coding> <system value="https://meshb.nlm.nih.gov/"/> <code value="Q000401"/> <display value="mortality"/> </coding> <coding> <code value="N"/> </coding> </classifier> <classifier> <coding> <system value="https://meshb.nlm.nih.gov/"/> <code value="D016638"/> <display value="Critical Illness"/> </coding> </classifier> <classifier> <coding> <system value="https://meshb.nlm.nih.gov/"/> <code value="D003907"/> <display value="Dexamethasone"/> </coding> <coding> <system value="https://meshb.nlm.nih.gov/"/> <code value="Q000627"/> <display value="therapeutic use"/> </coding> <coding> <code value="N"/> </coding> </classifier> <classifier> <coding> <system value="https://meshb.nlm.nih.gov/"/> <code value="D005938"/> <display value="Glucocorticoids"/> </coding> <coding> <system value="https://meshb.nlm.nih.gov/"/> <code value="Q000627"/> <display value="therapeutic use"/> </coding> <coding> <code value="Y"/> </coding> </classifier> <classifier> <coding> <system value="https://meshb.nlm.nih.gov/"/> <code value="D006801"/> <display value="Humans"/> </coding> </classifier> <classifier> <coding> <system value="https://meshb.nlm.nih.gov/"/> <code value="D006854"/> <display value="Hydrocortisone"/> </coding> <coding> <system value="https://meshb.nlm.nih.gov/"/> <code value="Q000627"/> <display value="therapeutic use"/> </coding> <coding> <code value="N"/> </coding> </classifier> <classifier> <coding> <system value="https://meshb.nlm.nih.gov/"/> <code value="D008775"/> <display value="Methylprednisolone"/> </coding> <coding> <system value="https://meshb.nlm.nih.gov/"/> <code value="Q000627"/> <display value="therapeutic use"/> </coding> <coding> <code value="N"/> </coding> </classifier> <classifier> <coding> <system value="https://meshb.nlm.nih.gov/"/> <code value="D058873"/> <display value="Pandemics"/> </coding> </classifier> <classifier> <coding> <system value="https://meshb.nlm.nih.gov/"/> <code value="D011024"/> <display value="Pneumonia, Viral"/> </coding> <coding> <system value="https://meshb.nlm.nih.gov/"/> <code value="Q000188"/> <display value="drug therapy"/> </coding> <coding> <code value="Y"/> </coding> <coding> <system value="https://meshb.nlm.nih.gov/"/> <code value="Q000401"/> <display value="mortality"/> </coding> <coding> <code value="N"/> </coding> </classifier> <classifier> <coding> <system value="https://meshb.nlm.nih.gov/"/> <code value="D016032"/> <display value="Randomized Controlled Trials as Topic"/> </coding> </classifier> <classifier> <coding> <system value="https://meshb.nlm.nih.gov/"/> <code value="D000086402"/> <display value="SARS-CoV-2"/> </coding> </classifier> </classification> <classification> <type> <coding> <system value="http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type"/> <code value="publication-type"/> <display value="Publication type"/> </coding> </type> <classifier> <coding> <system value="https://meshb.nlm.nih.gov/"/> <code value="D016428"/> <display value="Journal Article"/> </coding> </classifier> <classifier> <coding> <system value="https://meshb.nlm.nih.gov/"/> <code value="D017418"/> <display value="Meta-Analysis"/> </coding> </classifier> <classifier> <coding> <system value="https://meshb.nlm.nih.gov/"/> <code value="D013485"/> <display value="Research Support, Non-U.S. Gov't"/> </coding> </classifier> </classification> <classification> <type> <coding> <system value="http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type"/> <code value="supplemental-mesh-protocol"/> <display value="Supplemental MeSH for Protocol"/> </coding> </type> <classifier> <coding> <system value="https://meshb.nlm.nih.gov/"/> <code value="C000705127"/> <display value="COVID-19 drug treatment"/> </coding> </classifier> </classification> <classification> <type> <coding> <system