Release 5 Ballot
Clinical ReasoningThis page is part of the FHIR Specification (v5.0.0-ballot: FHIR R5 Ballot Preview). The current version which supercedes this version is 5.0.0. For a full list of available versions, see the Directory of published versions 
. Page versions: R5 R4B
| Clinical Decision Support Work Group | Maturity Level: N/A | Standards Status: Informative | Compartments: Not linked to any defined compartments |
Raw Turtle (+ also see Turtle/RDF Format Specification)
Effect of Alteplase vs No alteplase on mRS 0-2 at 90 days in Stroke 3-4.5 hours prior
@prefix fhir: <http://hl7.org/fhir/> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
# - resource -------------------------------------------------------------------
[a fhir:Evidence;
fhir:nodeRole fhir:treeRoot;
fhir:Resource.id [ fhir:value "example-stroke-3-4half-alteplase-vs-no-alteplase-mRS0-2"];
fhir:DomainResource.text [
fhir:Narrative.status [ fhir:value "generated" ];
fhir:Narrative.div "<div xmlns=\"http://www.w3.org/1999/xhtml\">\n <p>\n "Effect of Alteplase vs No alteplase on mRS 0-2 at 90 days in Stroke 3-4.5 hours prior" is a comparative effect estimate.\n </p>\n </div>"
];
fhir:Evidence.url [ fhir:value "http://hl7.org/fhir/Evidence/example-stroke-3-4half-alteplase-vs-no-alteplase-mRS0-2"];
fhir:Evidence.identifier [
fhir:index 0;
fhir:Identifier.system [ fhir:value "urn:ietf:rfc:3986" ];
fhir:Identifier.value [ fhir:value "urn:oid:2.16.840.1.113883.4.642.10.3" ]
];
fhir:Evidence.title [ fhir:value "Effect of Alteplase vs No alteplase on mRS 0-2 at 90 days in Stroke 3-4.5 hours prior"];
fhir:Evidence.status [ fhir:value "draft"];
fhir:Evidence.relatedArtifact [
fhir:index 0;
fhir:RelatedArtifact.type [ fhir:value "citation" ];
fhir:RelatedArtifact.label [ fhir:value "Lees 2016" ];
fhir:RelatedArtifact.display [ fhir:value "Figure 2 Lees 2016" ];
fhir:RelatedArtifact.citation [ fhir:value "Lees KR, Emberson J, Blackwell L, Bluhmki E, Davis SM, Donnan GA, et al; Stroke Thrombolysis Trialists’ Collaborators Group. Effects of alteplase for acute stroke on the distribution of functional outcomes: a pooled analysis of 9 trials. Stroke. 2016;47:2373-2379. PMID 27507856" ];
fhir:RelatedArtifact.document [
fhir:Attachment.url [ fhir:value "https://doi.org/10.1161/STROKEAHA.116.013644" ]
]
];
fhir:Evidence.description [ fhir:value "mRS 0-2 at 90 days Odds Ratio 1.2 for Alteplase vs. No Alteplase in patients with acute ischemic stroke 3-4.5 hours prior"];
fhir:Evidence.variableDefinition [
fhir:index 0;
fhir:Evidence.variableDefinition.variableRole [
fhir:CodeableConcept.coding [
fhir:index 0;
fhir:Coding.system [ fhir:value "http://terminology.hl7.org/CodeSystem/variable-role" ];
fhir:Coding.code [ fhir:value "population" ];
fhir:Coding.display [ fhir:value "population" ]
]
];
fhir:Evidence.variableDefinition.observed [
fhir:Reference.reference [ fhir:value "EvidenceVariable/Stroke-Thrombolysis-Trialists-2014-2016-IPD-MA-Cohort" ];
fhir:Reference.type [ fhir:value "EvidenceVariable" ];
fhir:Reference.display [ fhir:value "Stroke Thrombolysis Trialists’ 2014-2016 IPD-MA Cohort" ]
];
fhir:Evidence.variableDefinition.intended [
fhir:Reference.reference [ fhir:value "Group/AcuteIschemicStroke3-4halfHours" ];
