Risk of fatal ICH without alteplase for stroke

@prefix fhir: <http://hl7.org/fhir/> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

# - resource -------------------------------------------------------------------

[a fhir:Evidence ;
  fhir:nodeRole fhir:treeRoot ;
  fhir:id [ fhir:v "example-stroke-no-alteplase-fatalICH"] ; # 
  fhir:text [
     fhir:status [ fhir:v "generated" ] ;
     fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\">\n      \n      <p>\n        &quot;Risk of fatal ICH without alteplase for stroke&quot; is a univariate risk estimate.\n      </p>\n	\n    </div>"
  ] ; # 
  fhir:url [ fhir:v "http://hl7.org/fhir/Evidence/example-stroke-no-alteplase-fatalICH"^^xsd:anyURI] ; # 
  fhir:identifier ( [
     fhir:system [ fhir:v "urn:ietf:rfc:3986"^^xsd:anyURI ] ;
     fhir:value [ fhir:v "urn:oid:2.16.840.1.113883.4.642.10.4" ]
  ] ) ; # 
  fhir:name [ fhir:v "RiskOfFatalICHWithoutAlteplaseForStroke"] ; # 
  fhir:title [ fhir:v "Risk of fatal ICH without alteplase for stroke"] ; # 
  fhir:status [ fhir:v "draft"] ; # 
  fhir:relatedArtifact ( [
     fhir:type [ fhir:v "citation" ] ;
     fhir:label [ fhir:v "Emberson 2014" ] ;
     fhir:display [ fhir:v "Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials." ] ;
     fhir:citation [ fhir:v "Emberson J, Lees KR, Lyden P, Blackwell L, Albers G, Bluhmki E, et al;Stroke Thrombolysis Trialists' Collaborative Group. Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials. Lancet 2014 Nov 29;384(9958):1929-35 PMID 25106063" ] ;
     fhir:document [
       fhir:url [ fhir:v "https://doi.org/10.1016/S0140-6736(14)60584-5"^^xsd:anyURI ]
     ]
  ] ) ; # 
  fhir:description [ fhir:v "0.4% incidence of fatal intracranial hemorrhage within 7 days without alteplase in patients with acute ischemic stroke"] ; # 
  fhir:variableDefinition ( [
     fhir:variableRole [
       fhir:coding ( [
         fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/variable-role"^^xsd:anyURI ] ;
         fhir:code [ fhir:v "population" ] ;
         fhir:display [ fhir:v "population" ]
       ] )
     ] ;
     fhir:observed [
       fhir:reference [ fhir:v "Group/AcuteIschemicStroke" ] ;
       fhir:type [ fhir:v "Group"^^xsd:anyURI ] ;
       fhir:display [ fhir:v "adults with acute ischemic stroke" ]
     ] ;
     fhir:intended [
       fhir:reference [ fhir:v "Group/AcuteIschemicStroke" ] ;
       fhir:type [ fhir:v "Group"^^xsd:anyURI ] ;
       fhir:display [ fhir:v "adults with acute ischemic stroke" ]
     ]
  ] [
     fhir:variableRole [
       fhir:coding ( [
         fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/variable-role"^^xsd:anyURI ] ;
         fhir:code [ fhir:v "population" ] ;
         fhir:display [ fhir:v "population" ]
       ] )
     ] ;
     fhir:observed [
       fhir:reference [ fhir:v "Group/Emberson-2014-IPD-MA-No-Alteplase-Cohort" ] ;
       fhir:type [ fhir:v "Group"^^xsd:anyURI ] ;
       fhir:display [ fhir:v "Emberson 2014 IPD-MA No Alteplase Cohort" ]
     ] ;
     fhir:intended [
       fhir:reference [ fhir:v "Group/AcuteIschemicStrokeTreatedWithoutAlteplase" ] ;
       fhir:type [ fhir:v "Group"^^xsd:anyURI ] ;
       fhir:display [ fhir:v "adults with acute ischemic stroke treated without alteplase" ]
     ]
  ] [
     fhir:variableRole [
       fhir:coding ( [
         fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/variable-role"^^xsd:anyURI ] ;
         fhir:code [ fhir:v "measuredVariable" ] ;
         fhir:display [ fhir:v "measured variable" ]
       ] )
     ] ;
     fhir:observed [
       fhir:reference [ fhir:v "EvidenceVariable/example-fatal-ICH-in-7-days" ] ;
       fhir:type [ fhir:v "EvidenceVariable"^^xsd:anyURI ] ;
       fhir:display [ fhir:v "fatal ICH" ]
     ] ;
     fhir:intended [
       fhir:reference [ fhir:v "EvidenceVariable/example-fatal-ICH-in-7-days" ] ;
       fhir:type [ fhir:v "EvidenceVariable"^^xsd:anyURI ] ;
       fhir:display [ fhir:v "fatal ICH" ]
     ]
  ] ) ; # 
  fhir:synthesisType [
     fhir:coding ( [
       fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/synthesis-type"^^xsd:anyURI ] ;
       fhir:code [ fhir:v "IPD-MA" ] ;
       fhir:display [ fhir:v "individual patient data meta-analysis" ]
     ] )
  ] ; # 
  fhir:studyDesign ( [
     fhir:coding ( [
       fhir:system [ fhir:v "http://hl7.org/fhir/study-design"^^xsd:anyURI ] ;
       fhir:code [ fhir:v "SEVCO:01003" ] ;
       fhir:display [ fhir:v "randomized assignment" ]
     ] )
  ] ) ; # 
  fhir:statistic ( [
     fhir:statisticType [
       fhir:coding ( [
         fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/statistic-type"^^xsd:anyURI ] ;
         fhir:code [ fhir:v "C44256" ] ;
         fhir:display [ fhir:v "Proportion" ]
       ] )
     ] ;
     fhir:quantity [
       fhir:value [ fhir:v "0.00386298627"^^xsd:decimal ]
     ] ;
     fhir:numberOfEvents [ fhir:v "13"^^xsd:nonNegativeInteger ] ;
     fhir:sampleSize [
       fhir:numberOfStudies [ fhir:v "9"^^xsd:nonNegativeInteger ] ;
       fhir:numberOfParticipants [ fhir:v "3365"^^xsd:nonNegativeInteger ]
     ]
  ] )] . # 

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