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Orders and Observations Work Group | Maturity Level: N/A | Ballot Status: Informative | Compartments: Device, Encounter, Patient, Practitioner |
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An example of a HLA genotyping results report
@prefix fhir: <http://hl7.org/fhir/> . @prefix loinc: <http://loinc.org/rdf#> . @prefix owl: <http://www.w3.org/2002/07/owl#> . @prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> . @prefix xsd: <http://www.w3.org/2001/XMLSchema#> . # - resource ------------------------------------------------------------------- <http://hl7.org/fhir/Bundle/hla-1> a fhir:Bundle; fhir:nodeRole fhir:treeRoot; fhir:Resource.id [ fhir:value "hla-1"]; fhir:Bundle.type [ fhir:value "transaction"]; fhir:Bundle.entry [ fhir:index 0; fhir:Bundle.entry.fullUrl [ fhir:value "urn:uuid:b0a4b18e-94e7-4b1b-8031-c7ae4bdd8db9" ]; fhir:Bundle.entry.resource <urn:uuid:b0a4b18e-94e7-4b1b-8031-c7ae4bdd8db9>; fhir:Bundle.entry.request [ fhir:Bundle.entry.request.method [ fhir:value "POST" ]; fhir:Bundle.entry.request.url [ fhir:value "DiagnosticReport" ] ] ], [ fhir:index 1; fhir:Bundle.entry.fullUrl [ fhir:value "urn:uuid:8200dab6-18a2-4550-b913-a7db480c0804" ]; fhir:Bundle.entry.resource <urn:uuid:8200dab6-18a2-4550-b913-a7db480c0804>; fhir:Bundle.entry.request [ fhir:Bundle.entry.request.method [ fhir:value "POST" ]; fhir:Bundle.entry.request.url [ fhir:value "Sequence" ] ] ], [ fhir:index 2; fhir:Bundle.entry.fullUrl [ fhir:value "urn:uuid:7c393185-f15c-45bc-a714-c0fdbea32675" ]; fhir:Bundle.entry.resource <urn:uuid:7c393185-f15c-45bc-a714-c0fdbea32675>; fhir:Bundle.entry.request [ fhir:Bundle.entry.request.method [ fhir:value "POST" ]; fhir:Bundle.entry.request.url [ fhir:value "Sequence" ] ] ], [ fhir:index 3; fhir:Bundle.entry.fullUrl [ fhir:value "urn:uuid:65c85f14-c3a0-4b72-818f-820e04fcc621" ]; fhir:Bundle.entry.resource <urn:uuid:65c85f14-c3a0-4b72-818f-820e04fcc621>; fhir:Bundle.entry.request [ fhir:Bundle.entry.request.method [ fhir:value "POST" ]; fhir:Bundle.entry.request.url [ fhir:value "Sequence" ] ] ], [ fhir:index 4; fhir:Bundle.entry.fullUrl [ fhir:value "urn:uuid:fbba9fe7-0ece-4ec1-9233-a437a8d242a0" ]; fhir:Bundle.entry.resource <urn:uuid:fbba9fe7-0ece-4ec1-9233-a437a8d242a0>; fhir:Bundle.entry.request [ fhir:Bundle.entry.request.method [ fhir:value "POST" ]; fhir:Bundle.entry.request.url [ fhir:value "Sequence" ] ] ], [ fhir:index 5; fhir:Bundle.entry.fullUrl [ fhir:value "urn:uuid:cbabf93e-1b4b-46f2-ba1e-d84862670670" ]; fhir:Bundle.entry.resource <urn:uuid:cbabf93e-1b4b-46f2-ba1e-d84862670670>; fhir:Bundle.entry.request [ fhir:Bundle.entry.request.method [ fhir:value "POST" ]; fhir:Bundle.entry.request.url [ fhir:value "Sequence" ] ] ], [ fhir:index 6; fhir:Bundle.entry.fullUrl [ fhir:value "urn:uuid:c233ad3d-1572-48d6-93da-0a583535e138" ]; fhir:Bundle.entry.resource <urn:uuid:c233ad3d-1572-48d6-93da-0a583535e138>; fhir:Bundle.entry.request [ fhir:Bundle.entry.request.method [ fhir:value "POST" ]; fhir:Bundle.entry.request.url [ fhir:value "Sequence" ] ] ], [ fhir:index 7; fhir:Bundle.entry.fullUrl [ fhir:value "urn:uuid:05fa52d7-5c67-460a-8722-d3460b24d6fe" ]; fhir:Bundle.entry.resource <urn:uuid:05fa52d7-5c67-460a-8722-d3460b24d6fe>; fhir:Bundle.entry.request [ fhir:Bundle.entry.request.method [ fhir:value "POST" ]; fhir:Bundle.entry.request.url [ fhir:value "Sequence" ] ] ], [ fhir:index 8; fhir:Bundle.entry.fullUrl [ fhir:value "urn:uuid:db69e549-6267-4777-b4b9-8813f3329309" ]; fhir:Bundle.entry.resource <urn:uuid:db69e549-6267-4777-b4b9-8813f3329309>; fhir:Bundle.entry.request [ fhir:Bundle.entry.request.method [ fhir:value "POST" ]; fhir:Bundle.entry.request.url [ fhir:value "Sequence" ] ] ], [ fhir:index 9; fhir:Bundle.entry.fullUrl [ fhir:value "urn:uuid:bb55c2bc-5ad2-4bc1-8ff3-c407d06b12d0" ]; fhir:Bundle.entry.resource <urn:uuid:bb55c2bc-5ad2-4bc1-8ff3-c407d06b12d0>; fhir:Bundle.entry.request [ fhir:Bundle.entry.request.method [ fhir:value "POST" ]; fhir:Bundle.entry.request.url [ fhir:value "Sequence" ] ] ], [ fhir:index 10; fhir:Bundle.entry.fullUrl [ fhir:value "urn:uuid:46938bb2-0486-4e87-bfd3-89aab2d5e22f" ]; fhir:Bundle.entry.resource <urn:uuid:46938bb2-0486-4e87-bfd3-89aab2d5e22f>; fhir:Bundle.entry.request [ fhir:Bundle.entry.request.method [ fhir:value "POST" ]; fhir:Bundle.entry.request.url [ fhir:value "Sequence" ] ] ], [ fhir:index 11; fhir:Bundle.entry.fullUrl [ fhir:value "urn:uuid:2ae2ff34-279e-43c2-9018-b054fd3fc1ce" ]; fhir:Bundle.entry.resource <urn:uuid:2ae2ff34-279e-43c2-9018-b054fd3fc1ce>; fhir:Bundle.entry.request [ fhir:Bundle.entry.request.method [ fhir:value "POST" ]; fhir:Bundle.entry.request.url [ fhir:value "Sequence" ] ] ], [ fhir:index 12; fhir:Bundle.entry.fullUrl [ fhir:value "urn:uuid:19153ef1-68c6-47a2-9676-c4eefbd39af9" ]; fhir:Bundle.entry.resource <urn:uuid:19153ef1-68c6-47a2-9676-c4eefbd39af9>; fhir:Bundle.entry.request [ fhir:Bundle.entry.request.method [ fhir:value "POST" ]; fhir:Bundle.entry.request.url [ fhir:value "Sequence" ] ] ], [ fhir:index 