Oral Chemotherapy Example - Manufactured Product - Xeloda - includes a reference to a substance in ingredient element

{
  "resourceType": "Medication",
  "id": "medexample015",
  "text": {
    "status": "generated",
    "div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Medication</b><a name=\"medexample015\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Medication &quot;medexample015&quot; </p></div><p><b>code</b>: Capecitabine 500mg oral tablet (Xeloda) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/3.1.0/CodeSystem-v3-rxNorm.html\">RxNorm</a>#213293)</span></p><p><b>marketingAuthorizationHolder</b>: <a name=\"mmanu\"> </a></p><blockquote><p/><p><a name=\"mmanu\"> </a></p><p><b>name</b>: Medication Manufacturer</p></blockquote><p><b>doseForm</b>: Tablet dose form (qualifier value) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://browser.ihtsdotools.org/\">SNOMED CT</a>#385055001)</span></p><blockquote><p><b>ingredient</b></p><h3>Items</h3><table class=\"grid\"><tr><td>-</td><td><b>Reference</b></td></tr><tr><td>*</td><td><a name=\"sub04\"> </a><blockquote><p/><p><a name=\"sub04\"> </a></p><p><b>instance</b>: false</p><h3>Codes</h3><table class=\"grid\"><tr><td>-</td><td><b>Concept</b></td></tr><tr><td>*</td><td>Capecitabine (substance) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://browser.ihtsdotools.org/\">SNOMED CT</a>#386906001)</span></td></tr></table></blockquote></td></tr></table><p><b>strength</b>: 500 mg<span style=\"background: LightGoldenRodYellow\"> (Details: UCUM code mg = 'mg')</span>/1(unit TAB from http://terminology.hl7.org/CodeSystem/v3-orderableDrugForm)<span style=\"background: LightGoldenRodYellow\"> (Details: http://terminology.hl7.org/CodeSystem/v3-orderableDrugForm code TAB = 'Tablet')</span></p></blockquote><h3>Batches</h3><table class=\"grid\"><tr><td>-</td><td><b>LotNumber</b></td><td><b>ExpirationDate</b></td></tr><tr><td>*</td><td>9494788</td><td>2017-05-22</td></tr></table></div>"
  },
  "contained": [
    {
      "resourceType": "Organization",
      "id": "mmanu",
      "name": "Medication Manufacturer"
    },
    {
      "resourceType": "Substance",
      "id": "sub04",
      "instance": false,
      "code": {
        "concept": {
          "coding": [
            {
              "system": "http://snomed.info/sct",
              "code": "386906001",
              "display": "Capecitabine (substance)"
            }
          ]
        }
      }
    }
  ],
  "code": {
    "coding": [
      {
        "system": "http://www.nlm.nih.gov/research/umls/rxnorm",
        "code": "213293",
        "display": "Capecitabine 500mg oral tablet (Xeloda)"
      }
    ]
  },
  "marketingAuthorizationHolder": {
    "reference": "#mmanu"
  },
  "doseForm": {
    "coding": [
      {
        "system": "http://snomed.info/sct",
        "code": "385055001",
        "display": "Tablet dose form (qualifier value)"
      }
    ]
  },
  "ingredient": [
    {
      "item": {
        "reference": {
          "reference": "#sub04"
        }
      },
      "strengthRatio": {
        "numerator": {
          "value": 500,
          "system": "http://unitsofmeasure.org",
          "code": "mg"
        },
        "denominator": {
          "value": 1,
          "system": "http://terminology.hl7.org/CodeSystem/v3-orderableDrugForm",
          "code": "TAB"
        }
      }
    }
  ],
  "batch": {
    "lotNumber": "9494788",
    "expirationDate": "2017-05-22"
  }
}