fhir:Reference.type [ fhir:value "Group" ];
fhir:Reference.display [ fhir:value "stroke at 3-4.5 hours" ]
];
fhir:Evidence.variableDefinition.directnessMatch [
fhir:CodeableConcept.coding [
fhir:index 0;
fhir:Coding.system [ fhir:value "http://terminology.hl7.org/CodeSystem/directness" ];
fhir:Coding.code [ fhir:value "moderate" ];
fhir:Coding.display [ fhir:value "Moderate quality match" ]
]
]
], [
fhir:index 1;
fhir:Evidence.variableDefinition.variableRole [
fhir:CodeableConcept.coding [
fhir:index 0;
fhir:Coding.system [ fhir:value "http://terminology.hl7.org/CodeSystem/variable-role" ];
fhir:Coding.code [ fhir:value "measuredVariable" ];
fhir:Coding.display [ fhir:value "measured variable" ]
]
];
fhir:Evidence.variableDefinition.observed [
fhir:Reference.reference [ fhir:value "EvidenceVariable/example-mRS0-2-at-90days" ];
fhir:Reference.type [ fhir:value "EvidenceVariable" ];
fhir:Reference.display [ fhir:value "mRS 0-2 at 90 days" ]
];
fhir:Evidence.variableDefinition.intended [
fhir:Reference.reference [ fhir:value "EvidenceVariable/example-alive-independent-90day" ];
fhir:Reference.type [ fhir:value "EvidenceVariable" ];
fhir:Reference.display [ fhir:value "Alive and not functionally dependent at 90 days" ]
]
], [
fhir:index 2;
fhir:Evidence.variableDefinition.variableRole [
fhir:CodeableConcept.coding [
fhir:index 0;
fhir:Coding.system [ fhir:value "http://terminology.hl7.org/CodeSystem/variable-role" ];
fhir:Coding.code [ fhir:value "exposure" ];
fhir:Coding.display [ fhir:value "exposure" ]
]
];
fhir:Evidence.variableDefinition.observed [
fhir:Reference.reference [ fhir:value "EvidenceVariable/example-alteplase-for-stroke" ];
fhir:Reference.type [ fhir:value "EvidenceVariable" ];
fhir:Reference.display [ fhir:value "Alteplase for Stroke" ]
];
fhir:Evidence.variableDefinition.intended [
fhir:Reference.reference [ fhir:value "EvidenceVariable/example-alteplase-for-stroke" ];
fhir:Reference.type [ fhir:value "EvidenceVariable" ];
fhir:Reference.display [ fhir:value "Alteplase for Stroke" ]
]
], [
fhir:index 3;
fhir:Evidence.variableDefinition.variableRole [
fhir:CodeableConcept.coding [
fhir:index 0;
fhir:Coding.system [ fhir:value "http://terminology.hl7.org/CodeSystem/variable-role" ];
fhir:Coding.code [ fhir:value "referenceExposure" ];
fhir:Coding.display [ fhir:value "reference exposure" ]
]
];
fhir:Evidence.variableDefinition.observed [
fhir:Reference.reference [ fhir:value "EvidenceVariable/example-no-alteplase" ];
fhir:Reference.type [ fhir:value "EvidenceVariable" ];
fhir:Reference.display [ fhir:value "no alteplase" ]
];
fhir:Evidence.variableDefinition.intended [
fhir:Reference.reference [ fhir:value "EvidenceVariable/example-no-alteplase" ];
fhir:Reference.type [ fhir:value "EvidenceVariable" ];
fhir:Reference.display [ fhir:value "no alteplase" ]
]
];
fhir:Evidence.synthesisType [
fhir:CodeableConcept.coding [
fhir:index 0;
fhir:Coding.system [ fhir:value "http://terminology.hl7.org/CodeSystem/synthesis-type" ];
fhir:Coding.code [ fhir:value "IPD-MA" ];
fhir:Coding.display [ fhir:value "individual patient data meta-analysis" ]
]
];
fhir:Evidence.studyDesign [
fhir:index 0;