value="http://terminology.hl7.org/CodeSystem/cited-artifact-classification-type"/> <code value="citation-subset"/> <display value="Citation subset"/> </coding> </type> <classifier> <coding> <system value="https://www.nlm.nih.gov/bsd/licensee/elements_descriptions.html#citationsubset"/> <code value="AIM"/> <display value="AIM"/> </coding> </classifier> <classifier> <coding> <system value="https://www.nlm.nih.gov/bsd/licensee/elements_descriptions.html#citationsubset"/> <code value="IM"/> <display value="IM"/> </coding> </classifier> </classification> <classification> <type> <text value="Funding"/> </type> <classifier> <text value="The World Health Organization (Conflict of interest statements included notes on several fundings for co-investigators as well, albeit not directly funding this meta-analysis)"/> </classifier> <whoClassified> <person> <display value="Erfan Shamsoddin"/> </person> <organization> <display value="COVID-19 Knowledge Accelerator"/> </organization> <freeToShare value="true"/> </whoClassified> </classification> <contributorship> <complete value="true"/> <entry> <collectiveName value="WHO Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working Group"/> </entry> <entry> <name> <family value="Sterne"/> <given value="Jonathan A C"/> </name> <initials value="JAC"/> <affiliationInfo> <affiliation value="Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, England."/> </affiliationInfo> <affiliationInfo> <affiliation value="NIHR Bristol Biomedical Research Centre, Bristol, England."/> </affiliationInfo> <telecom> <system value="email"/> <value value="jonathan.sterne@bristol.ac.uk"/> </telecom> <correspondingContact value="true"/> </entry> <entry> <name> <family value="Murthy"/> <given value="Srinivas"/> </name> <initials value="S"/> <affiliationInfo> <affiliation value="Department of Pediatrics, University of British Columbia, Vancouver, Canada."/> </affiliationInfo> </entry> <entry> <name> <family value="Diaz"/> <given value="Janet V"/> </name> <initials value="JV"/> <affiliationInfo> <affiliation value="Clinical Unit, Health Emergencies Programme, World Health Organization, Geneva, Switzerland."/> </affiliationInfo> </entry> <entry> <name> <family value="Slutsky"/> <given value="Arthur S"/> </name> <initials value="AS"/> <affiliationInfo> <affiliation value="Applied Health Research Centre, Li Ka Shing Knowledge Institute of St Michael's Hospital, Department of Medicine, University of Toronto, Toronto, Ontario, Canada."/> </affiliationInfo> </entry> <entry> <name> <family value="Villar"/> <given value="Jesús"/> </name> <initials value="J"/> <affiliationInfo> <affiliation value="Research Unit, Hospital Universitario Dr Negrín, Las Palmas de Gran Canaria, Spain."/> </affiliationInfo> <affiliationInfo> <affiliation value="CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain."/> </affiliationInfo> </entry> <entry> <name> <family value="Angus"/> <given value="Derek C"/> </name> <initials value="DC"/> <affiliationInfo> <affiliation value="Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania."/> </affiliationInfo> </entry> <entry> <name> <family value="Annane"/> <given value="Djillali"/> </name> <initials value="D"/> <affiliationInfo> <affiliation value="Department of Intensive Care, Raymond Poincaré Hospital (APHP), School of Medicine Simone Veil, University Paris Saclay-UVSQ, Paris, France."/> </affiliationInfo> </entry> <entry> <name> <family value="Azevedo"/> <given value="Luciano Cesar Pontes"/> </name> <initials value="LCP"/> <affiliationInfo> <affiliation value="Hospital Sírio-Libanês, São Paulo, Brazil."/> </affiliationInfo> <affiliationInfo> <affiliation value="Emergency Medicine Department, University of São Paulo School of Medicine, São Paulo, Brazil."