13; fhir:Bundle.entry.fullUrl [ fhir:value "urn:uuid:b7765bbf-df40-486a-9f2f-404309643de6" ]; fhir:Bundle.entry.resource <urn:uuid:b7765bbf-df40-486a-9f2f-404309643de6>; fhir:Bundle.entry.request [ fhir:Bundle.entry.request.method [ fhir:value "POST" ]; fhir:Bundle.entry.request.url [ fhir:value "Observation" ] ] ], [ fhir:index 14; fhir:Bundle.entry.fullUrl [ fhir:value "urn:uuid:d98d92a7-0e86-4ae5-b036-b7e1bba6ec32" ]; fhir:Bundle.entry.resource <urn:uuid:d98d92a7-0e86-4ae5-b036-b7e1bba6ec32>; fhir:Bundle.entry.request [ fhir:Bundle.entry.request.method [ fhir:value "POST" ]; fhir:Bundle.entry.request.url [ fhir:value "Observation" ] ] ], [ fhir:index 15; fhir:Bundle.entry.fullUrl [ fhir:value "urn:uuid:49a86246-4004-42eb-9bdc-f542f93f9228" ]; fhir:Bundle.entry.resource <urn:uuid:49a86246-4004-42eb-9bdc-f542f93f9228>; fhir:Bundle.entry.request [ fhir:Bundle.entry.request.method [ fhir:value "POST" ]; fhir:Bundle.entry.request.url [ fhir:value "Observation" ] ] ], [ fhir:index 16; fhir:Bundle.entry.fullUrl [ fhir:value "urn:uuid:e2092243-2970-49d2-a90f-b90d1d49715a" ]; fhir:Bundle.entry.resource <urn:uuid:e2092243-2970-49d2-a90f-b90d1d49715a>; fhir:Bundle.entry.request [ fhir:Bundle.entry.request.method [ fhir:value "POST" ]; fhir:Bundle.entry.request.url [ fhir:value "Observation" ] ] ], [ fhir:index 17; fhir:Bundle.entry.fullUrl [ fhir:value "urn:uuid:792be53e-d4fb-4887-a367-815ef6c706e5" ]; fhir:Bundle.entry.resource <urn:uuid:792be53e-d4fb-4887-a367-815ef6c706e5>; fhir:Bundle.entry.request [ fhir:Bundle.entry.request.method [ fhir:value "POST" ]; fhir:Bundle.entry.request.url [ fhir:value "Observation" ] ] ], [ fhir:index 18; fhir:Bundle.entry.fullUrl [ fhir:value "urn:uuid:60613a43-c4cb-4502-b3e2-cf9215feaa70" ]; fhir:Bundle.entry.resource <urn:uuid:60613a43-c4cb-4502-b3e2-cf9215feaa70>; fhir:Bundle.entry.request [ fhir:Bundle.entry.request.method [ fhir:value "POST" ]; fhir:Bundle.entry.request.url [ fhir:value "Observation" ] ] ], [ fhir:index 19; fhir:Bundle.entry.fullUrl [ fhir:value "urn:uuid:709c5315-9403-4867-9d82-0b953836665f" ]; fhir:Bundle.entry.resource <urn:uuid:709c5315-9403-4867-9d82-0b953836665f>; fhir:Bundle.entry.request [ fhir:Bundle.entry.request.method [ fhir:value "POST" ]; fhir:Bundle.entry.request.url [ fhir:value "Observation" ] ] ], [ fhir:index 20; fhir:Bundle.entry.fullUrl [ fhir:value "urn:uuid:8b2aa21c-1426-4717-8ab0-a84d83df7d47" ]; fhir:Bundle.entry.resource <urn:uuid:8b2aa21c-1426-4717-8ab0-a84d83df7d47>; fhir:Bundle.entry.request [ fhir:Bundle.entry.request.method [ fhir:value "POST" ]; fhir:Bundle.entry.request.url [ fhir:value "Observation" ] ] ], [ fhir:index 21; fhir:Bundle.entry.fullUrl [ fhir:value "urn:uuid:0e0a780e-4486-4cd0-bfae-7243c579f208" ]; fhir:Bundle.entry.resource <urn:uuid:0e0a780e-4486-4cd0-bfae-7243c579f208>; fhir:Bundle.entry.request [ fhir:Bundle.entry.request.method [ fhir:value "POST" ]; fhir:Bundle.entry.request.url [ fhir:value "Observation" ] ] ] . <urn:uuid:b0a4b18e-94e7-4b1b-8031-c7ae4bdd8db9> a fhir:DiagnosticReport; fhir:DomainResource.text [ fhir:Narrative.status [ fhir:value "generated" ]; fhir:Narrative.div "<div xmlns=\"http://www.w3.org/1999/xhtml\">\n <h3>HLA-A,-B,-C genotyping report for Mary Chalmers (MRN:12345)</h3>\n <pre>\n LOCUS ALLELE 1 ALLELE 2\n HLA-A HLA-A:01:01G HLA-A*01:02\n HLA-B HLA-B*15:01:01G HLA-B*57:01:01G\n HLA-C HLA-C*01:02:01G HLA-C*03:04:01G\n </pre>\n <p>Allele assignments based on IMGT/HLA 3.23</p>\n <p>Effective date: 2015-12-15</p>\n <p>Method: Sequencing of exons 2 and 3 of HLA Class I genes</p>\n <p>Lab: aTypingLab Inc</p>\n <p>Note: Please refer the <a href=\"genomics.html#hla\">implementation guide </a> for more explanation on this\n carefully organized bundle example.</p>\n <pre>\n Bob Milius - NMDP - 2016-12-01\n\n Transaction bundle that creates and links:\n + DiagnosticReport summarizing genotyping for HLA-A,-B,-C typing of patient(donor)\n + Obervations for each genotype\n + Observations for each allele\n + Sequences for exons 2 and 3 for HLA-A,-B, -C\n\n The endpoints of the following resources are hardcoded into this transaction bundle\n because these are presumed to already exist when developing the DiagnosticRequest\n which was to generate this report bundle:\n\n Patient/119 (potential donor)\n Specimen/120 (buccal swab)\n Organization/68 (typing lab)\n ServiceRequest/123 (report is based on this request)\n </pre>\n </div>" ]; fhir:DomainResource.extension [ fhir:index 0; fhir:Extension.url [ fhir:value "http://hl7.org/fhir/StructureDefinition/hla-genotyping-results-allele-database" ]; fhir:Extension.valueCodeableConcept [ fhir:CodeableConcept.coding [ fhir:index 0; fhir:Coding.system [ fhir:value "http://www.ebi.ac.uk/ipd/imgt/hla" ]; fhir:Coding.version [ fhir:value "3.23" ] ]; fhir:CodeableConcept.text [ fhir:value "IMGT/HLA 3.23" ] ] ], [ fhir:index 1; fhir:Extension.url [ fhir:value "http://hl7.org/fhir/StructureDefinition/hla-genotyping-results-glstring" ]; fhir:Element.extension [ fhir:index 0; fhir:Extension.url [ fhir:value "text" ]; fhir:Extension.valueString [ fhir:value "HLA-A:01:01G+HLA-A*01:02^HLA-B*15:01:01:01+HLA-B*57:01:01^HLA-C*01:02:01+HLA-C*03:04:01:01" ] ], [ fhir:index 1; fhir:Extension.url [ fhir:value "uri" ]; fhir:Extension.valueUri [ fhir:value "https://gl.nmdp.org/imgt-hla/3.23.0/multilocus-unphased-genotype/i" ] ] ], [ fhir:index 2; fhir:Extension.url [ fhir:value "http://hl7.org/fhir/StructureDefinition/hla-genotyping-results-method" ]; fhir:Extension.valueCodeableConcept [ fhir:CodeableConcept.coding [ fhir:index 0; fhir:Coding.system [ fhir:value "http://www.ncbi.nlm.nih.gov/gtr/" ]; fhir:Coding.code [ fhir:value "GTR000000000.0" ] ]; fhir:CodeableConcept.text [ fhir:value "Next Generation Sequencing of exons 2 and 3 of HLA Class I genes" ] ] ]; fhir:DiagnosticReport.basedOn [ fhir:index 0; fhir:link <http://hl7.org/fhir/ServiceRequest/123>; fhir:Reference.reference [ fhir:value "ServiceRequest/123" ] ]; fhir:DiagnosticReport.status [ fhir:value "final"]; fhir:DiagnosticReport.category [ fhir:CodeableConcept.coding [ fhir:index 0; fhir:Coding.system [ fhir:value "http://terminology.hl7.org/CodeSystem/v2-0074" ]; fhir:Coding.code [ fhir:value "GE" ]; fhir:Coding.display [ fhir:value "Genetics" ] ] ]; fhir:DiagnosticReport.code [ fhir:CodeableConcept.coding [ fhir:index 0; a loinc:13303-3; fhir:Coding.system [ fhir:value "http://loinc.org" ]; fhir:Coding.code [ fhir:value "13303-3" ]; fhir:Coding.display [ fhir:value "HLA-A+B+C (class I) [Type]" ] ] ]; fhir:DiagnosticReport.subject [ fhir:link <http://hl7.org/fhir/Patient/119>; fhir:Reference.reference [ fhir:value "Patient/119" ]; fhir:Reference.display [ fhir:value "Mary Chalmers" ] ]; fhir:DiagnosticReport.effectiveDateTime [ fhir:value "2016-12-15"^^xsd:date]; fhir:DiagnosticReport.issued [ fhir:value "2016-12-15T14:15:30-06:00"^^xsd:dateTime]; fhir:DiagnosticReport.performer [ fhir:index 0; fhir:link <http://hl7.org/fhir/Organization/68>; fhir:Reference.reference [ fhir:value "Organization/68" ]; fhir:Reference.display [ fhir:value "aTypingLab Inc" ] ]; fhir:DiagnosticReport.specimen [ fhir:index 0; fhir:link <http://hl7.org/fhir/Specimen/67>; fhir:Reference.reference [ fhir:value "Specimen/67" ]; fhir:Reference.display [ fhir:value "buccal swab from Mary Chalmers" ] ]; fhir:DiagnosticReport.result [ fhir:index 0; fhir:Reference.reference [ fhir:value "urn:uuid:49a86246-4004-42eb-9bdc-f542f93f9228" ]; fhir:Reference.display [ fhir:value "HLA-A: HLA-A:01:01G+HLA-A*01:02" ] ], [ fhir:index 1; fhir:Reference.reference [ fhir:value "urn:uuid:60613a43-c4cb-4502-b3e2-cf9215feaa70" ]; fhir:Reference.display [ fhir:value "HLA-B: HLA-B*15:01:01G+HLA-B*57:01:01G" ] ], [ fhir:index 2; fhir:Reference.reference [ fhir:value "urn:uuid:0e0a780e-4486-4cd0-bfae-7243c579f208" ]; fhir:Reference.display [ fhir:value "HLA-C: HLA-C*01:02:01G+HLA-C*03:04:01G" ] ] . <http://hl7.org/fhir/ServiceRequest/123> a fhir:ServiceRequest . <http://hl7.org/fhir/Patient/119> a fhir:Patient . <http://hl7.org/fhir/Organization/68> a fhir:Organization . <http://hl7.org/fhir/Specimen/67> a fhir:Specimen . <urn:uuid:8200dab6-18a2-4550-b913-a7db480c0804> a fhir:Sequence; fhir:DomainResource.text [ fhir:Narrative.status [ fhir:value "generated" ]; fhir:Narrative.div "<div xmlns=\"http://www.w3.org/1999/xhtml\">\n <pre>"HLA-A*01:01:01:01, exon 2"</pre>\n </div>" ]; fhir:Sequence.type [ fhir:value "dna"]; fhir:Sequence.coordinateSystem [ fhir:value "0"^^xsd:integer]; fhir:Sequence.patient [ fhir:link <http://hl7.org/fhir/Patient/119>; fhir:Reference.reference [ fhir:value "Patient/119" ]; fhir:Reference.display [ fhir:value "Mary Chalmers" ] ]; fhir:Sequence.specimen [ fhir:link <http://hl7.org/fhir/Specimen/120>; fhir:Reference.reference [ fhir:value "Specimen/120" ]; fhir:Reference.display [ fhir:value "buccal swab from Mary Chalmers" ] ]; fhir:Sequence.referenceSeq [ fhir:Sequence.referenceSeq.referenceSeqId [ fhir:CodeableConcept.coding [ fhir:index 0; fhir:Coding.system [ fhir:value "http://www.ebi.ac.uk/ipd/imgt/hla" ]; fhir:Coding.version [ fhir:value "3.23" ]; fhir:Coding.code [ fhir:value "HLA00001" ] ]; fhir:CodeableConcept.text [ fhir:value "HLA-A*01:01:01:01" ] ]; fhir:Sequence.referenceSeq.windowStart [ fhir:value "503"^^xsd:integer ]; fhir:Sequence.referenceSeq.windowEnd [ fhir:value "773"^^xsd:integer ] ]; fhir:Sequence.observedSeq [ fhir:value "GCTCCCACTCCATGAGGTATTTCTTCACATCCGTGTCCCGGCCCGGCCGCGGGGAGCCCCGCTTCATCGCCGTGGGCTACGTGGACGACACGCAGTTCGTGCGGTTCGACAGCGACGCCGCGAGCCAGAAGATGGAGCCGCGGGCGCCGTGGATAGAGCAGGAGGGGCCGGAGTATTGGGACCAGGAGACACGGAATATGAAGGCCCACTCACAGACTGACCGAGCGAACCTGGGGACCCTGCGCGGCTACTACAACCAGAGCGAGGACG"] . <http://hl7.org/fhir/Specimen/120> a fhir:Specimen . <urn:uuid:7c393185-f15c-45bc-a714-c0fdbea32675> a fhir:Sequence; fhir:DomainResource.text [ fhir:Narrative.status [ fhir:value "generated" ]; fhir:Narrative.div "<div xmlns=\"http://www.w3.org/1999/xhtml\">\n <pre>"HLA-A*01:01:01:01, exon 3"</pre>\n </div>" ]; fhir:Sequence.type [ fhir:value "dna"]; fhir:Sequence.coordinateSystem [ fhir:value "0"^^xsd:integer]; fhir:Sequence.patient [ fhir:link <http://hl7.org/fhir/Patient/119>; fhir:Reference.reference [ fhir:value "Patient/119" ]; fhir:Reference.display [ fhir:value "Mary Chalmers" ] ]; fhir:Sequence.specimen [ fhir:link <http://hl7.org/fhir/Specimen/120>; fhir:Reference.reference [ fhir:value "Specimen/120" ]; fhir:Reference.display [ fhir:value "buccal swab from Mary Chalmers" ] ]; fhir:Sequence.referenceSeq [ fhir:Sequence.referenceSeq.referenceSeqId [ fhir:CodeableConcept.coding [ fhir:index 0; fhir:Coding.system [ fhir:value "http://www.ebi.ac.uk/ipd/imgt/hla" ]; fhir:Coding.version [ fhir:value "3.23" ]; fhir:Coding.code [ fhir:value "HLA00001" ] ]; fhir:CodeableConcept.text [ fhir:value "HLA-A*01:01:01:01" ] ]; fhir:Sequence.referenceSeq.windowStart [ fhir:value "1014"^^xsd:integer ]; fhir:Sequence.referenceSeq.windowEnd [ fhir:value "1290"^^xsd:integer ] ]; fhir:Sequence.observedSeq [ fhir:value "GTTCTCACACCATCCAGATAATGTATGGCTGCGACGTGGGGCCGGACGGGCGCTTCCTCCGCGGGTACCGGCAGGACGCCTACGACGGCAAGGATTACATCGCCCTGAACGAGGACCTGCGCTCTTGGACCGCGGCGGACATGGCAGCTCAGATCACCAAGCGCAAGTGGGAGGCGGTCCATGCGGCGGAGCAGCGGAGAGTCTACCTGGAGGGCCGGTGCGTGGACGGGCTCCGCAGATACCTGGAGAACGGGAAGGAGACGCTGCAGCGCACGG"] . <urn:uuid:65c85f14-c3a0-4b72-818f-820e04fcc621> a fhir:Sequence; fhir:DomainResource.text [ fhir:Narrative.status [ fhir:value "generated" ]; fhir:Narrative.div "<div xmlns=\"http://www.w3.org/1999/xhtml\">\n <pre>"HLA-A*01:02, exon 2"</pre>\n </div>" ]; fhir:Sequence.type [ fhir:value "dna"]; fhir:Sequence.coordinateSystem [ fhir:value "0"^^xsd:integer]; fhir:Sequence.patient [ fhir:link <http://hl7.org/fhir/Patient/119>; fhir:Reference.reference [ fhir:value "Patient/119" ]; fhir:Reference.display [ fhir:value "Mary Chalmers" ] ]; fhir:Sequence.specimen [ fhir:link <http://hl7.org/fhir/Specimen/120>; fhir:Reference.reference [ fhir:value "Specimen/120" ]; fhir:Reference.display [ fhir:value "buccal swab from Mary Chalmers" ] ]; fhir:Sequence.referenceSeq [ fhir:Sequence.referenceSeq.referenceSeqId [ fhir:CodeableConcept.coding [ fhir:index 0; fhir:Coding.system [ fhir:value "http://www.ebi.ac.uk/ipd/imgt/hla" ]; fhir:Coding.version [ fhir:value "3.23" ]; fhir:Coding.code [ fhir:value "HLA00002" ] ]; fhir:CodeableConcept.text [ fhir:value "HLA-A*01:02" ] ]; fhir:Sequence.referenceSeq.windowStart [ fhir:value "503"^^xsd:integer ]; fhir:Sequence.referenceSeq.windowEnd [ fhir:value "773"^^xsd:integer ] ]; fhir:Sequence.observedSeq [ fhir:value "GCTCCCACTCCATGAGGTATTTCTCCACATCCGTGTCCCGGCCCGGCAGTGGAGAGCCCCGCTTCATCGCAGTGGGCTACGTGGACGACACGCAGTTCGTGCGGTTCGACAGCGACGCCGCGAGCCAGAAGATGGAGCCGCGGGCGCCGTGGATAGAGCAGGAGGGGCCGGAGTATTGGGACCAGGAGACACGGAATATGAAGGCCCACTCACAGACTGACCGAGCGAACCTGGGGACCCTGCGCGGCTACTACAACCAGAGCGAGGACG"] . <urn:uuid:fbba9fe7-0ece-4ec1-9233-a437a8d242a0> a fhir:Sequence; fhir:DomainResource.text [ fhir:Narrative.status [ fhir:value "generated" ]; fhir:Narrative.div "<div xmlns=\"http://www.w3.org/1999/xhtml\">\n <pre>"HLA-A*01:02, exon 3"</pre>\n </div>" ]; fhir:Sequence.type [ fhir:value "dna"]; fhir:Sequence.coordinateSystem [ fhir:value "0"^^xsd:integer]; fhir:Sequence.patient [ fhir:link <http://hl7.org/fhir/Patient/119>; fhir:Reference.reference [ fhir:value "Patient/119" ]; fhir:Reference.display [ fhir:value "Mary Chalmers" ] ]; fhir:Sequence.specimen [ fhir:link <http://hl7.org/fhir/Specimen/120>; fhir:Reference.reference [ fhir:value "Specimen/120" ]; fhir:Reference.display [ fhir:value "buccal swab from Mary Chalmers" ] ]; fhir:Sequence.referenceSeq [ fhir:Sequence.referenceSeq.referenceSeqId [ fhir:CodeableConcept.coding [ fhir:index 0; fhir:Coding.system [ fhir:value "http://www.ebi.ac.uk/ipd/imgt/hla" ]; fhir:Coding.version [ fhir:value "3.23" ]; fhir:Coding.code [ fhir:value "HLA00002" ] ]; fhir:CodeableConcept.text [ fhir:value "HLA-A*01:02" ] ]; fhir:Sequence.referenceSeq.windowStart [ fhir:value "1014"^^xsd:integer ]; fhir:Sequence.referenceSeq.windowEnd [ fhir:value "1290"^^xsd:integer ] ]; fhir:Sequence.observedSeq [ fhir:value "GTTCTCACACCATCCAGATAATGTATGGCTGCGACGTGGGGCCGGACGGGCGCTTCCTCCGCGGGTACCGGCAGGACGCCTACGACGGCAAGGATTACATCGCCCTGAACGAGGACCTGCGCTCTTGGACCGCGGCGGACATGGCAGCTCAGATCACCAAGCGCAAGTGGGAGGCGGTCCATGCGGCGGAGCAGCGGAGAGTCTACCTGGAGGGCCGGTGCGTGGACGGGCTCCGCAGATACCTGGAGAACGGGAAGGAGACGCTGCAGCGCACGG"] . <urn:uuid:cbabf93e-1b4b-46f2-ba1e-d84862670670> a fhir:Sequence; fhir:DomainResource.text [ fhir:Narrative.status [ fhir:value "generated" ]; fhir:Narrative.div "<div xmlns=\"http://www.w3.org/1999/xhtml\">\n <pre>"HLA-B*15:01:01:01, exon 2"</pre>\n </div>" ]; fhir:Sequence.type [ fhir:value "dna"]; fhir:Sequence.coordinateSystem [ fhir:value "0"^^xsd:integer]; fhir:Sequence.patient [ fhir:link <http://hl7.org/fhir/Patient/119>; fhir:Reference.reference [ fhir:value "Patient/119" ]; fhir:Reference.display [ fhir:value "Mary Chalmers" ] ]; 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fhir:Sequence.referenceSeq.windowStart [ fhir:value "1001"^^xsd:integer ]; fhir:Sequence.referenceSeq.windowEnd [ fhir:value "1277"^^xsd:integer ] ]; fhir:Sequence.observedSeq [ fhir:value "GGTCTCACACCCTCCAGAGGATGTACGGCTGCGACGTGGGGCCGGACGGGCGCCTCCTCCGCGGGCATGACCAGTCCGCCTACGACGGCAAGGATTACATCGCCCTGAACGAGGACCTGAGCTCCTGGACCGCGGCGGACACGGCGGCTCAGATCACCCAGCGCAAGTGGGAGGCGGCCCGTGAGGCGGAGCAGTGGAGAGCCTACCTGGAGGGCCTGTGCGTGGAGTGGCTCCGCAGATACCTGGAGAACGGGAAGGAGACGCTGCAGCGCGCGG"] . <urn:uuid:05fa52d7-5c67-460a-8722-d3460b24d6fe> a fhir:Sequence; fhir:DomainResource.text [ fhir:Narrative.status [ fhir:value "generated" ]; fhir:Narrative.div "<div xmlns=\"http://www.w3.org/1999/xhtml\">\n <pre>"HLA-B*57:01:01, exon 2"</pre>\n </div>" ]; fhir:Sequence.type [ fhir:value "dna"]; fhir:Sequence.coordinateSystem [ fhir:value "0"^^xsd:integer]; fhir:Sequence.patient [ fhir:link <http://hl7.org/fhir/Patient/119>; fhir:Reference.reference [ fhir:value "Patient/119" ]; fhir:Reference.display [ fhir:value "Mary Chalmers" ] ]; fhir:Sequence.specimen [ fhir:link <http://hl7.org/fhir/Specimen/120>; fhir:Reference.reference [ fhir:value "Specimen/120" ]; fhir:Reference.display [ fhir:value "buccal swab from Mary Chalmers" ] ]; fhir:Sequence.referenceSeq [ fhir:Sequence.referenceSeq.referenceSeqId [ fhir:CodeableConcept.coding [ fhir:index 0; fhir:Coding.system [ fhir:value "http://www.ebi.ac.uk/ipd/imgt/hla" ]; fhir:Coding.version [ fhir:value "3.23" ]; fhir:Coding.code [ fhir:value "HLA00381" ] ]; fhir:CodeableConcept.text [ fhir:value "HLA-B*57:01:01" ] ]; fhir:Sequence.referenceSeq.windowStart [ fhir:value "485"^^xsd:integer ]; fhir:Sequence.referenceSeq.windowEnd [ fhir:value "755"^^xsd:integer ] ]; fhir:Sequence.observedSeq [ fhir:value "GCTCCCACTCCATGAGGTATTTCTACACCGCCATGTCCCGGCCCGGCCGCGGGGAGCCCCGCTTCATCGCAGTGGGCTACGTGGACGACACCCAGTTCGTGAGGTTCGACAGCGACGCCGCGAGTCCGAGGATGGCGCCCCGGGCGCCATGGATAGAGCAGGAGGGGCCGGAGTATTGGGACGGGGAGACACGGAACATGAAGGCCTCCGCGCAGACTTACCGAGAGAACCTGCGGATCGCGCTCCGCTACTACAACCAGAGCGAGGCCG"] . <urn:uuid:db69e549-6267-4777-b4b9-8813f3329309> a fhir:Sequence; 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fhir:Sequence.referenceSeq.windowStart [ fhir:value "1001"^^xsd:integer ]; fhir:Sequence.referenceSeq.windowEnd [ fhir:value "1277"^^xsd:integer ] ]; fhir:Sequence.observedSeq [ fhir:value "GGTCTCACATCATCCAGGTGATGTATGGCTGCGACGTGGGGCCGGACGGGCGCCTCCTCCGCGGGCATGACCAGTCCGCCTACGACGGCAAGGATTACATCGCCCTGAACGAGGACCTGAGCTCCTGGACCGCGGCGGACACGGCGGCTCAGATCACCCAGCGCAAGTGGGAGGCGGCCCGTGTGGCGGAGCAGCTGAGAGCCTACCTGGAGGGCCTGTGCGTGGAGTGGCTCCGCAGATACCTGGAGAACGGGAAGGAGACGCTGCAGCGCGCGG"] . <urn:uuid:bb55c2bc-5ad2-4bc1-8ff3-c407d06b12d0> a fhir:Sequence; fhir:DomainResource.text [ fhir:Narrative.status [ fhir:value "generated" ]; fhir:Narrative.div "<div xmlns=\"http://www.w3.org/1999/xhtml\">\n <pre>"HLA-C*01:02:01, exon 2"</pre>\n </div>" ]; fhir:Sequence.type [ fhir:value "dna"]; fhir:Sequence.coordinateSystem [ fhir:value "0"^^xsd:integer]; fhir:Sequence.patient [ fhir:link <http://hl7.org/fhir/Patient/119>; fhir:Reference.reference [ fhir:value "Patient/119" ]; fhir:Reference.display [ fhir:value "Mary Chalmers" ] ]; 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fhir:Observation.specimen [ fhir:link <http://hl7.org/fhir/Specimen/120>; fhir:Reference.reference [ fhir:value "Specimen/120" ]; fhir:Reference.display [ fhir:value "buccal swab from Mary Chalmers" ] ]; fhir:Observation.derivedFrom [ fhir:index 0; fhir:Reference.reference [ fhir:value "urn:uuid:8200dab6-18a2-4550-b913-a7db480c0804" ]; fhir:Reference.display [ fhir:value "HLA-A*01:01:01:01, exon 2" ] ], [ fhir:index 1; fhir:Reference.reference [ fhir:value "urn:uuid:7c393185-f15c-45bc-a714-c0fdbea32675" ]; fhir:Reference.display [ fhir:value "HLA-A*01:01:01:01, exon 3" ] ] . <urn:uuid:d98d92a7-0e86-4ae5-b036-b7e1bba6ec32> a fhir:Observation; fhir:DomainResource.text [ fhir:Narrative.status [ fhir:value "generated" ]; fhir:Narrative.div "<div xmlns=\"http://www.w3.org/1999/xhtml\">\n <pre>HLA-A*01:02</pre>\n </div>" ]; fhir:DomainResource.extension [ fhir:index 0; fhir:Extension.url [ fhir:value "http://hl7.org/fhir/StructureDefinition/observation-geneticsGene" ]; fhir:Extension.valueCodeableConcept [ fhir:CodeableConcept.coding [ fhir:index 0; 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fhir:Observation.effectiveDateTime [ fhir:value "2016-12-15"^^xsd:date]; fhir:Observation.specimen [ fhir:link <http://hl7.org/fhir/Specimen/120>; fhir:Reference.reference [ fhir:value "Specimen/120" ]; fhir:Reference.display [ fhir:value "buccal swab from Mary Chalmers" ] ]; fhir:Observation.derivedFrom [ fhir:index 0; fhir:Reference.reference [ fhir:value "urn:uuid:65c85f14-c3a0-4b72-818f-820e04fcc621" ]; fhir:Reference.display [ fhir:value "HLA-A*01:02, exon 2" ] ], [ fhir:index 1; fhir:Reference.reference [ fhir:value "urn:uuid:fbba9fe7-0ece-4ec1-9233-a437a8d242a0" ]; fhir:Reference.display [ fhir:value "HLA-A*01:02, exon 3" ] ] . <urn:uuid:49a86246-4004-42eb-9bdc-f542f93f9228> a fhir:Observation; fhir:DomainResource.text [ fhir:Narrative.status [ fhir:value "generated" ]; fhir:Narrative.div "<div xmlns=\"http://www.w3.org/1999/xhtml\">\n <pre>HLA-A:01:01G+HLA-A*01:02</pre>\n </div>" ]; fhir:DomainResource.extension [ fhir:index 0; fhir:Extension.url [ fhir:value "http://hl7.org/fhir/StructureDefinition/observation-geneticsGene" ]; fhir:Extension.valueCodeableConcept [ fhir:CodeableConcept.coding [ fhir:index 0; fhir:Coding.system [ fhir:value "http://www.genenames.org" ]; fhir:Coding.code [ fhir:value "HGNC:4931" ]; fhir:Coding.display [ fhir:value "HLA-A" ] ] ] ], [ fhir:index 1; fhir:Extension.url [ fhir:value "http://hl7.org/fhir/StructureDefinition/observation-geneticsGenomicSourceClass" ]; fhir:Extension.valueCodeableConcept [ fhir:CodeableConcept.coding [ fhir:index 0; a loinc:LA6683-2; fhir:Coding.system [ fhir:value "http://loinc.org" ]; fhir:Coding.code [ fhir:value "LA6683-2" ]; fhir:Coding.display [ fhir:value "germline" ] ] ] ]; fhir:Observation.status [ fhir:value "final"]; fhir:Observation.code [ fhir:CodeableConcept.coding [ fhir:index 0; a loinc:57290-9; fhir:Coding.system [ fhir:value "http://loinc.org" ]; fhir:Coding.code [ fhir:value "57290-9" ]; fhir:Coding.display [ fhir:value "HLA-A [Type] by High resolution" ] ] ]; fhir:Observation.subject [ fhir:link <http://hl7.org/fhir/Patient/119>; fhir:Reference.reference [ fhir:value "Patient/119" ]; fhir:Reference.display [ fhir:value "Mary Chalmers" ] ]; fhir:Observation.effectiveDateTime [ fhir:value "2016-12-15"^^xsd:date]; fhir:Observation.specimen [ fhir:link <http://hl7.org/fhir/Specimen/120>; fhir:Reference.reference [ fhir:value "Specimen/120" ]; fhir:Reference.display [ fhir:value "buccal swab from Mary Chalmers" ] ]; fhir:Observation.derivedFrom [ fhir:index 0; fhir:Reference.reference [ fhir:value "urn:uuid:b7765bbf-df40-486a-9f2f-404309643de6" ]; fhir:Reference.display [ fhir:value "HLA-A*01:01:01G, exons 2 and 3" ] ], [ fhir:index 1; fhir:Reference.reference [ fhir:value "urn:uuid:d98d92a7-0e86-4ae5-b036-b7e1bba6ec32" ]; fhir:Reference.display [ fhir:value "HLA-A*01:02, exons 2 and 3" ] ] . <urn:uuid:e2092243-2970-49d2-a90f-b90d1d49715a> a fhir:Observation; fhir:DomainResource.text [ fhir:Narrative.status [ fhir:value "generated" ]; fhir:Narrative.div "<div xmlns=\"http://www.w3.org/1999/xhtml\">\n <pre>HLA-B*15:01:01G</pre>\n </div>" ]; fhir:DomainResource.extension [ fhir:index 0; fhir:Extension.url [ fhir:value "http://hl7.org/fhir/StructureDefinition/observation-geneticsGene" ]; fhir:Extension.valueCodeableConcept [ fhir:CodeableConcept.coding [ fhir:index 0; fhir:Coding.system [ fhir:value "http://www.genenames.org" ]; fhir:Coding.code [ fhir:value "HGNC:4932" ]; fhir:Coding.display [ fhir:value "HLA-B" ] ] ] ], [ fhir:index 1; fhir:Extension.url [ fhir:value "http://hl7.org/fhir/StructureDefinition/observation-geneticsGenomicSourceClass" ]; fhir:Extension.valueCodeableConcept [ fhir:CodeableConcept.coding [ fhir:index 0; a loinc:LA6683-2; fhir:Coding.system [ fhir:value "http://loinc.org" ]; fhir:Coding.code [ fhir:value "LA6683-2" ]; fhir:Coding.display [ fhir:value "germline" ] ] ] ]; fhir:Observation.status [ fhir:value "final"]; fhir:Observation.code [ fhir:CodeableConcept.coding [ fhir:index 0; a loinc:57291-7; fhir:Coding.system [ fhir:value "http://loinc.org" ]; fhir:Coding.code [ fhir:value "57291-7" ]; fhir:Coding.display [ fhir:value "HLA-B [Type] by High resolution" ] ] ]; fhir:Observation.subject [ fhir:link <http://hl7.org/fhir/Patient/119>; fhir:Reference.reference [ fhir:value "Patient/119" ]; fhir:Reference.display [ fhir:value "Mary Chalmers" ] ]; fhir:Observation.effectiveDateTime [ fhir:value "2016-12-15"^^xsd:date]; fhir:Observation.specimen [ fhir:link <http://hl7.org/fhir/Specimen/120>; fhir:Reference.reference [ fhir:value "Specimen/120" ]; fhir:Reference.display [ fhir:value "buccal swab from Mary Chalmers" ] ]; fhir:Observation.derivedFrom [ fhir:index 0; fhir:Reference.reference [ fhir:value "urn:uuid:cbabf93e-1b4b-46f2-ba1e-d84862670670" ]; fhir:Reference.display [ fhir:value "HLA-B*15:01:01:01, exon 2" ] ], [ fhir:index 1; fhir:Reference.reference [ fhir:value "urn:uuid:c233ad3d-1572-48d6-93da-0a583535e138" ]; fhir:Reference.display [ fhir:value "HLA-B*15:01:01:01, exon 3" ] ] . <urn:uuid:792be53e-d4fb-4887-a367-815ef6c706e5> a fhir:Observation; fhir:DomainResource.text [ fhir:Narrative.status [ fhir:value "generated" ]; fhir:Narrative.div "<div xmlns=\"http://www.w3.org/1999/xhtml\">\n <pre>HLA-B*57:01:01G</pre>\n </div>" ]; fhir:DomainResource.extension [ fhir:index 0; fhir:Extension.url [ fhir:value "http://hl7.org/fhir/StructureDefinition/observation-geneticsGene" ]; fhir:Extension.valueCodeableConcept [ fhir:CodeableConcept.coding [ fhir:index 0; fhir:Coding.system [ fhir:value "http://www.genenames.org" ]; fhir:Coding.code [ fhir:value "HGNC:4932" ]; fhir:Coding.display [ fhir:value "HLA-B" ] ] ] ], [ fhir:index 1; fhir:Extension.url [ fhir:value "http://hl7.org/fhir/StructureDefinition/observation-geneticsGenomicSourceClass" ]; fhir:Extension.valueCodeableConcept [ fhir:CodeableConcept.coding [ fhir:index 0; a loinc:LA6683-2; fhir:Coding.system [ fhir:value "http://loinc.org" ]; fhir:Coding.code [ fhir:value "LA6683-2" ]; fhir:Coding.display [ fhir:value "germline" ] ] ] ]; fhir:Observation.status [ fhir:value "final"]; fhir:Observation.code [ fhir:CodeableConcept.coding [ fhir:index 0; a