Identifies what sort of change is permitted or has occurred between the therapy that was ordered and the therapy that was/will be provided.
               
 | Level | Code | Display | Definition | 
 | 1 | (_ActSubstanceAdminSubstitutionCode) |   | 
                        
                           Description: Substitution occurred or is permitted with another product that may potentially have different ingredients, but having the same biological and therapeutic effects. 
                      | 
 | 2 |   E  | equivalent | 
                        
                           Description: Substitution occurred or is permitted with another bioequivalent and therapeutically equivalent product. 
                      | 
 | 3 |     EC  | equivalent composition | 
                        
                           Description: 
                         
                        Substitution occurred or is permitted with another product that is a: 
                        
                           pharmaceutical alternative containing the same active ingredient but is formulated with different salt, ester
                           pharmaceutical equivalent that has the same active ingredient, strength, dosage form and route of administration
                        
                        
                           Examples: 
                         
                        
                           
                              Pharmaceutical alternative: Erythromycin Ethylsuccinate for Erythromycin Stearate
                           
                              Pharmaceutical equivalent: Lisonpril for Zestril
                        
                      | 
 | 4 |       BC  | brand composition | 
                        
                           Description: 
                         
                        Substitution occurred or is permitted between equivalent Brands but not Generics 
                        
                           Examples: 
                         
                        
                           Zestril  for Prinivil
                           Coumadin for Jantoven
                        
                      | 
 | 4 |       G  | generic composition | 
                        
                           Description: Substitution occurred or is permitted between equivalent Generics but not Brands 
                        
                           Examples: 
                         
                        
                           Lisnopril (Lupin Corp) for Lisnopril (Wockhardt Corp)
                        
                      | 
 | 3 |     TE  | therapeutic alternative | 
                        
                           Description: Substitution occurred or is permitted with another product having the same therapeutic objective and safety profile. 
                        
                           Examples: 
                         
                        
                           ranitidine for Tagamet
                        
                      | 
 | 4 |       TB  | therapeutic brand | 
                        
                           Description: Substitution occurred or is permitted between therapeutically equivalent Brands but not Generics 
>
                           Examples: 
                         
                        
                           Zantac for Tagamet
                        
                      | 
 | 4 |       TG  | therapeutic generic | 
                        
                           Description: Substitution occurred or is permitted between therapeutically equivalent Generics but not Brands 
>
                           Examples: 
                         
                        
                           Ranitidine  for cimetidine
                        
                      | 
 | 2 |   F  | formulary | 
                        
                           Description: This substitution was performed or is permitted based on formulary guidelines.  
                      | 
 | 2 |   N  | none | 
                        No substitution occurred or is permitted. 
                      |