/> </affiliationInfo> </entry> <entry> <name> <family value="Berwanger"/> <given value="Otavio"/> </name> <initials value="O"/> <affiliationInfo> <affiliation value="Academic Research Organization, Hospital Israelita Albert Einstein, São Paulo, Brazil."/> </affiliationInfo> </entry> <entry> <name> <family value="Cavalcanti"/> <given value="Alexandre B"/> </name> <initials value="AB"/> <affiliationInfo> <affiliation value="HCor Research Insitute, São Paulo, Brazil."/> </affiliationInfo> </entry> <entry> <name> <family value="Dequin"/> <given value="Pierre-Francois"/> </name> <initials value="PF"/> <affiliationInfo> <affiliation value="Médecine Intensive-Réanimation, INSERM CIC1415, CHRU de Tours, Tours, France."/> </affiliationInfo> <affiliationInfo> <affiliation value="CRICS-TriGGERSep Network, Centre d'Etude des Pathologies Respiratoires, Université de Tours, Tours, France."/> </affiliationInfo> </entry> <entry> <name> <family value="Du"/> <given value="Bin"/> </name> <initials value="B"/> <affiliationInfo> <affiliation value="Peking Union Medical College Hospital, Beijing, China."/> </affiliationInfo> </entry> <entry> <name> <family value="Emberson"/> <given value="Jonathan"/> </name> <initials value="J"/> <affiliationInfo> <affiliation value="Nuffield Department of Population Health, University of Oxford, Oxford, England."/> </affiliationInfo> <affiliationInfo> <affiliation value="MRC Population Health Research Unit, University of Oxford, Oxford, England."/> </affiliationInfo> </entry> <entry> <name> <family value="Fisher"/> <given value="David"/> </name> <initials value="D"/> <affiliationInfo> <affiliation value="MRC Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, Faculty of Population Health Sciences, University College London, London, England."/> </affiliationInfo> </entry> <entry> <name> <family value="Giraudeau"/> <given value="Bruno"/> </name> <initials value="B"/> <affiliationInfo> <affiliation value="CIC INSERM 1415-CHRU de Tours, Tours, France."/> </affiliationInfo> </entry> <entry> <name> <family value="Gordon"/> <given value="Anthony C"/> </name> <initials value="AC"/> <affiliationInfo> <affiliation value="Division of Anaesthetics, Pain Medicine and Intensive Care, Imperial College London, London, England."/> </affiliationInfo> </entry> <entry> <name> <family value="Granholm"/> <given value="Anders"/> </name> <initials value="A"/> <affiliationInfo> <affiliation value="Department of Intensive Care, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark."/> </affiliationInfo> </entry> <entry> <name> <family value="Green"/> <given value="Cameron"/> </name> <initials value="C"/> <affiliationInfo> <affiliation value="Australian and New Zealand Intensive Care Research Centre, School of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia."/> </affiliationInfo> </entry> <entry> <name> <family value="Haynes"/> <given value="Richard"/> </name> <initials value="R"/> <affiliationInfo> <affiliation value="Nuffield Department of Population Health, University of Oxford, Oxford, England."/> </affiliationInfo> <affiliationInfo> <affiliation value="MRC Population Health Research Unit, University of Oxford, Oxford, England."/> </affiliationInfo> </entry> <entry> <name> <family value="Heming"/> <given value="Nicholas"/> </name> <initials value="N"/> <affiliationInfo> <affiliation value="Department of Intensive Care, Raymond Poincaré Hospital (APHP), School of Medicine Simone Veil, University Paris Saclay-UVSQ, Paris, France."/> </affiliationInfo> </entry> <entry> <name> <family value="Higgins"/> <given value="Julian P T"/> </name> <initials value="JPT"/> <affiliationInfo> <affiliation value="Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, England."