Alteplase Dosing for Stroke to be used by an EvidenceVariable resource (id = "example-alteplase-dosing")

<?xml version="1.0" encoding="UTF-8"?>

<ActivityDefinition xmlns="http://hl7.org/fhir">
  <id value="example-alteplase-dosing"/> 
  <text> 
    <status value="generated"/> 
    <div xmlns="http://www.w3.org/1999/xhtml">
      <p> 
        &quot;Alteplase Dosing for Stroke&quot; defines a dosing instruction referenced
         from an EvidenceVariable resource.
      </p> 
  </div> 
  </text> 
  <url value="http://example.org/fhir/ActivityDefinition/example-alteplase-dosing"/> 
  <identifier> 
    <system value="urn:ietf:rfc:3986"/> 
    <value value="urn:oid:2.16.840.1.113883.4.642.19.3"/> 
  </identifier> 
  <name value="Alteplase Dosing for Stroke"/> 
  <status value="draft"/> 
  <kind value="MedicationRequest"/> 
  <code> 
    <coding> 
      <system value="http://www.nlm.nih.gov/research/umls/rxnorm"/> 
      <code value="1155608"/> 
      <display value="alteplase injectable product"/> 
    </coding> 
  </code> 
  <intent value="order"/> 
  <dosage> 
    <sequence value="1"/> 
      <text value="give 10% of dose over 1 minute"/> 
      <route> 
        <coding> 
          <system value="http://snomed.info/sct"/> 
          <code value="47625008"/> 
          <display value="Intravenous use"/> 
        </coding> 
      </route> 
      <doseAndRate> 
        <type> 
          <coding> 
            <system value="http://terminology.hl7.org/CodeSystem/dose-rate-type"/> 
            <code value="calculated"/> 
            <display value="Calculated"/> 
          </coding> 
        </type> 
          <doseQuantity> 
            <value value="0.9"/> 
      <system value="http://unitsofmeasure.org"/> 
            <code value="mg/kg"/> 
          </doseQuantity> 
      </doseAndRate> 
      <maxDosePerAdministration> 
        <value value="90"/> 
    <system value="http://unitsofmeasure.org"/> 
        <code value="mg"/> 
      </maxDosePerAdministration> 
  </dosage> 
  <dosage> 
    <sequence value="2"/> 
    <text value="give remaining 90% of dose over 1 hour"/> 
    <route> 
      <coding> 
        <system value="http://snomed.info/sct"/> 
        <code value="47625008"/> 
        <display value="Intravenous use"/> 
      </coding> 
    </route> 
    <doseAndRate> 
      <type> 
        <coding> 
          <system value="http://terminology.hl7.org/CodeSystem/dose-rate-type"/> 
          <code value="calculated"/> 
          <display value="Calculated"/> 
        </coding> 
      </type> 
      <doseQuantity> 
        <value value="0.9"/> 
    <system value="http://unitsofmeasure.org"/> 
        <code value="mg/kg"/> 
      </doseQuantity> 
    </doseAndRate> 
    <maxDosePerAdministration> 
      <value value="90"/> 
    <system value="http://unitsofmeasure.org"/> 
      <code value="mg"/> 
    </maxDosePerAdministration> 
  </dosage> 
</ActivityDefinition>