Risk of fatal ICH without alteplase for stroke

@prefix fhir: <http://hl7.org/fhir/> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

# - resource -------------------------------------------------------------------

[a fhir:Evidence;
  fhir:nodeRole fhir:treeRoot;
  fhir:Resource.id [ fhir:value "example-stroke-no-alteplase-fatalICH"];
  fhir:DomainResource.text [
     fhir:Narrative.status [ fhir:value "generated" ];
     fhir:Narrative.div "<div xmlns=\"http://www.w3.org/1999/xhtml\">\n      <p>\n        &quot;Risk of fatal ICH without alteplase for stroke&quot; is a univariate risk estimate.\n      </p>\n	</div>"
  ];
  fhir:Evidence.url [ fhir:value "http://hl7.org/fhir/Evidence/example-stroke-no-alteplase-fatalICH"];
  fhir:Evidence.identifier [
     fhir:index 0;
     fhir:Identifier.system [ fhir:value "urn:ietf:rfc:3986" ];
     fhir:Identifier.value [ fhir:value "urn:oid:2.16.840.1.113883.4.642.10.4" ]
  ];
  fhir:Evidence.title [ fhir:value "Risk of fatal ICH without alteplase for stroke"];
  fhir:Evidence.status [ fhir:value "draft"];
  fhir:Evidence.relatedArtifact [
     fhir:index 0;
     fhir:RelatedArtifact.type [ fhir:value "citation" ];
     fhir:RelatedArtifact.label [ fhir:value "Emberson 2014" ];
     fhir:RelatedArtifact.display [ fhir:value "Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials." ];
     fhir:RelatedArtifact.citation [ fhir:value "Emberson J, Lees KR, Lyden P, Blackwell L, Albers G, Bluhmki E, et al;Stroke Thrombolysis Trialists' Collaborative Group. Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials. Lancet 2014 Nov 29;384(9958):1929-35 PMID 25106063" ];
     fhir:RelatedArtifact.document [
       fhir:Attachment.url [ fhir:value "https://doi.org/10.1016/S0140-6736(14)60584-5" ]
     ]
  ];
  fhir:Evidence.description [ fhir:value "0.4% incidence of fatal intracranial hemorrhage within 7 days without alteplase in patients with acute ischemic stroke"];
  fhir:Evidence.variableDefinition [
     fhir:index 0;
     fhir:Evidence.variableDefinition.variableRole [
       fhir:CodeableConcept.coding [
         fhir:index 0;
         fhir:Coding.system [ fhir:value "http://terminology.hl7.org/CodeSystem/variable-role" ];
         fhir:Coding.code [ fhir:value "population" ];
         fhir:Coding.display [ fhir:value "population" ]
       ]
     ];
     fhir:Evidence.variableDefinition.observed [
       fhir:Reference.reference [ fhir:value "Group/AcuteIschemicStroke" ];
       fhir:Reference.type [ fhir:value "Group" ];
       fhir:Reference.display [ fhir:value "adults with acute ischemic stroke" ]
     ];
     fhir:Evidence.variableDefinition.intended [
       fhir:Reference.reference [ fhir:value "Group/AcuteIschemicStroke" ];
       fhir:Reference.type [ fhir:value "Group" ];
       fhir:Reference.display [ fhir:value "adults with acute ischemic stroke" ]
     ]
  ], [
     fhir:index 1;
     fhir:Evidence.variableDefinition.variableRole [
       fhir:CodeableConcept.coding [
         fhir:index 0;
         fhir:Coding.system [ fhir:value "http://terminology.hl7.org/CodeSystem/variable-role" ];
         fhir:Coding.code [ fhir:value "population" ];
         fhir:Coding.display [ fhir:value "population" ]
       ]
     ];
     fhir:Evidence.variableDefinition.observed [
       fhir:Reference.reference [ fhir:value "Group/Emberson-2014-IPD-MA-No-Alteplase-Cohort" ];
       fhir:Reference.type [ fhir:value "Group" ];
       fhir:Reference.display [ fhir:value "Emberson 2014 IPD-MA No Alteplase Cohort" ]
     ];
     fhir:Evidence.variableDefinition.intended [
       fhir:Reference.reference [ fhir:value "Group/AcuteIschemicStrokeTreatedWithoutAlteplase" ];
       fhir:Reference.type [ fhir:value "Group" ];
       fhir:Reference.display [ fhir:value "adults with acute ischemic stroke treated without alteplase" ]
     ]
  ], [
     fhir:index 2;
     fhir:Evidence.variableDefinition.variableRole [
       fhir:CodeableConcept.coding [
         fhir:index 0;
         fhir:Coding.system [ fhir:value "http://terminology.hl7.org/CodeSystem/variable-role" ];
         fhir:Coding.code [ fhir:value "measuredVariable" ];
         fhir:Coding.display [ fhir:value "measured variable" ]
       ]
     ];
     fhir:Evidence.variableDefinition.observed [
       fhir:Reference.reference [ fhir:value "EvidenceVariable/example-fatal-ICH-in-7-days" ];
       fhir:Reference.type [ fhir:value "EvidenceVariable" ];
       fhir:Reference.display [ fhir:value "fatal ICH" ]
     ];
     fhir:Evidence.variableDefinition.intended [
       fhir:Reference.reference [ fhir:value "EvidenceVariable/example-fatal-ICH-in-7-days" ];
       fhir:Reference.type [ fhir:value "EvidenceVariable" ];
       fhir:Reference.display [ fhir:value "fatal ICH" ]
     ]
  ];
  fhir:Evidence.synthesisType [
     fhir:CodeableConcept.coding [
       fhir:index 0;
       fhir:Coding.system [ fhir:value "http://terminology.hl7.org/CodeSystem/synthesis-type" ];
       fhir:Coding.code [ fhir:value "IPD-MA" ];
       fhir:Coding.display [ fhir:value "individual patient data meta-analysis" ]
     ]
  ];
  fhir:Evidence.studyDesign [
     fhir:index 0;
     fhir:CodeableConcept.coding [
       fhir:index 0;
       fhir:Coding.system [ fhir:value "http://hl7.org/fhir/research-study-classifiers" ];
       fhir:Coding.code [ fhir:value "SEVCO:01003" ];
       fhir:Coding.display [ fhir:value "randomized assignment" ]
     ]
  ];
  fhir:Evidence.statistic [
     fhir:index 0;
     fhir:Evidence.statistic.statisticType [
       fhir:CodeableConcept.coding [
         fhir:index 0;
         fhir:Coding.system [ fhir:value "http://terminology.hl7.org/CodeSystem/statistic-type" ];
         fhir:Coding.code [ fhir:value "C44256" ];
         fhir:Coding.display [ fhir:value "Proportion" ]
       ]
     ];
     fhir:Evidence.statistic.quantity [
       fhir:Quantity.value [ fhir:value "0.00386298627"^^xsd:decimal ]
     ];
     fhir:Evidence.statistic.numberOfEvents [ fhir:value "13"^^xsd:nonNegativeInteger ];
     fhir:Evidence.statistic.sampleSize [
       fhir:Evidence.statistic.sampleSize.numberOfStudies [ fhir:value "9"^^xsd:nonNegativeInteger ];
       fhir:Evidence.statistic.sampleSize.numberOfParticipants [ fhir:value "3365"^^xsd:nonNegativeInteger ]
     ]
  ]] .

# - ontology header ------------------------------------------------------------

[a owl:Ontology;
  owl:imports fhir:fhir.ttl] .

# -------------------------------------------------------------------------------------