fhir:CodeableConcept.coding [
fhir:index 0;
fhir:Coding.system [ fhir:value "http://hl7.org/fhir/research-study-classifiers" ];
fhir:Coding.code [ fhir:value "SEVCO:01003" ];
fhir:Coding.display [ fhir:value "randomized assignment" ]
]
];
fhir:Evidence.statistic [
fhir:index 0;
fhir:Evidence.statistic.statisticType [
fhir:CodeableConcept.coding [
fhir:index 0;
fhir:Coding.system [ fhir:value "http://terminology.hl7.org/CodeSystem/statistic-type" ];
fhir:Coding.code [ fhir:value "C16932" ];
fhir:Coding.display [ fhir:value "Odds Ratio" ]
]
];
fhir:Evidence.statistic.quantity [
fhir:Quantity.value [ fhir:value "1.2"^^xsd:decimal ]
];
fhir:Evidence.statistic.sampleSize [
fhir:Evidence.statistic.sampleSize.numberOfStudies [ fhir:value "9"^^xsd:nonNegativeInteger ]
];
fhir:Evidence.statistic.attributeEstimate [
fhir:index 0;
fhir:Evidence.statistic.attributeEstimate.description [ fhir:value "95% CI 1.06 to 1.3" ];
fhir:Evidence.statistic.attributeEstimate.type [
fhir:CodeableConcept.coding [
fhir:index 0;
fhir:Coding.system [ fhir:value "http://terminology.hl7.org/CodeSystem/attribute-estimate-type" ];
fhir:Coding.code [ fhir:value "C53324" ];
fhir:Coding.display [ fhir:value "Confidence interval" ]
]
];
fhir:Evidence.statistic.attributeEstimate.level [ fhir:value "0.95"^^xsd:decimal ];
fhir:Evidence.statistic.attributeEstimate.range [
fhir:Range.low [
fhir:Quantity.value [ fhir:value "1.06"^^xsd:decimal ]
];
fhir:Range.high [
fhir:Quantity.value [ fhir:value "1.3"^^xsd:decimal ]
]
]
]
];
fhir:Evidence.certainty [
fhir:index 0;
fhir:Evidence.certainty.description [ fhir:value "Very low certainty due to risk of bias, inconsistency, imprecision, and indirectness" ];
fhir:Evidence.certainty.type [
fhir:CodeableConcept.coding [
fhir:index 0;
fhir:Coding.system [ fhir:value "http://terminology.hl7.org/CodeSystem/certainty-type" ];
fhir:Coding.code [ fhir:value "Overall" ];
fhir:Coding.display [ fhir:value "Overall quality" ]
]
];
fhir:Evidence.certainty.rating [
fhir:CodeableConcept.coding [
fhir:index 0;
fhir:Coding.system [ fhir:value "http://terminology.hl7.org/CodeSystem/certainty-rating" ];
fhir:Coding.code [ fhir:value "very-low" ];
fhir:Coding.display [ fhir:value "Very low quality" ]
]
];
fhir:Evidence.certainty.subcomponent [
fhir:index 0;
fhir:Evidence.certainty.type [
fhir:CodeableConcept.coding [
fhir:index 0;
fhir:Coding.system [ fhir:value "http://terminology.hl7.org/CodeSystem/certainty-type" ];
fhir:Coding.code [ fhir:value "PublicationBias" ];
fhir:Coding.display [ fhir:value "Publication bias" ]
]
];
fhir:Evidence.certainty.rating [
fhir:CodeableConcept.coding [
fhir:index 0;
fhir:Coding.system [ fhir:value "http://terminology.hl7.org/CodeSystem/certainty-rating" ];
fhir:Coding.code [ fhir:value "no-concern" ];
fhir:Coding.display [ fhir:value "no serious concern" ]
]
]
], [
fhir:index 1;
fhir:Evidence.certainty.note [
fhir:index 0;
fhir:Annotation.text [ fhir:value "IST-3 had inconsistent results and contributed large proportion of data" ]
];
fhir:Evidence.certainty.type [
fhir:CodeableConcept.coding [
fhir:index 0;
fhir:Coding.system [ fhir:value "http://terminology.hl7.org/CodeSystem/certainty-type" ];
fhir:Coding.code [ fhir:value "Inconsistency" ];