/> </affiliationInfo> <affiliationInfo> <affiliation value="NIHR Bristol Biomedical Research Centre, Bristol, England."/> </affiliationInfo> <affiliationInfo> <affiliation value="NIHR Applied Research Collaboration West, University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, England."/> </affiliationInfo> </entry> <entry> <name> <family value="Horby"/> <given value="Peter"/> </name> <initials value="P"/> <affiliationInfo> <affiliation value="Nuffield Department of Medicine, University of Oxford, Oxford, England."/> </affiliationInfo> </entry> <entry> <name> <family value="Jüni"/> <given value="Peter"/> </name> <initials value="P"/> <affiliationInfo> <affiliation value="Applied Health Research Centre, Li Ka Shing Knowledge Institute of St Michael's Hospital, Department of Medicine, University of Toronto, Toronto, Ontario, Canada."/> </affiliationInfo> </entry> <entry> <name> <family value="Landray"/> <given value="Martin J"/> </name> <initials value="MJ"/> <affiliationInfo> <affiliation value="Nuffield Department of Population Health, University of Oxford, Oxford, England."/> </affiliationInfo> <affiliationInfo> <affiliation value="MRC Population Health Research Unit, University of Oxford, Oxford, England."/> </affiliationInfo> <affiliationInfo> <affiliation value="NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, England."/> </affiliationInfo> </entry> <entry> <name> <family value="Le Gouge"/> <given value="Amelie"/> </name> <initials value="A"/> <affiliationInfo> <affiliation value="CIC INSERM 1415-CHRU de Tours, Tours, France."/> </affiliationInfo> </entry> <entry> <name> <family value="Leclerc"/> <given value="Marie"/> </name> <initials value="M"/> <affiliationInfo> <affiliation value="CIC INSERM 1415-CHRU de Tours, Tours, France."/> </affiliationInfo> </entry> <entry> <name> <family value="Lim"/> <given value="Wei Shen"/> </name> <initials value="WS"/> <affiliationInfo> <affiliation value="Respiratory Medicine Department, Nottingham University Hospitals NHS Trust, Nottingham, England."/> </affiliationInfo> </entry> <entry> <name> <family value="Machado"/> <given value="Flávia R"/> </name> <initials value="FR"/> <affiliationInfo> <affiliation value="Anesthesiology, Pain, and Intensive Care Department, Federal University of São Paulo, São Paulo, Brazil."/> </affiliationInfo> </entry> <entry> <name> <family value="McArthur"/> <given value="Colin"/> </name> <initials value="C"/> <affiliationInfo> <affiliation value="Australian and New Zealand Intensive Care Research Centre, School of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia."/> </affiliationInfo> <affiliationInfo> <affiliation value="Department of Critical Care Medicine, Auckland City Hospital, Auckland, New Zealand."/> </affiliationInfo> </entry> <entry> <name> <family value="Meziani"/> <given value="Ferhat"/> </name> <initials value="F"/> <affiliationInfo> <affiliation value="Hôpitaux Universitaires de Strasbourg, Service de Médecine Intensive Réanimation, Nouvel Hôpital Civil, Strasbourg, France."/> </affiliationInfo> <affiliationInfo> <affiliation value="INSERM UMR 1260, Regenerative Nanomedicine, FMTS, Strasbourg, France."/> </affiliationInfo> </entry> <entry> <name> <family value="Møller"/> <given value="Morten Hylander"/> </name> <initials value="MH"/> <affiliationInfo> <affiliation value="Department of Intensive Care, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark."/> </affiliationInfo> </entry> <entry> <name> <family value="Perner"/> <given value="Anders"/> </name> <initials value="A"/> <affiliationInfo> <affiliation value="Department of Intensive Care, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark."/> </affiliationInfo> </entry> <entry> <name> <family value="Petersen"/> <given value="Marie Warrer"/> </name> <initials value="MW"/> <affiliationInfo> <affiliation value="Department of Intensive Care, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark."/> </affiliationInfo> </entry> <entry> <name> <family value="Savovic"/> <given value="Jelena"/> </name> <initials value="J"/> <affiliationInfo> <affiliation value="Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, England."/> </affiliationInfo> <affiliationInfo> <affiliation value="NIHR Applied Research Collaboration West, University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, England."/> </affiliationInfo> </entry> <entry> <name> <family value="Tomazini"/> <given value="Bruno"/> </name> <initials value="B"/> <affiliationInfo> <affiliation value="Hospital Sírio-Libanês, São Paulo, Brazil."/> </affiliationInfo> <affiliationInfo> <affiliation value="Department of Surgery, School of Medicine, University of São Paulo, São Paulo, Brazil."/> </affiliationInfo> </entry> <entry> <name> <family value="Veiga"/> <given value="Viviane C"/> </name> <initials value="VC"/> <affiliationInfo> <affiliation value="BP-A Beneficência Portuguesa de São Paulo, São Paulo, Brazil."/> </affiliationInfo> </entry> <entry> <name> <family value="Webb"/> <given value="Steve"/> </name> <initials value="S"/> <affiliationInfo> <affiliation value="Australian and New Zealand Intensive Care Research Centre, School of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia."/> </affiliationInfo> <affiliationInfo> <affiliation value="St John of God Healthcare, Subiaco, Australia."/> </affiliationInfo> </entry> <entry> <name> <family value="Marshall"/> <given value="John C"/> </name> <initials value="JC"/> <affiliationInfo> <affiliation value="Li Ka Shing Knowledge Institute, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada."/> </affiliationInfo> </entry> <summary> <type> <coding> <system value="http://terminology.hl7.org/CodeSystem/contributor-summary-type"/> <version value="5.0.0-snapshot1"/> <code value="author-string"/> <display value="Author string"/> </coding> </type> <source> <text value="articleCopy"/> </source> <value value="The WHO Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working Group Authors and Members of the Writing Committee: Jonathan A. C. Sterne, MA, MSc, PhD; Srinivas Murthy, MD, MSc; Janet V. Diaz, MD; Arthur S. Slutsky, CM, MD; Jesús Villar, MD, PhD; Derek C. Angus, MD, MPH; Djillali Annane, MD, PhD; Luciano Cesar Pontes Azevedo, MD, PhD; Otavio Berwanger, MD, PhD; Alexandre B. Cavalcanti, MD, PhD; Pierre-Francois Dequin, MD, PhD; Bin Du, MD; Jonathan Emberson, PhD; David Fisher, MSc; Bruno Giraudeau, PhD; Anthony C. Gordon, MBBS, MD; Anders Granholm, MD; Cameron Green, MSc; Richard Haynes, DM; Nicholas Heming, MD, PhD; Julian P. T. Higgins, BA, PhD; Peter Horby, PhD; Peter Jüni, MD; Martin J. Landray, PhD; Amelie Le Gouge, MSc; Marie Leclerc, MSc; Wei Shen Lim, BMedSci, BMBS, DM; Flávia R. Machado, MD, PhD; Colin McArthur, MBChB; Ferhat Meziani, MD, PhD; Morten Hylander Møller, MD, PhD; Anders Perner, MD, PhD; Marie Warrer Petersen, MD; Jelena Savović, BPharm, MSc, PhD; Bruno Tomazini, MD; Viviane C. Veiga, MD, PhD; Steve Webb, MBBS, MPH, PhD; John C. Marshall, MD."/> </summary> </contributorship> </citedArtifact> </Citation>
Usage note: every effort has been made to ensure that the examples are correct and useful, but they are not a normative part of the specification.
FHIR ®© HL7.org 2011+. FHIR R5 Draft Ballot hl7.fhir.core#5.0.0-snapshot1 generated on Sun, Dec 19, 2021 08:19+1100.
Links: Search |
Version History |
Table of Contents |
QA Page |
Compare to R4 |
|
Propose a change