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Clinical Decision Support Work Group | Maturity Level: N/A | Standards Status: Informative | Compartments: Not linked to any defined compartments |
This is the narrative for the resource. See also the XML, JSON or Turtle format. This example conforms to the profile Evidence.
Generated Narrative with Details
id: example
title: Corticosteroids vs No corticosteroids for Patients with Sepsis with Mortality (60 days to 1 year)
status: draft
relatedArtifact:
description: Mortality reduced with RR 0.94 with Corticosteroids vs no corticosteroids for patients with sepsis
- | Description | EvidenceSource | IntendedGroup | DirectnessMatch |
* | Patients with sepsis | ??? | Patients with sepsis | ??? (Details : {http://terminology.hl7.org/CodeSystem/directness code 'null' = 'null', given as '???'}) |
variableDefinition
description: Mortality Longer term (60 days to 1 year)
variableRole: measured variable (Details : {http://terminology.hl7.org/CodeSystem/variable-role code 'measuredVariable' = 'measured variable', given as 'measured variable'})
actualDefinition: many studies had shorter term outcomes
intendedDefinition: Mortality Longer term (Follow up: 60 days to 1 year)
directnessMatch: moderate (Details : {http://terminology.hl7.org/CodeSystem/directness code 'moderate' = 'Moderate quality match', given as 'moderate'})
variableDefinition
description: Corticosteroids
variableRole: exposure (Details : {http://terminology.hl7.org/CodeSystem/variable-role code 'exposure' = 'exposure', given as 'exposure'})
actualDefinition: ???
intendedDefinition: Corticosteroids
directnessMatch: ??? (Details : {http://terminology.hl7.org/CodeSystem/directness code 'null' = 'null', given as '???'})
variableDefinition
description: No corticosteroids
variableRole: referenceExposure (Details : {http://terminology.hl7.org/CodeSystem/variable-role code 'referenceExposure' = 'reference exposure', given as 'referenceExposure'})
actualDefinition: ???
intendedDefinition: No corticosteroids
directnessMatch: ??? (Details : {http://terminology.hl7.org/CodeSystem/directness code 'null' = 'null', given as '???'})
synthesisType: summary data meta-analysis (Details : {http://terminology.hl7.org/CodeSystem/synthesis-type code 'std-MA' = 'summary data meta-analysis', given as 'summary data meta-analysis'})
studyType: randomized trial (Details : {http://terminology.hl7.org/CodeSystem/study-type code 'RCT' = 'randomized trial', given as 'randomized trial'})
statistic: ,
certainty
description: Low, due to serious imprecision and indirectness.
rating: Low quality (Details : {http://terminology.hl7.org/CodeSystem/certainty-rating code 'low' = 'Low quality', given as 'Low quality'})
certaintySubcomponent
note: Note that all studies that reported 90 day to 1 year mortality also reported 28-30 day mortality: the CI 95% around the pooled effect for short term mortality also excludes no effect: RR 0.91 (CI 95% 0.84 - 0.98).
type: Risk of bias (Details : {http://terminology.hl7.org/CodeSystem/certainty-subcomponent-type code 'RiskOfBias' = 'Risk of bias', given as 'Risk of bias'})
rating: no serious concern (Details : {http://terminology.hl7.org/CodeSystem/certainty-subcomponent-rating code 'no-concern' = 'no serious concern', given as 'no serious concern'})
certaintySubcomponent
type: Inconsistency (Details : {http://terminology.hl7.org/CodeSystem/certainty-subcomponent-type code 'Inconsistency' = 'Inconsistency', given as 'Inconsistency'})
rating: no serious concern (Details : {http://terminology.hl7.org/CodeSystem/certainty-subcomponent-rating code 'no-concern' = 'no serious concern', given as 'no serious concern'})
certaintySubcomponent
note: Only a small proportion of studies reported longer-term mortality.
type: Indirectness (Details : {http://terminology.hl7.org/CodeSystem/certainty-subcomponent-type code 'Indirectness' = 'Indirectness', given as 'Indirectness'})
rating: serious concern (Details : {http://terminology.hl7.org/CodeSystem/certainty-subcomponent-rating code 'serious-concern' = 'serious concern', given as 'serious concern'})
certaintySubcomponent
note: Confidence interval includes no effect.
type: Imprecision (Details : {http://terminology.hl7.org/CodeSystem/certainty-subcomponent-type code 'Imprecision' = 'Imprecision', given as 'Imprecision'})
rating: serious concern (Details : {http://terminology.hl7.org/CodeSystem/certainty-subcomponent-rating code 'serious-concern' = 'serious concern', given as 'serious concern'})
certaintySubcomponent
type: Publication bias (Details : {http://terminology.hl7.org/CodeSystem/certainty-subcomponent-type code 'PublicationBias' = 'Publication bias', given as 'Publication bias'})
rating: no serious concern (Details : {http://terminology.hl7.org/CodeSystem/certainty-subcomponent-rating code 'no-concern' = 'no serious concern', given as 'no serious concern'})
Usage note: every effort has been made to ensure that the examples are correct and useful, but they are not a normative part of the specification.