fhir:Coding.display [ fhir:value "Inconsistency" ]
]
];
fhir:Evidence.certainty.rating [
fhir:CodeableConcept.coding [
fhir:index 0;
fhir:Coding.system [ fhir:value "http://terminology.hl7.org/CodeSystem/certainty-rating" ];
fhir:Coding.code [ fhir:value "serious-concern" ];
fhir:Coding.display [ fhir:value "serious concern" ]
]
]
], [
fhir:index 2;
fhir:Evidence.certainty.note [
fhir:index 0;
fhir:Annotation.text [ fhir:value "results derived from figure with limited data reported to support the specific effect estimate; derived odds ratio in figure does not match results from rates of mRS 0-2 reported in Supplementary Figure 3b" ]
];
fhir:Evidence.certainty.type [
fhir:CodeableConcept.coding [
fhir:index 0;
fhir:Coding.system [ fhir:value "http://terminology.hl7.org/CodeSystem/certainty-type" ];
fhir:Coding.code [ fhir:value "Imprecision" ];
fhir:Coding.display [ fhir:value "Imprecision" ]
]
];
fhir:Evidence.certainty.rating [
fhir:CodeableConcept.coding [
fhir:index 0;
fhir:Coding.system [ fhir:value "http://terminology.hl7.org/CodeSystem/certainty-rating" ];
fhir:Coding.code [ fhir:value "serious-concern" ];
fhir:Coding.display [ fhir:value "serious concern" ]
]
]
], [
fhir:index 3;
fhir:Evidence.certainty.note [
fhir:index 0;
fhir:Annotation.text [ fhir:value "resuts derived for 3 - 4.5 hours assume data from 0 - 6 hours is informative" ]
];
fhir:Evidence.certainty.type [
fhir:CodeableConcept.coding [
fhir:index 0;
fhir:Coding.system [ fhir:value "http://terminology.hl7.org/CodeSystem/certainty-type" ];
fhir:Coding.code [ fhir:value "Indirectness" ];
fhir:Coding.display [ fhir:value "Indirectness" ]
]
];
fhir:Evidence.certainty.rating [
fhir:CodeableConcept.coding [
fhir:index 0;
fhir:Coding.system [ fhir:value "http://terminology.hl7.org/CodeSystem/certainty-rating" ];
fhir:Coding.code [ fhir:value "serious-concern" ];
fhir:Coding.display [ fhir:value "serious concern" ]
]
]
], [
fhir:index 4;
fhir:Evidence.certainty.note [
fhir:index 0;
fhir:Annotation.text [ fhir:value "results largely influenced by IST-3 trial which was unblinded and ECASS III which had baseline imbalances" ]
];
fhir:Evidence.certainty.type [
fhir:CodeableConcept.coding [
fhir:index 0;
fhir:Coding.system [ fhir:value "http://terminology.hl7.org/CodeSystem/certainty-type" ];
fhir:Coding.code [ fhir:value "RiskOfBias" ];
fhir:Coding.display [ fhir:value "Risk of bias" ]
]
];
fhir:Evidence.certainty.rating [
fhir:CodeableConcept.coding [
fhir:index 0;
fhir:Coding.system [ fhir:value "http://terminology.hl7.org/CodeSystem/certainty-rating" ];
fhir:Coding.code [ fhir:value "serious-concern" ];
fhir:Coding.display [ fhir:value "serious concern" ]
]
]
]
]] .
# - ontology header ------------------------------------------------------------
[a owl:Ontology;
owl:imports fhir:fhir.ttl] .
# -------------------------------------------------------------------------------------
Usage note: every effort has been made to ensure that the examples are correct and useful, but they are not a normative part of the specification.
FHIR ®© HL7.org 2011+. FHIR R5 Ballot hl7.fhir.core#5.0.0-ballot generated on Wed, Sep 7, 2022 11:08+1000.
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