loinc:57291-7; fhir:Coding.system [ fhir:value "http://loinc.org" ]; fhir:Coding.code [ fhir:value "57291-7" ]; fhir:Coding.display [ fhir:value "HLA-B [Type] by High resolution" ] ] ]; fhir:Observation.subject [ fhir:link <http://hl7.org/fhir/Patient/119>; fhir:Reference.reference [ fhir:value "Patient/119" ]; fhir:Reference.display [ fhir:value "Mary Chalmers" ] ]; fhir:Observation.effectiveDateTime [ fhir:value "2016-12-15"^^xsd:date]; fhir:Observation.specimen [ fhir:link <http://hl7.org/fhir/Specimen/120>; fhir:Reference.reference [ fhir:value "Specimen/120" ]; fhir:Reference.display [ fhir:value "buccal swab from Mary Chalmers" ] ]; fhir:Observation.derivedFrom [ fhir:index 0; fhir:Reference.reference [ fhir:value "urn:uuid:05fa52d7-5c67-460a-8722-d3460b24d6fe" ]; fhir:Reference.display [ fhir:value "HLA-B*57:01:01, exon 2" ] ], [ fhir:index 1; fhir:Reference.reference [ fhir:value "urn:uuid:db69e549-6267-4777-b4b9-8813f3329309" ]; fhir:Reference.display [ fhir:value "HLA-B*57:01:01, exon 3" ] ] . <urn:uuid:60613a43-c4cb-4502-b3e2-cf9215feaa70> a fhir:Observation; fhir:DomainResource.text [ fhir:Narrative.status [ fhir:value "generated" ]; fhir:Narrative.div "<div xmlns=\"http://www.w3.org/1999/xhtml\">\n <pre>HLA-B*15:01:01G+HLA-B*57:01:01G</pre>\n </div>" ]; fhir:DomainResource.extension [ fhir:index 0; fhir:Extension.url [ fhir:value "http://hl7.org/fhir/StructureDefinition/observation-geneticsGene" ]; fhir:Extension.valueCodeableConcept [ fhir:CodeableConcept.coding [ fhir:index 0; fhir:Coding.system [ fhir:value "http://www.genenames.org" ]; fhir:Coding.code [ fhir:value "HGNC:4932" ]; fhir:Coding.display [ fhir:value "HLA-B" ] ] ] ], [ fhir:index 1; fhir:Extension.url [ fhir:value "http://hl7.org/fhir/StructureDefinition/observation-geneticsGenomicSourceClass" ]; fhir:Extension.valueCodeableConcept [ fhir:CodeableConcept.coding [ fhir:index 0; a loinc:LA6683-2; fhir:Coding.system [ fhir:value "http://loinc.org" ]; fhir:Coding.code [ fhir:value "LA6683-2" ]; fhir:Coding.display [ fhir:value "germline" ] ] ] ]; fhir:Observation.status [ fhir:value "final"]; fhir:Observation.code [ fhir:CodeableConcept.coding [ fhir:index 0; a loinc:57291-7; fhir:Coding.system [ fhir:value "http://loinc.org" ]; fhir:Coding.code [ fhir:value "57291-7" ]; fhir:Coding.display [ fhir:value "HLA-B [Type] by High resolution" ] ] ]; fhir:Observation.subject [ fhir:link <http://hl7.org/fhir/Patient/119>; fhir:Reference.reference [ fhir:value "Patient/119" ]; fhir:Reference.display [ fhir:value "Mary Chalmers" ] ]; fhir:Observation.effectiveDateTime [ fhir:value "2016-12-15"^^xsd:date]; fhir:Observation.specimen [ fhir:link <http://hl7.org/fhir/Specimen/120>; fhir:Reference.reference [ fhir:value "Specimen/120" ]; fhir:Reference.display [ fhir:value "buccal swab from Mary Chalmers" ] ]; fhir:Observation.derivedFrom [ fhir:index 0; fhir:Reference.reference [ fhir:value "urn:uuid:e2092243-2970-49d2-a90f-b90d1d49715a" ]; fhir:Reference.display [ fhir:value "HLA-B*15:01:01G, exons 2 and 3" ] ], [ fhir:index 1; fhir:Reference.reference [ fhir:value "urn:uuid:792be53e-d4fb-4887-a367-815ef6c706e5" ]; fhir:Reference.display [ fhir:value "HLA-B*57:01:01G, exons 2 and 3" ] ] . <urn:uuid:709c5315-9403-4867-9d82-0b953836665f> a fhir:Observation; fhir:DomainResource.text [ fhir:Narrative.status [ fhir:value "generated" ]; fhir:Narrative.div "<div xmlns=\"http://www.w3.org/1999/xhtml\">\n <pre>HLA-C*01:02:01</pre>\n </div>" ]; fhir:DomainResource.extension [ fhir:index 0; fhir:Extension.url [ fhir:value "http://hl7.org/fhir/StructureDefinition/observation-geneticsGene" ]; fhir:Extension.valueCodeableConcept [ fhir:CodeableConcept.coding [ fhir:index 0; fhir:Coding.system [ fhir:value "http://www.genenames.org" ]; fhir:Coding.code [ fhir:value "HGNC:4933" ]; fhir:Coding.display [ fhir:value "HLA-C" ] ] ] ], [ fhir:index 1; fhir:Extension.url [ fhir:value "http://hl7.org/fhir/StructureDefinition/observation-geneticsGenomicSourceClass" ]; fhir:Extension.valueCodeableConcept [ fhir:CodeableConcept.coding [ fhir:index 0; a loinc:LA6683-2; fhir:Coding.system [ fhir:value "http://loinc.org" ]; fhir:Coding.code [ fhir:value "LA6683-2" ]; fhir:Coding.display [ fhir:value "germline" ] ] ] ]; fhir:Observation.status [ fhir:value "final"]; fhir:Observation.code [ fhir:CodeableConcept.coding [ fhir:index 0; a loinc:77636-9; fhir:Coding.system [ fhir:value "http://loinc.org" ]; fhir:Coding.code [ fhir:value "77636-9" ]; fhir:Coding.display [ fhir:value "HLA-C [Type] by High resolution" ] ] ]; fhir:Observation.subject [ fhir:link <http://hl7.org/fhir/Patient/119>; fhir:Reference.reference [ fhir:value "Patient/119" ]; fhir:Reference.display [ fhir:value "Mary Chalmers" ] ]; fhir:Observation.effectiveDateTime [ fhir:value "2016-12-15"^^xsd:date]; fhir:Observation.specimen [ fhir:link <http://hl7.org/fhir/Specimen/120>; fhir:Reference.reference [ fhir:value "Specimen/120" ]; fhir:Reference.display [ fhir:value "buccal swab from Mary Chalmers" ] ]; fhir:Observation.derivedFrom [ fhir:index 0; fhir:Reference.reference [ fhir:value "urn:uuid:bb55c2bc-5ad2-4bc1-8ff3-c407d06b12d0" ]; fhir:Reference.display [ fhir:value "HLA-C*01:02:01, exon 2" ] ], [ fhir:index 1; fhir:Reference.reference [ fhir:value "urn:uuid:46938bb2-0486-4e87-bfd3-89aab2d5e22f" ]; fhir:Reference.display [ fhir:value "HLA-C*01:02:01, exon 3" ] ] . <urn:uuid:8b2aa21c-1426-4717-8ab0-a84d83df7d47> a fhir:Observation; fhir:DomainResource.text [ fhir:Narrative.status [ fhir:value "generated" ]; fhir:Narrative.div "<div xmlns=\"http://www.w3.org/1999/xhtml\">\n <pre>HLA-C*03:04:01:01</pre>\n </div>" ]; fhir:DomainResource.extension [ fhir:index 0; fhir:Extension.url [ fhir:value "http://hl7.org/fhir/StructureDefinition/observation-geneticsGene" ]; fhir:Extension.valueCodeableConcept [ fhir:CodeableConcept.coding [ fhir:index 0; fhir:Coding.system [ fhir:value "http://www.genenames.org" ]; fhir:Coding.code [ fhir:value "HGNC:4933" ]; fhir:Coding.display [ fhir:value "HLA-C" ] ] ] ], [ fhir:index 1; fhir:Extension.url [ fhir:value "http://hl7.org/fhir/StructureDefinition/observation-geneticsGenomicSourceClass" ]; fhir:Extension.valueCodeableConcept [ fhir:CodeableConcept.coding [ fhir:index 0; a loinc:LA6683-2; fhir:Coding.system [ fhir:value "http://loinc.org" ]; fhir:Coding.code [ fhir:value "LA6683-2" ]; fhir:Coding.display [ fhir:value "germline" ] ] ] ]; fhir:Observation.status [ fhir:value "final"]; fhir:Observation.code [ fhir:CodeableConcept.coding [ fhir:index 0; a loinc:77636-9; fhir:Coding.system [ fhir:value "http://loinc.org" ]; fhir:Coding.code [ fhir:value "77636-9" ]; fhir:Coding.display [ fhir:value "HLA-C [Type] by High resolution" ] ] ]; fhir:Observation.subject [ fhir:link <http://hl7.org/fhir/Patient/119>; fhir:Reference.reference [ fhir:value "Patient/119" ]; fhir:Reference.display [ fhir:value "Mary Chalmers" ] ]; fhir:Observation.effectiveDateTime [ fhir:value "2016-12-15"^^xsd:date]; fhir:Observation.specimen [ fhir:link <http://hl7.org/fhir/Specimen/120>; fhir:Reference.reference [ fhir:value "Specimen/120" ]; fhir:Reference.display [ fhir:value "buccal swab from Mary Chalmers" ] ]; fhir:Observation.derivedFrom [ fhir:index 0; fhir:Reference.reference [ fhir:value "urn:uuid:2ae2ff34-279e-43c2-9018-b054fd3fc1ce" ]; fhir:Reference.display [ fhir:value "HLA-C*03:04:01:01, exon 2" ] ], [ fhir:index 1; fhir:Reference.reference [ fhir:value "urn:uuid:19153ef1-68c6-47a2-9676-c4eefbd39af9" ]; fhir:Reference.display [ fhir:value "HLA-C*03:04:01:01, exon 3" ] ] . <urn:uuid:0e0a780e-4486-4cd0-bfae-7243c579f208> a fhir:Observation; fhir:DomainResource.text [ fhir:Narrative.status [ fhir:value "generated" ]; fhir:Narrative.div "<div xmlns=\"http://www.w3.org/1999/xhtml\">\n <pre>HLA-C*01:02:01G+HLA-C*03:04:01G</pre>\n </div>" ]; fhir:DomainResource.extension [ fhir:index 0; fhir:Extension.url [ fhir:value "http://hl7.org/fhir/StructureDefinition/observation-geneticsGene" ]; fhir:Extension.valueCodeableConcept [ fhir:CodeableConcept.coding [ fhir:index 0; fhir:Coding.system [ fhir:value "http://www.genenames.org" ]; fhir:Coding.code [ fhir:value "HGNC:4933" ]; fhir:Coding.display [ fhir:value "HLA-C" ] ] ] ], [ fhir:index 1; fhir:Extension.url [ fhir:value "http://hl7.org/fhir/StructureDefinition/observation-geneticsGenomicSourceClass" ]; fhir:Extension.valueCodeableConcept [ fhir:CodeableConcept.coding [ fhir:index 0; a loinc:LA6683-2; fhir:Coding.system [ fhir:value "http://loinc.org" ]; fhir:Coding.code [ fhir:value "LA6683-2" ]; fhir:Coding.display [ fhir:value "germline" ] ] ] ]; fhir:Observation.status [ fhir:value "final"]; fhir:Observation.code [ fhir:CodeableConcept.coding [ fhir:index 0; a loinc:77636-9; fhir:Coding.system [ fhir:value "http://loinc.org" ]; fhir:Coding.code [ fhir:value "77636-9" ]; fhir:Coding.display [ fhir:value "HLA-C [Type] by High resolution" ] ] ]; fhir:Observation.subject [ fhir:link <http://hl7.org/fhir/Patient/119>; fhir:Reference.reference [ fhir:value "Patient/119" ]; fhir:Reference.display [ fhir:value "Mary Chalmers" ] ]; fhir:Observation.effectiveDateTime [ fhir:value "2016-12-15"^^xsd:date]; fhir:Observation.specimen [ fhir:link <http://hl7.org/fhir/Specimen/120>; fhir:Reference.reference [ fhir:value "Specimen/120" ]; fhir:Reference.display [ fhir:value "buccal swab from Mary Chalmers" ] ]; fhir:Observation.derivedFrom [ fhir:index 0; fhir:Reference.reference [ fhir:value "urn:uuid:709c5315-9403-4867-9d82-0b953836665f" ]; fhir:Reference.display [ fhir:value "HLA-C*01:02:01G, exons 2 and 3" ] ], [ fhir:index 1; fhir:Reference.reference [ fhir:value "urn:uuid:8b2aa21c-1426-4717-8ab0-a84d83df7d47" ]; fhir:Reference.display [ fhir:value "HLA-C*03:04:01G, exons 2 and 3" ] ] . # - ontology header ------------------------------------------------------------ <http://hl7.org/fhir/Bundle/hla-1.ttl> a owl:Ontology; owl:imports fhir:fhir.ttl; owl:versionIRI <http://build.fhir.org/Bundle/hla-1.ttl> . # -------------------------------------------------------------------------------------
Usage note: every effort has been made to ensure that the examples are correct and useful, but they are not a normative part of the specification.